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Distinct expression and prognostic value of OTU domain‑containing proteins in non‑small‑cell lung cancer

  • Authors:
    • Jingjing Deng
    • Gouxin Hou
    • Zhixian Fang
    • Jialiang Liu
    • Xiao‑Dong Lv
  • View Affiliations / Copyright

    Affiliations: Department of Respiration, Key Medical Discipline of Jiaxing, Jiaxing Lung Cancer Innovation Team, The First Hospital of Jiaxing, The First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang 314000, P.R. China, Department of Oncology, The First Hospital of Jiaxing, The First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang 314000, P.R. China
    Copyright: © Deng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5417-5427
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    Published online on: September 19, 2019
       https://doi.org/10.3892/ol.2019.10883
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Abstract

The ubiquitin‑proteasome pathway is an important protein degradation regulatory system in cells. This pathway is also a reversible process that is strictly regulated, and the regulation of deubiquitinating enzymes (DUBs) represents an important facet of the process. Ovarian tumor‑associated proteases domain‑containing proteins (OTUDs), as a subfamily within the DUB family, serve an important role in regulatory mechanisms of several biological processes, through the regulation of gene transcription, cell cycle, immune response, inflammation and tumor growth processes, and may be important in the diagnosis of various diseases and constitute novel drug targets. However, the role of OTUDs in non‑small‑cell lung cancer (NSCLC) has not been fully elucidated. In the present study, the Oncomine database was used to examine gene expression in NSCLC, and the prognostic value of each gene was analyzed by Kaplan‑Meier analysis. The results indicated that high mRNA expression levels of OTUD1, OTUD3, OTUD4 and putative bifunctional UDP‑N‑acetylglucosamine transferase and deubiquitinase ALG13 were associated with improved prognosis in all NSCLC and adenocarcinoma, but not in squamous cell carcinoma. By contrast, high expression levels of OTUD2 mRNA were associated with poorer overall survival in patients with NSCLC. These data suggested that these OTUD isozymes may be a potential drug target for NSCLC.
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1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2018. CA Cancer J Clin. 68:7–30. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Torre L, Bray F, Siegel R, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Goldstraw P, Ball D, Jett J, Le Chevalier T, Lim E, Nicholson AG and Shepherd FA: Non-small-cell lung cancer. Lancet. 378:1727–1740. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Ramalingam S, Owonikoko T and Khuri F: Lung cancer: New biological insights and recent therapeutic advances. CA Cancer J Clin. 61:91–112. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Chaffer C and Weinberg R: A perspective on cancer cell metastasis. Science. 331:1559–1564. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Ramalingam S and Belani C: Systemic chemotherapy for advanced non-small cell lung cancer: Recent advances and future directions. Oncologist. 13 (Suppl 1):S5–S13. 2008. View Article : Google Scholar

7 

Detterbeck F, Boffa D and Tanoue L: The new lung cancer staging system. Chest. 136:260–271. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Lothrop AP, Torres MP and Fuchs SM: Deciphering post-translational modification codes. FEBS Lett. 587:1247–1257. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Husnjak K and Dikic I: Ubiquitin-binding proteins: Decoders of ubiquitin-mediated cellular functions. Annu Rev Biochem. 81:291–322. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Komander D, Clague M and Urbé S: Breaking the chains: Structure and function of the deubiquitinases. Nat Rev Mol Cell Biol. 10:550–563. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Clague M, Barsukov I, Coulson J, Liu H, Rigden D and Urbé S: Deubiquitylases from genes to organism. Physiol Rev. 93:1289–1315. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Swatek KN and Komander D: Ubiquitin modifications. Cell Res. 26:399–422. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Chen ZJ and Sun LJ: Nonproteolytic functions of ubiquitin in cell signaling. Molecular cell. 33:275–286. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Sippl W, Collura V and Colland F: Ubiquitin-specific proteases as cancer drug targets. Future Oncol. 7:619–632. 2011. View Article : Google Scholar : PubMed/NCBI

