Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
August-2019 Volume 18 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2019 Volume 18 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Prognostic value of the mRNA expression of gap junction α members in patients with gastric cancer

  • Authors:
    • Xuan Zhao
    • Chaoran Yu
    • Minhua Zheng
    • Jing Sun
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1669-1678
    |
    Published online on: June 21, 2019
       https://doi.org/10.3892/ol.2019.10516
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Gastric cancer remains one of the primary causes of cancer‑associated death worldwide. The gap junction α (GJA) family has been demonstrated to be involved in the cellular proliferation and metastasis of gastric cancer. However, the prognostic value of GJA in gastric cancer is yet to be elucidated. In the present study, the overall survival (OS) of patients with gastric cancer and the mRNA expression of GJA family members, including GJA1, GJA3, GJA4, GJA10 and GJA12, were analyzed using 593 patients with gastric cancer from the Kaplan‑Meier plotter database. High GJA1 and GJA10 mRNA expression levels were associated with a poorer patient outcome (P=0.0066 and P=0.015, respectively), whereas high mRNA expression levels of GJA4 and GJA12 were associated with longer survival times (P=0.0056 and P=0.0054, respectively). Furthermore, the values of specific prognostic indicators of different subtypes of gastric cancer, including human epidermal growth factor receptor 2 status, Lauren differentiation and tumor stage, were also analyzed. The findings of the present study suggested a potential role for GJA family members in gastric cancer, which warrants further investigation.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2017. CA Cancer J Clin. 67:7–30. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Balakrishnan M, George R, Sharma A and Graham DY: Changing trends in stomach cancer throughout the world. Curr Gastroenterol Rep. 19:362017. View Article : Google Scholar : PubMed/NCBI

3 

Goodenough DA and Paul DL: Gap junctions. Cold Spring Harb Perspect Biol. 1:a0025762009. View Article : Google Scholar : PubMed/NCBI

4 

Sohl G and Willecke K: Gap junctions and the connexin protein family. Cardiovasc Res. 62:228–232. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Naoi Y, Miyoshi Y, Taguchi T, Kim SJ, Arai T, Tamaki Y and Noguchi S: Connexin26 expression is associated with lymphatic vessel invasion and poor prognosis in human breast cancer. Breast Cancer Res Treat. 106:11–17. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Elzarrad MK, Haroon A, Willecke K, Dobrowolski R, Gillespie MN and Al-Mehdi AB: Connexin-43 upregulation in micrometastases and tumor vasculature and its role in tumor cell attachment to pulmonary endothelium. BMC Med. 6:202008. View Article : Google Scholar : PubMed/NCBI

7 

Laird DW: The gap junction proteome and its relationship to disease. Trends Cell Biol. 20:92–101. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Naus CC and Laird DW: Implications and challenges of connexin connections to cancer. Nat Rev Cancer. 10:435–441. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Czyz J: The stage-specific function of gap junctions during tumourigenesis. Cell Mol Biol Lett. 13:92–102. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Szasz AM, Lánczky A, Nagy A, Förster S, Hark K, Green JE, Boussioutas A, Busuttil R, Szabo A and Gyorffy B: Cross-validation of survival associated biomarkers in gastric cancer using transcriptomic data of 1,065 patients. Oncotarget. 7:49322–49333. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Jiang JX and Gu S: Gap junction- and hemichannel-independent actions of connexins. Biochim Biophys Acta. 1711:208–214. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Beyer EC and Berthoud VM: Gap junction structure: Unraveled, but not fully revealed. F1000Res. 6:5682017. View Article : Google Scholar : PubMed/NCBI

13 

Puebla C, Cisterna BA, Salas DP, Delgado-Lopez F, Lampe PD and Saez JC: Linoleic acid permeabilizes gastric epithelial cells by increasing connexin 43 levels in the cell membrane via a GPR40- and Akt-dependent mechanism. Biochim Biophys Acta. 1861:439–448. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Fasciani I, Temperan A, Perez-Atencio LF, Escudero A, Martinez-Montero P, Molano J, Gomez-Hernandez JM, Paino CL, Gonzalez-Nieto D and Barrio LC: Regulation of connexin hemichannel activity by membrane potential and the extracellular calcium in health and disease. Neuropharmacology. 75:479–490. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Maes M, Cogliati B, Crespo Yanguas S, Willebrords J and Vinken M: Roles of connexins and pannexins in digestive homeostasis. Cell Mol Life Sci. 72:2809–2821. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Carette D, Gilleron J, Chevallier D, Segretain D and Pointis G: Connexin a check-point component of cell apoptosis in normal and physiopathological conditions. Biochimie. 101:1–9. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Liu X, Furuya T, Li D, Xu J, Cao X, Li Q, Xu J, Xu Z, Sasaki K and Liu X: Connexin 26 expression correlates with less aggressive phenotype of intestinal type-gastric carcinomas. Int J Mol Med. 25:709–716. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Wang Y, Huang LH, Xu CX, Xiao J, Zhou L, Cao D, Liu XM and Qi Y: Connexin 32 and 43 promoter methylation in Helicobacter pylori-associated gastric tumorigenesis. World J Gastroenterol. 20:11770–11779. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Liu X, Cao K, Xu C, Hu T, Zhou L, Cao D, Xiao J, Luo L, Guo Y and Qi Y: GATA-3 augmentation down-regulates Connexin43 in Helicobacter pylori associated gastric carcinogenesis. Cancer Biol Ther. 16:987–996. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Yahiro K, Hirayama T, Moss J and Noda M: Helicobacter pylori VacA toxin causes cell death by inducing accumulation of cytoplasmic connexin 43. Cell Death Dis. 6:e19712015. View Article : Google Scholar : PubMed/NCBI

