Open Access

Characteristics of fecal gut microbiota in patients with colorectal cancer at different stages and different sites

  • Authors:
    • Qinsong Sheng
    • Haixia Du
    • Xiaofei Cheng
    • Xiaobin Cheng
    • Yunning Tang
    • Lelin Pan
    • Qunmin Wang
    • Jianjiang Lin
  • View Affiliations

  • Published online on: September 10, 2019     https://doi.org/10.3892/ol.2019.10841
  • Pages: 4834-4844
  • Copyright: © Sheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Numerous studies have revealed that the gut microbiota serves an important role in the pathogenesis of colorectal cancer (CRC). The present study aimed to investigate the populations present in the gut microbiota in patients with CRC of different stages and at different sites. Fecal samples were obtained from 67 CRC patients and 30 healthy controls, which were analyzed by sequencing the V3‑V4 region of the 16S rRNA gene. Increased diversity of the fecal gut microbiota in patients with CRC was reported compared with the healthy controls. In the present study, at the genus level, the relative abundances of Prevotella, Collinsella and Peptostreptococcus in the gut microbiota of CRC patients were substantially increased compared with healthy controls, while the relative abundance of Escherichia‑Shigella was significantly lower. In addition, differences in the fecal gut microbiota were also compared between patients with stage I‑IV CRC and healthy controls. The results revealed that the abundances of the genera Peptostreptococcus, Collinsella and Ruminococcus were significantly increased in patients with CRC stage I compared with the healthy controls, while Alistipes was enriched in patients with stage III CRC compared with patients with stage IV. Furthermore, the present study reported that the genera Veillonella and Coprobacter were more abundant in the proximal segments than in the distal segments of the colon. In conclusion, despite the low number of samples employed in the present study, a signature of genera indicating dysbiosis of the gut microbiota of patients with stage I‑IV CRC patients was proposed, which may provide insight into the mechanisms underlying the progression of CRC. These findings are also valuable for developing novel fecal diagnostic methods and therapeutic strategies for the treatment of CRC.
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November-2019
Volume 18 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Sheng Q, Du H, Cheng X, Cheng X, Tang Y, Pan L, Wang Q and Lin J: Characteristics of fecal gut microbiota in patients with colorectal cancer at different stages and different sites. Oncol Lett 18: 4834-4844, 2019
APA
Sheng, Q., Du, H., Cheng, X., Cheng, X., Tang, Y., Pan, L. ... Lin, J. (2019). Characteristics of fecal gut microbiota in patients with colorectal cancer at different stages and different sites. Oncology Letters, 18, 4834-4844. https://doi.org/10.3892/ol.2019.10841
MLA
Sheng, Q., Du, H., Cheng, X., Cheng, X., Tang, Y., Pan, L., Wang, Q., Lin, J."Characteristics of fecal gut microbiota in patients with colorectal cancer at different stages and different sites". Oncology Letters 18.5 (2019): 4834-4844.
Chicago
Sheng, Q., Du, H., Cheng, X., Cheng, X., Tang, Y., Pan, L., Wang, Q., Lin, J."Characteristics of fecal gut microbiota in patients with colorectal cancer at different stages and different sites". Oncology Letters 18, no. 5 (2019): 4834-4844. https://doi.org/10.3892/ol.2019.10841