STMN1 accumulation is associated with dysplastic and neoplastic lesions in patients with ulcerative colitis

Osone,Katsuya; Yokobori,Takehiko; Katayama,Chika; Takahashi,Ryo; Kato,Ryuji; Tatsuski,Hironori; Takada,Takahiro; Yajima,Reina; Motegi,Yoko; Ogawa,Hiroomi; Fujii,Takaaki; Ojima,Hitoshi; Nakamura,Junichi; Yao,Takashi; Shirabe,Ken; Kuwano,Hiroyuki

doi:10.3892/ol.2019.10814

November-2019 Volume 18 Issue 5

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November-2019 Volume 18 Issue 5

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Article Open Access

STMN1 accumulation is associated with dysplastic and neoplastic lesions in patients with ulcerative colitis

Authors:
- Katsuya Osone
- Takehiko Yokobori
- Chika Katayama
- Ryo Takahashi
- Ryuji Kato
- Hironori Tatsuski
- Takahiro Takada
- Reina Yajima
- Yoko Motegi
- Hiroomi Ogawa
- Takaaki Fujii
- Hitoshi Ojima
- Junichi Nakamura
- Takashi Yao
- Ken Shirabe
- Hiroyuki Kuwano
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Affiliations: Department of General Surgical Science, Gunma University, Graduate School of Medicine, Maebashi, Gunma 371‑8511, Japan, Department of Gastroenterological Surgery, Gunma Prefectural Cancer Center, Ohta, Gunma 373‑8550, Japan, Department of Gastroenterological Surgery, Saitama Red Cross Hospital, Ohmiya, Saitama 330‑8553, Japan, Department of Human Pathology, Juntendo University Graduate School of Medicine, Bunkyouku, Tokyo 113‑8421, Japan

Copyright: © Osone et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 4712-4718
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Published online on: September 5, 2019

https://doi.org/10.3892/ol.2019.10814
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Abstract

Ulcerative colitis (UC) is thought to be associated with precancerous lesions that can ultimately lead to colon cancer. Therefore, diagnostic markers for colorectal dysplasia and cancer are urgently needed for patients with UC. Stathmin 1 (STMN1) is a novel cancer biomarker that is also a novel target for treatment in several cancers, including colon cancer. However, few studies have investigated the relationship between STMN1 expression and clinical features in colorectal dysplasia and cancer in patients with UC. The present study examined the clinical significance of STMN1 expression in colorectal dysplasia and cancer with UC. The present study performed an immunohistochemical analysis of 31 clinical colorectal samples from eight patients with colorectal dysplasia and/or cancer to assess the relationships between STMN1 expression and clinicopathological features including mismatch repair protein expression, rate of Ki‑67 positivity, differentiation level, TNM stage, and UC duration. STNM1 expression was detected in 95.7% of dysplastic and cancerous lesions, whereas p53, the current diagnostic marker, was not expressed in 39.1% of dysplastic and cancerous lesions. Furthermore, STMN1 expression was associated with a high rate of positivity for Ki‑67, a proliferation marker. Our data suggest that STMN1 in the colonic mucosa of UC patients may be useful as an early diagnostic marker of dysplasia and colitic cancer.

