Screening and identification of potential target genes in head and neck cancer using bioinformatics analysis
- Authors:
- Fuhai Chen
- Anyuan Zheng
- Fen Li
- Silu Wen
- Shiming Chen
- Zezhang Tao
-
Affiliations: Department of Otolaryngology‑Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China - Published online on: July 15, 2019 https://doi.org/10.3892/ol.2019.10616
- Pages: 2955-2966
-
Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
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|
Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Bray F, Ferlay J, Laversanne M, Brewster DH, Gombe MC, Kohler B, Piñeros M, Steliarova-Foucher E, Swaminathan R, Antoni S, et al: cancer incidence in five continents: Inclusion criteria, highlights from volume X and the global status of cancer registration. Int J Cancer. 137:2060–2071. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Thibodeau BJ, Geddes TJ, Fortier LE, Ahmed S, Pruetz BL, Wobb J, Chen P, Wilson GD and Akervall JA: Gene expression characterization of HPV positive head and neck cancer to predict response to chemoradiation. Head Neck Pathol. 9:345–353. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Min SK, Lee SK, Park JS, Lee J, Paeng JY, Lee SI, Lee HJ, Kim Y, Pae HO, Lee SK and Kim EC: Endoplasmic reticulum stress is involved in hydrogen peroxide induced apoptosis in immortalized and malignant human oral keratinocytes. J Oral Pathol Med. 37:490–498. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Skvortsov S, Dudás J, Eichberger P, Witsch-Baumgartner M, Loeffler-Ragg J, Pritz C, Schartinger VH, Maier H, Hall J, Debbage P, et al: Rac1 as a potential therapeutic target for chemo-radioresistant head and neck squamous cell carcinomas (HNSCC). Br J Cancer. 110:2677–2687. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Y, Chen C, Wang X, Jin F, Liu Y, Liu H, Li T and Fu J: Lower DSC1 expression is related to the poor differentiation and prognosis of head and neck squamous cell carcinoma (HNSCC). J Cancer Res Clin Oncol. 142:2461–2468. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Edgar R, Domrachev M and Lash AE: Gene expression omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res. 30:207–210. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Barrett T, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky M, Marshall KA, Phillippy KH, Sherman PM, Holko M, et al: NCBI GEO: Archive for functional genomics data sets-update. Nucleic Acids Res 41 (Database Issue). D991–D995. 2013. | |
|
Lobert S, Graichen ME, Hamilton RD, Pitman KT, Garrett MR, Hicks C and Koganti T: Prognostic biomarkers for HNSCC using quantitative real-time PCR and microarray analysis: β-tubulin isotypes and the p53 interactome. Cytoskeleton (Hoboken). 71:628–637. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Huang DW, Sherman BT, Tan Q, Collins JR, Alvord WG, Roayaei J, Stephens R, Baseler MW, Lane HC and Lempicki RA: The DAVID gene functional classification tool: A novel biological module-centric algorithm to functionally analyze large gene lists. Genome Biol. 8:R1832007. View Article : Google Scholar : PubMed/NCBI | |
|
Kanehisa M, Sato Y, Kawashima M, Furumichi M and Tanabe M: KEGG as a reference resource for gene and protein annotation. Nucleic Acids Res. 44(D1): D457–D462. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Pinoli P, Chicco D and Masseroli M: Computational algorithms to predict gene ontology annotations. BMC Bioinformatics. 16 (Suppl 6):S42015. View Article : Google Scholar : PubMed/NCBI | |
|
Szklarczyk D, Franceschini A, Wyder S, Forslund K, Heller D, Huerta-Cepas J, Simonovic M, Roth A, Santos A, Tsafou KP, et al: STRING v10: Protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res 43 (Database issue). D447–D452. 2015. View Article : Google Scholar | |
