Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
September-2019 Volume 18 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2019 Volume 18 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Antibiotic use is a negative predictor of the efficacy and toxicity of epidermal growth factor receptor‑targeted therapy in advanced non‑small cell lung cancer

  • Authors:
    • Kejun Liu
    • Weiwei Zhang
    • Qinquan Tan
    • Guanming Jiang
    • Jun Jia
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Dongguan Institute for Clinical Cancer Research, Dongguan People's Hospital, Southern Medical University, Dongguan, Guangdong 523059, P.R. China, Department of Oncology, The Fifth People's Hospital of Chengdu, Chengdu, Sichuan 611130, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2677-2683
    |
    Published online on: June 14, 2019
       https://doi.org/10.3892/ol.2019.10481
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Non‑small cell lung cancer (NSCLC) is closely associated with inflammation and chronic infection. Antibiotics are frequently prescribed for NSCLC patients in combination with epidermal growth factor receptor (EGFR)‑targeted treatment in the presence of infection. The association between antibiotic use and the efficacy of EGFR tyrosine kinase inhibitors (EGFR‑TKIs) has not previously been thoroughly investigated. Therefore, the present study investigated whether antibiotics could affect the efficacy and toxicity of EGFR‑TKI treatment, with the aim of restricting the use of antibiotics in combination with targeted therapy in patients with advanced NSCLC in the near future. All patients received treatment with EGFR‑TKIs until disease progression, unacceptable toxicity or other factors, including death, pregnancy or unwillingness to further receive targeted therapy, were observed. Patients were retrospectively divided into two groups: Group A, which was treated with EGFR‑TKIs and antibiotics; and Group B, which was treated with EGFR‑TKIs alone. Patients having used antibiotics 6 months prior to EGFR‑TKI therapy were also included in the study. Antibiotic use negatively affected the median progression‑free survival (PFS) following EGFR‑TKI treatment in NSCLC compared with that in patients not treated with antibiotics; median PFS in Group A was 6.6 months, whereas median PFS in Group B was 10.1 months. Antibiotics also increased the toxicity of targeted therapy for advanced NSCLC. There were significant statistical differences between the two groups in the occurrence of the adverse events of diarrhea and dyspnea. In conclusion, antibiotics decreased the efficacy of first‑line targeted therapy in advanced NSCLC and increased incidences of diarrhea and dyspnea. Large randomized studies are needed to identify the impact of antibiotic use on EGFR‑TKI treatment for NSCLC.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2017. CA Cancer J Clin. 67:7–30. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Visbal AL, Leighl NB, Feld R and Shepherd FA: Adjuvant chemotherapy for early-stage non-small cell lung cancer. Chest. 128:2933–2943. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Chen F, Cole P and Bina WF: Time trend and geographic patterns of lung adenocarcinoma in the United States, 1973–2002. Cancer Epidemiol Biomarkers Prev. 16:2724–2729. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Zatloukal P, Petruzelka L, Zemanova M, Kolek V, Skricková J, Pesek M, Fojtů H, Grygárková I, Sixtová D, Roubec J, et al: Gemcitabine plus cisplatin vs. gemcitabine plus carboplatin in stage IIIb and IV non-small cell lung cancer: A phase III randomized trial. Lung Cancer. 41:321–331. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Mok TS, Wu YL, Thongprasert S, Yang CH, Chu DT, Saijo N, Sunpaweravong P, Han B, Margono B, Ichinose Y, et al: Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med. 361:947–957. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Kris MG, Natale RB, Herbst RS, Lynch TJ Jr, Prager D, Belani CP, Schiller JH, Kelly K, Spiridonidis H, Sandler A, et al: Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: A randomized trial. JAMA. 290:2149–2158. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Perez-Soler R, Chachoua A, Hammond LA, Rowinsky EK, Huberman M, Karp D, Rigas J, Clark GM, Santabárbara P and Bonomi P: Determinants of tumor response and survival with erlotinib in patients with non-small-cell lung cancer. J Clin Oncol. 22:3238–3247. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Gomes M, Teixeira AL, Coelho A, Araújo A and Medeiros R: The role of inflammation in lung cancer. Adv Exp Med Biol. 816:1–23. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Shiels MS, Pfeiffer RM, Hildesheim A, Engels EA, Kemp TJ, Park JH, Katki HA, Koshiol J, Shelton G, Caporaso NE, et al: Circulating inflammation markers and prospective risk for lung cancer. J Natl Cancer Inst. 105:1871–1880. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Hsu-Kim C, Hoag JB, Cheng GS and Lund ME: The microbiology of postobstructive pneumonia in lung cancer patients. J Bronchology Interv Pulmonol. 20:266–270. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Huemer F, Rinnerthaler G, Westphal T, Hackl H, Hutarew G, Gampenrieder SP, Weiss L and Greil R: Impact of antibiotic treatment on immune-checkpoint blockade efficacy in advanced non-squamous non-small cell lung cancer. Oncotarget. 9:16512–16520. 2018. View Article : Google Scholar : PubMed/NCBI

