Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
October-2019 Volume 18 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2019 Volume 18 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

NEDD9 promotes invasion and migration of colorectal cancer cell line HCT116 via JNK/EMT

  • Authors:
    • Haining Meng
    • Junyu Wu
    • Qiao Huang
    • Xi Yang
    • Kunao Yang
    • Yuexin Qiu
    • Jiwen Ren
    • Ruowu Shen
    • Hong Qi
  • View Affiliations / Copyright

    Affiliations: Department of Special Medicine, School of Basic Medical College, Qingdao University, Qingdao, Shandong 266021, P.R. China, Department of Emergency, First Affiliated Hospital of The People's Liberation Army General Hospital, Beijing 100037, P.R. China, Department of General Surgery, Qingdao Municipal Hospital, Qingdao, Shandong 266071, P.R. China
    Copyright: © Meng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4022-4029
    |
    Published online on: August 16, 2019
       https://doi.org/10.3892/ol.2019.10756
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Neural precursor cell‑expressed, developmentally‑downregulated 9 (NEDD9) is a multi‑domain skeleton protein that serves an important role in the cell signaling process via modulating invasion, metastasis, proliferation and apoptosis of tumor cells. The present study identified that the expression levels of NEDD9 in colorectal cancer were elevated. Therefore, the effect of downregulating the expression of NEDD9 in terms of invasion and migration of colorectal cancer cells was investigated and the role of the JNK pathway in these processes was also investigated. The data revealed that downregulation of NEDD9 and JNK inhibitors suppressed invasion and migration, decreased expression levels of phosphorylated JNK, increased the expression levels of E‑cadherin and decreased the expression levels of vimentin. In summary, NEDD9 promotes invasion and migration of colorectal cancer cells via the JNK pathway.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Siegel RL, Miller KD, Fedewa SA, Ahnen DJ, Meester RGS, Barzi A and Jemal A: Colorectal cancer statistics, 2017. CA Cancer J Clin. 67:177–193. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Siegel R, Desantis C and Jemal A: Colorectal cancer statistics, 2014. CA Cancer J Clin. 64:104–117. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Mcquade RM, Stojanovska V, Bornstein JC and Nurgali K: Colorectal cancer chemotherapy: The evolution of treatment and new approaches. Curr Med Chem. 24:1537–1557. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Izumchenko E, Singh MK, Plotnikova OV, Tikhmyanova N, Little JL, Serebriiskii IG, Seo S, Kurokawa M, Egleston BL, Klein-Szanto A, et al: NEDD9 promotes oncogenic signaling in mammary tumor development. Cancer Res. 69:7198–7206. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Kim M, Gans JD, Nogueira C, Wang A, Paik JH, Feng B, Brennan C, Hahn WC, Cordon-Cardo C, Wagner SN, et al: Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene. Cell. 125:1269–1281. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Sima N, Cheng X, Ye F, Ma D, Xie X and Lü W: The overexpression of scaffolding protein NEDD9 promotes migration and invasion in cervical cancer via tyrosine phosphorylated FAK and SRC. PLoS One. 8:e745942013. View Article : Google Scholar : PubMed/NCBI

7 

O'Neill G, Seo S, Serebriiskii IG, Lessin SR and Golemis EA: A new central scaffold for metastasis: Parsing HEF1/Cas-L/NEDD9. Cancer Res. 67:8975–8979. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Zhang S, Wu L, Liu Q, Chen K and Zhang X: Elevated expression of NEDD9 is associated with metastatic activity in gastric cancer. Onco Targets Ther. 8:633–640. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Kong C, Wang C, Wang L, Ma M, Niu C, Sun X, Du J, Dong Z, Zhu S, Lu J and Huang B: NEDD9 is a positive regulator of epithelial-mesenchymal transition and promotes invasion in aggressive breast cancer. PLoS One. 6:e226662011. View Article : Google Scholar : PubMed/NCBI

10 

Chang JX, Gao F, Zhao GQ and Zhang GJ: Expression and clinical significance of NEDD9 in lung tissues. Med Oncol. 29:2654–2660. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Cui X, Shen K, Xie Z, Liu T and Zhang H: Identification of key genes in colorectal cancer using random walk with restart. Mol Med Rep. 15:867–872. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Li P, Zhou H, Zhu X, Ma G, Liu C, Lin B and Mao W: High expression of NEDD9 predicts adverse outcomes of colorectal cancer patients. Int J Clin Exp Pathol. 7:2565–2570. 2014.PubMed/NCBI

13 

Dai J, Van Wie PG, Fai LY, Kim D, Wang L, Poyil P, Luo J and Zhang Z: Downregulation of NEDD9 by apigenin suppresses migration, invasion, and metastasis of colorectal cancer cells. Toxicol Appl Pharmacol. 311:106–112. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Thiery JP: Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer. 2:442–454. 2002. View Article : Google Scholar : PubMed/NCBI

