Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
October-2019 Volume 18 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2019 Volume 18 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Low expression of ryanodine receptor 2 is associated with poor prognosis in thyroid carcinoma

  • Authors:
    • Nizhen Xu
    • Deguang Zhang
    • Jian Chen
    • Gaofei He
    • Li Gao
  • View Affiliations / Copyright

    Affiliations: Department of Head and Neck Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3605-3612
    |
    Published online on: August 7, 2019
       https://doi.org/10.3892/ol.2019.10732
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Genetic alterations are vital in the progression of thyroid carcinoma. Ryanodine receptor 2 (RyR2) is reported to serve an important role in several types of human carcinoma. However, the expression and effect of RyR2 in thyroid carcinoma remain unknown. Therefore, the present study analyzed the status of RyR2 in thyroid carcinoma using bioinformatics tools. The mRNA profiles of thyroid carcinoma were downloaded from The Cancer Genome Atlas. RyR2 was distinguished as a differentially expressed gene that has not been reported in thyroid carcinoma. Further analysis indicated that there was selective downregulation of RyR2 expression in thyroid carcinoma tissues compared with that in normal thyroid tissues. Survival analysis showed that RyR2 expression was associated with poorer disease‑free survival (DFS) for all patients with thyroid carcinoma. Univariate analysis revealed that a low expression of RyR2 was significantly associated with lymphatic metastasis, extracapsular extension, and the Tumor‑Node‑Metastasis stage. Cox analysis demonstrated that RyR2 was an independent prognostic factor in thyroid carcinoma for DFS. The biological processes and signaling pathways of RyR2 were reviewed with Gene Set Enrichment Analysis. In conclusion, the present study has revealed that RyR2 is downregulated in thyroid carcinoma, and that low expression of RyR2 is associated with poor prognosis in patients with thyroid carcinoma. RyR2 may therefore serve as a promising tumor suppressor gene in thyroid carcinoma.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

La Vecchia C, Malvezzi M, Bosetti C, Garavello W, Bertuccio P, Levi F and Negri E: Thyroid cancer mortality and incidence: A global overview. Int J Cancer. 136:2187–2195. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Rahib L, Smith BD, Aizenberg R, Rosenzweig AB, Fleshman JM and Matrisian LM: Projecting cancer incidence and deaths to 2030: The unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res. 74:2913–2921. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Pellegriti G, Frasca F, Regalbuto C, Squatrito S and Vigneri R: Worldwide increasing incidence of thyroid cancer: Update on epidemiology and risk factors. J Cancer Epidemiol 2013. 9652122013.

4 

Siegel R, Ward E, Brawley O and Jemal A: Cancer statistics, 2011: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin. 61:212–236. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Weir HK, Thompson TD, Soman A, Møller B and Leadbetter S: The past, present, and future of cancer incidence in the United States: 1975 through 2020. Cancer. 121:1827–1837. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2016. CA Cancer J Clin. 66:7–30. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Jung KW, Won YJ, Kong HJ, Oh CM, Seo HG and Lee JS: Cancer statistics in Korea: Incidence, mortality, survival and prevalence in 2010. Cancer Res Treat. 45:1–14. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Cabanillas ME, McFadden DG and Durante C: Thyroid cancer. Lancet. 388:2783–2795. 2016. View Article : Google Scholar : PubMed/NCBI

10 

McLeod DS, Cooper DS, Ladenson PW, Ain KB, Brierley JD, Fein HG, Haugen BR, Jonklaas J, Magner J, Ross DS, et al: Prognosis of differentiated thyroid cancer in relation to serum thyrotropin and thyroglobulin antibody status at time of diagnosis. Thyroid. 24:35–42. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Han MA and Kim JH: Diagnostic X-Ray exposure and thyroid cancer risk: Systematic review and meta-analysis. Thyroid. 28:220–228. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Hong SH, Myung SK and Kim HS; Korean Meta-Analysis (KORMA) Study Group, : Alcohol intake and risk of thyroid cancer: A Meta-analysis of observational studies. Cancer Res Treat. 49:534–547. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Marotta V, Russo G, Gambardella C, Grasso M, La Sala D, Chiofalo MG, D'Anna R, Puzziello A, Docimo G, Masone S, et al: Human exposure to bisphenol AF and diethylhexylphthalate increases susceptibility to develop differentiated thyroid cancer in patients with thyroid nodules. Chemosphere. 218:885–894. 2019. View Article : Google Scholar : PubMed/NCBI