|
Su G, Morris JH, Demchak B and Bader GD: Biological network exploration with Cytoscape 3. Curr Protoc Bioinformatics. 47:8.13.1–24. 2014. View Article : Google Scholar | |
|
Bandettini WP, Kellman P, Mancini C, Booker OJ, Vasu S, Leung SW, Wilson JR, Shanbhag SM, Chen MY and Arai AE: Multi contrast delayed enhancement (MCODE) improves detection of subendocardial myocardial infarction by late gadolinium enhancement cardiovascular magnetic resonance: A clinical validation study. J Cardiovasc Magn Reson. 14:832012. View Article : Google Scholar : PubMed/NCBI | |
|
Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, et al: Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 6:pl12013. View Article : Google Scholar : PubMed/NCBI | |
|
Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, et al: The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2:401–404. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Rosenbloom KR, Armstrong J, Barber GP, Casper J, Clawson H, Diekhans M, Dreszer TR, Fujita PA, Guruvadoo L, Haeussler M, et al: The UCSC Genome Browser database: 2015 update. Nucleic Acids Res 43 (Database Issue). D670–D681. 2015. View Article : Google Scholar | |
|
Rhodes DR, Yu J, Shanker K, Deshpande N, Varambally R, Ghosh D, Barrette T, Pandey A and Chinnaiyan AM: ONCOMINE: A cancer microarray database and integrated data-mining platform. Neoplasia. 6:1–6. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Cromer A, Carles A, Millon R, Ganguli G, Chalmel F, Lemaire F, Young J, Dembélé D, Thibault C, Muller D, et al: Identification of genes associated with tumorigenesis and metastatic potential of hypopharyngeal cancer by microarray analysis. Oncogene. 23:2484–2498. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Estilo CL, O-charoenrat P, Talbot S, Socci ND, Carlson DL, Ghossein R, Williams T, Yonekawa Y, Ramanathan Y, Boyle JO, et al: Oral tongue cancer gene expression profiling: Identification of novel potential prognosticators by oligonucleotide microarray analysis. BMC Cancer. 9:112009. View Article : Google Scholar : PubMed/NCBI | |
|
Ginos MA, Page GP, Michalowicz BS, Patel KJ, Volker SE, Pambuccian SE, Ondrey FG, Adams GL and Gaffney PM: Identification of a gene expression signature associated with recurrent disease in squamous cell carcinoma of the head and neck. Cancer Res. 64:55–63. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
He H, Jazdzewski K, Li W, Liyanarachchi S, Nagy R, Volinia S, Calin GA, Liu CG, Franssila K, Suster S, et al: The role of microRNA genes in papillary thyroid carcinoma. Proc Natl Acad Sci USA. 102:19075–19080. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Peng CH, Liao CT, Peng SC, Chen YJ, Cheng AJ, Juang JL, Tsai CY, Chen TC, Chuang YJ, Tang CY, et al: A novel molecular signature identified by systems genetics approach predicts prognosis in oral squamous cell carcinoma. PLoS One. 6:e234522011. View Article : Google Scholar : PubMed/NCBI | |
|
Pyeon D, Newton MA, Lambert PF, den Boon JA, Sengupta S, Marsit CJ, Woodworth CD, Connor JP, Haugen TH, Smith EM, et al: Fundamental differences in cell cycle deregulation in human papillomavirus-positive and human papillomavirus-negative head/neck and cervical cancers. Cancer Res. 67:4605–4619. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Ye H, Yu T, Temam S, Ziober BL, Wang J, Schwartz JL, Mao L, Wong DT and Zhou X: Transcriptomic dissection of tongue squamous cell carcinoma. BMC Genomics. 9:692008. View Article : Google Scholar : PubMed/NCBI | |
|
