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Pancreatoduodenectomy with portal vein resection favors the survival time of patients with pancreatic ductal adenocarcinoma: A propensity score matching analysis

  • Authors:
    • Zhi‑Bo Xie
    • Ji Li
    • Ji‑Chun Gu
    • Chen Jin
    • Cai‑Feng Zou
    • De‑Liang Fu
  • View Affiliations / Copyright

    Affiliations: Department of Pancreatic Surgery, Pancreatic Disease Institute, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, P.R. China
    Copyright: © Xie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4563-4572
    |
    Published online on: September 6, 2019
       https://doi.org/10.3892/ol.2019.10822
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Abstract

Portal vein (PV) involvement is common in patients with pancreatic ductal adenocarcinoma (PDAC). To the best of our knowledge, pancreatectomy combined with PV resection (PVR) is the only radical therapy for patients with PV involvement. However, there remains a debate on whether patients with PV involvement could benefit from PVR or not. The present study aimed to compare the survival outcomes between patients receiving pancreatoduodenectomy (PD) with PVR and those receiving PD alone. A total of 377 patients with PDAC were enrolled, 138 patients with PV involvement were placed in the PVR group, while the other 239 patients were in the non‑PVR group. To reduce selection bias and estimate the causal effect, 123 pairs of propensity score matched (PSM) patients were selected and compared for the survival outcomes. Before PSM, the survival of patients in the PVR group was worse compared with those in the non‑PVR group (mean survival, 25.1 vs. 29.3 months; P=0.038). After balancing the baseline characteristics using the PSM method, the significant survival difference between the two groups was insignificant (mean survival, 25.9 vs. 31.2 months; P=0.364). Tumor stage, body mass index, serum albumin, R1 resection, lymph node metastasis, carbohydrate antigen (CA)125 and CA19‑9 were significant independent prognostic factors. The incidence of serious postoperative complications was similar between the two groups. PVR is safe and effective for patients with PDAC. Patients with PV involvement could achieve the similar survival outcome as patients without PV involvement, through radical resection combined with PVR, without increasing the risk of serious complications.
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Copy and paste a formatted citation
Spandidos Publications style
Xie ZB, Li J, Gu JC, Jin C, Zou CF and Fu DL: Pancreatoduodenectomy with portal vein resection favors the survival time of patients with pancreatic ductal adenocarcinoma: A propensity score matching analysis. Oncol Lett 18: 4563-4572, 2019.
APA
Xie, Z., Li, J., Gu, J., Jin, C., Zou, C., & Fu, D. (2019). Pancreatoduodenectomy with portal vein resection favors the survival time of patients with pancreatic ductal adenocarcinoma: A propensity score matching analysis. Oncology Letters, 18, 4563-4572. https://doi.org/10.3892/ol.2019.10822
MLA
Xie, Z., Li, J., Gu, J., Jin, C., Zou, C., Fu, D."Pancreatoduodenectomy with portal vein resection favors the survival time of patients with pancreatic ductal adenocarcinoma: A propensity score matching analysis". Oncology Letters 18.5 (2019): 4563-4572.
Chicago
Xie, Z., Li, J., Gu, J., Jin, C., Zou, C., Fu, D."Pancreatoduodenectomy with portal vein resection favors the survival time of patients with pancreatic ductal adenocarcinoma: A propensity score matching analysis". Oncology Letters 18, no. 5 (2019): 4563-4572. https://doi.org/10.3892/ol.2019.10822
Copy and paste a formatted citation
x
Spandidos Publications style
Xie ZB, Li J, Gu JC, Jin C, Zou CF and Fu DL: Pancreatoduodenectomy with portal vein resection favors the survival time of patients with pancreatic ductal adenocarcinoma: A propensity score matching analysis. Oncol Lett 18: 4563-4572, 2019.
APA
Xie, Z., Li, J., Gu, J., Jin, C., Zou, C., & Fu, D. (2019). Pancreatoduodenectomy with portal vein resection favors the survival time of patients with pancreatic ductal adenocarcinoma: A propensity score matching analysis. Oncology Letters, 18, 4563-4572. https://doi.org/10.3892/ol.2019.10822
MLA
Xie, Z., Li, J., Gu, J., Jin, C., Zou, C., Fu, D."Pancreatoduodenectomy with portal vein resection favors the survival time of patients with pancreatic ductal adenocarcinoma: A propensity score matching analysis". Oncology Letters 18.5 (2019): 4563-4572.
Chicago
Xie, Z., Li, J., Gu, J., Jin, C., Zou, C., Fu, D."Pancreatoduodenectomy with portal vein resection favors the survival time of patients with pancreatic ductal adenocarcinoma: A propensity score matching analysis". Oncology Letters 18, no. 5 (2019): 4563-4572. https://doi.org/10.3892/ol.2019.10822
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