Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
November-2019 Volume 18 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2019 Volume 18 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Ubiquitin ligase RNF5 serves an important role in the development of human glioma

  • Authors:
    • Yong Gao
    • Chengmin Xuan
    • Mingwei Jin
    • Qi An
    • Baobiao Zhuo
    • Xincheng Chen
    • Lei Wang
    • Yuan Wang
    • Qingzeng Sun
    • Yingchun Shi
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Xuzhou Children's Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221006, P.R. China, Department of Hematology, Xuzhou Children's Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221006, P.R. China, Department of Neurosurgery, Xinyi People's Hospital, Xinyi, Jiangsu 221400, P.R. China
    Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4659-4666
    |
    Published online on: September 4, 2019
       https://doi.org/10.3892/ol.2019.10801
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The ubiquitin ligase ring finger protein 5 (RNF5) has previously been associated with the development of breast cancer. Patients with breast cancer and high RNF5 expression have been demonstrated to have a shorter survival time compared with patients with low RNF5 expression. However, the role of RNF5 in human glioma has not been determined. The present study analyzed the role of RNF5 in gliomas using bioinformatics analysis. The results revealed that RNF5 was differentially expressed in non‑cancerous brain tissues and different grades of glioma. Furthermore, a high RNF5 expression in patients with glioma was associated with an improved prognosis compared with patients with low expression. Gene Set Enrichment Analysis revealed that RNF5 was particularly associated with ‘Wnt signaling pathway’, ‘apoptosis’, ‘focal adhesion’ and ‘cytokine‑cytokine receptor interaction’ in patients with glioma. Additionally, 4 potential ubiquitination substrates for RNF5 were predicted, including sorting nexin 10, proprotein convertase subtilisin/kexin type 1, leucine rich glioma inactivated 1 and solute carrier family 39 member 12. These findings provided the basis for further investigation on the role of RNF5 in tumors.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Stupp R and Roila F; ESMO Guidelines Working Group, : Malignant glioma: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann Oncol. 20 (Suppl 4):S126–S128. 2009. View Article : Google Scholar

2 

Meyer MA: Malignant gliomas in adults. N Engl J Med. 359:18502008. View Article : Google Scholar : PubMed/NCBI

3 

Stupp R, Hegi ME, van den Bent MJ, Mason WP, Weller M, Mirimanoff RO and Cairncross JG; European Organisation for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups; National Cancer Institute of Canada Clinical Trials Group, : Changing paradigms-an update on the multidisciplinary management of malignant glioma. Oncologist. 11:165–180. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Stupp R, Hottinger AF, van den Bent MJ, Dietrich PY and Brandes AA: Frequently asked questions in the medical management of high-grade glioma: A short guide with practical answers. Ann Oncol. 19 (Suppl 7):vii209–vii216. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Buonerba C, Di Lorenzo G, Marinelli A, Federico P, Palmieri G, Imbimbo M, Conti P, Peluso G, De Placido S and Sampson JH: A comprehensive outlook on intracerebral therapy of malignant gliomas. Crit Rev Oncol Hematol. 80:54–68. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Sherman JH, Hoes K, Marcus J, Komotar RJ, Brennan CW and Gutin PH: Neurosurgery for brain tumors: Update on recent technical advances. Curr Neurol Neurosci Rep. 11:313–319. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Kyushiki H, Kuga Y, Suzuki M, Takahashi E and Horie M: Cloning, expression and mapping of a novel RING-finger gene (RNF5), a human homologue of a putative zinc-finger gene from Caenorhabditis elegans. Cytogenet Cell Genet. 79:114–117. 1997. View Article : Google Scholar : PubMed/NCBI

8 

Matsuda N, Suzuki T, Tanaka K and Nakano A: Rma1, a novel type of RING finger protein conserved from Arabidopsis to human, is a membrane-bound ubiquitin ligase. J Cell Sci. 114:1949–1957. 2001.PubMed/NCBI

