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High WDR34 mRNA expression as a potential prognostic biomarker in patients with breast cancer as determined by integrated bioinformatics analysis

  • Authors:
    • Dao‑Jun Hu
    • Wen‑Jie Shi
    • Miao Yu
    • Li Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (Chongming Branch), Shanghai 202150, P.R. China, Department of Breast Surgery, Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541000, P.R. China
    Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3177-3187
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    Published online on: July 18, 2019
       https://doi.org/10.3892/ol.2019.10634
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Abstract

The WD‑repeat domain (WDR) family is distributed in the majority of eukaryotes and has several unique biological functions. It serves important roles in signal transduction, cytoskeleton assembly, protein transport, RNA processing, chromatin modification and transcription mechanisms. WD repeat domain 34 (WDR34) has been recently identified as a member of the WDR family. Overexpression of WDR34 was accompanied by the presence of multiple centrioles in the cell, suggesting that it was associated with tumor occurrence. However, its association with breast cancer was unclear. To the best of our knowledge, it has not yet been confirmed whether WDR34 gene expression is associated with breast cancer. Therefore, the current study attempted to clarify this by performing a comprehensive study using multiple datasets in the Oncomine, Breast Cancer Gene‑Expression Miner and Kaplan‑Meier Plotter databases. The analysis indicated that the mRNA expression levels of WDR34 were increased in breast cancer tissues compared with normal tissues. Consistent with this result, the Broad‑Novartis Cancer Cell Line Encyclopedia revealed that WDR34 mRNA expression levels were upregulated in breast cancer cell lines compared with other cancer cells. It was noted that high WDR34 mRNA expression was associated with forkhead box M1 and PTTG1 regulator of sister chromatid separation, securing in co‑expression analysis. Expression profile characteristics of WDR34 mRNA were identified in different molecular subtypes of breast cancer. Furthermore, survival analysis revealed that increased expression levels of WDR34 mRNA were associated with poor overall survival in patients with breast cancer, particularly in luminal B, lymph node status‑positive and estrogen receptor (ER)‑negative subgroups. Additionally, Kaplan‑Meier curves revealed that high WDR34 mRNA expression was associated with shorter relapse‑free survival in patients with breast cancer, particularly in ER‑positive, human epidermal growth factor receptor 2‑negative and progesterone receptor‑positive subgroups. These results suggested that WDR34 may be used as a prognosis predictor in breast cancer and may provide a novel target for the diagnosis and treatment of breast cancer.
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View References

1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2018. CA Cancer J Clin. 68:7–30. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Kadalayil L, Khan S, Nevanlinna H, Fasching PA, Couch FJ, Hopper JL, Liu J, Maishman T, Durcan L, Gerty S, et al: Germline variation in ADAMTSL1 is associated with prognosis following breast cancer treatment in young women. Nat Commun. 8:16322017. View Article : Google Scholar : PubMed/NCBI

3 

Si W, Shen J, Du C, Chen D, Gu X, Li C, Yao M, Pan J, Cheng J, Jiang D, et al: A miR-20a/MAPK1/c-Myc regulatory feedback loop regulates breast carcinogenesis and chemoresistance. Cell Death Differ. 25:406–420. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Nicolini A, Ferrari P and Duffy MJ: Prognostic and predictive biomarkers in breast cancer: Past, present and future. Semin Cancer Biol. 52:56–73. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Smith TF: Diversity of WD-repeat proteins. Subcell Biochem. 48:20–30. 2008. View Article : Google Scholar : PubMed/NCBI

6 

van Nocker S and Ludwig P: The WD-repeat protein superfamily in Arabidopsis: Conservation and divergence in structure and function. BMC Genomics. 4:502003. View Article : Google Scholar : PubMed/NCBI

7 

Gao D, Wang R, Li B, Yang Y, Zhai Z and Chen DY: WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-kappaB activation pathway. Cell Mol Life Sci. 66:2573–2584. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Huber C, Wu S, Kim AS, Sigaudy S, Sarukhanov A, Serre V, Baujat G, Le Quan Sang KH, Rimoin DL, Cohn DH, et al: WDR34 mutations that cause short-rib polydactyly syndrome type III/severe asphyxiating thoracic dysplasia reveal a role for the NF-κB pathway in cilia. Am J Hum Genet. 93:926–931. 2013. View Article : Google Scholar : PubMed/NCBI

