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Molecular profiling of transcription factors pinpoints MYC‑estrogen related receptor α‑regulatory factor X5 panel for characterizing the immune microenvironment and predicting the efficacy of immune checkpoint inhibitors in renal cell carcinoma

  • Authors:
    • Fei Liu
    • Hongxia Zhang
    • Lihua Xue
    • Qiankun Yang
    • Wanchun Yan
  • View Affiliations / Copyright

    Affiliations: Department of Nephrology, The 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Lanzhou, Gansu 730000, P.R. China, Department of Emergency Medicine, The First Hospital of the Chinese People's Liberation Army, Lanzhou, Gansu 730000, P.R. China, Department of Obstetrics and Gynecology, The Family Planning Service Center for Maternal and Child Health in Zhouqu County, Lanzhou, Gansu 730000, P.R. China, Department of Bone and Soft Tissue, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning 110042, P.R. China, Department of Geriatrics, The First Hospital of the Chinese People's Liberation Army, Lanzhou, Gansu 730000, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1895-1903
    |
    Published online on: June 24, 2019
       https://doi.org/10.3892/ol.2019.10523
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Abstract

Transcription factors (TFs) play key roles in biological processes, and previous studies revealed that they can control oncogenic processes. However, the functional impact of TFs on the prognosis of patients with cancer has not been extensively elucidated. In the context of The Cancer Genome Atlas, few studies have focused on the roles of TFs in tumorigenesis. In the present study, a TF‑based robust MYC‑estrogen related receptor α‑regulatory factor X5 (MYC‑ESRRA‑RFX5) signature was developed for predicting the survival of patients with renal cell carcinoma. Functional enrichment analysis of this signature revealed that it was associated with the immune system of these patients. Further analysis demonstrated that this panel could characterize the immune microenvironment and potentially predicts the effectiveness of immune checkpoint inhibitors. Therefore, the present study recommends future exploration on TF‑based biomarkers for their potential as prognostic predictors. Overall, the highlights of this study are: i) This novel study pinpoints a TF panel for the robust prediction of renal cell carcinoma prognosis, and ii) the MYC‑ESRRA‑RFX5 panel is proposed as a signature for characterizing the immune microenvironment, and to potentially predict the effectiveness of immune checkpoint inhibitors.
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Copy and paste a formatted citation
Spandidos Publications style
Liu F, Zhang H, Xue L, Yang Q and Yan W: Molecular profiling of transcription factors pinpoints MYC‑estrogen related receptor α‑regulatory factor X5 panel for characterizing the immune microenvironment and predicting the efficacy of immune checkpoint inhibitors in renal cell carcinoma. Oncol Lett 18: 1895-1903, 2019.
APA
Liu, F., Zhang, H., Xue, L., Yang, Q., & Yan, W. (2019). Molecular profiling of transcription factors pinpoints MYC‑estrogen related receptor α‑regulatory factor X5 panel for characterizing the immune microenvironment and predicting the efficacy of immune checkpoint inhibitors in renal cell carcinoma. Oncology Letters, 18, 1895-1903. https://doi.org/10.3892/ol.2019.10523
MLA
Liu, F., Zhang, H., Xue, L., Yang, Q., Yan, W."Molecular profiling of transcription factors pinpoints MYC‑estrogen related receptor α‑regulatory factor X5 panel for characterizing the immune microenvironment and predicting the efficacy of immune checkpoint inhibitors in renal cell carcinoma". Oncology Letters 18.2 (2019): 1895-1903.
Chicago
Liu, F., Zhang, H., Xue, L., Yang, Q., Yan, W."Molecular profiling of transcription factors pinpoints MYC‑estrogen related receptor α‑regulatory factor X5 panel for characterizing the immune microenvironment and predicting the efficacy of immune checkpoint inhibitors in renal cell carcinoma". Oncology Letters 18, no. 2 (2019): 1895-1903. https://doi.org/10.3892/ol.2019.10523
Copy and paste a formatted citation
x
Spandidos Publications style
Liu F, Zhang H, Xue L, Yang Q and Yan W: Molecular profiling of transcription factors pinpoints MYC‑estrogen related receptor α‑regulatory factor X5 panel for characterizing the immune microenvironment and predicting the efficacy of immune checkpoint inhibitors in renal cell carcinoma. Oncol Lett 18: 1895-1903, 2019.
APA
Liu, F., Zhang, H., Xue, L., Yang, Q., & Yan, W. (2019). Molecular profiling of transcription factors pinpoints MYC‑estrogen related receptor α‑regulatory factor X5 panel for characterizing the immune microenvironment and predicting the efficacy of immune checkpoint inhibitors in renal cell carcinoma. Oncology Letters, 18, 1895-1903. https://doi.org/10.3892/ol.2019.10523
MLA
Liu, F., Zhang, H., Xue, L., Yang, Q., Yan, W."Molecular profiling of transcription factors pinpoints MYC‑estrogen related receptor α‑regulatory factor X5 panel for characterizing the immune microenvironment and predicting the efficacy of immune checkpoint inhibitors in renal cell carcinoma". Oncology Letters 18.2 (2019): 1895-1903.
Chicago
Liu, F., Zhang, H., Xue, L., Yang, Q., Yan, W."Molecular profiling of transcription factors pinpoints MYC‑estrogen related receptor α‑regulatory factor X5 panel for characterizing the immune microenvironment and predicting the efficacy of immune checkpoint inhibitors in renal cell carcinoma". Oncology Letters 18, no. 2 (2019): 1895-1903. https://doi.org/10.3892/ol.2019.10523
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