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Cancer‑associated fibroblast stimulates cancer cell invasion in an interleukin‑1 receptor (IL‑1R)‑dependent manner

  • Authors:
    • Xianglan Zhang
    • Young Sun Hwang
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Yanbian University Hospital, Yanji, Jilin 133000, P.R. China, Department of Dental Hygiene, College of Health Science, Eulji University, Seongnam, Gyunggi‑Do 13135, Republic of Korea
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4645-4650
    |
    Published online on: August 27, 2019
       https://doi.org/10.3892/ol.2019.10784
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Abstract

Tumor microenvironment serves an important role in tumor growth and metastasis. Cancer cells can promote growth and malignancy by altering the surrounding stroma. Cancer‑associated fibroblast (CAF) are an abundant cell type present within the tumor microenvironment and provide tumorigenic features by secreting cytokines. In the current study, the CAF‑mediated invasion of oral squamous cell carcinoma (OSCC) was investigated and the associated mechanisms were elucidated. Cancer invasion was estimated using a Matrigel‑coated Transwell chamber and FITC‑gelatin matrix. To verify the effect of the tumor microenvironment, conditioned media (CM) from normal fibroblast (NF) and CAFs were prepared. An ELISA was performed to estimate the level of IL‑1β. A proteome profiler human protease array was performed to verify the proteases affected by stimulation with CM, from CAF. Recombinant IL‑1β protein increased the invasion of OSCC cells. IL‑1β expression was higher in CAF than NF. CM from CAF (CM‑CAF) increased cancer invasion and FITC‑gelatin matrix degradation. The invasive capacity provided by CAF was abrogated by an IL‑1 receptor (IL‑1R) antagonist. Additionally, CM‑CAF increased the secretion of ADAM 9 and Kallikrein 11 from OSCC cells. The invasion activity by CM‑CAF was partially abrogated by the neutralization of ADAM 9 or Kallikrein 11. In conclusion, by providing stromal factor, CAFs were a critical inducer of OSCC invasion, and CAF secretes the required amount of IL‑1β to increase cancer invasion activity. The invasive capacity of CAF was identified to be IL‑1R‑dependent. ADAM 9 and Kallikrein 11 were influencing factors involved in the increase of CAF‑mediated cancer invasion.
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1 

Wang M, Zhao J, Zhang L, Wei F, Lian Y, Wu Y, Gong Z, Zhang S, Zhou J, Cao K, et al: Role of tumor microenvironment in tumorigenesis. J Cancer. 8:761–773. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Chen F, Zhuang X, Lin L, Yu P, Wang Y, Shi Y, Hu G and Sun Y: New horizons in tumor microenvironment biology: Challenges and opportunities. BMC Med. 13:452015. View Article : Google Scholar : PubMed/NCBI

3 

Hwang YS, Park KK and Chung WY: Stromal transforming growth factor-beta 1 is crucial for reinforcing the invasive potential of low invasive cancer. Arch Oral Biol. 59:687–694. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Yuan Y, Jiang YC, Sun CK and Chen QM: Role of the tumor microenvironment in tumor progression and the clinical applications (review). Oncol Rep. 35:2499–2515. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Zi F, He J, He D, Li Y, Yang L and Cai Z: Fibroblast activation protein α in tumor microenvironment: Recent progression and implications (review). Mol Med Rep. 11:3203–3211. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Raman D, Baugher PJ, Thu YM and Richmond A: Role of chemokines in tumor growth. Cancer Lett. 256:137–165. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Hassona Y, Cirillo N, Heesom K, Parkinson EK and Prime SS: Senescent cancer-associated fibroblasts secrete active MMP-2 that promotes keratinocyte dis-cohesion and invasion. Br J Cancer. 111:1230–1237. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Zhang X, Cho IH, Park JH, Lee MK and Hwang YS: Fascin is involved in cancer cell invasion and is regulated by stromal factors. Oncol Rep. 41:465–474. 2019.PubMed/NCBI

9 

Hwang YS, Lee J, Zhang X and Lindholm PF: Lysophosphatidic acid activates the RhoA and NF-κB through Akt/IκBα signaling and promotes prostate cancer invasion and progression by enhancing functional invadopodia formation. Tumour Biol. 37:6775–6785. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Hoshino D, Branch KM and Weaver AM: Signaling inputs to invadopodia and podosomes. J Cell Sci. 126:2979–2989. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Lee D, Yu EJ, Ham IH and Hur H: Clinicopathological implication of insulin-like growth factor-II mRNA-binding protein 3 (IMP3) expression in gastric cancer. Anticancer Res. 37:135–142. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Murphy DA and Courtneidge SA: The ‘ins’ and ‘outs’ of podosomes and invadopodia: Characteristics, formation and function. Nat Rev Mol Cell Biol. 12:413–426. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Klemke RL: Trespassing cancer cells: ‘Fingerprinting’ invasive protrusions reveals metastatic culprits. Curr Opin Cell Biol. 24:662–669. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Kessenbrock K, Plaks V and Werb Z: Matrix metalloproteinases: Regulators of the tumor microenvironment. Cell. 141:52–67. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Tulotta C and Ottewell P: The role of IL-1B in breast cancer bone metastasis. Endocr Relat Cancer. 25:R421–R434. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Voronov E, Shouval DS, Krelin Y, Cagnano E, Benharroch D, Iwakura Y, Dinarello CA and Apte RN: IL-1 is required for tumor invasiveness and angiogenesis. Proc Natl Acad Sci USA. 100:2645–2650. 2003. View Article : Google Scholar : PubMed/NCBI

