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Case Report

Rapid decline of Philadelphia‑positive metaphases after nilotinib treatment in a cml patient expressing a rare e14a3 bcr‑abl1 fusion transcript: A case report

  • Authors:
    • Michele Massimino
    • Stefania Stella
    • Elena Tirrò
    • Maria Letizia Consoli
    • Maria Stella Pennisi
    • Adriana Puma
    • Silvia Rita Vitale
    • Chiara Romano
    • Valentina Zammit
    • Fabio Stagno
    • Francesco Di Raimondo
    • Livia Manzella
  • View Affiliations / Copyright

    Affiliations: Department of Clinical and Experimental Medicine, University of Catania, Catania I‑95123, Italy, Division of Hematology and Bone Marrow Transplant, A.O.U. Policlinico‑Vittorio Emanuele, Catania I‑95123, Italy
  • Pages: 2648-2653
    |
    Published online on: July 4, 2019
       https://doi.org/10.3892/ol.2019.10558
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Abstract

We report a case of chronic myeloid leukemia in a 52‑year‑old male expressing a rare e14a3 BCR‑ABL1 fusion transcript. Cytogenetic analysis showed the t(9;22) translocation and multiplex RT‑PCR detected an atypical fragment of approximately 230 base pairs. Using two primers recognizing exon 10 of BCR and exon 4 of ABL1, a larger PCR product was identified, cloned, sequenced and defined as an e14a3 BCR‑ABL1 rearrangement. The patient was treated with nilotinib and monitored measuring cytogenetic and hematological parameters, while BCR‑ABL1 transcripts were surveyed by conventional and semi‑nested PCR. The patient achieved a complete hematologic response after two months of treatment followed by a complete cytogenetic remission two months later. Furthermore, PCR and semi‑nested PCR failed to detect the e14a3 BCR‑ABL1 mRNA after 15 and 21 months of nilotinib, respectively.
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1 

Ren R: Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia. Nat Rev Cancer. 5:172–183. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Stella S, Tirrò E, Conte E, Stagno F, Di Raimondo F, Manzella L and Vigneri P: Suppression of survivin induced by a BCR-ABL/JAK2/STAT3 pathway sensitizes imatinib-resistant CML cells to different cytotoxic drugs. Mol Cancer Ther. 12:1085–1098. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Ishii Y, Nhiayi MK, Tse E, Cheng J, Massimino M, Durden DL, Vigneri P and Wang JY: Knockout serum replacement promotes cell survival by preventing BIM from inducing mitochondrial cytochrome C release. PLoS One. 10:e01405852015. View Article : Google Scholar : PubMed/NCBI

4 

Manzella L, Tirrò E, Pennisi MS, Massimino M, Stella S, Romano C, Vitale SR and Vigneri P: Roles of interferon regulatory factors in chronic myeloid leukemia. Curr Cancer Drug Targets. 16:594–605. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Preyer M, Vigneri P and Wang JY: Interplay between kinase domain autophosphorylation and F-actin binding domain in regulating imatinib sensitivity and nuclear import of BCR-ABL. PLoS One. 6:e170202011. View Article : Google Scholar : PubMed/NCBI

6 

Giallongo C, Tibullo D, La Cava P, Branca A, Parrinello N, Spina P, Stagno F, Conticello C, Chiarenza A, Vigneri P, et al: BRIT1/MCPH1 expression in chronic myeloid leukemia and its regulation of the G2/M checkpoint. Acta Haematol. 126:205–210. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Stagno F, Stella S, Spitaleri A, Pennisi MS, Di Raimondo F and Vigneri P: Imatinib mesylate in chronic myeloid leukemia: Frontline treatment and long-term outcomes. Expert Rev Anticancer Ther. 16:273–278. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Hochhaus A, Larson RA, Guilhot F, Radich JP, Branford S, Hughes TP, Baccarani M, Deininger MW, Cervantes F, Fujihara S, et al: Long-term outcomes of imatinib treatment for chronic myeloid leukemia. N Engl J Med. 376:917–927. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Hochhaus A, Rosti G, Cross NC, Steegmann JL, le Coutre P, Ossenkoppele G, Petrov L, Masszi T, Hellmann A, Griskevicius L, et al: Frontline nilotinib in patients with chronic myeloid leukemia in chronic phase: Results from the European ENEST1st study. Leukemia. 30:57–64. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Cortes JE, Saglio G, Kantarjian HM, Baccarani M, Mayer J, Boqué C, Shah NP, Chuah C, Casanova L, Bradley-Garelik B, et al: Final 5-year study results of DASISION: The dasatinib versus imatinib study in treatment-naïve chronic myeloid leukemia patients trial. J Clin Oncol. 34:2333–2340. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Stagno F, Vigneri P, Cupri A, Stella S and Di Raimondo F: Personalized strategies for CML patients considering discontinuation of tyrosine kinase inhibitors treatment. Leuk Res. 36:1208–1209. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Cortes JE, Gambacorti-Passerini C, Deininger MW, Mauro MJ, Chuah C, Kim DW, Dyagil I, Glushko N, Milojkovic D, le Coutre P, et al: Bosutinib versus imatinib for newly diagnosed chronic myeloid leukemia: Results from the randomized BFORE trial. J Clin Oncol. 36:231–237. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Stagno F, Vigneri P, Del Fabro V, Stella S, Cupri A, Massimino M, Consoli C, Tambè L, Consoli ML, Antolino A, et al: Influence of complex variant chromosomal translocations in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors. Acta Oncol. 49:506–508. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Laurent E, Talpaz M, Kantarjian H and Kurzrock R: The BCR gene and philadelphia chromosome-positive leukemogenesis. Cancer Res. 61:2343–2355. 2001.PubMed/NCBI

