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Article

Causal associations of autoimmune thyroiditis and papillary thyroid carcinoma: mRNA expression of selected nuclear receptors and other molecular targets

  • Authors:
    • Dana Macejova
    • Jan Podoba
    • Lucia Toporova
    • Marianna Grigerova
    • Karol Kajo
    • Katarina Machalekova
    • Julius Brtko
  • View Affiliations / Copyright

    Affiliations: Department of Endocrine Regulations and Psychopharmacology, Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, 845 05 Bratislava, Slovak Republic, Department of Endocrinology, Slovak Medical University and St. Elisabeth Cancer Institute, 812 50 Bratislava, Slovak Republic, Department of Pathology, Slovak Medical University and St. Elisabeth Cancer Institute, 812 50 Bratislava, Slovak Republic
  • Pages: 4270-4277
    |
    Published online on: August 22, 2019
       https://doi.org/10.3892/ol.2019.10770
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Abstract

Potential causal associations of autoimmune thyroiditis (AIT) and papillary thyroid carcinoma (PTC) have been studied previously. The mRNA expression patterns of thyroid hormone receptors (TR), retinoid receptors (RAR), rexinoid receptors (RXR), dihydroxyvitamin D3 receptors (VDR), and progesterone receptors (PR) in PTC tissue of patients without autoimmune thyroiditis (PTC/AIT‑) and in PTC tissue of patients with coexisting AIT (PTC/AIT+) have been investigated in order to judge whether the observed changes may take part in the promotion and progression of thyroid cancer. Tumours with or without AIT were classified histologically and the semiquantitative PCR was performed. The results revealed that there was decreased expression of TRα, TRβα, RARα and PR mRNA in PTC/AIT+ tumours when compared with PTC/AIT‑ tumours. Decreased expression of RARα in PTC/AIT+ was detected when compared with PTC/AIT‑ patients. A similar effect of AIT was observed with a decrease in RARγ expression in PTC/AIT+ patients. On the other hand, there was an increased expression of VDR in thyroid tumours (PTC/AIT+) when compared with PTC/AIT‑. PR mRNA was decreased in the thyroid tumours of PTC/AIT+ patients when compared with PTC/AIT‑ patients. In addition, there was an increased expression of MKi67 and complement C3 in PTC of PTC/AIT+ when compared with PTC/AIT‑. In the PTC/AIT+ group, a decreased level of IGF‑1 mRNA was found when compared with the PTC/AIT‑ group. According to the significant differences of the studied markers in PTC/AIT+ compared with PTC/AIT‑, it was indicated that AIT may be a predisposing factor for the development of PTC.
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1 

Bozec A, Lassalle S, Hofman V, Ilie M, Santini J and Hofman P: The thyroid gland: A crossroad in inflammation-induced carcinoma? An ongoing debate with new therapeutic potential. Curr Med Chem. 17:3449–3461. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Muzza M, Degl'Innocenti D, Colombo C, Perrino M, Ravasi E, Rossi S, Cirello V, Beck-Peccoz P, Borrello MG and Fugazzola L: The tight relationship between papillary thyroid cancer, autoimmunity and inflammation: Clinical and molecular studies. Clin Endocrinol (Oxf). 72:702–708. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Babli S, Payne RJ, Mitmaker E and Rivera J: Effects of chronic lymphocytic thyroiditis on the clinicopathological features of papillary thyroid cancer. Eur Thyroid J. 7:95–101. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Ott RA, Calandra DB, McCall A, Shah KH, Lawrence AM and Paloyan E: The incidence of thyroid carcinoma in patients with Hashimoto's thyroiditis and solitary cold nodules. Surgery. 98:1202–1206. 1985.PubMed/NCBI

5 

Schäffer A, Palitzsch KD, Seiffarth C, Hohne HM, Riedhammer FJ, Hofstädter F, Schölmerich J and Rüschoff J: Coexistent thyroiditis is associated with lower tumour stage in thyroid carcinoma. Eur J Clin Invest. 28:838–844. 1998. View Article : Google Scholar : PubMed/NCBI

6 

Loh KCH, Greenspan FS, Dong F, Miller TR and Yeo PPB: Influence of lymphocytic thyroiditis on the prognostic outcome of patients with papillary thyroid carcinoma. J Clin Endocrinol Metab. 84:458–463. 1999. View Article : Google Scholar : PubMed/NCBI

7 

Shih ML, Lee JA, Hsieh CB, Yu JC, Liu HD, Kebebew E, Clark OH and Duh QY: Thyroidectomy for Hashimoto's thyroiditis: Complications and associated cancers. Thyroid. 18:729–734. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Fiore E, Rago T, Latrofa F, Provenzale MA, Piaggi P, Delitala A, Scutari M, Basolo F, Di Coscio G, Grasso L, et al: Hashimoto's thyroiditis is associated with papillary thyroid carcinoma: Role of TSH and of treatment with L-thyroxine. Endocr Relat Cancer. 18:429–437. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Vaccarella S, Franceschi S, Bray F, Wild CP, Plummer M and Dal Maso L: Worldwide thyroid-cancer epidemic? The increasing impact of overdiagnosis. N Engl J Med. 7:614–617. 2016. View Article : Google Scholar