15 

McClurg UL and Robson CN: Deubiquitinating enzymes as oncotargets. Oncotarget. 6:9657–9668. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Kee Y and Huang TT: Role of Deubiquitinating enzymes in DNA repair. Mol Cell Biol. 36:524–544. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Clague MJ, Coulson JM and Urbé S: Cellular functions of the DUBs. J Cell Sci. 125:277–286. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Yang JM: Emerging roles of deubiquitinating enzymes in human cancer. Acta Pharmacol Sin. 28:1325–1330. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Schwickart M, Huang X, Lill JR, Liu J, Ferrando R, French DM, Maecker H, O'Rourke K, Bazan F, Eastham-Anderson J, et al: Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Nature. 463:103–107. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Priolo C, Tang D, Brahamandan M, Benassi B, Sicinska E, Ogino S, Farsetti A, Porrello A, Finn S, Zimmermann J, et al: The isopeptidase USP2a protects human prostate cancer from apoptosis. Cancer Res. 66:8625–8632. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Popov N, Wanzel M, Madiredjo M, Zhang D, Beijersbergen R, Bernards R, Moll R, Elledge SJ and Eilers M: The ubiquitin-specific protease USP28 is required for MYC stability. Nat Cell Biol. 9:765–774. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Coyne ES and Wing SS: The business of deubiquitination-location, location, location. F1000Res. 5:F1000 Faculty Rev-163. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Mevissen TE, Hospenthal MK, Geurink PP, Elliott PR, Akutsu M, Arnaudo N, Ekkebus R, Kulathu Y, Wauer T, El Oualid F, et al: OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. Cell. 154:169–184. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Carneiro AP, Reis CF, Morari EC, Maia YC, Nascimento R, Bonatto JM, de Souza MA, Goulart LR and Ward LS: A putative OTU domain-containing protein 1 deubiquitinating enzyme is differentially expressed in thyroid cancer and identifies less-aggressive tumours. Br J Cancer. 111:551–558. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Zhang Z, Fan Y, Xie F, Zhou H, Jin K, Shao L, Shi W, Fang P, Yang B, van Dam H, et al: Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7. Nat Commun. 8:21162017. View Article : Google Scholar : PubMed/NCBI

26 

Piao S, Pei HZ, Huang B and Baek SH: Ovarian tumor domain-containing protein 1 deubiquitinates and stabilizes p53. Cell Signal. 33:22–29. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Yuan L, Lv Y, Li H, Gao H, Song S, Zhang Y, Xing G, Kong X, Wang L, Li Y, et al: Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis. Nat Cell Biol. 17:1169–1181. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Zhao Y, Majid MC, Soll JM, Brickner JR, Dango S and Mosammaparast N: Noncanonical regulation of alkylation damage resistance by the OTUD4 deubiquitinase. EMBO J. 34:1687–1703. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Luo J, Lu Z, Lu X, Chen L, Cao J, Zhang S, Ling Y and Zhou X: OTUD5 regulates p53 stability by deubiquitinating p53. PLoS One. 8:e776822013. View Article : Google Scholar : PubMed/NCBI

30 

Sobol A, Askonas C, Alani S, Weber MJ, Ananthanarayanan V, Osipo C and Bocchetta M: Deubiquitinase OTUD6B isoforms are important regulators of growth and proliferation. Mol Cancer Res. 15:117–127. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Rhodes D, Yu J, Shanker K, Deshpande N, Varambally R, Ghosh D, Barrette T, Pandey A and Chinnaiyan AM: ONCOMINE: A cancer microarray database and integrated data-mining platform. Neoplasia. 6:1–6. 2004. View Article : Google Scholar : PubMed/NCBI

32 

Rhodes D, Kalyana-Sundaram S, Mahavisno V, Varambally R, Yu J, Briggs BB, Barrette TR, Anstet MJ, Kincead-Beal C, Kulkarni P, et al: Oncomine 3.0: Genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles. Neoplasia. 9:166–180. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Györffy B, Lanczky A, Eklund AC, Denkert C, Budczies J, Li Q and Szallasi Z: An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients. Breast Cancer Res Treat. 123:725–731. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Győrffy B, Surowiak P, Budczies J and Lánczky A: Online survival analysis software to assess the prognostic value of biomarkers using transcriptomic data in non-small-cell lung cancer. PLoS One. 8:e822412013. View Article : Google Scholar : PubMed/NCBI