15 

Burmeister T and Reinhardt R: A multiplex PCR for improved detection of typical and atypical BCR-ABL fusion transcripts. Leuk Res. 32:579–585. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Gui X, Zhang Y, Pan J, Qiu H, Cen J, Xue Y, Chen S, Shen H, Yao L, Zhang J, et al: Chronic myeloid leukemia with e14a3 BCR-ABL transcript: Analysis of characteristics and prognostic significance. Leuk Lymphoma. 56:3343–3347. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Chisti MM and Sanders DS: Chronic myeloid leukemia with b3a3 (e14a3) fusion: A rare BCR/ABL rearrangement presenting with thrombocytosis-does MTHFR polymorphism matter. Case Rep Oncol. 11:485–492. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Cross NCP: Detection of BCR-ABL in hematological malignancies by RT-PCR. Methods Mol Med. 6:25–36. 1996.PubMed/NCBI

19 

Vigneri P, Stagno F, Stella S, Cupri A, Forte S, Massimino M, Antolino A, Siragusa S, Mannina D, Impera SS, et al: High BCR-ABL/GUSIS levels at diagnosis of chronic phase CML are associated with unfavorable responses to standard-dose imatinib. Clin Cancer Res. 23:7189–7198. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Vella V, Puppin C, Damante G, Vigneri R, Sanfilippo M, Vigneri P, Tell G and Frasca F: DeltaNp73alpha inhibits PTEN expression in thyroid cancer cells. Int J Cancer. 124:2539–2548. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Jinawath N, Norris-Kirby A, Smith BD, Gocke CD, Batista DA, Griffin CA and Murphy KM: A rare e14a3 (b3a3) BCR-ABL fusion transcript in chronic myeloid leukemia: Diagnostic challenges in clinical laboratory practice. J Mol Diagn. 11:359–363. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Massimino M, Consoli ML, Mesuraca M, Stagno F, Tirrò E, Stella S, Pennisi MS, Romano C, Buffa P, Bond HM, et al: IRF5 is a target of BCR-ABL kinase activity and reduces CML cell proliferation. Carcinogenesis. 35:1132–1143. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Hu LH, Pu LF, Yang DD, Zhang C, Wang HP, Ding YY, Li MM, Zhai ZM and Xiong S: How to detect the rare BCR-ABL (e14a3) transcript: A case report and literature review. Oncol Lett. 14:5619–5623. 2017.PubMed/NCBI

24 

Cai H, Yang L, Shen K, Zhang W, Xiong J, Zhang M, Mao X, Wang Y and Xiao M: A rare e14a3 BCR/ABL fusion transcript in acute lymphoblastic leukemia patient treated with CAR-modified T-cell therapy. Oncol Lett. 15:2491–2494. 2018.PubMed/NCBI

25 

Buffa P, Romano C, Pandini A, Massimino M, Tirrò E, Di Raimondo F, Manzella L, Fraternali F and Vigneri PG: BCR-ABL residues interacting with ponatinib are critical to preserve the tumorigenic potential of the oncoprotein. FASEB J. 28:1221–1236. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Massimino M, Stella S, Tirrò E, Romano C, Pennisi MS, Puma A, Manzella L, Zanghì A, Stagno F, Di Raimondo F and Vigneri P: Non ABL-directed inhibitors as alternative treatment strategies for chronic myeloid leukemia. Mol Cancer. 17:562018. View Article : Google Scholar : PubMed/NCBI

27 

Yao J, Douer D, Wang L, Arcila ME, Nafa K and Chiu A: A case of acute myeloid leukemia with e6a2 BCR-ABL fusion transcript acquired after progressing from chronic myelomonocytic leukemia. Leuk Res Rep. 7:17–19. 2017.PubMed/NCBI