Giordano TJ, Au AY, Kuick R, Thomas DG, Rhodes DR, Wilhelm KJ Jr, Vinco M, Misek DE, Sanders D, Zhu Z, et al: Delineation, functional validation, and bioinformatic evaluation of gene expression in thyroid follicular carcinomas with the PAX8-PPARG translocation. Clin Cancer Res. 12:1983–1993. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Vasko V, Espinosa AV, Scouten W, He H, Auer H, Liyanarachchi S, Larin A, Savchenko V, Francis GL, de la Chapelle A, et al: Gene expression and functional evidence of epithelial-to-mesenchymal transition in papillary thyroid carcinoma invasion. Proc Natl Acad Sci USA. 104:2803–2808. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Forastiere A, Koch W, Trotti A and Sidransky D: Head and neck cancer. N Engl J Med. 345:1890–900. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Bozec A, Ilie M, Dassonville O, Long E, Poissonnet G, Santini J, Chamorey E, Ettaiche M, Chauviere D, Peyrade F, et al: Significance of circulating tumor cell detection using the Cell search system in patients with locally advanced head and neck squamous cell carcinoma. Eur Arch Otorhinolaryngol. 270:2745–2749. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Rettig EM and D'Souza G: Epidemiology of head and neck cancer. Surg Oncol Clin N Am. 24:379–396. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Marullo R, Werner E, Zhang H, Chen GZ, Shin DM and Doetsch PW: HPV16 E6 and E7 proteins induce a chronic oxidative stress response via NOX2 that causes genomic instability and increased susceptibility to DNA damage in head and neck cancer cells. Carcinogenesis. 36:1397–1406. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Boscolo-Rizzo P, Zorzi M, Del Mistro A, Da Mosto MC, Tirelli G, Buzzoni C, Rugge M, Polesel J and Guzzinati S; AIRTUM Working Group, : The evolution of the epidemiological landscape of head and neck cancer in Italy: Is there evidence for an increase in the incidence of potentially HPV-related carcinomas? PLoS One. 13:e01926212018. View Article : Google Scholar : PubMed/NCBI | |
|
Cheraghlou S, Torabi SJ, Husain ZA, Otremba MD, Osborn HA, Mehra S, Yarbrough WG, Burtness BA and Judson BL: HPV status in unknown primary head and neck cancer: Prognosis and treatment outcomes. Laryngoscope. 129:684–691. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Kreimer AR, Clifford GM, Boyle P and Franceschi S: Human papillomavirus types in head and neck squamous cell carcinomas worldwide: A systematic review. Cancer Epidemiol Biomarkers Prev. 14:467–475. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Wu X, Cao W, Wang X, Zhang J, Lv Z, Qin X, Wu Y and Chen W: TGM3, a candidate tumor suppressor gene, contributes to human head and neck cancer. Mol Cancer. 12:1512013. View Article : Google Scholar : PubMed/NCBI | |
|
Masui T, Ota I, Itaya-Hironaka A, Takeda M, Kasai T, Yamauchi A, Sakuramoto-Tsuchida S, Mikami S, Yane K, Takasawa S and Hosoi H: Expression of REG III and prognosis in head and neck cancer. Oncol Rep. 30:573–578. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Andratschke M, Hagedorn H and Nerlich A: Expression of the epithelial cell adhesion molecule and cytokeratin 8 in head and neck squamous cell cancer: A comparative study. Anticancer Res. 35:3953–3960. 2015.PubMed/NCBI | |
|
