Open Access

Ubiquitin ligase RNF5 serves an important role in the development of human glioma

  • Authors:
    • Yong Gao
    • Chengmin Xuan
    • Mingwei Jin
    • Qi An
    • Baobiao Zhuo
    • Xincheng Chen
    • Lei Wang
    • Yuan Wang
    • Qingzeng Sun
    • Yingchun Shi
  • View Affiliations

  • Published online on: September 4, 2019     https://doi.org/10.3892/ol.2019.10801
  • Pages: 4659-4666
  • Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The ubiquitin ligase ring finger protein 5 (RNF5) has previously been associated with the development of breast cancer. Patients with breast cancer and high RNF5 expression have been demonstrated to have a shorter survival time compared with patients with low RNF5 expression. However, the role of RNF5 in human glioma has not been determined. The present study analyzed the role of RNF5 in gliomas using bioinformatics analysis. The results revealed that RNF5 was differentially expressed in non‑cancerous brain tissues and different grades of glioma. Furthermore, a high RNF5 expression in patients with glioma was associated with an improved prognosis compared with patients with low expression. Gene Set Enrichment Analysis revealed that RNF5 was particularly associated with ‘Wnt signaling pathway’, ‘apoptosis’, ‘focal adhesion’ and ‘cytokine‑cytokine receptor interaction’ in patients with glioma. Additionally, 4 potential ubiquitination substrates for RNF5 were predicted, including sorting nexin 10, proprotein convertase subtilisin/kexin type 1, leucine rich glioma inactivated 1 and solute carrier family 39 member 12. These findings provided the basis for further investigation on the role of RNF5 in tumors.
View Figures
View References

Related Articles

Journal Cover

November-2019
Volume 18 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Gao Y, Xuan C, Jin M, An Q, Zhuo B, Chen X, Wang L, Wang Y, Sun Q, Shi Y, Shi Y, et al: Ubiquitin ligase RNF5 serves an important role in the development of human glioma. Oncol Lett 18: 4659-4666, 2019
APA
Gao, Y., Xuan, C., Jin, M., An, Q., Zhuo, B., Chen, X. ... Shi, Y. (2019). Ubiquitin ligase RNF5 serves an important role in the development of human glioma. Oncology Letters, 18, 4659-4666. https://doi.org/10.3892/ol.2019.10801
MLA
Gao, Y., Xuan, C., Jin, M., An, Q., Zhuo, B., Chen, X., Wang, L., Wang, Y., Sun, Q., Shi, Y."Ubiquitin ligase RNF5 serves an important role in the development of human glioma". Oncology Letters 18.5 (2019): 4659-4666.
Chicago
Gao, Y., Xuan, C., Jin, M., An, Q., Zhuo, B., Chen, X., Wang, L., Wang, Y., Sun, Q., Shi, Y."Ubiquitin ligase RNF5 serves an important role in the development of human glioma". Oncology Letters 18, no. 5 (2019): 4659-4666. https://doi.org/10.3892/ol.2019.10801