28 

Cayuela JM, Rousselot P, Nicolini F, Espinouse D, Ollagnier C, Bui-Thi MH, Chabane K, Raffoux E, Callet-Bauchu E, Tigaud I, et al: Identification of a rare e8a2 BCR-ABL fusion gene in three novel chronic myeloid leukemia patients treated with imatinib. Leukemia. 19:2334–2336. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Stagno F, Vigneri P, Consoli ML, Cupri A, Stella S, Tambè L, Massimino M, Manzella L and Di Raimondo F: Hyperdiploidy associated with a high BCR-ABL transcript level may identify patients at risk of progression in chronic myeloid leukemia. Acta Haematol. 127:7–9. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Fujisawa S, Nakamura S, Naito K, Kobayashi M and Ohnishi K: A variant transcript, e1a3, of the minor BCR-ABL fusion gene in acute lymphoblastic leukemia: Case report and review of the literature. Int J Hematol. 87:184–188. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Snyder DS, McMahon R, Cohen SR and Slovak ML: Chronic myeloid leukemia with an e13a3 BCR-ABL fusion: Benign course responsive to imatinib with an RT-PCR advisory. Am J Hematol. 75:92–95. 2004. View Article : Google Scholar : PubMed/NCBI

32 

Smith KM, Yacobi R and Van Etten RA: Autoinhibition of Bcr-Abl through its SH3 domain. Mol Cell. 12:27–37. 2003. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Massimino M, Stella S, Tirrò E, Consoli ML, Pennisi MS, Puma A, Vitale SR, Romano C, Zammit V, Stagno F, Stagno F, et al: Rapid decline of Philadelphia‑positive metaphases after nilotinib treatment in a cml patient expressing a rare e14a3 bcr‑abl1 fusion transcript: A case report. Oncol Lett 18: 2648-2653, 2019.
APA
Massimino, M., Stella, S., Tirrò, E., Consoli, M.L., Pennisi, M.S., Puma, A. ... Manzella, L. (2019). Rapid decline of Philadelphia‑positive metaphases after nilotinib treatment in a cml patient expressing a rare e14a3 bcr‑abl1 fusion transcript: A case report. Oncology Letters, 18, 2648-2653. https://doi.org/10.3892/ol.2019.10558
MLA
Massimino, M., Stella, S., Tirrò, E., Consoli, M. L., Pennisi, M. S., Puma, A., Vitale, S. R., Romano, C., Zammit, V., Stagno, F., Di Raimondo, F., Manzella, L."Rapid decline of Philadelphia‑positive metaphases after nilotinib treatment in a cml patient expressing a rare e14a3 bcr‑abl1 fusion transcript: A case report". Oncology Letters 18.3 (2019): 2648-2653.
Chicago
Massimino, M., Stella, S., Tirrò, E., Consoli, M. L., Pennisi, M. S., Puma, A., Vitale, S. R., Romano, C., Zammit, V., Stagno, F., Di Raimondo, F., Manzella, L."Rapid decline of Philadelphia‑positive metaphases after nilotinib treatment in a cml patient expressing a rare e14a3 bcr‑abl1 fusion transcript: A case report". Oncology Letters 18, no. 3 (2019): 2648-2653. https://doi.org/10.3892/ol.2019.10558
Copy and paste a formatted citation
x
Spandidos Publications style
Massimino M, Stella S, Tirrò E, Consoli ML, Pennisi MS, Puma A, Vitale SR, Romano C, Zammit V, Stagno F, Stagno F, et al: Rapid decline of Philadelphia‑positive metaphases after nilotinib treatment in a cml patient expressing a rare e14a3 bcr‑abl1 fusion transcript: A case report. Oncol Lett 18: 2648-2653, 2019.
APA
Massimino, M., Stella, S., Tirrò, E., Consoli, M.L., Pennisi, M.S., Puma, A. ... Manzella, L. (2019). Rapid decline of Philadelphia‑positive metaphases after nilotinib treatment in a cml patient expressing a rare e14a3 bcr‑abl1 fusion transcript: A case report. Oncology Letters, 18, 2648-2653. https://doi.org/10.3892/ol.2019.10558
MLA
Massimino, M., Stella, S., Tirrò, E., Consoli, M. L., Pennisi, M. S., Puma, A., Vitale, S. R., Romano, C., Zammit, V., Stagno, F., Di Raimondo, F., Manzella, L."Rapid decline of Philadelphia‑positive metaphases after nilotinib treatment in a cml patient expressing a rare e14a3 bcr‑abl1 fusion transcript: A case report". Oncology Letters 18.3 (2019): 2648-2653.
Chicago
Massimino, M., Stella, S., Tirrò, E., Consoli, M. L., Pennisi, M. S., Puma, A., Vitale, S. R., Romano, C., Zammit, V., Stagno, F., Di Raimondo, F., Manzella, L."Rapid decline of Philadelphia‑positive metaphases after nilotinib treatment in a cml patient expressing a rare e14a3 bcr‑abl1 fusion transcript: A case report". Oncology Letters 18, no. 3 (2019): 2648-2653. https://doi.org/10.3892/ol.2019.10558
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