17 

Hwang YS, Xianglan Z, Park KK and Chung WY: Functional invadopodia formation through stabilization of the PDPN transcript by IMP-3 and cancer-stromal crosstalk for PDPN expression. Carcinogenesis. 33:2135–2146. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Goicoechea SM, García-Mata R, Staub J, Valdivia A, Sharek L, McCulloch CG, Hwang RF, Urrutia R, Yeh JJ, Kim HJ and Otey CA: Palladin promotes invasion of pancreatic cancer cells by enhancing invadopodia formation in cancer-associated fibroblasts. Oncogene. 33:1265–1273. 2014. View Article : Google Scholar : PubMed/NCBI

19 

De Veirman K, Rao L, De Bruyne E, Menu E, Van Valckenborgh E, Van Riet I, Frassanito MA, Di Marzo L, Vacca A and Vanderkerken K: Cancer associated fibroblasts and tumor growth: Focus on multiple myeloma. Cancers (Basel). 6:1363–1381. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Wang FT, Sun W, Zhang JT and Fan YZ: Cancer-associated fibroblast regulation of tumor neo-angiogenesis as a therapeutic target in cancer. Oncol Lett. 17:3055–3065. 2019.PubMed/NCBI

21 

Tanasubsinn P, Aung WPP, Pata S, Laopajon W, Makeudom A, Sastraruji T, Kasinrerk W and Krisanaprakornkit S: Overexpression of ADAM9 in oral squamous cell carcinoma. Oncol Lett. 15:495–502. 2018.PubMed/NCBI

22 

Sung SY, Kubo H, Shigemura K, Arnold RS, Logani S, Wang R, Konaka H, Nakagawa M, Mousses S, Amin M, et al: Oxidative stress induces ADAM9 protein expression in human prostate cancer cells. Cancer Res. 66:9519–9526. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Yousef GM, Scorilas A and Diamandis EP: Genomic organization, mapping, tissue expression and hormonal regulation of trypsin-like serine protease (TLSP PRSS20), a new member of the human kallikrein gene family. Genomics. 63:88–96. 2000. View Article : Google Scholar : PubMed/NCBI

24 

Stavropoulou P, Gregorakis AK, Plebani M and Scorilas A: Expression analysis and prognostic significance of human kallikrein 11 in prostate cancer. Clin Chim Acta. 357:190–195. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Sano A, Sangai T, Maeda H, Nakamura M, Hasebe T and Ochiai A: Kallikrein 11 expressed in human breast cancer cells releases insulin-like growth factor through degradation of IGFBP-3. Int J Oncol. 30:1493–1498. 2007.PubMed/NCBI

26 

Diamandis EP, Okui A, Mitsui S, Luo LY, Soosaipillai A, Grass L, Nakamura T, Howarth DJ and Yamaguchi N: Human kallikrein 11: A new biomarker of prostate and ovarian carcinoma. Cancer Res. 62:295–300. 2002.PubMed/NCBI

27 

Kohga K, Tatsumi T, Tsunematsu H, Aono S, Shimizu S, Kodama T, Hikita H, Yamamoto M, Oze T, Aketa H, et al: Interleukin-1β enhances the production of soluble MICA in human hepatocellular carcinoma. Cancer Immunol Immunother. 61:1425–1432. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang X and Hwang YS: Cancer‑associated fibroblast stimulates cancer cell invasion in an interleukin‑1 receptor (IL‑1R)‑dependent manner. Oncol Lett 18: 4645-4650, 2019.
APA
Zhang, X., & Hwang, Y.S. (2019). Cancer‑associated fibroblast stimulates cancer cell invasion in an interleukin‑1 receptor (IL‑1R)‑dependent manner. Oncology Letters, 18, 4645-4650. https://doi.org/10.3892/ol.2019.10784
MLA
Zhang, X., Hwang, Y. S."Cancer‑associated fibroblast stimulates cancer cell invasion in an interleukin‑1 receptor (IL‑1R)‑dependent manner". Oncology Letters 18.5 (2019): 4645-4650.
Chicago
Zhang, X., Hwang, Y. S."Cancer‑associated fibroblast stimulates cancer cell invasion in an interleukin‑1 receptor (IL‑1R)‑dependent manner". Oncology Letters 18, no. 5 (2019): 4645-4650. https://doi.org/10.3892/ol.2019.10784
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang X and Hwang YS: Cancer‑associated fibroblast stimulates cancer cell invasion in an interleukin‑1 receptor (IL‑1R)‑dependent manner. Oncol Lett 18: 4645-4650, 2019.
APA
Zhang, X., & Hwang, Y.S. (2019). Cancer‑associated fibroblast stimulates cancer cell invasion in an interleukin‑1 receptor (IL‑1R)‑dependent manner. Oncology Letters, 18, 4645-4650. https://doi.org/10.3892/ol.2019.10784
MLA
Zhang, X., Hwang, Y. S."Cancer‑associated fibroblast stimulates cancer cell invasion in an interleukin‑1 receptor (IL‑1R)‑dependent manner". Oncology Letters 18.5 (2019): 4645-4650.
Chicago
Zhang, X., Hwang, Y. S."Cancer‑associated fibroblast stimulates cancer cell invasion in an interleukin‑1 receptor (IL‑1R)‑dependent manner". Oncology Letters 18, no. 5 (2019): 4645-4650. https://doi.org/10.3892/ol.2019.10784
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