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Cancer stem‑like cells with increased expression of NY‑ESO‑1 initiate breast cancer metastasis

  • Authors:
    • Mai‑Ying Liu
    • Hang Su
    • Hua‑Lan Huang
    • Jing‑Qi Chen
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong 510260, P.R. China, Stem Cell Translational Medicine Centre, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong 510260, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3664-3672
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    Published online on: August 1, 2019
       https://doi.org/10.3892/ol.2019.10699
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Abstract

Breast cancer stem‑like cells (BCSLCs) with a CD44+/CD24‑/low phenotype initiate the invasion and metastasis of breast cancer. The expression of New York oesophageal squamous cell carcinoma 1 (NY‑ESO‑1), one of the most immunogenic cancer‑testicular antigens, is largely restricted to cancer and germ cells/placental trophoblasts, with little to no expression in normal adult somatic cells. Currently, few studies have reported the expression or function of NY‑ESO‑1 in BCSLCs. In the present study, immunohistochemistry indicated enhanced expression levels of NY‑ESO‑1/CD44 (P<0.01) and decreased expression levels of CD24 (P<0.01) in metastatic breast cancer tissues (MBCT) compared with non‑MBCT. Additionally, the co‑localization of CD44, CD24 and NY‑ESO‑1 in tissue samples was determined using immunofluorescence analysis. The results revealed that the expression of NY‑ESO‑1/CD44/CD24 was associated with breast cancer metastasis. Moreover, Spearman's rank correlation analysis indicated that CD44/CD24 expression was significantly correlated with that of NY‑ESO‑1. In the present study, mammosphere culture, a valuable method of BCSLC enrichment, was used to enrich MCF‑7 and SK‑BR‑3 BCSLCs; immunofluorescence, western blotting and flow cytometry demonstrated increased expression levels of NY‑ESO‑1 and CD44, and low expression levels of CD24 in BCSLCs. Furthermore, the cell migration and invasion assays verified that BCSLCs with an increased NY‑ESO‑1 expression level exhibited greater invasive and migratory capacity compared with parental breast cancer cells. In addition to previously reported findings from the Oncomine database, it was ascertained that CD44+/CD24‑/low BCSLCs with an increased level of NY‑ESO‑1 expression initiated the invasion and metastasis of breast cancer; therefore, NY‑ESO‑1 may serve as a novel target for metastatic breast cancer immunotherapy.
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1 

Marino N, Woditschka S, Reed LT, Nakayama J, Mayer M, Wetzel M and Steeg PS: Breast cancer metastasis. Am J Pathol. 183:1084–1095. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Yin C, Li H, Zhang B, Liu Y, Lu G, Lu S, Sun L, Qi Y, Li X and Chen W: Erratum to: RAGE-binding S100A8/A9 promotes the migration and invasion of human breast cancer cells through actin polymerization and epithelial-mesenchymal transition. Breast Cancer Res Treat. 156:407–408. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Mukherjee D and Zhao J: The Role of chemokine receptor CXCR4 in breast cancer metastasis. Am J Cancer Res. 3:46–57. 2013.PubMed/NCBI

4 

Paget S: The distribution of secondary growths in cancer of the breast. 1889. Cancer Metastasis Rev. 8:98–101. 1989.PubMed/NCBI

5 

Chambers AF, Groom AC and MacDonald IC: Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer. 2:563–572. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Croker AK, Goodale D, Chu J, Postenka C, Hedley BD, Hess DA and Allan AL: High aldehyde dehydrogenase and expression of cancer stem cell markers selects for breast cancer cells with enhanced malignant and metastatic ability. J Cell Mol Med. 13:2236–2252. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Sottoriva A, Verhoeff JJ, Borovski T, McWeeney SK, Naumov L, Medema JP, Sloot PM and Vermeulen L: Cancer stem cell tumor model reveals invasive morphology and increased phenotypical heterogeneity. Cancer Res. 70:46–56. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Lawson JC, Blatch GL and Edkins AL: Cancer stem cells in breast cancer and metastasis. Breast Cancer Res Treat. 118:241–254. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Li F, Tiede B, Massagué J and Kang Y: Beyond tumorigenesis: Cancer stem cells in metastasis. Cell Res. 17:3–14. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Shiozawa Y, Nie B, Pienta KJ, Morgan TM and Taichman RS: Cancer stem cells and their role in metastasis. Pharmacol Ther. 138:285–293. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Salmaninejad A, Zamani MR, Pourvahedi M, Golchehre Z, Hosseini Bereshneh A and Rezaei N: Cancer/testis antigens: Expression, regulation, tumor invasion, and use in immunotherapy of cancers. Immunol Invest. 45:619–640. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Fratta E, Coral S, Covre A, Parisi G, Colizzi F, Danielli R, Nicolay HJ, Sigalotti L and Maio M: The biology of cancer testis antigens: Putative function, regulation and therapeutic potential. Mol Oncol. 5:164–182. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Thomas R, Al-Khadairi G, Roelands J, Hendrickx W, Dermime S, Bedognetti D and Decock J: NY-ESO-1 based immunotherapy of cancer: Current perspectives. Front Immunol. 9:9472018. View Article : Google Scholar : PubMed/NCBI

