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Article

Comparative analysis of the serum proteome profiles of thyroid cancer: An initial focus on the lipid profile

  • Authors:
    • Dandan Li
    • Liangrui Zhou
    • Chaochao Ma
    • Wenhu Chen
    • Yimin Zhang
    • Songlin Yu
    • Danchen Wang
    • Yutong Zou
    • Jie Wu
    • Ling Qiu
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science, Beijing 100730, P.R. China, Department of Pathology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science, Beijing 100730, P.R. China, Department of Clinical Laboratory, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China
  • Pages: 3349-3357
    |
    Published online on: July 24, 2019
       https://doi.org/10.3892/ol.2019.10655
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Abstract

The serum lipid profile and clinical outcomes of cancer patients are commonly correlated in a wide range of carcinomas. However, few studies have investigated the serum lipid profile of patients with thyroid cancer (TC). The present study therefore aimed to analyze the lipid profiles of patients with TC. The serum proteomes of 31 participants with stage I‑IV TC were screened using Orbitrap Q Exactive Plus. Analytical data collected between November 1, 2013 and November 11, 2018 from the laboratory information system included the total cholesterol (CHO), triglyceride (TG), high‑density lipoprotein‑cholesterol (HDL‑C), low‑density lipoprotein cholesterol (LDL‑C), apolipoprotein A1 (ApoA1), lipoprotein (a) and apolipoprotein B (ApoB) levels that were used to validate the screening results. A total of 3875 outpatients were enrolled in this study. A number of 17 differentially expressed proteins were identified. An Ingenuity pathway analysis identified activation of the liver X receptor/retinoid X receptor (LXR/RXR) activation, which is a crucial pathway involved in lipid metabolism. The results demonstrated that the total CHO levels were significantly different between patients with TC and control groups, both in men and women. In women, the levels of TG, HDL‑C, Apo A1 and LDL‑C/HDL‑C were significantly different between patients with TC and control groups (all P<0.05). Higher concentrations of TG and LDL‑C/HDL‑C were observed in the cancer group compared with the control group. However, lower levels of Apo A1 and HDL‑C were observed in women from the cancer group compared with the control group. The results from the present study revealed the presence of a disordered lipid profile in patients with TC. The molecular mechanism underlying the association between lipid metabolism and cancer requires further investigation and may be used to develop novel diagnostic biomarkers and therapeutic targets in human cancers.
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1 

Scopa CD: Histopathology of thyroid tumors. An overview. Hormones (Athens). 3:100–110. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Holmes L Jr, Hossain J and Opara F: Pediatric thyroid carcinoma incidence and temporal trends in the USA (1973–2007): Race or shifting diagnostic paradigm? ISRN Oncol. 2012:9061972012.PubMed/NCBI

3 

Faquin WC: The thyroid gland: Recurring problems in histologic and cytologic evaluation. Arch Pathol Lab Med. 132:622–632. 2008.PubMed/NCBI

4 

Navas-Carrillo D, Rios A, Rodriguez JM, Parrilla P and Orenes-Piñero E: Familial nonmedullary thyroid cancer: Screening, clinical, molecular and genetic findings. Biochim Biophys Acta. 1846:468–476. 2014.PubMed/NCBI

5 

Howlader N, Noone AM, Krapcho M, Miller D, Brest A, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, et al: SEER Cancer Statistics Review, 1975–2016. National Cancer Institute; Bethesda, MD: https://seer.cancer.gov/csr/1975_2016/based on November 2018 SEER data submission, posted to the SEER web site. April. 2019