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1	Morson BC: Cancer in ulcerative colitis. Gut. 7:425–426. 1966. View Article : Google Scholar : PubMed/NCBI
2	Van Assche G, Dignass A, Bokemeyer B, Danese S, Gionchetti P, Moser G, Beaugerie L, Gomollón F, Häuser W, Herrlinger K, et al: Second European evidence-based consensus on the diagnosis and management of ulcerative colitis part 3: Special situations. J Crohns Colitis. 7:1–33. 2013. View Article : Google Scholar : PubMed/NCBI
3	Eaden J, Abrams K, McKay H, Denley H and Mayberry J: Inter-observer variation between general and specialist gastrointestinal pathologists when grading dysplasia in ulcerative colitis. J Pathol. 194:152–157. 2001. View Article : Google Scholar : PubMed/NCBI
4	Kobayashi K, Tomita H, Shimizu M, Tanaka T, Suzui N, Miyazaki T and Hara A: p53 Expression as a diagnostic biomarker in ulcerative colitis-associated cancer. Int J Mol Sci. 18:E12842017. View Article : Google Scholar : PubMed/NCBI
5	Wong NA, Mayer NJ, MacKell S, Gilmour HM and Harrison DJ: Immunohistochemical assessment of Ki67 and p53 expression assists the diagnosis and grading of ulcerative colitis-related dysplasia. Histopathology. 37:108–114. 2000. View Article : Google Scholar : PubMed/NCBI
6	Shigaki K, Mitomi H, Fujimori T, Ichikawa K, Tomita S, Imura J, Fujii S, Itabashi M, Kameoka S, Sahara R and Takenoshita S: Immunohistochemical analysis of chromogranin A and p53 expressions in ulcerative colitis-associated neoplasia: Neuroendocrine differentiation as an early event in the colitis-neoplasia sequence. Hum Pathol. 44:2393–2399. 2013. View Article : Google Scholar : PubMed/NCBI
7	Tahara T, Inoue N, Hisamatsu T, Kashiwagi K, Takaishi H, Kanai T, Watanabe M, Ishii H and Hibi T: Clinical significance of microsatellite instability in the inflamed mucosa for the prediction of colonic neoplasms in patients with ulcerative colitis. J Gastroenterol Hepatol. 20:710–715. 2005. View Article : Google Scholar : PubMed/NCBI
8	Liu X, Goldblum JR, Zhao Z, Landau M, Heald B, Pai R and Lin J: Distinct clinicohistologic features of inflammatory bowel disease-associated colorectal adenocarcinoma: In comparison with sporadic microsatellite-stable and Lynch syndrome-related colorectal adenocarcinoma. Am J Surg Pathol. 36:1228–1233. 2012. View Article : Google Scholar : PubMed/NCBI
9	Baldassarre G, Belletti B, Nicoloso MS, Schiappacassi M, Vecchione A, Spessotto P, Morrione A, Canzonieri V and Colombatti A: p27(Kip1)-stathmin interaction influences sarcoma cell migration and invasion. Cancer Cell. 7:51–63. 2005. View Article : Google Scholar : PubMed/NCBI
10	Zhang HQ, Guo X, Guo SQ, Wang Q, Chen XQ, Li XN and Guo LS: STMN1 in colon cancer: Expression and prognosis in Chinese patients. Eur Rev Med Pharmacol Sci. 20:2038–2044. 2016.PubMed/NCBI
11	Bruwer M, Schmid KW, Senninger N and Schurmann G: Immunohistochemical expression of P53 and oncogenes in ulcerative colitis-associated colorectal carcinoma. World J Surg. 26:390–396. 2002. View Article : Google Scholar : PubMed/NCBI
12	Watanabe T, Konishi T, Kishimoto J, Kotake K, Muto T and Sugihara K; Japanese Society for Cancer of the Colon and Rectum, : Ulcerative colitis-associated colorectal cancer shows a poorer survival than sporadic colorectal cancer: A nationwide Japanese study. Inflamm Bowel Dis. 17:802–808. 2011. View Article : Google Scholar : PubMed/NCBI
13	Bhagirath D, Abrol N, Khan R, Sharma M, Seth A and Sharma A: Expression of CD147, BIGH3 and Stathmin and their potential role as diagnostic marker in patients with urothelial carcinoma of the bladder. Clin Chim Acta. 413:1641–1646. 2012. View Article : Google Scholar : PubMed/NCBI
14	Ullman TA and Itzkowitz SH: Intestinal inflammation and cancer. Gastroenterology. 140:1807–1816. 2011. View Article : Google Scholar : PubMed/NCBI
15	Carney BK and Cassimeris L: Stathmin/oncoprotein 18, a microtubule regulatory protein, is required for survival of both normal and cancer cell lines lacking the tumor suppressor, p53. Cancer Biol Ther. 9:699–709. 2010. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

STMN1 accumulation is associated with dysplastic and neoplastic lesions in patients with ulcerative colitis

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