15 

Kalluri R and Weinberg RA: The basics of epithelial-mesenchymal transition. J Clin Invest. 119:1420–1428. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Min J, Liu L, Li X, Jiang J, Wang J, Zhang B, Cao D, Yu D, Tao D, Hu J, et al: Absence of DAB2IP promotes cancer stem cell like signatures and indicates poor survival outcome in colorectal cancer. Sci Rep. 5:165782015. View Article : Google Scholar : PubMed/NCBI

17 

Guerrero MS, Parsons JT and Bouton AH: Cas and NEDD9 contribute to tumor progression through dynamic regulation of the cytoskeleton. Genes Cancer. 3:371–381. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Wang Z, Shen M, Lu P, Li X, Zhu S and Yue S: NEDD9 may regulate hepatocellular carcinoma cell metastasis by promoting epithelial-mesenchymal-transition and stemness via repressing Smad7. Oncotarget. 8:1714–1724. 2017.PubMed/NCBI

19 

Weston CR and Davis RJ: The JNK signal transduction pathway. Curr Opin Genet Dev. 12:14–21. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Wagner EF and Nebreda AR: Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer. 9:537–549. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Bode AM and Dong Z: The functional contrariety of JNK. Mol Carcinog. 46:591–598. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Zhao X, Wu X, Qian M, Song Y, Wu D and Zhang W: Knockdown of TGF-β1 expression in human umbilical cord mesenchymal stem cells reverts their exosome-mediated EMT promoting effect on lung cancer cells. Cancer Lett. 428:34–44. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Wang Y, Xu Y, Yan W, Han P, Liu J, Gong J, Li D, Ding X, Wang H, Lin Z, et al: CFIm25 inhibits hepatocellular carcinoma metastasis by suppressing the p38 and JNK/c-Jun signaling pathways. Oncotarget. 9:11783–11793. 2018.PubMed/NCBI

24 

Dong Y, Wu Z, He M, Chen Y, Chen Y, Shen X, Zhao X, Zhang L, Yuan B and Zeng Z: ADAM9 mediates the interleukin-6-induced Epithelial-Mesenchymal transition and metastasis through ROS production in hepatoma cells. Cancer Lett. 421:1–14. 2018. View Article : Google Scholar : PubMed/NCBI

25 

Edge SB and Compton CC: The American Joint Committee on Cancer: The 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 17:1471–1474. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Scanlon CS, Van Tubergen EA, Inglehart RC and D'Silva NJ: Biomarkers of epithelial-mesenchymal transition in squamous cell carcinoma. J Dent Res. 92:114–121. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Morimoto K, Tanaka T, Nitta Y, Ohnishi K, Kawashima H and Nakatani T: NEDD9 crucially regulates TGF-β-triggered epithelial-mesenchymal transition and cell invasion in prostate cancer cells: Involvement in cancer progressiveness. Prostate. 74:901–910. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Miao Y, Li AL, Wang L, Fan CF, Zhang XP, Xu HT, Yang LH, Liu Y and Wang EH: Overexpression of NEDD9 is associated with altered expression of E-cadherin, β-catenin and N-cadherin and predictive of poor prognosis in non-small cell lung cancer. Pathol Oncol Res. 19:281–286. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Feng J, Zhao J, Xie H, Yin Y, Luo G, Zhang J, Feng Y and Li Z: Involvement of NEDD9 in the invasion and migration of gastric cancer. Tumour Biol. 36:3621–3628. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Khan GJ, Gao Y, Gu M, Wang L, Khan S, Naeem F, Semukunzi H, Roy D, Yuan S and Sun L: TGF-β1 Causes EMT by regulating N-Acetyl glucosaminyl transferases via downregulation of non muscle myosin II-A through JNK/P38/PI3K pathway in lung cancer. Curr Cancer Drug Targets. 18:209–219. 2018. View Article : Google Scholar : PubMed/NCBI

32 

Choi Y, Ko YS, Park J, Choi Y, Kim Y, Pyo JS, Jang BG, Hwang DH, Kim WH and Lee BL: HER2-induced metastasis is mediated by AKT/JNK/EMT signaling pathway in gastric cancer. World J Gastroenterol. 22:9141–9153. 2016. View Article : Google Scholar : PubMed/NCBI

33 

An J, Guo Y, Wang T, Pantuck AJ and Rettig MB: Pomegranate extract inhibits EMT in clear cell renal cell carcinoma in a NF-κB and JNK dependent manner. Asian J Urol. 2:38–45. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Grauzam S, Brock AM, Holmes CO, Tiedeken JA, Boniface SG, Pierson BN, Patterson DG, Coaxum SD, Neskey DM and Rosenzweig SA: NEDD9 stimulated MMP9 secretion is required for invadopodia formation in oral squamous cell carcinoma. Oncotarget. 9:25503–25516. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Feng Y, Wang Y, Wang Z, Fang Z, Li F, Gao Y, Liu H, Xiao T, Li F, Zhou Y, et al: The CRTC1-NEDD9 signaling axis mediates lung cancer progression caused by LKB1 loss. Cancer Res. 72:6502–6511. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Chu Q, Zhang J and Sun F: Study on mechanism of mi R-203 inhibiting migration and invasion of breast cancer cell MDA-MB-231 by regulating NEDD9 protein. J Diagnostics Concepts Pract. 2014.

