Open Access

Sonic Hedgehog signaling pathway as a potential target to inhibit the progression of hepatocellular carcinoma (Review)

  • Authors:
    • Kuo‑Shyang Jeng
    • Chi‑Juei Jeng
    • Wen‑Juei Jeng
    • I‑Shyan Sheen
    • Shih‑Yun Li
    • Chuen‑Miin Leu
    • Yeou‑Guang Tsay
    • Chiung‑Fang Chang
  • View Affiliations

  • Published online on: September 9, 2019     https://doi.org/10.3892/ol.2019.10826
  • Pages: 4377-4384
  • Copyright: © Jeng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer‑associated mortality worldwide. Hepatocarcinogenesis involves numerous interlinked factors and processes, including the Sonic hedgehog (Shh) signaling pathway, which participates in the carcinogenesis, progression, invasiveness, recurrence and cancer stem cell maintenance of HCC. The Shh signaling pathway is activated by ligands that bind to their receptor protein, Protein patched homolog (Ptch). The process of Shh ligand binding to Ptch weakens the inhibition of smoothened homolog (SMO) and activates signal transduction via glioma‑associated oncogene homolog (Gli) transcription factors. The overexpression of Shh pathway molecules, including Shh, Ptch‑1, Gli and SMO has been indicated in patients with HCC. It has also been suggested that the Shh signaling pathway exhibits cross‑talk between numerous other signaling pathways. The inactivation of the Shh signaling pathway reduces HCC growth, increases radio‑sensitivity and increases the beneficial effect of chemotherapy in HCC treatment. Therefore, inhibition of the Shh pathway may be an effective target therapy that can be used in the treatment of HCC.
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November-2019
Volume 18 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Jeng KS, Jeng CJ, Jeng WJ, Sheen IS, Li SY, Leu CM, Tsay YG and Chang CF: Sonic Hedgehog signaling pathway as a potential target to inhibit the progression of hepatocellular carcinoma (Review). Oncol Lett 18: 4377-4384, 2019
APA
Jeng, K., Jeng, C., Jeng, W., Sheen, I., Li, S., Leu, C. ... Chang, C. (2019). Sonic Hedgehog signaling pathway as a potential target to inhibit the progression of hepatocellular carcinoma (Review). Oncology Letters, 18, 4377-4384. https://doi.org/10.3892/ol.2019.10826
MLA
Jeng, K., Jeng, C., Jeng, W., Sheen, I., Li, S., Leu, C., Tsay, Y., Chang, C."Sonic Hedgehog signaling pathway as a potential target to inhibit the progression of hepatocellular carcinoma (Review)". Oncology Letters 18.5 (2019): 4377-4384.
Chicago
Jeng, K., Jeng, C., Jeng, W., Sheen, I., Li, S., Leu, C., Tsay, Y., Chang, C."Sonic Hedgehog signaling pathway as a potential target to inhibit the progression of hepatocellular carcinoma (Review)". Oncology Letters 18, no. 5 (2019): 4377-4384. https://doi.org/10.3892/ol.2019.10826