14 

Kurata A: Differentiated thyroid cancer: Why does it affect predominantly women during the reproductive period and have higher incidence of mutual association with breast cancer. Med Hypotheses. 122:5–7. 2019. View Article : Google Scholar : PubMed/NCBI

15 

Yan Z, Pan J, Gao F, An Z, Liu H, Huang Y and Wang X: Seawater quality criteria derivation and ecological risk assessment for oil pollution in China. Mar Pollut Bull. 142:25–30. 2019. View Article : Google Scholar : PubMed/NCBI

16 

Bai L, Wang J, Ma X and Lu H: Air pollution forecasts: An overview. Int J Environ Res Public Health. 15(pii): E7802018. View Article : Google Scholar : PubMed/NCBI

17 

Dehghani MH, Mosavi MF, Ale-Sheikh AA, Heidarinejad Z and Yousefi M: Experimental data of designing an optimal system for storage, collection and transfer of household waste in the GIS environment: A case study of Tehran, district 22, Iran. Data Brief. 19:1605–1613. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Chae Y and An YJ: Current research trends on plastic pollution and ecological impacts on the soil ecosystem: A review. Environ Pollut. 240:387–395. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Albi E, Cataldi S, Lazzarini A, Codini M, Beccari T, Ambesi-Impiombato FS and Curcio F: Radiation and thyroid cancer. Int J Mol Sci. 18(pii): E9112017. View Article : Google Scholar : PubMed/NCBI

20 

Salem R, Haibe Y, Dagher C, Salem C, Shamseddine A, Bitar N, Makdessi J, Khatib S, Boussen H, Benna F, et al: Female oncologists in the Middle East and North Africa: Progress towards gender equality. ESMO Open. 4:e0004872019. View Article : Google Scholar : PubMed/NCBI

21 

Siraj AK, Pratheeshkumar P, Parvathareddy SK, Bu R, Masoodi T, Iqbal K, Al-Rasheed M, Al-Dayel F, Al-Sobhi SS, Alzahrani AS, et al: Prognostic significance of DNMT3A alterations in Middle Eastern papillary thyroid carcinoma. Eur J Cancer. 117:133–144. 2019. View Article : Google Scholar : PubMed/NCBI

22 

Markovina S, Grigsby PW, Schwarz JK, DeWees T, Moley JF, Siegel BA and Perkins SM: Treatment approach, surveillance, and outcome of well-differentiated thyroid cancer in childhood and adolescence. Thyroid. 24:1121–1126. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Amaral L, Bufalo NE, Peres KC, Barreto IS, Campos A and Ward LS: ID proteins may reduce aggressiveness of thyroid tumors. Endocr Pathol. 30:24–30. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Zanotti-Fregonara P, Rubello D and Hindié E: Bone metastases of differentiated thyroid cancer: The importance of early diagnosis and 131I therapy on prognosis. J Nucl Med. 49:1902–1903. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Ding Z, Yuan J, Liang Y, Wu J, Gong H, Ye Y, Jiang G, Yin P, Li Y, Zhang G, et al: Ryanodine receptor type 2 plays a role in the development of cardiac fibrosis under mechanical stretch through TGFβ-1. Int Heart J. 58:957–961. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Görlach A, Klappa P and Kietzmann T: The endoplasmic reticulum: Folding, calcium homeostasis, signaling, and redox control. Antioxid Redox Signal. 8:1391–1418. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Shin DH, Leem DG, Shin JS, Kim JI, Kim KT, Choi SY, Lee MH, Choi JH and Lee KT: Compound K induced apoptosis via endoplasmic reticulum Ca2+ release through ryanodine receptor in human lung cancer cells. J Ginseng Res. 42:165–174. 2018. View Article : Google Scholar : PubMed/NCBI

