Distinct expression pattern and prognostic values of pituitary tumor transforming gene family genes in non‑small cell lung cancer

Yang,Shaolong; Wang,Xiaodi; Liu,Jingxing; Ding,Bisha; Shi,Kairi; Chen,Jing; Lou,Weiyang

doi:10.3892/ol.2019.10844

Distinct expression pattern and prognostic values of pituitary tumor transforming gene family genes in non‑small cell lung cancer

Authors:
- Shaolong Yang
- Xiaodi Wang
- Jingxing Liu
- Bisha Ding
- Kairi Shi
- Jing Chen
- Weiyang Lou
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Affiliations: Department of Pathology, Zhengzhou Railway Vocational and Technical College, Zhengzhou, Henan 451460, P.R. China, Department of Emergency Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China, Department of Intensive Care Unit, Changxing People's Hospital of Zhejiang, Huzhou, Zhejiang 313100, P.R. China, Department of Surgery, Program of Innovative Cancer Therapeutics, Division of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, College of Medicine, Zhejiang University, Key Laboratory of Combined Multi‑Organ Transplantation, Ministry of Public Health, Key Laboratory of Organ Transplantation, Hangzhou, Zhejiang 310003, P.R. China, Department of Orthopedics and Traumatology, Traditional Chinese Medicine Hospital of Cixi, Ningbo, Zhejiang 315300, P.R. China, Department of Oncology, First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang 314000, P.R. China
Published online on: September 10, 2019 https://doi.org/10.3892/ol.2019.10844
Pages: 4481-4494
Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Members of the pituitary tumor transforming gene (PTTG) family, including PTTG1, PTTG2 and PTTG3P, exhibit pivotal roles in the onset and progression of certain types of human cancer. However, to the best of our knowledge, a systematic study regarding the expression pattern and the prognostic values of PTTG family genes in non‑small cell lung cancer (NSCLC) remains to be performed. The expression levels of PTTG family genes in NSCLC were successively determined using the Gene Expression Profiling Interactive Analysis, UALCAN and Oncomine databases. Subsequently, the Kaplan‑Meier plotter database was used to assess the prognostic value of the PTTG family genes in patients with NSCLC, and to determine the associations between PTTG expression levels and the prognosis of patients based on different clinicopathological features, including cancer stage, grade, chemotherapy, radiotherapy, lymph node status, smoking history, and sex. PTTG1 was identified to be significantly upregulated in NSCLC in all three databases, whereas PTTG2 and PTTG3P were significantly upregulated in NSCLC in only the UALCAN database. Patients with NSCLC with higher expression levels of the three PTTG genes demonstrated shorter overall survival times. In summary, the results of the present study suggested that increased expression of PTTG family genes may serve as promising prognostic biomarkers for patients with NSCLC.

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