37 

Shagisultanova E, Gaponova AV, Gabbasov R, Nicolas E and Golemis EA: Preclinical and clinical studies of the NEDD9 scaffold protein in cancer and other diseases. Gene. 567:1–11. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Guerrero MS, Parsons JT and Bouton AH: Cas and NEDD9 contribute to tumor progression through dynamic regulation of the cytoskeleton. Genes Cancer. 3:371–381. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Sulzmaier FJ, Jean C and Schlaepfer DD: FAK in cancer: Mechanistic findings and clinical applications. Nat Rev Cancer. 14:598–610. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Tikhmyanova N, Little JL and Golemis EA: CAS proteins in normal and pathological cell growth control. Cell Mol Life Sci. 67:1025–1048. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Ding X, Sun W and Chen J: IL-2 augments the sorafenib-induced apoptosis in liver cancer by promoting mitochondrial fission and activating the JNK/TAZ pathway. Cancer Cell Int. 18:1762018. View Article : Google Scholar : PubMed/NCBI

42 

Li Z, Lim SK, Liang X and Lim YP: The transcriptional coactivator WBP2 primes triple-negative breast cancer cells for responses to Wnt signaling via the JNK/Jun kinase pathway. J Biol Chem. 293:20014–20028. 2018. View Article : Google Scholar : PubMed/NCBI

43 

Chen X, Liu C, Zhao R, Zhao P, Wu J, Zhou N and Ying M: Synergetic and antagonistic molecular effects mediated by the feedback loop of p53 and JNK between Saikosaponin D and SP600125 on lung cancer A549 cells. Mol Pharm. 15:4974–4984. 2018. View Article : Google Scholar : PubMed/NCBI

44 

Kubala MH, Punj V, Placencio-Hickok VR, Fang H, Fernandez GE, Sposto R and DeClerck YA: Plasminogen activator Inhibitor-1 promotes the recruitment and polarization of macrophages in cancer. Cell Rep. 25:2177–2191.e7. 2018. View Article : Google Scholar : PubMed/NCBI

45 

Hu Z, Tie Y, Lv G, Zhu J, Fu H and Zheng X: Transcriptional activation of miR-320a by ATF2, ELK1 and YY1 induces cancer cell apoptosis under ionizing radiation conditions. Int J Oncol. 53:1691–1702. 2018.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Meng H, Wu J, Huang Q, Yang X, Yang K, Qiu Y, Ren J, Shen R and Qi H: NEDD9 promotes invasion and migration of colorectal cancer cell line HCT116 via JNK/EMT. Oncol Lett 18: 4022-4029, 2019.
APA
Meng, H., Wu, J., Huang, Q., Yang, X., Yang, K., Qiu, Y. ... Qi, H. (2019). NEDD9 promotes invasion and migration of colorectal cancer cell line HCT116 via JNK/EMT. Oncology Letters, 18, 4022-4029. https://doi.org/10.3892/ol.2019.10756
MLA
Meng, H., Wu, J., Huang, Q., Yang, X., Yang, K., Qiu, Y., Ren, J., Shen, R., Qi, H."NEDD9 promotes invasion and migration of colorectal cancer cell line HCT116 via JNK/EMT". Oncology Letters 18.4 (2019): 4022-4029.
Chicago
Meng, H., Wu, J., Huang, Q., Yang, X., Yang, K., Qiu, Y., Ren, J., Shen, R., Qi, H."NEDD9 promotes invasion and migration of colorectal cancer cell line HCT116 via JNK/EMT". Oncology Letters 18, no. 4 (2019): 4022-4029. https://doi.org/10.3892/ol.2019.10756
Copy and paste a formatted citation
x
Spandidos Publications style
Meng H, Wu J, Huang Q, Yang X, Yang K, Qiu Y, Ren J, Shen R and Qi H: NEDD9 promotes invasion and migration of colorectal cancer cell line HCT116 via JNK/EMT. Oncol Lett 18: 4022-4029, 2019.
APA
Meng, H., Wu, J., Huang, Q., Yang, X., Yang, K., Qiu, Y. ... Qi, H. (2019). NEDD9 promotes invasion and migration of colorectal cancer cell line HCT116 via JNK/EMT. Oncology Letters, 18, 4022-4029. https://doi.org/10.3892/ol.2019.10756
MLA
Meng, H., Wu, J., Huang, Q., Yang, X., Yang, K., Qiu, Y., Ren, J., Shen, R., Qi, H."NEDD9 promotes invasion and migration of colorectal cancer cell line HCT116 via JNK/EMT". Oncology Letters 18.4 (2019): 4022-4029.
Chicago
Meng, H., Wu, J., Huang, Q., Yang, X., Yang, K., Qiu, Y., Ren, J., Shen, R., Qi, H."NEDD9 promotes invasion and migration of colorectal cancer cell line HCT116 via JNK/EMT". Oncology Letters 18, no. 4 (2019): 4022-4029. https://doi.org/10.3892/ol.2019.10756
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team