28 

Cui C, Merritt R, Fu L and Pan Z: Targeting calcium signaling in cancer therapy. Acta Pharm Sin B. 7:3–17. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Carpi S, Polini B, Poli G, Alcantara Barata G, Fogli S, Romanini A, Tuccinardi T, Guella G, Frontini FP, Nieri P and Di Giuseppe G: Anticancer activity of Euplotin C, isolated from the marine ciliate Euplotes crassus, against human melanoma cells. Mar Drugs. 16(pii): E1662018. View Article : Google Scholar : PubMed/NCBI

30 

Lu H, Chen I, Shimoda LA, Park Y, Zhang C, Tran L, Zhang H and Semenza GL: Chemotherapy-Induced Ca2+ release stimulates breast cancer stem cell enrichment. Cell Rep. 18:1946–1957. 2017. View Article : Google Scholar : PubMed/NCBI

31 

McCarthy TV, Datar S and Mackrill JJ: Activation of ryanodine receptor/Ca2+ release channels downregulates CD38 in the Namalwa B lymphoma. FEBS Lett. 554:133–137. 2003. View Article : Google Scholar : PubMed/NCBI

32 

Mariot P, Prevarskaya N, Roudbaraki MM, Le Bourhis X, Van Coppenolle F, Vanoverberghe K and Skryma R: Evidence of functional ryanodine receptor involved in apoptosis of prostate cancer (LNCaP) cells. Prostate. 43:205–214. 2000. View Article : Google Scholar : PubMed/NCBI

33 

R Core Team. R, . A language and environment for statistical computing. R Foundation for Statistical Computing; Vienna, Austria: 2012, ISBN 3-900051-07-0, URL. http://www.R-project.org/

34 

Amin MB, Greene FL, Edge SB, Compton CC, Gershenwald JE, Brookland RK, Meyer L, Gress DM, Byrd DR and Winchester DP: The Eighth edition AJCC cancer staging manual: Continuing to build a bridge from a population-based to a more ‘personalized’ approach to cancer staging. CA Cancer J Clin. 67:93–99. 2017. View Article : Google Scholar : PubMed/NCBI

35 

George N, Agarwal A, Kumari N, Agarwal S, Krisnani N and Gupta SK: Molecular profiling of follicular variant of papillary thyroid cancer reveals Low-risk noninvasive follicular thyroid neoplasm with papillary-like nuclear features: A paradigm shift to reduce aggressive treatment of indolent tumors. Indian J Endocrinol Metab. 22:339–346. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Yang L, Yuan Y, Sun T, Li H and Wang N: Population-based cancer incidence analysis in Beijing, 2008–2012. Chin J Cancer Res. 27:13–21. 2015.PubMed/NCBI

37 

Berridge MJ, Lipp P and Bootman MD: The versatility and universality of calcium signalling. Nat Rev Mol Cell Biol. 1:11–21. 2000. View Article : Google Scholar : PubMed/NCBI

38 

Kondratskyi A, Yassine M, Kondratska K, Skryma R, Slomianny C and Prevarskaya N: Calcium-permeable ion channels in control of autophagy and cancer. Front Physiol. 4:2722013. View Article : Google Scholar : PubMed/NCBI

39 

Zhu H, Zhang H, Jin F, Fang M, Huang M, Yang CS, Chen T, Fu L and Pan Z: Elevated Orai1 expression mediates tumor-promoting intracellular Ca2+ oscillations in human esophageal squamous cell carcinoma. Oncotarget. 5:3455–3471. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Dolai S, Pal S, Yadav RK and Adak S: Endoplasmic reticulum stress-induced apoptosis in Leishmania through Ca2+-dependent and caspase-independent mechanism. J Biol Chem. 286:13638–13646. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Santulli G and Marks AR: Essential roles of intracellular calcium release channels in muscle, brain, metabolism, and aging. Curr Mol Pharmaco. 8:206–222. 2015. View Article : Google Scholar

42 

Xu C, Luo J, He L, Montell C and Perrimon N: Oxidative stress induces stem cell proliferation via TRPA1/RyR-mediated Ca2+ signaling in the Drosophila midgut. Elife. 6(pii): e224412017. View Article : Google Scholar : PubMed/NCBI

43 

Wolf IM, Diercks BP, Gattkowski E, Czarniak F, Kempski J, Werner R, Schetelig D, Mittrücker HW, Schumacher V, von Osten M, et al: Frontrunners of T cell activation: Initial, localized Ca2+ signals mediated by NAADP and the type 1 ryanodine receptor. Sci Signal. 8:ra1022015. View Article : Google Scholar : PubMed/NCBI