12 

van Vliet MJ, Harmsen HJ, de Bont ES and Tissing WJ: The role of intestinal microbiota in the development and severity of chemotherapy-induced mucositis. PLoS Pathog. 6:e10008792010. View Article : Google Scholar : PubMed/NCBI

13 

Marin M, Gudiol C, Ardanuy C, Garcia-Vidal C, Calvo M, Arnan M and Carratalà J: Bloodstream infections in neutropenic patients with cancer: Differences between patients with haematological malignancies and solid tumours. J Infect. 69:417–423. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Shi YK, Wang L, Han BH, Li W, Yu P, Liu YP, Ding CM, Song X, Ma ZY, Ren XL, et al: First-line icotinib versus cisplatin/pemetrexed plus pemetrexed maintenance therapy for patients with advanced EGFR mutation-positive lung adenocarcinoma (CONVINCE): A phase 3, open-label, randomized study. Ann Oncol. 28:2443–2450. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Wu YL, Zhou C, Hu CP, Feng J, Lu S, Huang Y, Li W, Hou M, Shi JH, Lee KY, et al: Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancer harbouring EGFR mutations (LUX-Lung 6): An open-label, randomised phase 3 trial. Lancet Oncol. 15:213–222. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Broderick JM, Hussey J, Kennedy MJ and O'Donnell DM: Patients over 65 years are assigned lower ECOG PS scores than younger patients, although objectively measured physical activity is no different. J Geriatr Oncol. 5:49–56. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Zhang S, Liang F and Tannock I: Use and misuse of common terminology criteria for adverse events in cancer clinical trials. BMC Cancer. 16:3922016. View Article : Google Scholar : PubMed/NCBI

18 

Beck TF, Mullikin JC; NISC Comparative Sequencing Program, ; Biesecker LG: Systematic evaluation of sanger validation of next-generation sequencing variants. Clin Chem. 62:647–654. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Timmer-Bonte JN, de Boo TM, Smit HJ, Biesma B, Wilschut FA, Cheragwandi SA, Termeer A, Hensing CA, Akkermans J, Adang EM, et al: Prevention of chemotherapy-induced febrile neutropenia by prophylactic antibiotics plus or minus granulocyte colony-stimulating factor in small-cell lung cancer: A Dutch Randomized Phase III Study. J Clin Oncol. 23:7974–7984. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Le Bastard Q, Ward T, Sidiropoulos D, Hillmann BM, Chun CL, Sadowsky MJ, Knights D and Montassier E: Fecal microbiota transplantation reverses antibiotic and chemotherapy-induced gut dysbiosis in mice. Sci Rep. 8:62192018. View Article : Google Scholar : PubMed/NCBI