21 

Radin JN, Gonzalez-Rivera C, Frick-Cheng AE, Sheng J, Gaddy JA, Rubin DH, Algood HM, McClain MS and Cover TL: Role of connexin 43 in Helicobacter pylori VacA-induced cell death. Infect Immu. 82:423–432. 2014. View Article : Google Scholar

22 

Tang B, Peng ZH, Yu PW, Yu G and Qian F: Expression and significance of Cx43 and E-cadherin in gastric cancer and metastatic lymph nodes. Med Oncol. 28:502–508. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Tang B, Peng ZH, Yu PW, Yu G, Qian F, Zeng DZ, Zhao YL, Shi Y, Hao YX and Luo HX: Aberrant expression of Cx43 is associated with the peritoneal metastasis of gastric cancer and Cx43-mediated gap junction enhances gastric cancer cell diapedesis from peritoneal mesothelium. PLoS One. 8:e745272013. View Article : Google Scholar : PubMed/NCBI

24 

Liu D, Zhou H, Wu J, Liu W, Li Y, Shi G, Yue X, Sun X, Zhao Y, Hu X, et al: Infection by Cx43 adenovirus increased chemotherapy sensitivity in human gastric cancer BGC-823 cells: Not involving in induction of cell apoptosis. Gene. 574:217–224. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Yeh ES, Williams CJ, Williams CB, Bonilla IV, Klauber-DeMore N and Phillips SL: Dysregulated connexin 43 in HER2-positive drug resistant breast cancer cells enhances proliferation and migration. Oncotarget. 8:109358–109369. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Teleki I, Szasz AM, Maros ME, Gyorffy B, Kulka J, Meggyeshazi N, Kiszner G, Balla P, Samu A and Krenacs T: Correlations of differentially expressed gap junction connexins Cx26, Cx30, Cx32, Cx43 and Cx46 with breast cancer progression and prognosis. PLoS One. 9:e1125412014. View Article : Google Scholar : PubMed/NCBI

27 

Teleki I, Krenacs T, Szasz MA, Kulka J, Wichmann B, Leo C, Papassotiropoulos B, Riemenschnitter C, Moch H and Varga Z: The potential prognostic value of connexin 26 and 46 expression in neoadjuvant-treated breast cancer. BMC Cancer. 13:502013. View Article : Google Scholar : PubMed/NCBI

28 

Banerjee D, Gakhar G, Madgwick D, Hurt A, Takemoto D and Nguyen TA: A novel role of gap junction connexin46 protein to protect breast tumors from hypoxia. Int J Cancer. 127:839–848. 2010.PubMed/NCBI

29 

Yuan L, Guo Y, Yi J, Xiao J, Yuan J, Xiong W, Xu H, Yang Z, Zhang J and Deng H: Identification of a novel GJA3 mutation in congenital nuclear cataract. Optom Vis Sci. 92:337–342. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Morel S, Burnier L, Roatti A, Chassot A, Roth I, Sutter E, Galan K, Pfenniger A, Chanson M and Kwak BR: Unexpected role for the human Cx37 C1019T polymorphism in tumour cell proliferation. Carcinogenesis. 31:1922–1931. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Good ME, Nelson TK, Simon AM and Burt JM: A functional channel is necessary for growth suppression by Cx37. J Cell Sci. 124:2448–2456. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Jing Y, Guo S, Zhang X, Sun A, Tao F, Ju H and Qian H: Effects of small interfering RNA interference of connexin 37 on subcutaneous gastric tumours in mice. Mol Med Rep. 10:2955–2960. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Sohl G, Joussen A, Kociok N and Willecke K: Expression of connexin genes in the human retina. BMC Ophthalmol. 10:272010. View Article : Google Scholar : PubMed/NCBI

34 

Shen B, Fang T, Dai M, Jones G and Zhang S: Independent losses of visual perception genes Gja10 and Rbp3 in echolocating bats (Order: Chiroptera). PLoS One. 8:e688672013. View Article : Google Scholar : PubMed/NCBI