Squarize CH, Castilho RM, Abrahao AC, Molinolo A, Lingen MW and Gutkind JS: PTEN deficiency contributes to the development and progression of head and neck cancer. Neoplasia. 15:461–471. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Gross AM, Orosco RK, Shen JP, Egloff AM, Carter H, Hofree M, Choueiri M, Coffey CS, Lippman SM, Hayes DN, et al: Multi-tiered genomic analysis of head and neck cancer ties TP53 mutation to 3p loss. Nat Genet. 46:939–943. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Psyrri A, Seiwert TY and Jimeno A: Molecular pathways in head and neck cancer: EGFR, PI3K, and more. Am Soc Clin Oncol Educ Book. 246–255. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Mahjabeen I, Baig RM, Masood N, Sabir M, Inayat U, Malik FA and Kayani MA: Genetic variations in XRCC1 gene in sporadic head and neck cancer (HNC) patients. Pathol Oncol Res. 19:183–188. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Boeckx C, Weyn C, Vanden Bempt I, Deschoolmeester V, Wouters A, Specenier P, Van Laer C, Van den Weyngaert D, Kockx M, Vermorken JB, et al: Mutation analysis of genes in the EGFR pathway in Head and Neck cancer patients: Implications for anti-EGFR treatment response. BMC Res Notes. 7:3372014. View Article : Google Scholar : PubMed/NCBI | |
|
Gilkes DM, Semenza GL and Wirtz D: Hypoxia and the extracellular matrix: Drivers of tumour metastasis. Nat Rev Cancer. 14:430–439. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Malik R, Lelkes PI and Cukierman E: Biomechanical and biochemical remodeling of stromal extracellular matrix in cancer. Trends Biotechnol. 33:230–236. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Trulsson M, Yu H, Gisselsson L, Chao Y, Urbano A, Aits S, Mossberg AK and Svanborg C: HAMLET binding to α-actinin facilitates tumor cell detachment. PLoS One. 6:e171792011. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang HJ, Tao J, Sheng L, Hu X, Rong RM, Xu M and Zhu TY: Twist2 promotes kidney cancer cell proliferation and invasion by regulating ITGA6 and CD44 expression in the ECM-receptor interaction pathway. Onco Targets Ther. 9:1801–1812. 2016.PubMed/NCBI | |
|
Eke I and Cordes N: Focal adhesion signaling and therapy resistance in cancer. Semin Cancer Biol. 31:65–75. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Blackstone BN, Li R, Ackerman WT, Ghadiali SN, Powell HM and Kniss DA: Myoferlin depletion elevates focal adhesion kinase and paxillin phosphorylation and enhances cell-matrix adhesion in breast cancer cells. Am J Physiol Cell Physiol. 308:C642–C649. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Johnson AL, Edson KZ, Totah RA and Rettie AE: Cytochrome P450 ω-hydroxylases in inflammation and cancer. Adv Pharmacol. 74:223–262. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Ravegnini G, Sammarini G, Hrelia P and Angelini S: Key genetic and epigenetic mechanisms in chemical carcinogenesis. Toxicol Sci. 148:2–13. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Van Damme J, Rampart M, Conings R, Decock B, Van Osselaer N, Willems J and Billiau A: The neutrophil-activating proteins interleukin 8 and beta-thromboglobulin: In vitro and in vivo comparison of NH2-terminally processed forms. Eur J Immunol. 20:2113–2118. 1990. View Article : Google Scholar : PubMed/NCBI | |
|
Lo MC, Yip TC, Ngan KC, Cheng WW, Law CK, Chan PS, Chan KC, Wong CK, Wong RN, Lo KW, et al: Role of MIF/CXCL8/CXCR2 signaling in the growth of nasopharyngeal carcinoma tumor spheres. Cancer Lett. 335:81–92. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Chan LP, Wang LF, Chiang FY, Lee KW, Kuo PL and Liang CH: IL-8 promotes HNSCC progression on CXCR1/2-meidated NOD1/RIP2 signaling pathway. Oncotarget. 7:61820–61831. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Christofakis EP, Miyazaki H, Rubink DS and Yeudall WA: Roles of CXCL8 in squamous cell carcinoma proliferation and migration. Oral Oncol. 44:920–926. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Curry JM, Sprandio J, Cognetti D, Luginbuhl A, Bar-ad V, Pribitkin E and Tuluc M: Tumor microenvironment in head and neck squamous cell carcinoma. Semin Oncol. 41:217–234. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Fang W, Ye L, Shen L, Cai J, Huang F, Wei Q, Fei X, Chen X, Guan H, Wang W, et al: Tumor-associated macrophages promote the metastatic potential of thyroid papillary cancer by releasing CXCL8. Carcinogenesis. 35:1780–1787. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Tominaga K, Yoshimoto T, Torigoe K, Kurimoto M, Matsui K, Hada T, Okamura H and Nakanishi K: IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells. Int Immunol. 12:151–160. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Stanam A, Gibson-Corley KN, Love-Homan L, Ihejirika N and Simons AL: Interleukin-1 blockade overcomes erlotinib resistance in head and neck squamous cell carcinoma. Oncotarget. 7:76087–76100. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Kim HS, Kwon HJ, Jung I, Yun MR, Ahn MJ, Kang BW, Sun JM, Kim SB, Yoon DH, Park KU, et al: Phase II clinical and exploratory biomarker study of dacomitinib in patients with recurrent and/or metastatic squamous cell carcinoma of head and neck. Clin Cancer Res. 21:544–552. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Kwon CH, Park HJ, Choi JH, Lee JR, Kim HK, Jo HJ, Kim HS, Oh N, Song GA and Park DY: Snail and serpinA1 promote tumor progression and predict prognosis in colorectal cancer. Oncotarget. 6:20312–20326. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Kawahara R, Bollinger JG, Rivera C, Ribeiro AC, Brandão TB, Paes Leme AF and MacCoss MJ: A targeted proteomic strategy for the measurement of oral cancer candidate biomarkers in human saliva. Proteomics. 16:159–173. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Qu T, Li YP, Li XH and Chen Y: Identification of potential biomarkers and drugs for papillary thyroid cancer based on gene expression profile analysis. Mol Med Rep. 14:5041–5048. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Vierlinger K, Mansfeld MH, Koperek O, Nöhammer C, Kaserer K and Leisch F: Identification of SERPINA1 as single marker for papillary thyroid carcinoma through microarray meta analysis and quantification of its discriminatory power in independent validation. BMC Med Genomics. 4:302011. View Article : Google Scholar : PubMed/NCBI | |
|
Fialka F, Gruber RM, Hitt R, Opitz L, Brunner E, Schliephake H and Kramer FJ: CPA6, FMO2, LGI1, SIAT1 and TNC are differentially expressed in early- and late-stage oral squamous cell carcinoma-a pilot study. Oral Oncol. 44:941–948. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Renkonen S, Heikkilä P, Haglund C, Mäkitie AA and Hagström J: Tenascin-C, GLUT-1, and syndecan-2 expression in juvenile nasopharyngeal angiofibroma: Correlations to vessel density and tumor stage. Head Neck. 35:1036–1042. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Qiu F, Sun R, Deng N, Guo T, Cao Y, Yu Y, Wang X, Zou B, Zhang S, Jing T, et al: miR-29a/b enhances cell migration and invasion in nasopharyngeal carcinoma progression by regulating SPARC and COL3A1 gene expression. PLoS One. 10:e01209692015. View Article : Google Scholar : PubMed/NCBI | |
|
Suresh A, Vannan M, Kumaran D, Gümüs ZH, Sivadas P, Murugaian EE, Kekatpure V, Iyer S, Thangaraj K and Kuriakose MA: Resistance/response molecular signature for oral tongue squamous cell carcinoma. Dis Markers. 32:51–64. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Sepiashvili L, Hui A, Ignatchenko V, Shi W, Su S, Xu W, Huang SH, O'Sullivan B, Waldron J, Irish JC, et al: Potentially novel candidate biomarkers for head and neck squamous cell carcinoma identified using an integrated cell line-based discovery strategy. Mol Cell Proteomics. 11:1404–1415. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Gu M, Guan J, Zhao L, Ni K, Li X and Han Z: Correlation of ECM1 expression level with the pathogenesis and metastasis of laryngeal carcinoma. Int J Clin Exp Pathol. 6:1132–1137. 2013.PubMed/NCBI | |