9 

Younger JM, Chen L, Ren HY, Rosser MF, Turnbull EL, Fan CY, Patterson C and Cyr DM: Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator. Cell. 126:571–582. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Grove DE, Fan CY, Ren HY and Cyr DM: The endoplasmic reticulum-associated Hsp40 DNAJB12 and Hsc70 cooperate to facilitate RMA1 E3-dependent degradation of nascent CFTRDeltaF508. Mol Biol Cell. 22:301–314. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Didier C, Broday L, Bhoumik A, Israeli S, Takahashi S, Nakayama K, Thomas SM, Turner CE, Henderson S, Sabe H and Ronai Z: RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization. Mol Cell Biol. 23:5331–5345. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Zhong B, Zhang L, Lei C, Li Y, Mao AP, Yang Y, Wang YY, Zhang XL and Shu HB: The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. Immunity. 30:397–407. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Jeon YJ, Khelifa S, Ratnikov B, Scott DA, Feng Y, Parisi F, Ruller C, Lau E, Kim H, Brill LM, et al: Regulation of glutamine carrier proteins by RNF5 determines breast cancer response to ER stress-inducing chemotherapies. Cancer Cell. 27:354–369. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Gao Y, Han D, Sun L, Huang Q, Gai G, Wu Z, Meng W and Chen X: PPARα regulates the proliferation of human glioma cells through miR-214 and E2F2. Biomed Res Int. 2018:38427532018. View Article : Google Scholar : PubMed/NCBI

15 

Gravendeel LA, Kouwenhoven MC, Gevaert O, de Rooi JJ, Stubbs AP, Duijm JE, Daemen A, Bleeker FE, Bralten LB, Kloosterhof NK, et al: Intrinsic gene expression profiles of gliomas are a better predictor of survival than histology. Cancer Res. 69:9065–9072. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Sun L, Hui A, Su Q, Vortmeyer A, Kotliarov Y, Pastorino S, Passaniti A, Menon J, Walling J, Bailey R, et al: Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain. Cancer Cell. 9:287–300. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta DeltaC(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Zhang X, Tian Q, Wang L, Liu Y, Li B, Liang Z, Gao P, Zheng K, Zhao B and Lu H: Radiomics strategy for molecular subtype stratification of lower-grade glioma: Detecting IDH and TP53 mutations based on multimodal MRI. J Magn Reson Imaging. 48:916–926. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Lehrer S, Rheinstein PH, Green S and Rosenzweig KE: von Willebrand factor gene expression in primary lower grade glioma: Mutually Co-occurring mutations in von Willebrand factor, ATRX, and TP53. Brain Tumor Res Treat. 7:33–38. 2019. View Article : Google Scholar : PubMed/NCBI

20 

Malmer B, Gronberg H, Andersson U, Jonsson BA and Henriksson R: Microsatellite instability, PTEN and p53 germline mutations in glioma families. Acta Oncol. 40:633–637. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Bromberg KD, Kluger HM, Delaunay A, Abbas S, DiVito KA, Krajewski S and Ronai Z: Increased expression of the E3 ubiquitin ligase RNF5 is associated with decreased survival in breast cancer. Cancer Res. 67:8172–8179. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Shi H, Zheng B, Wu Y, Tang Y, Wang L, Gao Y, Gong H, Du J and Yu R: Ubiquitin ligase Siah1 promotes the migration and invasion of human glioma cells by regulating HIF-1α signaling under hypoxia. Oncol Rep. 33:1185–1190. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Wu Y, Wang L, Bao H, Zou S, Fu C, Gong H, Gao Y, Tang Y, Yu R and Shi H: Nrdp1S, short variant of Nrdp1, inhibits human glioma progression by increasing Nrdp1-mediated ErbB3 ubiquitination and degradation. J Cell Mol Med. 20:422–429. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Shi H, Du J, Wang L, Zheng B, Gong H, Wu Y, Tang Y, Gao Y and Yu R: Lower expression of Nrdp1 in human glioma contributes tumor progression by reducing apoptosis. IUBMB Life. 66:704–710. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Shi H, Gong H, Cao K, Zou S, Zhu B, Bao H, Wu Y, Gao Y, Tang Y and Yu R: Nrdp1-mediated ErbB3 degradation inhibits glioma cell migration and invasion by reducing cytoplasmic localization of p27(Kip1). J Neurooncol. 124:357–364. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Runnebaum IB, Nagarajan M, Bowman M, Soto D and Sukumar S: Mutations in p53 as potential molecular markers for human breast cancer. Proc Natl Acad Sci USA. 88:10657–10661. 1991. View Article : Google Scholar : PubMed/NCBI

27 

Nieves-Neira W and Pommier Y: Apoptotic response to camptothecin and 7-hydroxystaurosporine (UCN-01) in the 8 human breast cancer cell lines of the NCI Anticancer Drug Screen: Multifactorial relationships with topoisomerase I, protein kinase C, Bcl-2, p53, MDM-2 and caspase pathways. Int J Cancer. 82:396–404. 1999. View Article : Google Scholar : PubMed/NCBI

