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Article Open Access

Downregulating SynCAM and MPP6 expression is associated with ovarian cancer progression

  • Authors:
    • Feixue Xu
    • Xiaoqiang Si
    • Jingran Du
    • Feihua Xu
    • Aihong Yang
    • Caixia Zhang
    • Xiucai Zhang
    • Yongxiu Yang
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China, Department of Plastic Surgery, The Gansu Provincial Hospital, Lanzhou, Gansu 730000, P.R. China, Department of Labor and Environmental Health, The School of Public Health of Lanzhou University, Lanzhou, Gansu 730000, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2477-2483
    |
    Published online on: June 28, 2019
       https://doi.org/10.3892/ol.2019.10542
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Abstract

Synaptic cell adhesion molecules (SynCAMs) are single transmembrane proteins that belong to the immunoglobulin superfamily of cell adhesion molecules. In the present study, a decrease in SynCAM levels in ovarian tumor tissues compared with normal tissues is reported; the downregulation was accompanied by the grade malignancy. The observations suggested that SynCAM may be essential for important novel functions in ovarian cancer. Further experiments showed that low SynCAM expression inhibited membrane palmitoylated protein 6 (MPP6) expression, a member of the palmitoylated membrane protein subfamily of peripheral membrane‑associated guanylate kinases. In addition, low levels of MPP6 in ovarian tumor tissues correlated with shorter patient survival. A SynCAM‑regulated pathway may provide molecular targets for the treatment of ovarian cancer and novel biomarkers to be used in clinical diagnosis.
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Copy and paste a formatted citation
Spandidos Publications style
Xu F, Si X, Du J, Xu F, Yang A, Zhang C, Zhang X and Yang Y: Downregulating SynCAM and MPP6 expression is associated with ovarian cancer progression. Oncol Lett 18: 2477-2483, 2019.
APA
Xu, F., Si, X., Du, J., Xu, F., Yang, A., Zhang, C. ... Yang, Y. (2019). Downregulating SynCAM and MPP6 expression is associated with ovarian cancer progression. Oncology Letters, 18, 2477-2483. https://doi.org/10.3892/ol.2019.10542
MLA
Xu, F., Si, X., Du, J., Xu, F., Yang, A., Zhang, C., Zhang, X., Yang, Y."Downregulating SynCAM and MPP6 expression is associated with ovarian cancer progression". Oncology Letters 18.3 (2019): 2477-2483.
Chicago
Xu, F., Si, X., Du, J., Xu, F., Yang, A., Zhang, C., Zhang, X., Yang, Y."Downregulating SynCAM and MPP6 expression is associated with ovarian cancer progression". Oncology Letters 18, no. 3 (2019): 2477-2483. https://doi.org/10.3892/ol.2019.10542
Copy and paste a formatted citation
x
Spandidos Publications style
Xu F, Si X, Du J, Xu F, Yang A, Zhang C, Zhang X and Yang Y: Downregulating SynCAM and MPP6 expression is associated with ovarian cancer progression. Oncol Lett 18: 2477-2483, 2019.
APA
Xu, F., Si, X., Du, J., Xu, F., Yang, A., Zhang, C. ... Yang, Y. (2019). Downregulating SynCAM and MPP6 expression is associated with ovarian cancer progression. Oncology Letters, 18, 2477-2483. https://doi.org/10.3892/ol.2019.10542
MLA
Xu, F., Si, X., Du, J., Xu, F., Yang, A., Zhang, C., Zhang, X., Yang, Y."Downregulating SynCAM and MPP6 expression is associated with ovarian cancer progression". Oncology Letters 18.3 (2019): 2477-2483.
Chicago
Xu, F., Si, X., Du, J., Xu, F., Yang, A., Zhang, C., Zhang, X., Yang, Y."Downregulating SynCAM and MPP6 expression is associated with ovarian cancer progression". Oncology Letters 18, no. 3 (2019): 2477-2483. https://doi.org/10.3892/ol.2019.10542
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