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Effect of marital status on duodenal adenocarcinoma survival: A Surveillance Epidemiology and End Results population analysis

  • Authors:
    • Na Wang
    • Qingting Bu
    • Qingqing Liu
    • Jin Yang
    • Hairong He
    • Jie Liu
    • Xuequn Ren
    • Jun Lyu
  • View Affiliations / Copyright

    Affiliations: Clinical Research Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, Department of Genetics, Northwest Women's and Children's Hospital, Xi'an, Shaanxi 710061, P.R. China, School of Nursing and Health, Henan University, Kaifeng, Henan 475001, P.R. China, Center for Evidence‑Based Medicine and Clinical Research, Huaihe Hospital of Henan University, Kaifeng, Henan 475000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1904-1914
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    Published online on: June 14, 2019
       https://doi.org/10.3892/ol.2019.10475
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Abstract

Numerous studies have shown that marital status may be a prognostic factor in various malignancies, but little is known about its effect on duodenal adenocarcinoma. The aim of the present study was to determine the association between marital status and survival in patients with duodenal adenocarcinoma. The Surveillance, Epidemiology and End Results database was utilized to analyze 2,018 patients who had been diagnosed with duodenal adenocarcinoma between January 2004 and December 2015. Kaplan‑Meier and Cox regression analyses were also used to determine the impact of marital status on overall survival (OS) and cause‑specific survival (CSS). The 5‑year OS rate was higher in married patients (32.6%) compared with unmarried (26.8%) patients (P<0.001), as was the 5‑year CSS rate (38.8 vs. 33.7%; P<0.001). Multivariate analysis demonstrated that marital status was an independent prognostic factor for duodenal adenocarcinoma, with married patients having improved OS (P<0.001) and CSS (P=0.001) compared with unmarried patients. Subgroup analysis showed that marital status played a role in the survival of patients at American Joint Committee on Cancer Tumor‑Node‑Metastasis stage I, but not of patients at stages II, III or IV. The survival outcomes for duodenal adenocarcinoma are improved in married patients compared with those in unmarried patients. Therefore, attention should be paid to the impact of social factors and socio‑economic factors on unmarried patients, in order to improve their survival outcomes.
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Copy and paste a formatted citation
Spandidos Publications style
Wang N, Bu Q, Liu Q, Yang J, He H, Liu J, Ren X and Lyu J: Effect of marital status on duodenal adenocarcinoma survival: A Surveillance Epidemiology and End Results population analysis. Oncol Lett 18: 1904-1914, 2019.
APA
Wang, N., Bu, Q., Liu, Q., Yang, J., He, H., Liu, J. ... Lyu, J. (2019). Effect of marital status on duodenal adenocarcinoma survival: A Surveillance Epidemiology and End Results population analysis. Oncology Letters, 18, 1904-1914. https://doi.org/10.3892/ol.2019.10475
MLA
Wang, N., Bu, Q., Liu, Q., Yang, J., He, H., Liu, J., Ren, X., Lyu, J."Effect of marital status on duodenal adenocarcinoma survival: A Surveillance Epidemiology and End Results population analysis". Oncology Letters 18.2 (2019): 1904-1914.
Chicago
Wang, N., Bu, Q., Liu, Q., Yang, J., He, H., Liu, J., Ren, X., Lyu, J."Effect of marital status on duodenal adenocarcinoma survival: A Surveillance Epidemiology and End Results population analysis". Oncology Letters 18, no. 2 (2019): 1904-1914. https://doi.org/10.3892/ol.2019.10475
Copy and paste a formatted citation
x
Spandidos Publications style
Wang N, Bu Q, Liu Q, Yang J, He H, Liu J, Ren X and Lyu J: Effect of marital status on duodenal adenocarcinoma survival: A Surveillance Epidemiology and End Results population analysis. Oncol Lett 18: 1904-1914, 2019.
APA
Wang, N., Bu, Q., Liu, Q., Yang, J., He, H., Liu, J. ... Lyu, J. (2019). Effect of marital status on duodenal adenocarcinoma survival: A Surveillance Epidemiology and End Results population analysis. Oncology Letters, 18, 1904-1914. https://doi.org/10.3892/ol.2019.10475
MLA
Wang, N., Bu, Q., Liu, Q., Yang, J., He, H., Liu, J., Ren, X., Lyu, J."Effect of marital status on duodenal adenocarcinoma survival: A Surveillance Epidemiology and End Results population analysis". Oncology Letters 18.2 (2019): 1904-1914.
Chicago
Wang, N., Bu, Q., Liu, Q., Yang, J., He, H., Liu, J., Ren, X., Lyu, J."Effect of marital status on duodenal adenocarcinoma survival: A Surveillance Epidemiology and End Results population analysis". Oncology Letters 18, no. 2 (2019): 1904-1914. https://doi.org/10.3892/ol.2019.10475
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