28 

Kawasoe T, Takeshima H, Yamashita S, Mizuguchi S, Fukushima T, Yokogami K and Yamasaki K: Detection of p53 mutations in proliferating vascular cells in glioblastoma multiforme. J Neurosurg. 122:317–323. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Marutani M, Tonoki H, Tada M, Takahashi M, Kashiwazaki H, Hida Y, Hamada J, Asaka M and Moriuchi T: Dominant-negative mutations of the tumor suppressor p53 relating to early onset of glioblastoma multiforme. Cancer Res. 59:4765–4769. 1999.PubMed/NCBI

30 

Lin C, Liang Y, Zhu H, Zhang J and Zhong X: R280T mutation of p53 gene promotes proliferation of human glioma cells through GSK-3β/PTEN pathway. Neurosci Lett. 529:60–65. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Robertson LB, Armstrong GN, Olver BD, Lloyd AL, Shete S, Lau C, Claus EB, Barnholtz-Sloan J, Lai R, Il'yasova D, et al: Survey of familial glioma and role of germline p16INK4A/p14ARF and p53 mutation. Fam Cancer. 9:413–421. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Cui W, Wu R, Cao H, Gao J, Wang X and Ren Q: P53 gene mutation and expression of MDM2, P53, P16 protein and their relationship in human glioma. J Huazhong Univ Sci Technolog Med Sci. 25:622–624, 635. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Hayashi Y, Yamashita J and Yamaguchi K: Timing and role of p53 gene mutation in the recurrence of glioma. Biochem Biophys Res Commun. 180:1145–1150. 1991. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Gao Y, Xuan C, Jin M, An Q, Zhuo B, Chen X, Wang L, Wang Y, Sun Q, Shi Y, Shi Y, et al: Ubiquitin ligase RNF5 serves an important role in the development of human glioma. Oncol Lett 18: 4659-4666, 2019.
APA
Gao, Y., Xuan, C., Jin, M., An, Q., Zhuo, B., Chen, X. ... Shi, Y. (2019). Ubiquitin ligase RNF5 serves an important role in the development of human glioma. Oncology Letters, 18, 4659-4666. https://doi.org/10.3892/ol.2019.10801
MLA
Gao, Y., Xuan, C., Jin, M., An, Q., Zhuo, B., Chen, X., Wang, L., Wang, Y., Sun, Q., Shi, Y."Ubiquitin ligase RNF5 serves an important role in the development of human glioma". Oncology Letters 18.5 (2019): 4659-4666.
Chicago
Gao, Y., Xuan, C., Jin, M., An, Q., Zhuo, B., Chen, X., Wang, L., Wang, Y., Sun, Q., Shi, Y."Ubiquitin ligase RNF5 serves an important role in the development of human glioma". Oncology Letters 18, no. 5 (2019): 4659-4666. https://doi.org/10.3892/ol.2019.10801
Copy and paste a formatted citation
x
Spandidos Publications style
Gao Y, Xuan C, Jin M, An Q, Zhuo B, Chen X, Wang L, Wang Y, Sun Q, Shi Y, Shi Y, et al: Ubiquitin ligase RNF5 serves an important role in the development of human glioma. Oncol Lett 18: 4659-4666, 2019.
APA
Gao, Y., Xuan, C., Jin, M., An, Q., Zhuo, B., Chen, X. ... Shi, Y. (2019). Ubiquitin ligase RNF5 serves an important role in the development of human glioma. Oncology Letters, 18, 4659-4666. https://doi.org/10.3892/ol.2019.10801
MLA
Gao, Y., Xuan, C., Jin, M., An, Q., Zhuo, B., Chen, X., Wang, L., Wang, Y., Sun, Q., Shi, Y."Ubiquitin ligase RNF5 serves an important role in the development of human glioma". Oncology Letters 18.5 (2019): 4659-4666.
Chicago
Gao, Y., Xuan, C., Jin, M., An, Q., Zhuo, B., Chen, X., Wang, L., Wang, Y., Sun, Q., Shi, Y."Ubiquitin ligase RNF5 serves an important role in the development of human glioma". Oncology Letters 18, no. 5 (2019): 4659-4666. https://doi.org/10.3892/ol.2019.10801
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team