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Correlation analysis of mRNA expression and prognosis of hOGG1 gene polymorphism in patients with non-small cell lung cancer

  • Authors:
    • Jing Wang
    • Puzhao Wu
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Xiang Yang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang, Hubei 441000, P.R. China, Department of Interventional Oncology, Xiang Yang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang, Hubei 441000, P.R. China
  • Pages: 2310-2315
    |
    Published online on: July 5, 2019
       https://doi.org/10.3892/ol.2019.10586
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Abstract

Level of mRNA expression and gene polymorphism of human 8-hydroxyguanine glycosidase 1 (hOGG1) in patients with non-small cell lung cancer (NSCLC) were investigated. A polymorphism analysis of hOGG1 gene rs1052133 locus in 182 NSCLC patients (NSCLC group) surgically treated in Xiang Yang No. 1 People's Hospital, Hubei University of Medicine from January 2008 to January 2012 and 200 healthy individuals (control group) was performed. The expression level of hOGG1 was compared between cancer tissues and adjacent tissues of NSCLC patients, and the survival rate was analyzed. The expression level of hOGG1 was significantly higher in cancer tissues than that in adjacent tissues (P<0.001). Taqman probe method was used to detect the genotypes of hOGG1 polymorphism locus rs1052133, with the genotype distribution frequencies of NSCLC group (P=0.411) and control group (P=0.354) consistent with the Hardy-Weinberg equilibrium. The proportion of C/C gene was significantly higher in NSCLC group than that in control group (P=0.008, OR=2.2, 95%, CI=1.27-4.52). The median value of the hOGG1 expression level in detection results as the boundary, NSCLC patients were divided into hOGG1 high expression group (≥3.61) with 91 cases and hOGG1 low expression group (<3.61) with 91 cases. The 1-, 2- and 3-year survival rates of patients in hOGG1 low expression group were significantly higher than those in hOGG1 high expression group (P=0.007). The 3-year survival rate in hOGG1 low expression group is significantly higher than that in hOGG1 high expression group (P=0.007). The sensitivity, specificity and AUC of hOGG1 to patient survival prediction were 83.33%, 64.29%, and 0.816, respectively. In conclusion, hOGG1 is highly expressed in NSCLC tissues. Compared to S/S and S/C genotypes, the C/C gene was found to be more common in NSCLC group than in control group. Thus, hOGG1 has a high predictive value for patient survival.
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1 

Fehrenbacher L, Spira A, Ballinger M, Kowanetz M, Vansteenkiste J, Mazieres J, Park K, Smith D, Artal-Cortes A, Lewanski C, et al POPLAR Study Group, : Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): A multicentre, open-label, phase 2 randomised controlled trial. Lancet. 387:1837–1846. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Masters GA, Johnson DH and Temin S: Systemic therapy for stage IV non-small-cell lung cancer: American Society of Clinical Oncology Clinical Practice Guideline Update. J Oncol Pract. 12:90–93. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Jamal-Hanjani M, Wilson GA, McGranahan N, Birkbak NJ, Watkins TBK, Veeriah S, Shafi S, Johnson DH, Mitter R, Rosenthal R, et al TRACERx Consortium, : Tracking the evolution of non-small-cell lung cancer. N Engl J Med. 376:2109–2121. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Gettinger S, Rizvi NA, Chow LQ, Borghaei H, Brahmer J, Ready N, Gerber DE, Shepherd FA, Antonia S, Goldman JW, et al: Nivolumab monotherapy for first-line treatment of advanced non-small-cell lung cancer. J Clin Oncol. 34:2980–2987. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Planchard D, Yokoi T, McCleod MJ, Fischer JR, Kim YC, Ballas M, Shi K and Soria JC: A phase III study of durvalumab (MEDI4736) with or without tremelimumab for previously treated patients with advanced NSCLC: Rationale and protocol design of the ARCTIC study. Clin Lung Cancer. 17:232–236.e1. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Emdad L, Lebedeva IV, Su ZZ, Gupta P, Sarkar D, Settleman J and Fisher PB: Combinatorial treatment of non-small-cell lung cancers with gefitinib and Ad.mda-7 enhances apoptosis-induction and reverses resistance to a single therapy. J Cell Physiol. 210:549–559. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Cravens SL and Stivers JT: Comparative effects of ions, molecular crowding, and bulk DNA on the damage search mechanisms of hOGG1 and hUNG. Biochemistry. 55:5230–5242. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Kadıoğlu E, Taçoy G, Özçağlı E, Okyay K, Akboğa MK, Çengel A and Şardaş S: The role of oxidative DNA damage and GSTM1, GSTT1, and hOGG1 gene polymorphisms in coronary artery disease risk. Anatol J Cardiol. 16:931–938. 2016.PubMed/NCBI

