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Review Open Access

Sonic Hedgehog signaling pathway as a potential target to inhibit the progression of hepatocellular carcinoma (Review)

  • Authors:
    • Kuo‑Shyang Jeng
    • Chi‑Juei Jeng
    • Wen‑Juei Jeng
    • I‑Shyan Sheen
    • Shih‑Yun Li
    • Chuen‑Miin Leu
    • Yeou‑Guang Tsay
    • Chiung‑Fang Chang
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Far Eastern Memorial Hospital, New Taipei City 22060, Taiwan, R.O.C., Graduate Institute of Clinical Medicine, National Taiwan University, Taipei City 10617, Taiwan, R.O.C., Department of Hepato‑Gastroenterology, Chang‑Gung Memorial Hospital, Linkou Medical Center, Chang‑Gung University, Taoyuan City 33305, Taiwan, R.O.C., Department of Medical Research, Far Eastern Memorial Hospital, New Taipei City 22060, Taiwan, R.O.C., Institute of Microbiology and Immunology, National Yang‑Ming University, Taipei City 11221, Taiwan, R.O.C., Institute of Biochemistry and Molecular Biology, National Yang‑Ming University, Taipei City 11221, Taiwan, R.O.C.
    Copyright: © Jeng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4377-4384
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    Published online on: September 9, 2019
       https://doi.org/10.3892/ol.2019.10826
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Abstract

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer‑associated mortality worldwide. Hepatocarcinogenesis involves numerous interlinked factors and processes, including the Sonic hedgehog (Shh) signaling pathway, which participates in the carcinogenesis, progression, invasiveness, recurrence and cancer stem cell maintenance of HCC. The Shh signaling pathway is activated by ligands that bind to their receptor protein, Protein patched homolog (Ptch). The process of Shh ligand binding to Ptch weakens the inhibition of smoothened homolog (SMO) and activates signal transduction via glioma‑associated oncogene homolog (Gli) transcription factors. The overexpression of Shh pathway molecules, including Shh, Ptch‑1, Gli and SMO has been indicated in patients with HCC. It has also been suggested that the Shh signaling pathway exhibits cross‑talk between numerous other signaling pathways. The inactivation of the Shh signaling pathway reduces HCC growth, increases radio‑sensitivity and increases the beneficial effect of chemotherapy in HCC treatment. Therefore, inhibition of the Shh pathway may be an effective target therapy that can be used in the treatment of HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Jeng KS, Jeng CJ, Jeng WJ, Sheen IS, Li SY, Leu CM, Tsay YG and Chang CF: Sonic Hedgehog signaling pathway as a potential target to inhibit the progression of hepatocellular carcinoma (Review). Oncol Lett 18: 4377-4384, 2019.
APA
Jeng, K., Jeng, C., Jeng, W., Sheen, I., Li, S., Leu, C. ... Chang, C. (2019). Sonic Hedgehog signaling pathway as a potential target to inhibit the progression of hepatocellular carcinoma (Review). Oncology Letters, 18, 4377-4384. https://doi.org/10.3892/ol.2019.10826
MLA
Jeng, K., Jeng, C., Jeng, W., Sheen, I., Li, S., Leu, C., Tsay, Y., Chang, C."Sonic Hedgehog signaling pathway as a potential target to inhibit the progression of hepatocellular carcinoma (Review)". Oncology Letters 18.5 (2019): 4377-4384.
Chicago
Jeng, K., Jeng, C., Jeng, W., Sheen, I., Li, S., Leu, C., Tsay, Y., Chang, C."Sonic Hedgehog signaling pathway as a potential target to inhibit the progression of hepatocellular carcinoma (Review)". Oncology Letters 18, no. 5 (2019): 4377-4384. https://doi.org/10.3892/ol.2019.10826
Copy and paste a formatted citation
x
Spandidos Publications style
Jeng KS, Jeng CJ, Jeng WJ, Sheen IS, Li SY, Leu CM, Tsay YG and Chang CF: Sonic Hedgehog signaling pathway as a potential target to inhibit the progression of hepatocellular carcinoma (Review). Oncol Lett 18: 4377-4384, 2019.
APA
Jeng, K., Jeng, C., Jeng, W., Sheen, I., Li, S., Leu, C. ... Chang, C. (2019). Sonic Hedgehog signaling pathway as a potential target to inhibit the progression of hepatocellular carcinoma (Review). Oncology Letters, 18, 4377-4384. https://doi.org/10.3892/ol.2019.10826
MLA
Jeng, K., Jeng, C., Jeng, W., Sheen, I., Li, S., Leu, C., Tsay, Y., Chang, C."Sonic Hedgehog signaling pathway as a potential target to inhibit the progression of hepatocellular carcinoma (Review)". Oncology Letters 18.5 (2019): 4377-4384.
Chicago
Jeng, K., Jeng, C., Jeng, W., Sheen, I., Li, S., Leu, C., Tsay, Y., Chang, C."Sonic Hedgehog signaling pathway as a potential target to inhibit the progression of hepatocellular carcinoma (Review)". Oncology Letters 18, no. 5 (2019): 4377-4384. https://doi.org/10.3892/ol.2019.10826
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