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Article

MicroRNA‑21 promotes proliferation in acute myeloid leukemia by targeting Krüppel‑like factor 5

  • Authors:
    • Chan Li
    • Hua Yan
    • Jie Yin
    • Jian Ma
    • Ang Liao
    • Shengyou Yang
    • Lijuan Wang
    • Yongxiang Huang
    • Chon Lin
    • Zhiqiang Dong
    • Bo Yang
    • Ting Cao
    • Guo Liu
    • Lv Wang
  • View Affiliations / Copyright

    Affiliations: Department of Hematology and Oncology, Changzhi Medical College Affiliated Heji Hospital, Changzhi, Shanxi 046000, P.R. China, Department of Nuclear Medicine, Guizhou Provincial People's Hospital, Guiyang, Guizhou 550000, P.R. China
  • Pages: 3367-3372
    |
    Published online on: July 25, 2019
       https://doi.org/10.3892/ol.2019.10667
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Abstract

Abnormal expression of microRNA (miR)‑21 has been reported in various types of cancers. However, the role and mechanism of miR‑21 remain to be elucidated in acute myeloid leukemia (AML). In the present study, it was observed that miR‑21 was upregulated and Krüppel‑like factor 5 (KLF5) was downregulated in AML cells compared with normal bone marrow cells. Dual luciferase reporter assays revealed that KLF5 was a direct target of miR‑21. Indeed, miR‑21 overexpression resulted in a downregulation of KLF5 expression, while miR‑21 inhibition had the opposite effect in AML cells. In addition, miR‑21 overexpression promoted the proliferation of AML cells in vitro. Notably, using a mouse xenograft model, miR‑21 overexpression was demonstrated to result in enhanced tumor growth and suppressed KLF5 expression in the xenograft tumors in vivo. In conclusion, the present results indicated that miR‑21 promoted proliferation through directly regulating KLF5 expression in AML cells. miR‑21 may thus serve as an oncogene in AML, providing a potential target for AML therapy.
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1 

Graubert TA and Mardis ER: Genomics of acute myeloid leukemia. Cancer J. 17:487–491. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Bosshard R, O'Reilly K, Ralston S, Chadda S and Cork D: Systematic reviews of economic burden and health-related quality of life in patients with acute myeloid leukemia. Cancer Treat. Rev. 69:224–232. 2018.

3 

Yang X and Wang J: Precision therapy for acute myeloid leukemia. J Hematol Oncol. 11:32018. View Article : Google Scholar : PubMed/NCBI

4 

Mao J, Li S, Zhao H, Zhu Y, Hong M, Zhu H, Qian S and Li J: Effects of chidamide and its combination with decitabine on proliferation and apoptosis of leukemia cell lines. Am J Transl Res. 10:2567–2578. 2018.PubMed/NCBI

5 

McGuire A, Brown JA and Kerin MJ: Metastatic breast cancer: The potential of miRNA for diagnosis and treatment monitoring. Cancer Metastasis Rev. 34:145–155. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Zhang C, Bai G, Zhu W, Bai D and Bi G: Identification of miRNA-mRNA network associated with acute myeloid leukemia survival. Med Sci Monit. 23:4705–4714. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Liu L, Cai X, Liu E, Tian X and Tian C: MicroRNA-18a promotes proliferation and metastasis in hepatocellular carcinoma via targeting KLF4. Oncotarget. 8:68263–68269. 2017.PubMed/NCBI

8 

Tian C, Wu H, Li C, Tian X, Sun Y, Liu E, Liao X and Song W: Downreguation of FoxM1 by miR-214 inhibits proliferation and migration in hepatocellular carcinoma. Gene Ther. 25:312–319. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Hartmann JU, Bräuer-Hartmann D, Kardosova M, Wilke F, Schödel C, Gerloff D, Katzerke C, Krakowsky R, Namasu CY, Bill M, et al: MicroRNA-143 targets ERK5 in granulopoiesis and predicts outcome of patients with acute myeloid leukemia. Cell Death Dis. 9:8142018. View Article : Google Scholar : PubMed/NCBI

10 

Huang Y, Zou Y, Lin L, Ma X and Chen H: Identification of serum miR-34a as a potential biomarker in acute myeloid leukemia. Cancer Biomark. 22:799–805. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Ding Q, Wang Q, Ren Y, Zhu HQ and Huang Z: MicroRNA-126 attenuates cell apoptosis by targeting TRAF7 in acute myeloid leukemia cells. Biochem Cell Biol. 25:(Epub ahead of print). 2018.

12 

Badr M, Said H, Louka ML, Elghazaly HA, Gaballah A and Atef Abd El Mageed M: MicroRNA-21 as a predictor and prognostic factor for trastuzumab therapy in human epidermal growth factor receptor 2-positive metastatic breast cancer. J Cell Biochem. 120:3459–3466. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Riccioni R, Lulli V, Castelli G, Biffoni M, Tiberio R, Pelosi E, Lo-Coco F and Testa U: miR-21 is overexpressed in NPM1-mutant acute myeloid leukemias. Leuk Res. 39:221–228. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Li Y, Sui X, Hu X and Hu Z: Overexpression of KLF5 inhibits puromycin-induced apoptosis of podocytes. Mol Med Rep. 18:3843–3849. 2018.PubMed/NCBI

15 

Ma Y, Wang Q, Liu F, Ma X, Wu L, Guo F, Zhao S, Huang F and Qin G: KLF5 promotes the tumorigenesis and metastatic potential of thyroid cancer cells through the NF-κB signaling pathway. Oncol Rep. 40:2608–2618. 2018.PubMed/NCBI