|
Meng XY, Liu J, Lv F, Liu MQ and Wan JM: Study on the correlation between extracellular matrix protein-1 and the growth, metastasis and angiogenesis of laryngeal carcinoma. Asian Pac J Cancer Prev. 16:2313–2316. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Pavón MA, Arroyo-Solera I, Céspedes MV, Casanova I, León X and Mangues R: uPA/uPAR and SERPINE1 in head and neck cancer: Role in tumor resistance, metastasis, prognosis and therapy. Oncotarget. 7:57351–57366. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Pavón MA, Arroyo-Solera I, Téllez-Gabriel M, León X, Virós D, López M, Gallardo A, Céspedes MV, Casanova I, López-Pousa A, et al: Enhanced cell migration and apoptosis resistance may underlie the association between high SERPINE1 expression and poor outcome in head and neck carcinoma patients. Oncotarget. 6:29016–29033. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Van Tubergen EA, Banerjee R, Liu M, Vander Broek R, Light E, Kuo S, Feinberg SE, Willis AL, Wolf G, Carey T, et al: Inactivation or loss of TTP promotes invasion in head and neck cancer via transcript stabilization and secretion of MMP9, MMP2, and IL-6. Clin Cancer Res. 19:1169–1179. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Pietruszewska W, Bojanowska-Poźniak K and Kobos J: Matrix metalloproteinases MMP1, MMP2, MMP9 and their tissue inhibitors TIMP1, TIMP2, TIMP3 in head and neck cancer: An immunohistochemical study. Otolaryngol Pol. 70:32–43. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang C, Li C, Zhu M, Zhang Q, Xie Z, Niu G, Song X, Jin L, Li G and Zheng H: Meta-analysis of MMP2, MMP3, and MMP9 promoter polymorphisms and head and neck cancer risk. PLoS One. 8:e620232013. View Article : Google Scholar : PubMed/NCBI | |
|
Vincent-Chong VK, Salahshourifar I, Karen-Ng LP, Siow MY, Kallarakkal TG, Ramanathan A, Yang YH, Khor GH, Rahman ZA, Ismail SM, et al: Overexpression of MMP13 is associated with clinical outcomes and poor prognosis in oral squamous cell carcinoma. ScientificWorldJournal. 2014:8975232014. View Article : Google Scholar : PubMed/NCBI | |
|
Pradhan-Palikhe P, Vesterinen T, Tarkkanen J, Leivo I, Sorsa T, Salo T and Mattila PS: Plasma level of tissue inhibitor of matrix metalloproteinase-1 but not that of matrix metalloproteinase-8 predicts survival in head and neck squamous cell cancer. Oral Oncol. 46:514–518. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Huang CF, Yu GT, Wang WM, Liu B and Sun ZJ: Prognostic and predictive values of SPP1, PAI and caveolin-1 in patients with oral squamous cell carcinoma. Int J Clin Exp Pathol. 7:6032–6039. 2014.PubMed/NCBI | |
|
Aquino G, Sabatino R, Cantile M, Aversa C, Ionna F, Botti G, La Mantia E, Collina F, Malzone G, Pannone G, et al: Expression analysis of SPARC/osteonectin in oral squamous cell carcinoma patients: From saliva to surgical specimen. Biomed Res Int. 2013:7364382013. View Article : Google Scholar : PubMed/NCBI | |
|
Li L, Lei Q, Zhang S, Kong L and Qin B: Screening and identification of key biomarkers in hepatocellular carcinoma: Evidence from bioinformatic analysis. Oncol Rep. 38:2607–2618. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Saha SK, Jeong Y, Cho S and Cho SG: Systematic expression alteration analysis of master reprogramming factor OCT4 and its three pseudogenes in human cancer and their prognostic outcomes. Sci Rep. 8:148062018. View Article : Google Scholar : PubMed/NCBI | |
|
Yang Y, Dong X, Xie B, Ding N, Chen J, Li Y, Zhang Q, Qu H and Fang X: Databases and web tools for cancer genomics study. Genomics Proteomics Bioinformatics. 13:46–50. 2015. View Article : Google Scholar : PubMed/NCBI |