6 

Rahbari R, Zhang L and Kebebew E: Thyroid cancer gender disparity. Future Oncol. 6:1771–1779. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Paricharttanakul NM, Saharat K, Chokchaichamnankit D, Punyarit P, Srisomsap C and Svasti J: Unveiling a novel biomarker panel for diagnosis and classification of well-differentiated thyroid carcinomas. Oncol Rep. 35:2286–2296. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Villanueva J, Martorella AJ, Lawlor K, Philip J, Fleisher M, Robbins RJ and Tempst P: Serum peptidome patterns that distinguish metastatic thyroid carcinoma from cancer-free controls are unbiased by gender and age. Mol Cell Proteomics. 5:1840–1852. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Wang JX, Yu JK, Wang L, Liu QL, Zhang J and Zheng S: Application of serum protein fingerprint in diagnosis of papillary thyroid carcinoma. Proteomics. 6:5344–5349. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Cohen A, Wang E, Chisholm KA, Kostyleva R, O'Connor-McCourt M and Pinto DM: A mass spectrometry-based plasma protein panel targeting the tumor microenvironment in patients with breast cancer. J Proteomics. 81:135–147. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Egertson JD, Kuehn A, Merrihew GE, Bateman NW, MacLean BX, Ting YS, Canterbury JD, Marsh DM, Kellmann M, Zabrouskov V, et al: Multiplexed MS/MS for improved data-independent acquisition. Nat Methods. 10:744–746. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Maan M, Peters JM, Dutta M and Patterson AD: Lipid metabolism and lipophagy in cancer. Biochem Biophys Res Commun. 504:582–589. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Tamura K, Horikawa M, Sato S, Miyake H and Setou M: Discovery of lipid biomarkers correlated with disease progression in clear cell renal cell carcinoma using desorption electrospray ionization imaging mass spectrometry. Oncotarget. 10:1688–1703. 2019. View Article : Google Scholar : PubMed/NCBI

14 

Ma MZ, Yuan SQ, Chen YM and Zhou ZW: Preoperative apolipoprotein B/apolipoprotein A1 ratio: A novel prognostic factor for gastric cancer. Onco Targets Ther. 11:2169–2176. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Wang D, Cheng X, Yu S, Qiu L, Lian X, Guo X, Hu Y, Lu S, Yang G and Liu H: Data mining: Seasonal and temperature fluctuations in thyroid-stimulating hormone. Clin Biochem. 60:59–63. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Thompson L: World Health Organization classification of tumours: Pathology and genetics of head and neck tumours. Ear Nose Throat J. 85:742006. View Article : Google Scholar : PubMed/NCBI

17 

Long J, Zhang CJ, Zhu N, Du K, Yin YF, Tan X, Liao DF and Qin L: Lipid metabolism and carcinogenesis, cancer development. Am J Cancer Res. 8:778–791. 2018.PubMed/NCBI

18 

Nikitin PV, Potapov AA, Ryzhova MV, Shurkhay VA, Kulikov EE, Zhvanskiy ES, Popov IA and Nikolaev EN: The role of lipid metabolism disorders, atypical isoforms of protein kinase C, and mutational status of cytosolic and mitochondrial forms of isocitrate dehydrogenase in carcinogenesis of glial tumors. Zh Vopr Neirokhir Im N N Burdenko. 82:112–120. 2018.(In Russian). View Article : Google Scholar : PubMed/NCBI

19 

Ulmer H, Borena W, Rapp K, Klenk J, Strasak A, Diem G, Concin H and Nagel G: Serum triglyceride concentrations and cancer risk in a large cohort study in Austria. Br J Cancer. 101:1202–1206. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Martin RM, Vatten L, Gunnell D, Romundstad P and Nilsen TI: Components of the metabolic syndrome and risk of prostate cancer: The HUNT 2 cohort, Norway. Cancer Causes Control. 20:1181–1192. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Breslow JL, Ross D, McPherson J, Williams H, Kurnit D, Nussbaum AL, Karathanasis SK and Zannis VI: Isolation and characterization of cDNA clones for human apolipoprotein A-I. Proc Natl Acad Sci USA. 79:6861–6865. 1982. View Article : Google Scholar : PubMed/NCBI

22 

Cine N, Baykal AT, Sunnetci D, Canturk Z, Serhatli M and Savli H: Identification of ApoA1, HPX and POTEE genes by omic analysis in breast cancer. Oncol Rep. 32:1078–1086. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Hong TT, Shen D, Chen XP, Wu XH and Hua D: Preoperative serum lipid profile and outcome in nonmetastatic colorectal cancer. Chronic Dis Transl Med. 2:241–249. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Zhao R, Cheng G, Wang B, Qin C, Liu Y, Pan Y, Wang J, Hua L, Zhu W and Wang Z: BMI and serum lipid parameters predict increasing risk and aggressive prostate cancer in Chinese people. Oncotarget. 8:66051–66060. 2017.PubMed/NCBI