16 

Jia L, Zhou Z, Liang H, Wu J, Shi P, Li F, Wang Z, Wang C, Chen W, Zhang H, et al: KLF5 promotes breast cancer proliferation, migration and invasion in part by upregulating the transcription of TNFAIP2. Oncogene. 35:2040–2051. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Gong T, Cui L, Wang H, Wang H and Han N: Knockdown of KLF5 suppresses hypoxia-induced resistance to cisplatin in NSCLC cells by regulating HIF-1α-dependent glycolysis through inactivation of the PI3K/Akt/mTOR pathway. J Transl Med. 16:1642018. View Article : Google Scholar : PubMed/NCBI

18 

Du C, Gao Y, Xu S, Jia J, Huang Z, Fan J, Wang X, He D and Guo P: KLF5 promotes cell migration by up-regulating FYN in bladder cancer cells. FEBS Lett. 590:408–418. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Diakiw SM, Kok CH, To LB, Lewis ID, Brown AL and D'Andrea RJ: The granulocyte-associated transcription factor Krüppel-like factor 5 is silenced by hypermethylation in acute myeloid leukemia. Leuk Res. 36:110–116. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Yang C, Shao T, Zhang H, Zhang N, Shi X, Liu X, Yao Y, Xu L, Zhu S, Cao J, et al: MiR-425 expression profiling in acute myeloid leukemia might guide the treatment choice between allogeneic transplantation and chemotherapy. J Transl Med. 16:2672018. View Article : Google Scholar : PubMed/NCBI

21 

Liu X, Abraham JM, Cheng Y, Wang Z, Wang Z, Zhang G, Ashktorab H, Smoot DT, Cole RN, Boronina TN, et al: Synthetic circular RNA functions as a miR-21 sponge to suppress gastric carcinoma cell proliferation. Mol Ther Nucleic Acids. 13:312–321. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Ding T, Cui P, Zhou Y, Chen C, Zhao J, Wang H, Guo M, He Z and Xu L: Antisense oligonucleotides against miR-21 inhibit the growth and metastasis of colorectal carcinoma via the DUSP8 pathway. Mol Ther Nucleic Acids. 13:244–255. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Wang Z, Yang H and Ren L: MiR-21 promoted proliferation and migration in hepatocellular carcinoma through negative regulation of Navigator-3. Biochem Biophys Res Commun. 464:1228–1234. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li C, Yan H, Yin J, Ma J, Liao A, Yang S, Wang L, Huang Y, Lin C, Dong Z, Dong Z, et al: MicroRNA‑21 promotes proliferation in acute myeloid leukemia by targeting Krüppel‑like factor 5. Oncol Lett 18: 3367-3372, 2019.
APA
Li, C., Yan, H., Yin, J., Ma, J., Liao, A., Yang, S. ... Wang, L. (2019). MicroRNA‑21 promotes proliferation in acute myeloid leukemia by targeting Krüppel‑like factor 5. Oncology Letters, 18, 3367-3372. https://doi.org/10.3892/ol.2019.10667
MLA
Li, C., Yan, H., Yin, J., Ma, J., Liao, A., Yang, S., Wang, L., Huang, Y., Lin, C., Dong, Z., Yang, B., Cao, T., Liu, G., Wang, L."MicroRNA‑21 promotes proliferation in acute myeloid leukemia by targeting Krüppel‑like factor 5". Oncology Letters 18.3 (2019): 3367-3372.
Chicago
Li, C., Yan, H., Yin, J., Ma, J., Liao, A., Yang, S., Wang, L., Huang, Y., Lin, C., Dong, Z., Yang, B., Cao, T., Liu, G., Wang, L."MicroRNA‑21 promotes proliferation in acute myeloid leukemia by targeting Krüppel‑like factor 5". Oncology Letters 18, no. 3 (2019): 3367-3372. https://doi.org/10.3892/ol.2019.10667
Copy and paste a formatted citation
x
Spandidos Publications style
Li C, Yan H, Yin J, Ma J, Liao A, Yang S, Wang L, Huang Y, Lin C, Dong Z, Dong Z, et al: MicroRNA‑21 promotes proliferation in acute myeloid leukemia by targeting Krüppel‑like factor 5. Oncol Lett 18: 3367-3372, 2019.
APA
Li, C., Yan, H., Yin, J., Ma, J., Liao, A., Yang, S. ... Wang, L. (2019). MicroRNA‑21 promotes proliferation in acute myeloid leukemia by targeting Krüppel‑like factor 5. Oncology Letters, 18, 3367-3372. https://doi.org/10.3892/ol.2019.10667
MLA
Li, C., Yan, H., Yin, J., Ma, J., Liao, A., Yang, S., Wang, L., Huang, Y., Lin, C., Dong, Z., Yang, B., Cao, T., Liu, G., Wang, L."MicroRNA‑21 promotes proliferation in acute myeloid leukemia by targeting Krüppel‑like factor 5". Oncology Letters 18.3 (2019): 3367-3372.
Chicago
Li, C., Yan, H., Yin, J., Ma, J., Liao, A., Yang, S., Wang, L., Huang, Y., Lin, C., Dong, Z., Yang, B., Cao, T., Liu, G., Wang, L."MicroRNA‑21 promotes proliferation in acute myeloid leukemia by targeting Krüppel‑like factor 5". Oncology Letters 18, no. 3 (2019): 3367-3372. https://doi.org/10.3892/ol.2019.10667
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