10 

Antonaci A, Consorti F, Mardente S and Giovannone G: Clinical and biological relationship between chronic lymphocytic thyroiditis and papillary thyroid carcinoma. Oncol Res. 17:495–503. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Prescott SM and Fitzpatrick FA: Cyclooxygenase-2 and carcinogenesis. Biochim Biophys Acta. 1470:M69–M78. 2000.PubMed/NCBI

12 

Cornetta A, Russell JP, Cunnane M, Keane WM and Rothstein JL: Cyclooxygenase-2 expression in human thyroid carcinoma and Hashimoto's thyroiditis. Laryngoscope. 112:238–242. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Schmidt JA, Allen NE, Almquist M, Franceschi S, Rinaldi S, Tipper SJ, Tsilidis KK, Weiderpass E, Overvad K, Tjønneland A, et al: Insulin-like growth factor-i and risk of differentiated thyroid carcinoma in the European prospective investigation into cancer and nutrition. Cancer Epidemiol Biomarkers Prev. 23:976–985. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Yu J, Mai W, Ciu Y and Kong L: Key genes and pathways predicted in papillary thyroid carcinoma based on bioinformatics analysis. J Endocrinol Invest. 39:1285–1293. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Eldien MMS, Abdou AG, Rageh T, Abdelrazek E and Elkholy E: Immunohistochemical expression of ER-α and PR in papillary thyroid carcinoma. Ecancermedicalscience. 11:7482017. View Article : Google Scholar : PubMed/NCBI

16 

Brierley JD, Gospodarowicz MK and Wittekind C: TNM classification of malignant tumours8th. Oxford: Wiley Blackwell. ISBN 9781119263579. 2017

17 

Brtko J, Sejnová D, Ondková S and Macejová D: Malignant Triton tumour exhibits a complete expression pattern of nuclear retinoid and rexinoid receptor subtypes. Gen Physiol Biophys. 28:425–427. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Macejová D, Galbavý S, Podoba J, Bialešová L and Brtko J: mRNA expression pattern of retinoic acid and retinoid X nuclear receptor subtypes in human thyroid papillary carcinoma. Oncol Rep. 30:2371–2378. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Franceschi S, Boyle P, Maisonneuve P, La Vecchia C, Burt AD, Kerr DJ and MacFarlane GJ: The epidemiology of thyroid carcinoma. Crit Rev Oncog. 4:25–52. 1993.PubMed/NCBI

20 

Lai X, Xia Y, Zhang B, Li J and Jiang Y: A meta-analysis of Hashimoto's thyroiditis and papillary thyroid carcinoma risk. Oncotarget. 8:62414–62424. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Paolieri F, Salmaso C, Battifora M, Montagna P, Pesce G, Bagnasco M, Richiusa P, Galluzzo A and Giordano C: Possible pathogenetic relevance of interleukin-1 beta in ‘destructive’ organ-specific autoimmune disease (Hashimoto's thyroiditis). Ann N Y Acad Sci. 876:221–228. 1999. View Article : Google Scholar : PubMed/NCBI

22 

Liu L and Gudas LJ: Retinoic acid induces expression of the interleukin-1beta gene in cultured normal human mammary epithelial cells and in human breast carcinoma lines. J Cell Physiol. 193:244–252. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Ciampolillo A, De Tullio C and Giorgino F: The IGF-I/IGF-I receptor pathway: Implications in the pathophysiology of thyroid cancer. Curr Med Chem. 12:2881–2891. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Surmacz E and Bartucci M: Role of estrogen receptor alpha in modulating IGF-I receptor signaling and function in breast cancer. J Exp Clin Cancer Res. 23:385–394. 2004.PubMed/NCBI

25 

Garcia-Solis P and Aceves C: 5′Deiodinase in two breast cancer cell lines: Effect of triiodothyronine, isoproterenol and retinoids. Mol Cell Endocrinol. 201:25–31. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Dhiman VK, Bolt MJ and White KP: Nuclear receptors in cancer-uncovering new and evolving roles through genomic analysis. Nat Rev Genet. 19:160–174. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Kim WG and Cheng SY: Thyroid hormone receptors and cancer. Biochim Biophys Acta. 1830:3928–3936. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Nugroho J and Schweiger B: Isotretinoin as a possible environmental trigger to autoimmunity in genetically susceptible patients. Case Rep Pediatr. 2017:42076562017.PubMed/NCBI

