Integrin α‑5 as a potential biomarker of head and neck squamous cell carcinoma

Zou,Bo; Wang,Dong; Xu,Kai; Yuan,Dao‑Ying; Meng,Zhen; Zhang,Bin

doi:10.3892/ol.2019.10773

Integrin α‑5 as a potential biomarker of head and neck squamous cell carcinoma

Authors:
- Bo Zou
- Dong Wang
- Kai Xu
- Dao‑Ying Yuan
- Zhen Meng
- Bin Zhang
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Affiliations: Department of Oral and Maxillofacial Surgery, Liaocheng People's Hospital, Medical College of Liaocheng University, Liaocheng, Shandong 252000, P.R. China, Key Laboratory of Oral Maxillofacial‑Head and Neck Medical Biology of Shandong Province, Liaocheng People's Hospital, Liaocheng, Shandong 252000, P.R. China
Published online on: August 22, 2019 https://doi.org/10.3892/ol.2019.10773
Pages: 4048-4055
Copyright: © Zou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Head and neck squamous cell carcinoma (HNSCC) is one of the most common malignant tumors that endanger human health. In recent years, the incidence of HNSCC has been increasing, without any significant improvement in the prognosis. Therefore, increased knowledge on the molecular mechanism underlying HNSCC development will allow the development of new strategies for therapy. The present study attempted to identify key genes involved in HNSCC development. Expression proﬁles of HNSCC and normal samples were downloaded from The Cancer Genome Atlas database. Differentially expressed genes (DEGs) between the HNSCC and normal samples were identified and subjected to Gene Oncology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways analysis. A protein‑protein interaction (PPI) network was constructed, and Cytoscape CentiScape and Gene Expression Profiling Interactive Analysis were used to identify key DEGs. Finally, expression proﬁles of HNSCCs, including 500 HNSCCs and 44 normal samples, were included in the analysis. A total of 1,181 DEGs were screened, among which 354 genes were upregulated and 827 genes were downregulated in HNSCC compared with normal tissues. The GO enrichment analysis showed that the DEGs were mainly involved in chloride transmembrane transporter, metalloendopeptidase and substrate‑specific channel activities. The KEGG pathway analysis revealed that the DEGs were mainly associated with ‘protein digestion and absorption’, as well as ‘extracellular matrix‑receptor interaction’. Integrin α‑5 (ITGA5) was identified as a hub gene, based on the PPI network complex, and was confirmed to be significantly associated with the overall survival rate. Moreover, ITGA5 was overexpressed specifically in HNSCC. The genes found, notably ITGA5, are potential diagnostic biomarkers and therapeutic targets in HNSCC.

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