9 

You SH, Lee YS, Lee CP, Lin CP, Lin CY, Tsai CL, Chang YL, Cheng PJ, Wang TH and Chang SD: Identification of a c.544C>T mutation in WDR34 as a deleterious recessive allele of short rib-polydactyly syndrome. Taiwan J Obstet Gynecol. 56:857–862. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Wu C, Li J, Peterson A, Tao K and Wang B: Loss of dynein-2 intermediate chain Wdr34 results in defects in retrograde ciliary protein trafficking and Hedgehog signaling in the mouse. Hum Mol Genet. 26:2386–2397. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Yamamoto JI, Kasamatsu A, Okubo Y, Nakashima D, Fushimi K, Minakawa Y, Kasama H, Shiiba M, Tanzawa H and Uzawa K: Evaluation of tryptophan-aspartic acid repeat-containing protein 34 as a novel tumor-suppressor molecule in human oral cancer. Biochem Biophys Res Commun. 495:2469–2474. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Mares J, Szakacsova M, Soukup V, Duskova J, Horinek A and Babjuk M: Prediction of recurrence in low and intermediate risk non-muscle invasive bladder cancer by real-time quantitative PCR analysis: cDNA microarray results. Neoplasma. 60:295–301. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Jiang Y, Zhang L, Kong F, Zhang M, Lv H, Liu G, Liao M, Feng R, Li J and Zhang R: MCPerm: A Monte Carlo permutation method for accurately correcting the multiple testing in a meta-analysis of genetic association studies. PLoS One. 9:e892122014. View Article : Google Scholar : PubMed/NCBI

14 

Jézéquel P, Campone M, Gouraud W, Guérin-Charbonnel C, Leux C, Ricolleau G and Campion L: bc-GenExMiner: An easy-to-use online platform for gene prognostic analyses in breast cancer. Breast Cancer Res Treat. 131:765–775. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Jézéquel P, Frénel JS, Campion L, Guérin-Charbonnel C, Gouraud W, Ricolleau G and Campone M: bc-GenExMiner 3.0: New mining module computes breast cancer gene expression correlation analyses. Database (Oxford). 2013:bas0602013. View Article : Google Scholar : PubMed/NCBI

16 

Lánczky A, Nagy Á, Bottai G, Munkácsy G, Szabó A, Santarpia L and Győrffy B: miRpower: A web-tool to validate survival-associated miRNAs utilizing expression data from 2178 breast cancer patients. Breast Cancer Res Treat. 160:439–446. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, et al: Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 6:pl12013. View Article : Google Scholar : PubMed/NCBI

18 

Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, et al: The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2:401–404. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Curtis C, Shah SP, Chin SF, Turashvili G, Rueda OM, Dunning MJ, Speed D, Lynch AG, Samarajiwa S, Yuan Y, et al: The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups. Nature. 486:346–352. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Goda AA, Siddique AB, Mohyeldin M, Ayoub NM and El Sayed KA: The maxi-K (BK) channel antagonist penitrem a as a novel breast cancer-targeted therapeutic. Mar Drugs. 16(pii): E1572018. View Article : Google Scholar : PubMed/NCBI

21 

Goldhirsch A, Glick JH, Gelber RD, Coates AS, Thurlimann B and Senn HJ; Panel members, : Meeting highlights: International expert consensus on the primary therapy of early breast cancer 2005. Ann Oncol. 16:1569–1583. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Sorlie T, Tibshirani R, Parker J, Hastie T, Marron JS, Nobel A, Deng S, Johnsen H, Pesich R, Geisler S, et al: Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc Natl Acad Sci USA. 100:8418–8423. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Perou CM, Sorlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, et al: Molecular portraits of human breast tumours. Nature. 406:747–752. 2000. View Article : Google Scholar : PubMed/NCBI

24 

Wang C, Sun X, Wang K, Wang Y, Yang F and Wang H: Breast cancer targeted chemotherapy based on doxorubicin-loaded bombesin peptide modified nanocarriers. Drug Deliv. 23:2697–2702. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Mahaddalkar T and Lopus M: From natural products to designer drugs: Development and molecular mechanisms action of novel anti-microtubule breast cancer therapeutics. Curr Top Med Chem. 17:2559–2568. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Li JJ and Xie D: RACK1, a versatile hub in cancer. Oncogene. 34:1890–1898. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Giuliano AE, Connolly JL, Edge SB, Mittendorf EA, Rugo HS, Solin LJ, Weaver DL, Winchester DJ and Hortobagyi GN: Breast Cancer-Major changes in the American Joint Committee on Cancer eighth edition cancer staging manual. CA Cancer J Clin. 67:290–303. 2017. View Article : Google Scholar : PubMed/NCBI

