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Article

BNP as a marker for early prediction of anthracycline‑induced cardiotoxicity in patients with breast cancer

  • Authors:
    • Xiang Lu
    • Yingying Zhao
    • Caiping Chen
    • Chao Han
    • Li Xue
    • Dan Xing
    • Ou Huang
    • Min Tao
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China, Department of Breast Surgery, The First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang 314001, P.R. China, Comprehensive Breast Health Centre, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China
  • Pages: 4992-5001
    |
    Published online on: September 9, 2019
       https://doi.org/10.3892/ol.2019.10827
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Abstract

Anthracycline chemotherapy serves an important role in treating patients with breast cancer but is associated with cardiotoxicity. Although brain natriuretic peptide (BNP) is not the ideal marker for detecting the presence of diseases of the heart, several studies have demonstrated the predictive utility of BNP in the diagnosis of anthracycline‑induced cardiotoxicity (AIC). The aim of the present study was to evaluate the role of BNP as a marker for the early prediction of AIC in patients with breast cancer. In the present study, a total of 149 patients with breast cancer who received anthracycline therapy were evaluated. The levels of BNP and echocardiography were detected during the anthracycline‑based chemotherapy and patients were followed up after chemotherapy to determine the cardiotoxicity‑free survival times. In the patients who received chemotherapy, an increase in the levels of BNP was observed. The concentration of BNP was significantly higher in the cardiotoxicity group during anthracycline chemotherapy (P=0.022) compared with the non‑cardiotoxicity group and it was an independent predictor of cardiotoxicity (P=0.028). The optimal diagnostic threshold of BNP after the last anthracycline chemotherapy treatment was 107.9 pg/ml, the diagnostic sensitivity was 0.538, the specificity was 0.794, the Youden index was 0.332, the positive predictive value was 0.583 and the negative predictive value was 0.762. Based on the BNP threshold, a log‑rank test was performed and it was determined that the cardiotoxicity‑free survival rate of the group with higher levels of BNP was always lower compared with the group with lower levels of BNP. BNP elevation was associated with cardiotoxicity during the anthracycline chemotherapy. Detecting BNP after the final treatment of anthracycline chemotherapy may contribute to the early detection of cardiotoxicity.
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1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Meinardi MT, van Veldhuisen DJ, Gietema JA, Dolsma WV, Boomsma F, van den Berg MP, Volkers C, Haaksma J, de Vries EG, Sleijfer DT and van der Graaf WT: Prospective evaluation of early cardiac damage induced by epirubicin- containing adjuvant chemotherapy and locoregional radiotherapy in breast cancer patients. J Clin Oncol. 19:2746–2753. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Lipshultz SE, Lipsitz SR, Sallan SE, Dalton VM, Mone SM, Gelber RD and Colan SD: Chronic progressive cardiac dysfunction years after doxorubicin therapy for childhood acute lymphoblastic leukemia. J Clin Oncol. 23:2629–2636. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Keefe DL: Anthracycline-induced cardiomyopathy. Semin Oncol. 28 (Suppl 12):S2–S7. 2001. View Article : Google Scholar

5 

Armenian SH, Gelehrter SK, Vase T, Venkatramani R, Landier W, Wilson KD, Herrera C, Reichman L, Menteer JD, Mascarenhas L, et al: Screening for cardiac dysfunction in anthracycline-exposed childhood cancer survivors. Clin Cancer Res. 20:6314–6323. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Kilickap S, Barista I, Akgul E, Aytemir K, Aksoyek S, Aksoy S, Celik I, Kes S and Tekuzman G: cTnT can be a useful marker for early detection of anthracycline cardiotoxicity. Ann Oncol. 16:798–804. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Clerico A, Fontana M, Zyw L, Passino C and Emdin M: Comparison of the diagnostic accuracy of brain natriuretic peptide (BNP) and the N-terminal part of the propeptide of BNP immunoassays in chronic and acute heart failure: A systematic review. Clin Chem. 53:813–822. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Ledwidge M, Gallagher J, Conlon C, Tallon E, O'Connell E, Dawkins I, Watson C, O'Hanlon R, Bermingham M, Patle A, et al: Natriuretic peptide-based screening and collaborative care for heart failure: The STOP-HF randomized trial. JAMA. 310:66–74. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Wang P, Zhang S, Zhang XB, Li WJ, Hao XM and Zhang J: Protective effect of dexrazoxane on cardiotoxicity in breast cancer patients who received anthracycline-containing chemotherapy. Zhonghua Zhong Liu Za Zhi. 35:135–139. 2013.(In Chinese). PubMed/NCBI