29 

Schmutzler C, Brtko J, Winzer R, Jakobs TC, Meissner-Weigl J, Simon D, Goretzki PE and Köhrle J: Functional retinoid and thyroid hormone receptors in human thyroid-carcinoma cell lines and tissues. Int J Cancer. 76:368–376. 1998. View Article : Google Scholar : PubMed/NCBI

30 

Hoftijzer HC, Liu YY, Morreau H, van Wezel T, Pereira AM, Corssmit EP, Romijn JA and Smit JW: Retinoic acid receptor and retinoid X receptor subtype expression for the differential diagnosis of thyroid neoplasms. Eur J Endocrinol. 160:631–638. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Haugen BR, Larson LL, Pugazhenthi U, Hays WR, Klopper JP, Kramer CA and Sharma V: Retinoic acid and retinoid X receptors are differentially expressed in thyroid cancer and thyroid carcinoma cell lines and predict response to treatment with retinoids. J Clin Endocrinol Metab. 89:272–280. 2004. View Article : Google Scholar : PubMed/NCBI

32 

Kim D: The role of vitamin D in thyroid diseases. Int J Mol Sci. 18(pii): E19492017. View Article : Google Scholar : PubMed/NCBI

33 

Casula S and Bianco AC: Thyroid hormone deiodinases and cancer. Front Endocrinol (Lausanne). 3:742012. View Article : Google Scholar : PubMed/NCBI

34 

Chen W, Wang S, Tian T, Bai J, Hu Z, Xu Y, Dong J, Chen F, Wang X and Shen H: Phenotypes and genotypes of insulin-like growth factor 1, IGF-binding protein-3 and cancer risk: Evidence from 96 studies. Eur J Hum Genet. 17:1668–1675. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Lin K, He S, He L, Chen J, Cheng X, Zhang G and Zhu B: Complement component 3 is a prognostic factor of non-small cell lung cancer. Mol Med Rep. 10:811–817. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Macejova D, Podoba J, Toporova L, Grigerova M, Kajo K, Machalekova K and Brtko J: Causal associations of autoimmune thyroiditis and papillary thyroid carcinoma: mRNA expression of selected nuclear receptors and other molecular targets. Oncol Lett 18: 4270-4277, 2019.
APA
Macejova, D., Podoba, J., Toporova, L., Grigerova, M., Kajo, K., Machalekova, K., & Brtko, J. (2019). Causal associations of autoimmune thyroiditis and papillary thyroid carcinoma: mRNA expression of selected nuclear receptors and other molecular targets. Oncology Letters, 18, 4270-4277. https://doi.org/10.3892/ol.2019.10770
MLA
Macejova, D., Podoba, J., Toporova, L., Grigerova, M., Kajo, K., Machalekova, K., Brtko, J."Causal associations of autoimmune thyroiditis and papillary thyroid carcinoma: mRNA expression of selected nuclear receptors and other molecular targets". Oncology Letters 18.4 (2019): 4270-4277.
Chicago
Macejova, D., Podoba, J., Toporova, L., Grigerova, M., Kajo, K., Machalekova, K., Brtko, J."Causal associations of autoimmune thyroiditis and papillary thyroid carcinoma: mRNA expression of selected nuclear receptors and other molecular targets". Oncology Letters 18, no. 4 (2019): 4270-4277. https://doi.org/10.3892/ol.2019.10770
Copy and paste a formatted citation
x
Spandidos Publications style
Macejova D, Podoba J, Toporova L, Grigerova M, Kajo K, Machalekova K and Brtko J: Causal associations of autoimmune thyroiditis and papillary thyroid carcinoma: mRNA expression of selected nuclear receptors and other molecular targets. Oncol Lett 18: 4270-4277, 2019.
APA
Macejova, D., Podoba, J., Toporova, L., Grigerova, M., Kajo, K., Machalekova, K., & Brtko, J. (2019). Causal associations of autoimmune thyroiditis and papillary thyroid carcinoma: mRNA expression of selected nuclear receptors and other molecular targets. Oncology Letters, 18, 4270-4277. https://doi.org/10.3892/ol.2019.10770
MLA
Macejova, D., Podoba, J., Toporova, L., Grigerova, M., Kajo, K., Machalekova, K., Brtko, J."Causal associations of autoimmune thyroiditis and papillary thyroid carcinoma: mRNA expression of selected nuclear receptors and other molecular targets". Oncology Letters 18.4 (2019): 4270-4277.
Chicago
Macejova, D., Podoba, J., Toporova, L., Grigerova, M., Kajo, K., Machalekova, K., Brtko, J."Causal associations of autoimmune thyroiditis and papillary thyroid carcinoma: mRNA expression of selected nuclear receptors and other molecular targets". Oncology Letters 18, no. 4 (2019): 4270-4277. https://doi.org/10.3892/ol.2019.10770
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