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Article Open Access

Long non‑coding RNAs as prognostic biomarkers in papillary renal cell carcinoma

  • Authors:
    • Feilong Yang
    • Yimeng Song
    • Liyuan Ge
    • Guojiang Zhao
    • Cheng Liu
    • Lulin Ma
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Peking University Third Hospital, Beijing 100191, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3691-3697
    |
    Published online on: July 29, 2019
       https://doi.org/10.3892/ol.2019.10684
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Abstract

The aim of the present study was to identify long non‑coding RNA (lncRNA)‑based prognostic biomarkers in papillary renal cell carcinoma (pRCC). lncRNA expression data and corresponding clinical data from patients with pRCC were obtained from The Cancer Genome Atlas. R software and packages were used for data analysis. Univariate Cox regression analysis and least absolute shrinkage and selection operator regression were performed to identify key lncRNAs, which were then used to construct a prognostic model using multivariate Cox regression analysis. Patients were divided into high‑ and low‑risk groups, and Kaplan‑Meier (KM) survival curves and time‑dependent receiver operating characteristic (ROC) curves were plotted. The C‑index was calculated to estimate the model's prognostic power. The hazard ratio (HR), 95% confidence interval (CI), and statistical significance of each key lncRNA were also calculated by multivariate Cox regression. Based on the result of the multivariate Cox regression analysis, KM survival plots were plotted for each significantly associated lncRNA. The subcellular locations of the prognostic biomarkers were predicted using lncRNAMap and lncLocator. A total of 17 lncRNA signatures were identified as key lncRNAs. Overall survival rate was significantly higher in the low‑risk group compared with the high‑risk group. The areas under the ROC curve were 0.93 (3‑year ROC) and 0.902 (5‑year ROC), and the C‑index was 0.915. A forest plot was used to illustrate the HR and 95% CI of key lncRNAs. KM survival analysis revealed the prognostic significance of two protective biomarkers, AC024022.1 and GAS6‑AS1, and three adverse biomarkers, AC087379.2, AL352984.1, and AL499627.1. It was predicted that AC024022.1 and AC087379.2 may be located in the cytoplasm and GAS6‑AS1 may be located in the cytosol. The present study may contribute to the management of pRCC and serve as a foundation for further investigations into the underlying mechanism of tumorigenesis and progression of pRCC.
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1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Courthod G, Tucci M, Di Maio M and Scagliotti GV: Papillary renal cell carcinoma: A review of the current therapeutic landscape. Crit Rev Oncol Hematol. 96:100–112. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Cheng P: A prognostic 3-long noncoding RNA signature for patients with gastric cancer. J Cell Biochem. 119:9261–9269. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Quinn JJ and Chang HY: Unique features of long non-coding RNA biogenesis and function. Nat Rev Genet. 17:47–62. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Rinn JL and Chang HY: Genome regulation by long noncoding RNAs. Annu Rev Biochem. 81:145–166. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Ponting CP, Oliver PL and Reik W: Evolution and functions of long noncoding RNAs. Cell. 136:629–641. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Esteller M: Non-coding RNAs in human disease. Nat Rev Genet. 12:861–874. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Martens-Uzunova ES, Bottcher R, Croce CM, Jenster G, Visakorpi T and Calin GA: Long noncoding RNA in prostate, bladder, and kidney cancer. Eur Urol. 65:1140–1151. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Jin Y, Feng SJ, Qiu S, Shao N and Zheng JH: LncRNA MALAT1 promotes proliferation and metastasis in epithelial ovarian cancer via the PI3K-AKT pathway. Eur Rev Med Pharmacol Sci. 21:3176–3184. 2017.PubMed/NCBI

10 

Gupta RA, Shah N, Wang KC, Kim J, Horlings HM, Wong DJ, Tsai MC, Hung T, Argani P, Rinn JL, et al: Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature. 464:1071–1076. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Deng M, Bragelmann J, Schultze JL and Perner S: Web-TCGA: an online platform for integrated analysis of molecular cancer data sets. BMC Bioinformatics. 17:722016. View Article : Google Scholar : PubMed/NCBI

12 

R Core Team. R, . A language and environment for statistical computing. R Foundation for Statistical Computing; Vienna: 2012, http://www.r-project.org/

13 

RStudio Team (2015), . RStudio: Integrated Development for R. RStudio, Inc., Boston, MA, 2015. http://www.rstudio.com/

14 

Robinson MD, McCarthy DJ and Smyth GK: edgeR: A Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 26:139–140. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Tibshirani R: Regression shrinkage and selection via the lasso: A retrospective. J Royal Statist Soc Series B. 73:273–282. 2011. View Article : Google Scholar

