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Article Open Access

5‑Hydroxymethylcytosine as a potential epigenetic biomarker in papillary thyroid carcinoma

  • Authors:
    • Mengying Tong
    • Shuhang Gao
    • Wenjing Qi
    • Chang Shi
    • Meng Qiu
    • Fang Yang
    • Shanshan Bai
    • Husha Li
    • Zhizhou Wang
    • Zhigang Sun
    • Lina Wang
    • Ying Che
  • View Affiliations / Copyright

    Affiliations: Department of Ultrasound, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116044, P.R. China, Department of Pathology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116044, P.R. China, Clinical Laboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116044, P.R. China
    Copyright: © Tong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2304-2309
    |
    Published online on: June 27, 2019
       https://doi.org/10.3892/ol.2019.10531
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Abstract

DNA methylation at the 5 position of cytosine (5‑mC) is an epigenetic hallmark that is critical in various biological and pathological processes such as DNA methylation regulation, and initiation and development of cancers. 5‑mC can be oxidized to 5‑hydroxymethylcytosine (5‑hmC) by the ten‑eleven translocation family of DNA hydroxylases. Accumulating evidence has reported that loss of 5‑hmC is associated with cancer development. However, its level in papillary thyroid carcinoma (PTC) remains unclear. The present study reports that the loss of 5‑hmC is an epigenetic mark of PTCs, associated with their malignant biological behavior, providing diagnostic and predictive advantages over DNA hypomethylation (5‑mC), an acknowledged epigenetic alteration in cancer. In addition, the 5‑hmC staining levels were decreased in cases of micro‑carcinoma with lymph node metastasis, which suggests that 5‑hmC expression levels could be used as valuable biomarkers for predicting malignant potential and assist in the selection of therapeutic strategies in PTC; therefore, 5‑hmC has the potential to provide a more precise direction for PTC therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Tong M, Gao S, Qi W, Shi C, Qiu M, Yang F, Bai S, Li H, Wang Z, Sun Z, Sun Z, et al: 5‑Hydroxymethylcytosine as a potential epigenetic biomarker in papillary thyroid carcinoma. Oncol Lett 18: 2304-2309, 2019.
APA
Tong, M., Gao, S., Qi, W., Shi, C., Qiu, M., Yang, F. ... Che, Y. (2019). 5‑Hydroxymethylcytosine as a potential epigenetic biomarker in papillary thyroid carcinoma. Oncology Letters, 18, 2304-2309. https://doi.org/10.3892/ol.2019.10531
MLA
Tong, M., Gao, S., Qi, W., Shi, C., Qiu, M., Yang, F., Bai, S., Li, H., Wang, Z., Sun, Z., Wang, L., Che, Y."5‑Hydroxymethylcytosine as a potential epigenetic biomarker in papillary thyroid carcinoma". Oncology Letters 18.3 (2019): 2304-2309.
Chicago
Tong, M., Gao, S., Qi, W., Shi, C., Qiu, M., Yang, F., Bai, S., Li, H., Wang, Z., Sun, Z., Wang, L., Che, Y."5‑Hydroxymethylcytosine as a potential epigenetic biomarker in papillary thyroid carcinoma". Oncology Letters 18, no. 3 (2019): 2304-2309. https://doi.org/10.3892/ol.2019.10531
Copy and paste a formatted citation
x
Spandidos Publications style
Tong M, Gao S, Qi W, Shi C, Qiu M, Yang F, Bai S, Li H, Wang Z, Sun Z, Sun Z, et al: 5‑Hydroxymethylcytosine as a potential epigenetic biomarker in papillary thyroid carcinoma. Oncol Lett 18: 2304-2309, 2019.
APA
Tong, M., Gao, S., Qi, W., Shi, C., Qiu, M., Yang, F. ... Che, Y. (2019). 5‑Hydroxymethylcytosine as a potential epigenetic biomarker in papillary thyroid carcinoma. Oncology Letters, 18, 2304-2309. https://doi.org/10.3892/ol.2019.10531
MLA
Tong, M., Gao, S., Qi, W., Shi, C., Qiu, M., Yang, F., Bai, S., Li, H., Wang, Z., Sun, Z., Wang, L., Che, Y."5‑Hydroxymethylcytosine as a potential epigenetic biomarker in papillary thyroid carcinoma". Oncology Letters 18.3 (2019): 2304-2309.
Chicago
Tong, M., Gao, S., Qi, W., Shi, C., Qiu, M., Yang, F., Bai, S., Li, H., Wang, Z., Sun, Z., Wang, L., Che, Y."5‑Hydroxymethylcytosine as a potential epigenetic biomarker in papillary thyroid carcinoma". Oncology Letters 18, no. 3 (2019): 2304-2309. https://doi.org/10.3892/ol.2019.10531
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