9 

Alanazi M, Pathan AAK, Shaik JP, Alhadheq A, Khan Z, Khan W, Al Naeem A and Parine NR: The hOGG1 Ser326Cys gene polymorphism and breast cancer risk in Saudi population. Pathol Oncol Res. 23:525–535. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Sliwinska A, Kwiatkowski D, Czarny P, Toma M, Wigner P, Drzewoski J, Fabianowska-Majewska K, Szemraj J, Maes M, Galecki P, et al: The levels of 7,8-dihydrodeoxyguanosine (8-oxoG) and 8-oxoguanine DNA glycosylase 1 (OGG1) - A potential diagnostic biomarkers of Alzheimer's disease. J Neurol Sci. 368:155–159. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Li Z, Guan W, Li MX, Zhong ZY, Qian CY, Yang XQ, Liao L, Li ZP and Wang D: Genetic polymorphism of DNA base-excision repair genes (APE1, OGG1 and XRCC1) and their correlation with risk of lung cancer in a Chinese population. Arch Med Res. 42:226–234. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Cao WJ, Lu JZ, Li C, Gao YJ, Lu KQ, Wang HZ and Wang ZP: The hOGG1 Ser326Cys gene polymorphism and susceptibility for bladder cancer: A meta-analysis. Int Braz J Urol. 42:883–896. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Sanjari Moghaddam A, Nazarzadeh M, Bidel Z, Karamatinia A, Darvish H and Mosavi Jarrahi A: hOGG1 gene polymorphism and breast cancer risk: A systematic review and meta-analysis study. Breast J. 24:70–73. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Zhang M and Mo R: Association of hOGG1 Ser326Cys polymorphism with colorectal cancer risk: An updated meta-analysis including 5235 cases and 8438 controls. Tumour Biol. 35:12627–12633. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Lukina MV, Kuznetsova AA, Kuznetsov NA and Fedorova OS: The kinetic analysis of recognition of the damaged nucleotides by mutant forms of the 8-oxoguanine DNA glycosylase hOGG1. Russ J Bioorganic Chem. 43:1–12. 2017. View Article : Google Scholar

17 

Kohno T, Shinmura K, Tosaka M, Tani M, Kim SR, Sugimura H, Nohmi T, Kasai H and Yokota J: Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA. Oncogene. 16:3219–3225. 1998. View Article : Google Scholar : PubMed/NCBI

18 

Wang W, Dang S, Li Y, Sun M, Jia X, Wang R and Liu J: hOGG1 Ser326Cys polymorphism and risk of hepatocellular carcinoma among East Asians: A meta-analysis. PLoS One. 8:e601782013. View Article : Google Scholar : PubMed/NCBI

19 

Xie Y, Wu Y, Zhou X, Yao M, Ning S and Wei Z: Association of polymorphisms hOGGI rs1052133 and hMUTYH rs3219472 with risk of nasopharyngeal carcinoma in a Chinese population. Onco Targets Ther. 9:755–760. 2016.PubMed/NCBI

20 

Tan H: On the protective effects of gene SNPs against human cancer. EBioMedicine. 33:4–5. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Corella D, Ramírez-Sabio JB, Coltell O, Ortega-Azorín C, Estruch R, Martínez-González MA, Salas-Salvadó J, Sorlí JV, Castañer O, Arós F, et al: Effects of the Ser326Cys polymorphism in the DNA repair OGG1 gene on cancer, cardiovascular and all-cause mortality in the PREDIMED study: Modulation by diet. J Acad Nutr Diet. 118:589–605. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Wang Y, Gao X, Wei F, Zhang X, Yu J, Zhao H, Sun Q, Yan F, Yan C, Li H, et al: The hOGG1 Ser326Cys polymorphism contributes to digestive system cancer susceptibility: Evidence from 48 case-control studies. Tumour Biol. 36:1029–1038. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Zhou F, Zhang W, Wei Y, Zhou D, Su Z, Meng X, Hui L and Tian W: The changes of oxidative stress and human 8-hydroxyguanine glycosylase1 gene expression in depressive patients with acute leukemia. Leuk Res. 31:387–393. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang J and Wu P: Correlation analysis of mRNA expression and prognosis of hOGG1 gene polymorphism in patients with non-small cell lung cancer. Oncol Lett 18: 2310-2315, 2019.
APA
Wang, J., & Wu, P. (2019). Correlation analysis of mRNA expression and prognosis of hOGG1 gene polymorphism in patients with non-small cell lung cancer. Oncology Letters, 18, 2310-2315. https://doi.org/10.3892/ol.2019.10586
MLA
Wang, J., Wu, P."Correlation analysis of mRNA expression and prognosis of hOGG1 gene polymorphism in patients with non-small cell lung cancer". Oncology Letters 18.3 (2019): 2310-2315.
Chicago
Wang, J., Wu, P."Correlation analysis of mRNA expression and prognosis of hOGG1 gene polymorphism in patients with non-small cell lung cancer". Oncology Letters 18, no. 3 (2019): 2310-2315. https://doi.org/10.3892/ol.2019.10586
Copy and paste a formatted citation
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Spandidos Publications style
Wang J and Wu P: Correlation analysis of mRNA expression and prognosis of hOGG1 gene polymorphism in patients with non-small cell lung cancer. Oncol Lett 18: 2310-2315, 2019.
APA
Wang, J., & Wu, P. (2019). Correlation analysis of mRNA expression and prognosis of hOGG1 gene polymorphism in patients with non-small cell lung cancer. Oncology Letters, 18, 2310-2315. https://doi.org/10.3892/ol.2019.10586
MLA
Wang, J., Wu, P."Correlation analysis of mRNA expression and prognosis of hOGG1 gene polymorphism in patients with non-small cell lung cancer". Oncology Letters 18.3 (2019): 2310-2315.
Chicago
Wang, J., Wu, P."Correlation analysis of mRNA expression and prognosis of hOGG1 gene polymorphism in patients with non-small cell lung cancer". Oncology Letters 18, no. 3 (2019): 2310-2315. https://doi.org/10.3892/ol.2019.10586
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