28 

O'Regan RM and Nahta R: Targeting forkhead box M1 transcription factor in breast cancer. Biochem Pharmacol. 154:407–413. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Song X, Fiati Kenston SS, Zhao J, Yang D and Gu Y: Roles of FoxM1 in cell regulation and breast cancer targeting therapy. Med Oncol. 34:412017. View Article : Google Scholar : PubMed/NCBI

30 

Lee JJ, Lee HJ, Son BH, Kim SB, Ahn JH, Ahn SD, Cho EY and Gong G: Expression of FOXM1 and related proteins in breast cancer molecular subtypes. Int J Exp Pathol. 97:170–177. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Nakachi I, Helfrich BA, Spillman MA, Mickler EA, Olson CJ, Rice JL, Coldren CD, Heasley LE, Geraci MW and Stearman RS: PTTG1 levels are predictive of saracatinib sensitivity in ovarian cancer cell lines. Clin Transl Sci. 9:293–301. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Repo H, Gurvits N, Löyttyniemi E, Nykänen M, Lintunen M, Karra H, Kurki S, Kuopio T, Talvinen K, Söderström M and Kronqvist P: PTTG1-interacting protein (PTTG1IP/PBF) predicts breast cancer survival. BMC Cancer. 17:7052017. View Article : Google Scholar : PubMed/NCBI

33 

Yoon CH, Kim MJ, Lee H, Kim RK, Lim EJ, Yoo KC, Lee GH, Cui YH, Oh YS, Gye MC, et al: PTTG1 oncogene promotes tumor malignancy via epithelial to mesenchymal transition and expansion of cancer stem cell population. J Biol Chem. 287:19516–19527. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Ren G, Tian Q, An Y, Feng B, Lu Y, Liang J, Li K, Shang Y, Nie Y, Wang X and Fan D: Coronin 3 promotes gastric cancer metastasis via the up-regulation of MMP-9 and cathepsin K. Mol Cancer. 11:672012. View Article : Google Scholar : PubMed/NCBI

35 

Iizaka M, Han HJ, Akashi H, Furukawa Y, Nakajima Y, Sugano S, Ogawa M and Nakamura Y: Isolation and chromosomal assignment of a novel human gene, CORO1C, homologous to coronin-like actin-binding proteins. Cytogenet Cell Genet. 88:221–224. 2000. View Article : Google Scholar : PubMed/NCBI

36 

Thal D, Xavier CP, Rosentreter A, Linder S, Friedrichs B, Waha A, Pietsch T, Stumpf M, Noegel A and Clemen C: Expression of coronin-3 (coronin-1C) in diffuse gliomas is related to malignancy. J Pathol. 214:415–424. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Li M, Ouyang L, Zheng Z, Xiang D, Ti A, Li L, Dan Y, Yu C and Li W: E3 ubiquitin ligase FBW7α inhibits cholangiocarcinoma cell proliferation by downregulating c-Myc and cyclin E. Oncol Rep. 37:1627–1636. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Wang J, Wang H, Peters M, Ding N, Ribback S, Utpatel K, Cigliano A, Dombrowski F, Xu M, Chen X, et al: Loss of Fbxw7 synergizes with activated AKT signaling to promote c-Myc dependent cholangiocarcinogenesis. J Hepatol. pii:S0168–8278, 30342-30343. 2019.

39 

Zhao D, Zheng HQ, Zhou Z and Chen C: The Fbw7 tumor suppressor targets KLF5 for ubiquitin-mediated degradation and suppresses breast cell proliferation. Cancer Res. 70:4728–4738. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Krishnamurti U and Silverman JF: HER2 in breast cancer: A review and update. Adv Anat Pathol. 21:100–107. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Zhang K, Hong R, Kaping L, Xu F, Xia W, Qin G, Zheng Q, Lu Q, Zhai Q, Shi Y, et al: CDK4/6 inhibitor palbociclib enhances the effect of pyrotinib in HER2-positive breast cancer. Cancer Lett. 447:130–140. 2019. View Article : Google Scholar : PubMed/NCBI