21 

Routy B, Le Chatelier E, Derosa L, Duong CPM, Alou MT, Daillère R, Fluckiger A, Messaoudene M, Rauber C, Roberti MP, et al: Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors. Science. 359:91–97. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Zaura E, Brandt BW, Teixeira de Mattos MJ, Buijs MJ, Caspers MP, Rashid MU, Weintraub A, Nord CE, Savell A, Hu Y, et al: Same exposure but two radically different responses to antibiotics: Resilience of the salivarymicrobiome versus long-term microbial shifts in feces. MBio. 6:e01693–e01615. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Clemente JC, Ursell LK, Parfrey LW and Knight R: The impact of the gut microbiota on human health: An integrative view. Cell. 148:1258–1270. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Modi SR, Collins JJ and Relman DA: Antibiotics and the gut microbiota. J Clin Invest. 124:4212–4218. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Roberts SE, Wotton CJ, Williams JG, Griffith M and Goldacre MJ: Perinatal and early life risk factors for inflammatory bowel disease. World J Gastroenterol. 17:743–749. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Willing BP, Russell SL and Finlay BB: Shifting the balance: Antibiotic effects on host-microbiota mutualism. Nat Rev Microbiol. 9:233–243. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu K, Zhang W, Tan Q, Jiang G and Jia J: Antibiotic use is a negative predictor of the efficacy and toxicity of epidermal growth factor receptor‑targeted therapy in advanced non‑small cell lung cancer. Oncol Lett 18: 2677-2683, 2019.
APA
Liu, K., Zhang, W., Tan, Q., Jiang, G., & Jia, J. (2019). Antibiotic use is a negative predictor of the efficacy and toxicity of epidermal growth factor receptor‑targeted therapy in advanced non‑small cell lung cancer. Oncology Letters, 18, 2677-2683. https://doi.org/10.3892/ol.2019.10481
MLA
Liu, K., Zhang, W., Tan, Q., Jiang, G., Jia, J."Antibiotic use is a negative predictor of the efficacy and toxicity of epidermal growth factor receptor‑targeted therapy in advanced non‑small cell lung cancer". Oncology Letters 18.3 (2019): 2677-2683.
Chicago
Liu, K., Zhang, W., Tan, Q., Jiang, G., Jia, J."Antibiotic use is a negative predictor of the efficacy and toxicity of epidermal growth factor receptor‑targeted therapy in advanced non‑small cell lung cancer". Oncology Letters 18, no. 3 (2019): 2677-2683. https://doi.org/10.3892/ol.2019.10481
Copy and paste a formatted citation
x
Spandidos Publications style
Liu K, Zhang W, Tan Q, Jiang G and Jia J: Antibiotic use is a negative predictor of the efficacy and toxicity of epidermal growth factor receptor‑targeted therapy in advanced non‑small cell lung cancer. Oncol Lett 18: 2677-2683, 2019.
APA
Liu, K., Zhang, W., Tan, Q., Jiang, G., & Jia, J. (2019). Antibiotic use is a negative predictor of the efficacy and toxicity of epidermal growth factor receptor‑targeted therapy in advanced non‑small cell lung cancer. Oncology Letters, 18, 2677-2683. https://doi.org/10.3892/ol.2019.10481
MLA
Liu, K., Zhang, W., Tan, Q., Jiang, G., Jia, J."Antibiotic use is a negative predictor of the efficacy and toxicity of epidermal growth factor receptor‑targeted therapy in advanced non‑small cell lung cancer". Oncology Letters 18.3 (2019): 2677-2683.
Chicago
Liu, K., Zhang, W., Tan, Q., Jiang, G., Jia, J."Antibiotic use is a negative predictor of the efficacy and toxicity of epidermal growth factor receptor‑targeted therapy in advanced non‑small cell lung cancer". Oncology Letters 18, no. 3 (2019): 2677-2683. https://doi.org/10.3892/ol.2019.10481
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team