35 

Alvi MA, Liu X, O'Donovan M, Newton R, Wernisch L, Shannon NB, Shariff K, di Pietro M, Bergman JJ, Ragunath K and Fitzgerald RC: DNA methylation as an adjunct to histopathology to detect prevalent, inconspicuous dysplasia and early-stage neoplasia in Barrett's esophagus. Clin Cancer Res. 19:878–888. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Finegold DN, Baty CJ, Knickelbein KZ, Perschke S, Noon SE, Campbell D, Karlsson JM, Huang D, Kimak MA, Lawrence EC, et al: Connexin 47 mutations increase risk for secondary lymphedema following breast cancer treatment. Clin Cancer Res. 18:2382–2390. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Kang KS, Yun JW, Yoon B, Lim YK and Lee YS: Preventive effect of germanium dioxide on the inhibition of gap junctional intercellular communication by TPA. Cancer Lett. 166:147–153. 2001. View Article : Google Scholar : PubMed/NCBI

38 

Yamasaki H, Krutovskikh V, Mesnil M, Tanaka T, Zaidan-Dagli ML and Omori Y: Role of connexin (gap junction) genes in cell growth control and carcinogenesis. C R Acad Sci III. 322:151–159. 1999. View Article : Google Scholar : PubMed/NCBI

39 

Yamasaki H, Omori Y, Zaidan-Dagli ML, Mironov N, Mesnil M and Krutovskikh V: Genetic and epigenetic changes of intercellular communication genes during multistage carcinogenesis. Cancer Detect Prev. 23:273–279. 1999. View Article : Google Scholar : PubMed/NCBI

40 

Ruch RJ, Porter S, Koffler LD, Dwyer-Nield LD and Malkinson AM: Defective gap junctional intercellular communication in lung cancer: Loss of an important mediator of tissue homeostasis and phenotypic regulation. Exp Lung Res. 27:231–243. 2001. View Article : Google Scholar : PubMed/NCBI

41 

Trosko JE: The role of stem cells and gap junctional intercellular communication in carcinogenesis. J Biochem Mol Biol. 36:43–48. 2003.PubMed/NCBI

42 

Trosko JE and Ruch RJ: Cell-cell communication in carcinogenesis. Front Biosci. 3:d208–d236. 1998. View Article : Google Scholar : PubMed/NCBI

43 

Gravalos C and Jimeno A: HER2 in gastric cancer: A new prognostic factor and a novel therapeutic target. Ann Oncol. 19:1523–1529. 2008. View Article : Google Scholar : PubMed/NCBI

44 

Kanczuga-Koda L, Sulkowski S, Lenczewski A, Koda M, Wincewicz A, Baltaziak M and Sulkowska M: Increased expression of connexins 26 and 43 in lymph node metastases of breast cancer. J Clin Pathol. 59:429–433. 2006. View Article : Google Scholar : PubMed/NCBI

45 

Ezumi K, Yamamoto H, Murata K, Higashiyama M, Damdinsuren B, Nakamura Y, Kyo N, Okami J, Ngan CY, Takemasa I, et al: Aberrant expression of connexin 26 is associated with lung metastasis of colorectal cancer. Clin Cancer Res. 14:677–684. 2008. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhao X, Yu C, Zheng M and Sun J: Prognostic value of the mRNA expression of gap junction α members in patients with gastric cancer. Oncol Lett 18: 1669-1678, 2019.
APA
Zhao, X., Yu, C., Zheng, M., & Sun, J. (2019). Prognostic value of the mRNA expression of gap junction α members in patients with gastric cancer. Oncology Letters, 18, 1669-1678. https://doi.org/10.3892/ol.2019.10516
MLA
Zhao, X., Yu, C., Zheng, M., Sun, J."Prognostic value of the mRNA expression of gap junction α members in patients with gastric cancer". Oncology Letters 18.2 (2019): 1669-1678.
Chicago
Zhao, X., Yu, C., Zheng, M., Sun, J."Prognostic value of the mRNA expression of gap junction α members in patients with gastric cancer". Oncology Letters 18, no. 2 (2019): 1669-1678. https://doi.org/10.3892/ol.2019.10516
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao X, Yu C, Zheng M and Sun J: Prognostic value of the mRNA expression of gap junction α members in patients with gastric cancer. Oncol Lett 18: 1669-1678, 2019.
APA
Zhao, X., Yu, C., Zheng, M., & Sun, J. (2019). Prognostic value of the mRNA expression of gap junction α members in patients with gastric cancer. Oncology Letters, 18, 1669-1678. https://doi.org/10.3892/ol.2019.10516
MLA
Zhao, X., Yu, C., Zheng, M., Sun, J."Prognostic value of the mRNA expression of gap junction α members in patients with gastric cancer". Oncology Letters 18.2 (2019): 1669-1678.
Chicago
Zhao, X., Yu, C., Zheng, M., Sun, J."Prognostic value of the mRNA expression of gap junction α members in patients with gastric cancer". Oncology Letters 18, no. 2 (2019): 1669-1678. https://doi.org/10.3892/ol.2019.10516
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team