10 

Lipshultz SE, Miller TL, Scully RE, Lipsitz SR, Rifai N, Silverman LB, Colan SD, Neuberg DS, Dahlberg SE, Henkel JM, et al: Changes in cardiac biomarkers during doxorubicin treatment of pediatric patients with high-risk acute lymphoblastic leukemia: Associations with long-term echocardiographic outcomes. J Clin Oncol. 30:1042–1049. 2012. View Article : Google Scholar : PubMed/NCBI

11 

De Iuliis F, Salerno G, Taglieri L, De Biase L, Lanza R, Cardelli P and Scarpa S: Serum biomarkers evaluation to predict chemotherapy-induced cardiotoxicity in breast cancer patients. Tumour Biol. 37:3379–3387. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Lenihan DJ, Stevens PL, Massey M, Plana JC, Araujo DM, Fanale MA, Fayad LE, Fisch MJ and Yeh ET: The utility of point-of-care biomarkers to detect cardiotoxicity during anthracycline chemotherapy: A feasibility study. J Card Fail. 22:433–438. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Zidan A, Sherief LM, El-sheikh A, Saleh SH, Shahbah DA, Kamal NM, Sherbiny HS and Ahmad H: NT-proBNP as early marker of subclinical late cardiotoxicity after doxorubicin therapy and mediastinal irradiation in childhood cancer survivors. Dis Markers. 2015:5132192015. View Article : Google Scholar : PubMed/NCBI

14 

Sinn HP, Helmchen B and Wittekind CH: TNM classification of breast cancer: Changes and comments on the 7th edition. Pathologe. 31:361–366. 2010.(In German). View Article : Google Scholar : PubMed/NCBI

15 

Wolff AC, Hammond MEH, Allison KH, Harvey BE, Mangu PB, Bartlett JMS, Bilous M, Ellis IO, Fitzgibbons P, Hanna W, et al: Human epidermal growth factor receptor 2 testing in breast cancer: American society of clinical oncology/college of American pathologists clinical practice guideline focused update. Arch Pathol Lab Med. 142:1364–1382. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Pichon MF, Cvitkovic F, Hacene K, Delaunay J, Lokiec F, Collignon MA and Pecking AP: Drug-induced cardiotoxicity studied by longitudinal B-type natriuretic peptide assays and radionuclide ventriculography. In Vivo. 19:567–576. 2005.PubMed/NCBI

17 

Potter E and Marwick TH: Assessment of left ventricular function by echocardiography: The case for routinely adding global longitudinal strain to ejection fraction. JACC Cardiovasc Imaging. 11:260–274. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Chang SA, Lim BK, Lee YJ, Hong MK, Choi JO and Jeon ES: A novel angiotensin type I receptor antagonist, fimasartan, prevents doxorubicin-induced cardiotoxicity in rats. J Korean Med Sci. 30:559–568. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Nitta D, Kinugawa K, Imamura T, Kato NP and Komuro I: High dose β-blocker therapy triggers additional reverse remodeling in patients with idiopathic non-ischemic cardiomyopathy. Int Heart J. 57:717–724. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Shimomura Y, Baba R, Watanabe A, Horikoshi Y, Asami K, Hyakuna N, Iwai A, Matsushita T, Yamaji K, Hori T, et al: Japanese childhood cancer and leukemia study group (JCCLSG): Assessment of late cardiotoxicity of pirarubicin (THP) in children with acute lymphoblastic leukemia. Pediatr Blood Cancer. 57:461–466. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Bird BR and Swain SM: Cardiac toxicity in breast cancer survivors: Review of potential cardiac problems. Clin Cancer Res. 14:14–24. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Visscher H, Ross CJ, Rassekh SR, Barhdadi A, Dubé MP, Al-Saloos H, Sandor GS, Caron HN, van Dalen EC, Kremer LC, et al: Canadian pharmacogenomics network for drug safety consortium: Pharmacogenomic prediction of anthracycline-induced cardiotoxicity in children. J Clin Oncol. 30:1422–1428. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Cao L, Zhu W, Wagar EA and Meng QH: Biomarkers for monitoring chemotherapy-induced cardiotoxicity. Crit Rev Clin Lab Sci. 54:87–101. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Leger KJ, Leonard D, Nielson D, de Lemos JA, Mammen PP and Winick NJ: Circulating microRNAs: Potential markers of cardiotoxicity in children and young adults treated with anthracycline chemotherapy. J Am Heart Assoc. 6:e0046532017. View Article : Google Scholar : PubMed/NCBI