44 

Abdul M, Ramlal S and Hoosein N: Ryanodine receptor expression correlates with tumor grade in breast cancer. Pathol Oncol Res. 14:157–160. 2008. View Article : Google Scholar : PubMed/NCBI

45 

Tran B, Roshan D, Abraham E, Wang L, Garibotto N, Wykes J, Campbell P and Ebrahimi A: An analysis of the American Joint Committee on Cancer 8th Edition T Staging system for papillary thyroid carcinoma. J Clin Endocrinol Metab. 103:2199–2206. 2018. View Article : Google Scholar : PubMed/NCBI

46 

Wu MH, Shen WT, Gosnell J and Duh QY: Prognostic significance of extranodal extension of regional lymph node metastasis in papillary thyroid cancer. Head Neck. 37:1336–1343. 2015. View Article : Google Scholar : PubMed/NCBI

47 

Kim HI, Kim TH, Choe JH, Kim JH, Kim JS, Oh YL, Hahn SY, Shin JH, Jang HW, Kim YN, et al: Restratification of survival prognosis of N1b papillary thyroid cancer by lateral lymph node ratio and largest lymph node size. Cancer Med. 6:2244–2251. 2017. View Article : Google Scholar : PubMed/NCBI

48 

Kim HI, Kim K, Park SY, Choe JH, Kim JH, Kim JS, Oh YL, Hahn SY, Shin JH, Ahn HS, et al: Refining the eighth edition AJCC TNM classification and prognostic groups for papillary thyroid cancer with lateral nodal metastasis. Oral Oncol. 78:80–86. 2018. View Article : Google Scholar : PubMed/NCBI

49 

Kim M, Jeon MJ, Oh HS, Park S, Song DE, Sung TY, Kim TY, Chung KW, Kim WB, Shong YK, et al: Prognostic Implication of N1b classification in the Eighth edition of the Tumor-Node-Metastasis staging system of differentiated thyroid cancer. Thyroid. 28:496–503. 2018. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xu N, Zhang D, Chen J, He G and Gao L: Low expression of ryanodine receptor 2 is associated with poor prognosis in thyroid carcinoma. Oncol Lett 18: 3605-3612, 2019.
APA
Xu, N., Zhang, D., Chen, J., He, G., & Gao, L. (2019). Low expression of ryanodine receptor 2 is associated with poor prognosis in thyroid carcinoma. Oncology Letters, 18, 3605-3612. https://doi.org/10.3892/ol.2019.10732
MLA
Xu, N., Zhang, D., Chen, J., He, G., Gao, L."Low expression of ryanodine receptor 2 is associated with poor prognosis in thyroid carcinoma". Oncology Letters 18.4 (2019): 3605-3612.
Chicago
Xu, N., Zhang, D., Chen, J., He, G., Gao, L."Low expression of ryanodine receptor 2 is associated with poor prognosis in thyroid carcinoma". Oncology Letters 18, no. 4 (2019): 3605-3612. https://doi.org/10.3892/ol.2019.10732
Copy and paste a formatted citation
x
Spandidos Publications style
Xu N, Zhang D, Chen J, He G and Gao L: Low expression of ryanodine receptor 2 is associated with poor prognosis in thyroid carcinoma. Oncol Lett 18: 3605-3612, 2019.
APA
Xu, N., Zhang, D., Chen, J., He, G., & Gao, L. (2019). Low expression of ryanodine receptor 2 is associated with poor prognosis in thyroid carcinoma. Oncology Letters, 18, 3605-3612. https://doi.org/10.3892/ol.2019.10732
MLA
Xu, N., Zhang, D., Chen, J., He, G., Gao, L."Low expression of ryanodine receptor 2 is associated with poor prognosis in thyroid carcinoma". Oncology Letters 18.4 (2019): 3605-3612.
Chicago
Xu, N., Zhang, D., Chen, J., He, G., Gao, L."Low expression of ryanodine receptor 2 is associated with poor prognosis in thyroid carcinoma". Oncology Letters 18, no. 4 (2019): 3605-3612. https://doi.org/10.3892/ol.2019.10732
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team