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Review Open Access

Multiple roles of microRNA‑146a in immune responses and hepatocellular carcinoma (Review)

  • Authors:
    • Huihui Wang
    • Xuemei Li
    • Tao Li
    • Lianzi Wang
    • Xian Wu
    • Jiaqing Liu
    • Yuanhong Xu
    • Wei Wei
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China, Key Laboratory of Anti‑Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti‑Inflammatory and Immune Medicine, Institute of Clinical Pharmacology, Anhui Medical University, Hefei, Anhui 230032, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5033-5042
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    Published online on: September 12, 2019
       https://doi.org/10.3892/ol.2019.10862
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Abstract

MicroRNAs (miRNAs/miRs), consisting of ~22 nucleotides of single‑stranded RNA, participate in post‑transcriptional gene regulation by binding to the 3'‑untranslated region (UTR) of mRNAs, repressing their translation and promoting their degradation. Studies have shown that certain miRNAs play a key role in the control of various cellular activities, such as inhibiting inflammation, modulating cell differentiation and suppressing cancer growth. The role of miR‑146a in the immune response and in the pathogenesis of hepatocellular carcinoma (HCC) has also been investigated. Although some studies have shown that increased miR‑146a levels are associated with HCC, others have revealed that miR‑146a suppresses cancer cell proliferation, invasion and metastasis. Toll‑like receptor 4 (TLR4) signaling has an important role in regulating innate and adaptive immune responses. In addition, TLR4 is functionally expressed in HCC cells and promotes HCC cell proliferation, which can be regulated by miR‑146a. The present review focuses on the recent progress in analyzing the multiple roles of miR‑146a in mediating the TLR4 pathway and adaptive immune response. Finally, the function of miR‑146a in the pathogenesis of HCC is also discussed.
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Copy and paste a formatted citation
Spandidos Publications style
Wang H, Li X, Li T, Wang L, Wu X, Liu J, Xu Y and Wei W: Multiple roles of microRNA‑146a in immune responses and hepatocellular carcinoma (Review). Oncol Lett 18: 5033-5042, 2019.
APA
Wang, H., Li, X., Li, T., Wang, L., Wu, X., Liu, J. ... Wei, W. (2019). Multiple roles of microRNA‑146a in immune responses and hepatocellular carcinoma (Review). Oncology Letters, 18, 5033-5042. https://doi.org/10.3892/ol.2019.10862
MLA
Wang, H., Li, X., Li, T., Wang, L., Wu, X., Liu, J., Xu, Y., Wei, W."Multiple roles of microRNA‑146a in immune responses and hepatocellular carcinoma (Review)". Oncology Letters 18.5 (2019): 5033-5042.
Chicago
Wang, H., Li, X., Li, T., Wang, L., Wu, X., Liu, J., Xu, Y., Wei, W."Multiple roles of microRNA‑146a in immune responses and hepatocellular carcinoma (Review)". Oncology Letters 18, no. 5 (2019): 5033-5042. https://doi.org/10.3892/ol.2019.10862
Copy and paste a formatted citation
x
Spandidos Publications style
Wang H, Li X, Li T, Wang L, Wu X, Liu J, Xu Y and Wei W: Multiple roles of microRNA‑146a in immune responses and hepatocellular carcinoma (Review). Oncol Lett 18: 5033-5042, 2019.
APA
Wang, H., Li, X., Li, T., Wang, L., Wu, X., Liu, J. ... Wei, W. (2019). Multiple roles of microRNA‑146a in immune responses and hepatocellular carcinoma (Review). Oncology Letters, 18, 5033-5042. https://doi.org/10.3892/ol.2019.10862
MLA
Wang, H., Li, X., Li, T., Wang, L., Wu, X., Liu, J., Xu, Y., Wei, W."Multiple roles of microRNA‑146a in immune responses and hepatocellular carcinoma (Review)". Oncology Letters 18.5 (2019): 5033-5042.
Chicago
Wang, H., Li, X., Li, T., Wang, L., Wu, X., Liu, J., Xu, Y., Wei, W."Multiple roles of microRNA‑146a in immune responses and hepatocellular carcinoma (Review)". Oncology Letters 18, no. 5 (2019): 5033-5042. https://doi.org/10.3892/ol.2019.10862
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