25 

Malik A, Jeyaraj PA, Calton R, Uppal B, Negi P, Shankar A, Patil J and Mahajan MK: Are biomarkers predictive of anthracycline-induced cardiac dysfunction? Asian Pac J Cancer Prev. 17:2301–2305. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Swain SM, Whaley FS and Ewer MS: Congestive heart failure in patients treated with doxorubicin: A retrospective analysis of three trials. Cancer. 97:2869–2879. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Nachom P and Ratanasit N: Incidence and predictors of long-term adverse outcomes in patients with rheumatic mitral stenosis in sinus rhythm. J Med Assoc Thai. 99:374–380. 2016.PubMed/NCBI

28 

Singletary GE, Morris NA, Lynne O'Sullivan M, Gordon SG and Oyama MA: Prospective evaluation of NT-proBNP assay to detect occult dilated cardiomyopathy and predict survival in Doberman Pinschers. J Vet Intern Med. 26:1330–1336. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Addetia K, Michel C, Holcroft CA, Sheppard R and Rudski LG: Early improvement in serial echocardiographic studies in heart failure patients predicts long term survival-a pilot study. J Card Fail. 21:470–478. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Inoue T, Kawai M, Nakane T, Nojiri A, Minai K, Komukai K, Ogawa T, Hongo K, Matsushima M and Yoshimura M: Influence of low-grade inflammation on plasma B-type natriuretic peptide levels. Intern Med. 49:2659–2668. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Silva FB, Romero WG, Carvalho AL, Borgo MV, Amorim MH, Gouvea SA and Abreu GR: Hormone therapy with tamoxifen reduces plasma levels of NT-B-type natriuretic peptide but does not change ventricular ejection fraction after chemotherapy in women with breast cancer. Braz J Med Biol Res. 48:154–160. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Sawaya H, Sebag IA, Plana JC, Januzzi JL, Ky B, Tan TC, Cohen V, Banchs J, Carver JR, Wiegers SE, et al: Assessment of echocardiography and biomarkers for the extended prediction of cardiotoxicity in patients treated with anthracyclines, taxanes, and trastuzumab. Circ Cardiovasc Imaging. 5:596–603. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Ponde N, Bradbury I, Lambertini M, Ewer M, Campbell C, Ameels H, Zardavas D, Di Cosimo S, Baselga J, Huober J, et al: Cardiac biomarkers for early detection and prediction of trastuzumab and/or lapatinib-induced cardiotoxicity in patients with HER2-positive early-stage breast cancer: A NeoALTTO sub-study (BIG 1–06). Breast Cancer Res Treat. 168:631–638. 2018. View Article : Google Scholar : PubMed/NCBI

34 

Matos E, Jug B, Blagus R and Zakotnik B: A Prospective cohort study on cardiotoxicity of adjuvant trastuzumab therapy in breast cancer patients. Arq Bras Cardiol. 107:40–47. 2016.(In English, Portuguese). PubMed/NCBI

