Open Access

Extracellular AGR3 regulates breast cancer cells migration via Src signaling

  • Authors:
    • Joanna Obacz
    • Lucia Sommerova
    • Daria Sicari
    • Michal Durech
    • Tony Avril
    • Filippo Iuliano
    • Silvia Pastorekova
    • Roman Hrstka
    • Eric Chevet
    • Frederic Delom
    • Delphine Fessart
  • View Affiliations

  • Published online on: September 10, 2019     https://doi.org/10.3892/ol.2019.10849
  • Pages: 4449-4456
  • Copyright: © Obacz et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Human anterior gradient proteins AGR2 and AGR3 are overexpressed in a variety of adenocarcinomas and are often secreted in cancer patients' specimens, which suggests a role for AGR proteins in intra and extracellular compartments. Although these proteins exhibit high sequence homology, AGR2 is predominantly described as a pro‑oncogene and a potential prognostic biomarker. However, little is known about the function of AGR3. Therefore, the aim of the present study was to investigate the role of AGR3 in breast cancer. The results demonstrated that breast cancer cells secrete AGR3. Furthermore, it was revealed that extracellular AGR3 (eAGR3) regulates tumor cell adhesion and migration. The current study indicated that the pharmacological and genetic perturbation of Src kinase signaling, through treatment with Dasatinib (protein kinase inhibitor) or investigating cells that express a dominant‑negative form of Src, significantly abrogated eAGR3‑mediated breast cancer cell migration. Therefore, the results indicated that eAGR3 may control tumor cell migration via activation of Src kinases. The results of the present study indicated that eAGR3 may serve as a microenvironmental signaling molecule in tumor‑associated processes.
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November-2019
Volume 18 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Obacz J, Sommerova L, Sicari D, Durech M, Avril T, Iuliano F, Pastorekova S, Hrstka R, Chevet E, Delom F, Delom F, et al: Extracellular AGR3 regulates breast cancer cells migration via Src signaling. Oncol Lett 18: 4449-4456, 2019
APA
Obacz, J., Sommerova, L., Sicari, D., Durech, M., Avril, T., Iuliano, F. ... Fessart, D. (2019). Extracellular AGR3 regulates breast cancer cells migration via Src signaling. Oncology Letters, 18, 4449-4456. https://doi.org/10.3892/ol.2019.10849
MLA
Obacz, J., Sommerova, L., Sicari, D., Durech, M., Avril, T., Iuliano, F., Pastorekova, S., Hrstka, R., Chevet, E., Delom, F., Fessart, D."Extracellular AGR3 regulates breast cancer cells migration via Src signaling". Oncology Letters 18.5 (2019): 4449-4456.
Chicago
Obacz, J., Sommerova, L., Sicari, D., Durech, M., Avril, T., Iuliano, F., Pastorekova, S., Hrstka, R., Chevet, E., Delom, F., Fessart, D."Extracellular AGR3 regulates breast cancer cells migration via Src signaling". Oncology Letters 18, no. 5 (2019): 4449-4456. https://doi.org/10.3892/ol.2019.10849