25 

Liu BZ, Tao L, Chen YZ, Li XZ, Dong YL, Ma YJ, Li SG, Li F and Zhang WJ: Preoperative body mass index, blood albumin and triglycerides predict survival for patients with gastric cancer. PLoS One. 11:e01574012016. View Article : Google Scholar : PubMed/NCBI

26 

You S, Zhong C, Xu J, Han Q, Zhang X, Liu H, Zhang Y, Shi J, Huang Z, Xiao G, et al: LDL-C/HDL-C ratio and risk of all-cause mortality in patients with intracerebral hemorrhage. Neurol Res. 38:903–908. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Liao T, Wang YJ, Hu JQ, Wang Y, Han LT, Ma B, Shi RL, Qu N, Wei WJ, Guan Q, et al: Histone methyltransferase KMT5A gene modulates oncogenesis and lipid metabolism of papillary thyroid cancer in vitro. Oncol Rep. 39:2185–2192. 2018.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li D, Zhou L, Ma C, Chen W, Zhang Y, Yu S, Wang D, Zou Y, Wu J, Qiu L, Qiu L, et al: Comparative analysis of the serum proteome profiles of thyroid cancer: An initial focus on the lipid profile. Oncol Lett 18: 3349-3357, 2019.
APA
Li, D., Zhou, L., Ma, C., Chen, W., Zhang, Y., Yu, S. ... Qiu, L. (2019). Comparative analysis of the serum proteome profiles of thyroid cancer: An initial focus on the lipid profile. Oncology Letters, 18, 3349-3357. https://doi.org/10.3892/ol.2019.10655
MLA
Li, D., Zhou, L., Ma, C., Chen, W., Zhang, Y., Yu, S., Wang, D., Zou, Y., Wu, J., Qiu, L."Comparative analysis of the serum proteome profiles of thyroid cancer: An initial focus on the lipid profile". Oncology Letters 18.3 (2019): 3349-3357.
Chicago
Li, D., Zhou, L., Ma, C., Chen, W., Zhang, Y., Yu, S., Wang, D., Zou, Y., Wu, J., Qiu, L."Comparative analysis of the serum proteome profiles of thyroid cancer: An initial focus on the lipid profile". Oncology Letters 18, no. 3 (2019): 3349-3357. https://doi.org/10.3892/ol.2019.10655
Copy and paste a formatted citation
x
Spandidos Publications style
Li D, Zhou L, Ma C, Chen W, Zhang Y, Yu S, Wang D, Zou Y, Wu J, Qiu L, Qiu L, et al: Comparative analysis of the serum proteome profiles of thyroid cancer: An initial focus on the lipid profile. Oncol Lett 18: 3349-3357, 2019.
APA
Li, D., Zhou, L., Ma, C., Chen, W., Zhang, Y., Yu, S. ... Qiu, L. (2019). Comparative analysis of the serum proteome profiles of thyroid cancer: An initial focus on the lipid profile. Oncology Letters, 18, 3349-3357. https://doi.org/10.3892/ol.2019.10655
MLA
Li, D., Zhou, L., Ma, C., Chen, W., Zhang, Y., Yu, S., Wang, D., Zou, Y., Wu, J., Qiu, L."Comparative analysis of the serum proteome profiles of thyroid cancer: An initial focus on the lipid profile". Oncology Letters 18.3 (2019): 3349-3357.
Chicago
Li, D., Zhou, L., Ma, C., Chen, W., Zhang, Y., Yu, S., Wang, D., Zou, Y., Wu, J., Qiu, L."Comparative analysis of the serum proteome profiles of thyroid cancer: An initial focus on the lipid profile". Oncology Letters 18, no. 3 (2019): 3349-3357. https://doi.org/10.3892/ol.2019.10655
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