35 

Criscitiello C and Curigliano G: HER2 signaling pathway and trastuzumab cardiotoxicity. Future Oncol. 9:179–181. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Baldini E, Prochilo T, Salvadori B, Bolognesi A, Aldrighetti D, Venturini M, Rosso R, Carnino F, Gallo L, Giannessi P, et al: Multicenter randomized phase III trial of epirubicin plus paclitaxel vs epirubicin followed by paclitaxel in metastatic breast cancer patients: Focus on cardiac safety. Br J Cancer. 91:45–49. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Vogelsang TW, Jensen RJ, Hesse B and Kjaer A: BNP cannot replace gated equilibrium radionuclide ventriculography in monitoring of anthracycline-induced cardiotoxity. Int J Cardiol. 124:193–197. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Kittiwarawut A, Vorasettakarnkij Y, Tanasanvimon S, Manasnayakorn S and Sriuranpong V: Serum NT-proBNP in the early detection of doxorubicin-induced cardiac dysfunction. Asia Pac J Clin Oncol. 9:155–161. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Feola M, Garrone O, Occelli M, Francini A, Biggi A, Visconti G, Albrile F, Bobbio M and Merlano M: Cardiotoxicity after anthracycline chemotherapy in breast carcinoma: Effects on left ventricular ejection fraction, troponin I and brain natriuretic peptide. Int J Cardiol. 148:194–198. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Skovgaard D, Hasbak P and Kjaer A: BNP predicts chemotherapy-related cardiotoxicity and death: Comparison with gated equilibrium radionuclide ventriculography. PLoS One. 9:e967362014. View Article : Google Scholar : PubMed/NCBI

41 

Romano S, Fratini S, Ricevuto E, Procaccini V, Stifano G, Mancini M, Di Mauro M, Ficorella C and Penco M: Serial measurements of NT-proBNP are predictive of not-high-dose anthracycline cardiotoxicity in breast cancer patients. Br J Cancer. 105:1663–1668. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Zhang C, Shi D and Yang P: BNP as a potential biomarker for cardiac damage of breast cancer after radiotherapy: A meta-analysis. Medicine (Baltimore). 98:e165072019. View Article : Google Scholar : PubMed/NCBI

43 

Michel L, Rassaf T and Totzeck M: Biomarkers for the detection of apparent and subclinical cancer therapy-related cardiotoxicity. J Thorac Dis. 10 (Suppl 35):S4282–S4295. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lu X, Zhao Y, Chen C, Han C, Xue L, Xing D, Huang O and Tao M: BNP as a marker for early prediction of anthracycline‑induced cardiotoxicity in patients with breast cancer. Oncol Lett 18: 4992-5001, 2019.
APA
Lu, X., Zhao, Y., Chen, C., Han, C., Xue, L., Xing, D. ... Tao, M. (2019). BNP as a marker for early prediction of anthracycline‑induced cardiotoxicity in patients with breast cancer. Oncology Letters, 18, 4992-5001. https://doi.org/10.3892/ol.2019.10827
MLA
Lu, X., Zhao, Y., Chen, C., Han, C., Xue, L., Xing, D., Huang, O., Tao, M."BNP as a marker for early prediction of anthracycline‑induced cardiotoxicity in patients with breast cancer". Oncology Letters 18.5 (2019): 4992-5001.
Chicago
Lu, X., Zhao, Y., Chen, C., Han, C., Xue, L., Xing, D., Huang, O., Tao, M."BNP as a marker for early prediction of anthracycline‑induced cardiotoxicity in patients with breast cancer". Oncology Letters 18, no. 5 (2019): 4992-5001. https://doi.org/10.3892/ol.2019.10827
Copy and paste a formatted citation
x
Spandidos Publications style
Lu X, Zhao Y, Chen C, Han C, Xue L, Xing D, Huang O and Tao M: BNP as a marker for early prediction of anthracycline‑induced cardiotoxicity in patients with breast cancer. Oncol Lett 18: 4992-5001, 2019.
APA
Lu, X., Zhao, Y., Chen, C., Han, C., Xue, L., Xing, D. ... Tao, M. (2019). BNP as a marker for early prediction of anthracycline‑induced cardiotoxicity in patients with breast cancer. Oncology Letters, 18, 4992-5001. https://doi.org/10.3892/ol.2019.10827
MLA
Lu, X., Zhao, Y., Chen, C., Han, C., Xue, L., Xing, D., Huang, O., Tao, M."BNP as a marker for early prediction of anthracycline‑induced cardiotoxicity in patients with breast cancer". Oncology Letters 18.5 (2019): 4992-5001.
Chicago
Lu, X., Zhao, Y., Chen, C., Han, C., Xue, L., Xing, D., Huang, O., Tao, M."BNP as a marker for early prediction of anthracycline‑induced cardiotoxicity in patients with breast cancer". Oncology Letters 18, no. 5 (2019): 4992-5001. https://doi.org/10.3892/ol.2019.10827
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