14 

Tavakoli Koudehi A, Mahjoubi B, Mirzaei R, Shabani S and Mahjoubi F: AKAP4, SPAG9 and NY-ESO-1 in iranian colorectal cancer patients as probable diagnostic and prognostic biomarkers. Asian Pac J Cancer Prev. 19:463–469. 2018.PubMed/NCBI

15 

Sharma P, Gnjatic S, Jungbluth AA, Williamson B, Herr H, Stockert E, Dalbagni G, Donat SM, Reuter VE, Santiago D, et al: Frequency of NY-ESO-1 and LAGE-1 expression in bladder cancer and evidence of a new NY-ESO-1 T-cell epitope in a patient with bladder cancer. Cancer Immun. 3:192003. View Article : Google Scholar : PubMed/NCBI

16 

Akcakanat A, Kanda T, Koyama Y, Watanabe M, Kimura E, Yoshida Y, Komukai S, Nakagawa S, Odani S, Fujii H and Hatakeyama K: NY-ESO-1 expression and its serum immunoreactivity in esophageal cancer. Cancer Chemother Pharmacol. 54:95–100. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Odunsi K, Jungbluth AA, Stockert E, Qian F, Gnjatic S, Tammela J, Intengan M, Beck A, Keitz B, Santiago D, et al: NY-ESO-1 and LAGE-1 cancer-testis antigens are potential targets for immunotherapy in epithelial ovarian cancer. Cancer Res. 63:6076–6083. 2003.PubMed/NCBI

18 

Fossa A, Berner A, Fossa SD, Hernes E, Gaudernack G and Smeland EB: NY-ESO-1 protein expression and humoral immune responses in prostate cancer. Prostate. 59:440–447. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Raghavendra A, Kalita-de Croft P, Vargas AC, Smart CE, Simpson PT, Saunus JM and Lakhani SR: Expression of MAGE-A and NY-ESO-1 cancer/testis antigens is enriched in triple-negative invasive breast cancers. Histopathology. 73:68–80. 2018. View Article : Google Scholar : PubMed/NCBI

20 

Wang Y, Wu XJ, Zhao AL, Yuan YH, Chen YT, Jungbluth AA, Gnjatic S, Santiago D, Ritter G, Chen WF, et al: Cancer/testis antigen expression and autologous humoral immunity to NY-ESO-1 in gastric cancer. Cancer Immun. 4:112004.PubMed/NCBI

21 

Aung PP, Liu YC, Ballester LY, Robbins PF, Rosenberg SA and Lee CC: Expression of New York esophageal squamous cell carcinoma-1 in primary and metastatic melanoma. Hum Pathol. 45:259–267. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Cronwright G, Le Blanc K, Götherström C, Darcy P, Ehnman M and Brodin B: Cancer/testis antigen expression in human mesenchymal stem cells: Down-regulation of SSX impairs cell migration and matrix metalloproteinase 2 expression. Cancer Res. 65:2207–2215. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Yawata T, Nakai E, Park KC, Chihara T, Kumazawa A, Toyonaga S, Masahira T, Nakabayashi H, Kaji T and Shimizu K: Enhanced expression of cancer testis antigen genes in glioma stem cells. Mol Carcinog. 49:532–544. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Coombes RC, Caballero OL, Shousha S, Ghaem-Maghami S, Woodley-Barker L, Wilhelm-Benartzi CS and Neville AM: NY-ESO-1 expression in DCIS: A new predictor of good prognosis. Oncoscience. 4:33–40. 2017.PubMed/NCBI

25 

Hou GX, Liu P, Yang J and Wen S: Mining expression and prognosis of topoisomerase isoforms in non-small-cell lung cancer by using Oncomine and Kaplan-Meier plotter. PLoS One. 12:e1745152017. View Article : Google Scholar

26 

Choudhary D, Hegde P, Voznesensky O, Choudhary S, Kopsiaftis S, Claffey KP, Pilbeam CC and Taylor JA III: Increased expression of L-selectin (CD62L) in high-grade urothelial carcinoma: A potential marker for metastatic disease. Urol Oncol. 33:317–387. 2015. View Article : Google Scholar

27 

Ademuyiwa FO, Bshara W, Attwood K, Morrison C, Edge SB, Karpf AR, James SA, Ambrosone CB, O'Connor TL, Levine EG, et al: NY-ESO-1 cancer testis antigen demonstrates high immunogenicity in triple negative breast cancer. PLoS One. 7:e387832012. View Article : Google Scholar : PubMed/NCBI