42 

Ahmed S, Sami A and Xiang J: HER2-directed therapy: Current treatment options for HER2-positive breast cancer. Breast Cancer. 22:101–116. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Mercogliano MF, De Martino M, Venturutti L, Rivas MA, Proietti CJ, Inurrigarro G, Frahm I, Allemand DH, Deza EG, Ares S, et al: TNFα-induced mucin 4 expression elicits trastuzumab resistance in HER2-positive breast cancer. Clin Cancer Res. 23:636–648. 2017. View Article : Google Scholar : PubMed/NCBI

44 

Hearne BJ, Teare MD, Butt M and Donaldson L: Comparison of Nottingham Prognostic Index and Adjuvant Online prognostic tools in young women with breast cancer: Review of a single-institution experience. BMJ Open. 5:e0055762015. View Article : Google Scholar : PubMed/NCBI

45 

Albergaria A, Ricardo S, Milanezi F, Carneiro V, Amendoeira I, Vieira D, Cameselle-Teijeiro J and Schmitt F: Nottingham Prognostic Index in triple-negative breast cancer: A reliable prognostic tool? BMC Cancer. 11:2992011. View Article : Google Scholar : PubMed/NCBI

46 

Kabbage M, Trimeche M, Ben Nasr H, Hammann P, Kuhn L, Hamrita B and Chahed K: Tropomyosin-4 correlates with higher SBR grades and tubular differentiation in infiltrating ductal breast carcinomas: An immunohistochemical and proteomics-based study. Tumour Biol. 34:3593–3602. 2013. View Article : Google Scholar : PubMed/NCBI

47 

Song R, Wang ZD and Schapira M: Disease association and druggability of WD40 repeat proteins. J Proteome Res. 16:3766–3773. 2017. View Article : Google Scholar : PubMed/NCBI

48 

Yuan Y, Qi G, Shen H, Guo A, Cao F, Zhu Y, Xiao C, Chang W and Zheng S: Clinical significance and biological function of WD repeat domain 54 as an oncogene in colorectal cancer. Int J Cancer. 144:1584–1595. 2019.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Hu DJ, Shi WJ, Yu M and Zhang L: High WDR34 mRNA expression as a potential prognostic biomarker in patients with breast cancer as determined by integrated bioinformatics analysis . Oncol Lett 18: 3177-3187, 2019.
APA
Hu, D., Shi, W., Yu, M., & Zhang, L. (2019). High WDR34 mRNA expression as a potential prognostic biomarker in patients with breast cancer as determined by integrated bioinformatics analysis . Oncology Letters, 18, 3177-3187. https://doi.org/10.3892/ol.2019.10634
MLA
Hu, D., Shi, W., Yu, M., Zhang, L."High WDR34 mRNA expression as a potential prognostic biomarker in patients with breast cancer as determined by integrated bioinformatics analysis ". Oncology Letters 18.3 (2019): 3177-3187.
Chicago
Hu, D., Shi, W., Yu, M., Zhang, L."High WDR34 mRNA expression as a potential prognostic biomarker in patients with breast cancer as determined by integrated bioinformatics analysis ". Oncology Letters 18, no. 3 (2019): 3177-3187. https://doi.org/10.3892/ol.2019.10634
Copy and paste a formatted citation
x
Spandidos Publications style
Hu DJ, Shi WJ, Yu M and Zhang L: High WDR34 mRNA expression as a potential prognostic biomarker in patients with breast cancer as determined by integrated bioinformatics analysis . Oncol Lett 18: 3177-3187, 2019.
APA
Hu, D., Shi, W., Yu, M., & Zhang, L. (2019). High WDR34 mRNA expression as a potential prognostic biomarker in patients with breast cancer as determined by integrated bioinformatics analysis . Oncology Letters, 18, 3177-3187. https://doi.org/10.3892/ol.2019.10634
MLA
Hu, D., Shi, W., Yu, M., Zhang, L."High WDR34 mRNA expression as a potential prognostic biomarker in patients with breast cancer as determined by integrated bioinformatics analysis ". Oncology Letters 18.3 (2019): 3177-3187.
Chicago
Hu, D., Shi, W., Yu, M., Zhang, L."High WDR34 mRNA expression as a potential prognostic biomarker in patients with breast cancer as determined by integrated bioinformatics analysis ". Oncology Letters 18, no. 3 (2019): 3177-3187. https://doi.org/10.3892/ol.2019.10634
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