16 

Chan WL, Huang HD and Chang JG: lncRNAMap: A map of putative regulatory functions in the long non-coding transcriptome. Comput Biol Chem. 50:41–49. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Cao Z, Pan X, Yang Y, Huang Y and Shen HB: The lncLocator: A subcellular localization predictor for long non-coding RNAs based on a stacked ensemble classifier. Bioinformatics. 34:2185–2194. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Schmitt AM and Chang HY: Long noncoding RNAs in cancer pathways. Cancer Cell. 29:452–463. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Shen Y, Wang Z, Loo LW, Ni Y, Jia W, Fei P, Risch HA, Katsaros D and Yu H: LINC00472 expression is regulated by promoter methylation and associated with disease-free survival in patients with grade 2 breast cancer. Breast Cancer Res Treat. 154:473–482. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Wang KC and Chang HY: Molecular mechanisms of long noncoding RNAs. Mol Cell. 43:904–914. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Lee JT: Epigenetic regulation by long noncoding RNAs. Science. 338:1435–1439. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Yu Y, Yang J, Li Q, Xu B, Lian Y and Miao L: LINC00152: A pivotal oncogenic long non-coding RNA in human cancers. Cell Prolif. 50:2017. View Article : Google Scholar

23 

Yue B, Qiu S, Zhao S, Liu C, Zhang D, Yu F, Peng Z and Yan D: LncRNA-ATB mediated E-cadherin repression promotes the progression of colon cancer and predicts poor prognosis. J Gastroenterol Hepatol. 31:595–603. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Ellinger J, Gevensleben H, Muller SC and Dietrich D: The emerging role of non-coding circulating RNA as a biomarker in renal cell carcinoma. Expert Rev Mol Diagn. 16:1059–1065. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Huang HW, Xie H, Ma X, Zhao F and Gao Y: Upregulation of LncRNA PANDAR predicts poor prognosis and promotes cell proliferation in cervical cancer. Eur Rev Med Pharmacol Sci. 21:4529–4535. 2017.PubMed/NCBI

26 

Bao X, Duan J, Yan Y, Ma X, Zhang Y, Wang H, Ni D, Wu S, Peng C, Fan Y, et al: Upregulation of long noncoding RNA PVT1 predicts unfavorable prognosis in patients with clear cell renal cell carcinoma. Cancer Biomark. 21:55–63. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Wang PQ, Wu YX, Zhong XD, Liu B and Qiao G: Prognostic significance of overexpressed long non-coding RNA TUG1 in patients with clear cell renal cell carcinoma. Eur Rev Med Pharmacol Sci. 21:82–86. 2017.PubMed/NCBI

28 

Xu Y, Tong Y, Zhu J, Lei Z, Wan L, Zhu X, Ye F and Xie L: An increase in long non-coding RNA PANDAR is associated with poor prognosis in clear cell renal cell carcinoma. BMC Cancer. 17:3732017. View Article : Google Scholar : PubMed/NCBI

29 

Ning L, Li Z, Wei D, Chen H and Yang C: LncRNA, NEAT1 is a prognosis biomarker and regulates cancer progression via epithelial-mesenchymal transition in clear cell renal cell carcinoma. Cancer Biomark. 19:75–83. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Han L, Kong R, Yin DD, Zhang EB, Xu TP, De W and Shu YQ: Low expression of long noncoding RNA GAS6-AS1 predicts a poor prognosis in patients with NSCLC. Med Oncol. 30:6942013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yang F, Song Y, Ge L, Zhao G, Liu C and Ma L: Long non‑coding RNAs as prognostic biomarkers in papillary renal cell carcinoma. Oncol Lett 18: 3691-3697, 2019.
APA
Yang, F., Song, Y., Ge, L., Zhao, G., Liu, C., & Ma, L. (2019). Long non‑coding RNAs as prognostic biomarkers in papillary renal cell carcinoma. Oncology Letters, 18, 3691-3697. https://doi.org/10.3892/ol.2019.10684
MLA
Yang, F., Song, Y., Ge, L., Zhao, G., Liu, C., Ma, L."Long non‑coding RNAs as prognostic biomarkers in papillary renal cell carcinoma". Oncology Letters 18.4 (2019): 3691-3697.
Chicago
Yang, F., Song, Y., Ge, L., Zhao, G., Liu, C., Ma, L."Long non‑coding RNAs as prognostic biomarkers in papillary renal cell carcinoma". Oncology Letters 18, no. 4 (2019): 3691-3697. https://doi.org/10.3892/ol.2019.10684
Copy and paste a formatted citation
x
Spandidos Publications style
Yang F, Song Y, Ge L, Zhao G, Liu C and Ma L: Long non‑coding RNAs as prognostic biomarkers in papillary renal cell carcinoma. Oncol Lett 18: 3691-3697, 2019.
APA
Yang, F., Song, Y., Ge, L., Zhao, G., Liu, C., & Ma, L. (2019). Long non‑coding RNAs as prognostic biomarkers in papillary renal cell carcinoma. Oncology Letters, 18, 3691-3697. https://doi.org/10.3892/ol.2019.10684
MLA
Yang, F., Song, Y., Ge, L., Zhao, G., Liu, C., Ma, L."Long non‑coding RNAs as prognostic biomarkers in papillary renal cell carcinoma". Oncology Letters 18.4 (2019): 3691-3697.
Chicago
Yang, F., Song, Y., Ge, L., Zhao, G., Liu, C., Ma, L."Long non‑coding RNAs as prognostic biomarkers in papillary renal cell carcinoma". Oncology Letters 18, no. 4 (2019): 3691-3697. https://doi.org/10.3892/ol.2019.10684
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