28 

Theurillat JP, Ingold F, Frei C, Zippelius A, Varga Z, Seifert B, Chen YT, Jäger D, Knuth A and Moch H: NY-ESO-1 protein expression in primary breast carcinoma and metastases: Correlation with CD8+ T-cell and CD79a+ plasmacytic/B-cell infiltration. Int J Cancer. 120:2411–2417. 2017. View Article : Google Scholar

29 

Shao J, Fan W, Ma B and Wu Y: Breast cancer stem cells expressing different stem cell markers exhibit distinct biological characteristics. Mol Med Rep. 14:4991–4998. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Dontu G, Abdallah WM, Foley JM, Jackson KW, Clarke MF, Kawamura MJ and Wicha MS: In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev. 17:1253–1270. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Ponti D, Costa A, Zaffaroni N, Pratesi G, Petrangolini G, Coradini D, Pilotti S, Pierotti MA and Daidone MG: Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties. Cancer Res. 65:5506–5511. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Li HY, Cui XY, Wu W, Yu FY, Yao HR, Liu Q, Song EW and Chen JQ: Pyk2 and Src mediate signaling to CCL18-induced breast cancer metastasis. J Cell Biochem. 115:596–603. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Ma XJ, Dahiya S, Richardson E, Erlander M and Sgroi DC: Gene expression profiling of the tumor microenvironment during breast cancer progression. Breast Cancer Res. 11:R72009. View Article : Google Scholar : PubMed/NCBI

34 

Bonnet D and Dick JE: Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med. 3:730–737. 1997. View Article : Google Scholar : PubMed/NCBI

35 

Lapidot T, Sirard C, Vormoor J, Murdoch B, Hoang T, Caceres-Cortes J, Minden M, Paterson B, Caligiuri MA and Dick JE: A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature. 367:645–648. 1994. View Article : Google Scholar : PubMed/NCBI

36 

Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ and Clarke MF: Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA. 100:3983–3988. 2003. View Article : Google Scholar : PubMed/NCBI

37 

Liu H, Patel MR, Prescher JA, Patsialou A, Qian D, Lin J, Wen S, Chang YF, Bachmann MH, Shimono Y, et al: Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models. Proc Natl Acad Sci USA. 107:18115–18120. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Liu C, Kelnar K, Liu B, Chen X, Calhoun-Davis T, Li H, Patrawala L, Yan H, Jeter C, Honorio S, et al: The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. Nat Med. 17:211–215. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Zhou J, Wulfkuhle J, Zhang H, Gu P, Yang Y, Deng J, Margolick JB, Liotta LA, Petricoin E III and Zhang Y: Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance. Proc Natl Acad Sci USA. 104:16158–16163. 2007. View Article : Google Scholar : PubMed/NCBI

40 

Whitehurst AW: Cause and consequence of cancer/testis antigen activation in cancer. Annu Rev Pharmacol Toxicol. 54:251–272. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu MY, Su H, Huang HL and Chen JQ: Cancer stem‑like cells with increased expression of NY‑ESO‑1 initiate breast cancer metastasis. Oncol Lett 18: 3664-3672, 2019.
APA
Liu, M., Su, H., Huang, H., & Chen, J. (2019). Cancer stem‑like cells with increased expression of NY‑ESO‑1 initiate breast cancer metastasis. Oncology Letters, 18, 3664-3672. https://doi.org/10.3892/ol.2019.10699
MLA
Liu, M., Su, H., Huang, H., Chen, J."Cancer stem‑like cells with increased expression of NY‑ESO‑1 initiate breast cancer metastasis". Oncology Letters 18.4 (2019): 3664-3672.
Chicago
Liu, M., Su, H., Huang, H., Chen, J."Cancer stem‑like cells with increased expression of NY‑ESO‑1 initiate breast cancer metastasis". Oncology Letters 18, no. 4 (2019): 3664-3672. https://doi.org/10.3892/ol.2019.10699
Copy and paste a formatted citation
x
Spandidos Publications style
Liu MY, Su H, Huang HL and Chen JQ: Cancer stem‑like cells with increased expression of NY‑ESO‑1 initiate breast cancer metastasis. Oncol Lett 18: 3664-3672, 2019.
APA
Liu, M., Su, H., Huang, H., & Chen, J. (2019). Cancer stem‑like cells with increased expression of NY‑ESO‑1 initiate breast cancer metastasis. Oncology Letters, 18, 3664-3672. https://doi.org/10.3892/ol.2019.10699
MLA
Liu, M., Su, H., Huang, H., Chen, J."Cancer stem‑like cells with increased expression of NY‑ESO‑1 initiate breast cancer metastasis". Oncology Letters 18.4 (2019): 3664-3672.
Chicago
Liu, M., Su, H., Huang, H., Chen, J."Cancer stem‑like cells with increased expression of NY‑ESO‑1 initiate breast cancer metastasis". Oncology Letters 18, no. 4 (2019): 3664-3672. https://doi.org/10.3892/ol.2019.10699
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