35 

Ivanova L, Zandberga E, Siliņa K, Kalniņa Z, Ābols A, Endzeliņš E, Vendina I, Romanchikova N, Hegmane A, Trapencieris P, et al: Prognostic relevance of carbonic anhydrase IX expression is distinct in various subtypes of breast cancer and its silencing suppresses self-renewal capacity of breast cancer cells. Cancer Chemother Pharmacol. 75:235–246. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Wertz IE, Newton K, Seshasayee D¸, Kusam S, Lam C, Zhang J, Popovych N, Helgason E, Schoeffler A, Jeet S, et al: Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Nature. 528:370–375. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Xu Z, Zheng Y, Zhu Y, Kong X and Hu L: Evidence for OTUD-6B participation in B lymphocytes cell cycle after cytokine stimulation. PLoS One. 6:e145142011. View Article : Google Scholar : PubMed/NCBI

38 

Ettinger DS, Wood DE, Aisner DL, Akerley W, Bauman J, Chirieac LR, D'Amico TA, DeCamp MM, Dilling TJ, Dobelbower M, et al: Non-small cell lung cancer, version 5.2017, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 15:504–535. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Hou J, Aerts J, den Hamer B, van Ijcken W, den Bakker M, Riegman P, van der Leest C, van der Spek P, Foekens JA, Hoogsteden HC, et al: Gene expression-based classification of non-small cell lung carcinomas and survival prediction. PLoS One. 5:e103122010. View Article : Google Scholar : PubMed/NCBI

40 

Garber ME, Troyanskaya OG, Schluens K, Petersen S, Thaesler Z, Pacyna-Gengelbach M, van de Rijn M, Rosen GD, Perou CM, Whyte RI, et al: Diversity of gene expression in adenocarcinoma of the lung. Proc Natl Acad Sci USA. 98:13784–13789. 2001. View Article : Google Scholar : PubMed/NCBI

41 

Yamagata N, Shyr Y, Yanagisawa K, Edgerton M, Dang TP, Gonzalez A, Nadaf S, Larsen P, Roberts JR, Nesbitt JC, et al: A training-testing approach to the molecular classification of resected non-small cell lung cancer. Clin Cancer Res. 9:4695–4704. 2003.PubMed/NCBI

42 

Selamat SA, Chung BS, Girard L, Zhang W, Zhang Y, Campan M, Siegmund KD, Koss MN, Hagen JA, Lam WL, et al: Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression. Genome Res. 22:1197–1211. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Makarova KS, Aravind L and Koonin EV: A novel superfamily of predicted cysteine proteases from eukaryotes, viruses and Chlamydia pneumoniae. Trends Biochem Sci. 25:50–52. 2000. View Article : Google Scholar : PubMed/NCBI

44 

Cancer Genome Atlas Research Network, . Comprehensive molecular characterization of urothelial bladder carcinoma. Nature. 507:315–322. 2014. View Article : Google Scholar : PubMed/NCBI

45 

Flierman D, van der Heden van Noort GJ, Ekkebus R, Geurink PP, Mevissen TE, Hospenthal MK, Komander D and Ovaa H: Non-hydrolyzable diubiquitin probes reveal linkage-specific reactivity of deubiquitylating enzymes mediated by S2 pockets. Cell Chem Biol. 23:472–482. 2016. View Article : Google Scholar : PubMed/NCBI

46 

Rumpf S and Jentsch S: Functional division of substrate processing cofactors of the ubiquitin-selective Cdc48 chaperone. Mol Cell. 21:261–269. 2006. View Article : Google Scholar : PubMed/NCBI

47 

Li X, Wang S, Zhu R, Li H, Han Q and Zhao RC: Lung tumor exosomes induce a pro-inflammatory phenotype in mesenchymal stem cells via NFκB-TLR signaling pathway. J Hematol Oncol. 9:422016. View Article : Google Scholar : PubMed/NCBI

48 

Lu Z, Li Y, Wang J, Che Y, Sun S, Huang J, Chen Z and He J: Long non-coding RNA NKILA inhibits migration and invasion of non-small cell lung cancer via NF-κB/Snail pathway. J Exp Clin Cancer Res. 36:542017. View Article : Google Scholar : PubMed/NCBI

49 

Richardson JSM, Aminudin N and Abd Malek SN: Chalepin: A compound from Ruta angustifolia L. pers exhibits cell cycle arrest at S phase, suppresses nuclear factor-kappa B (NF-κB) pathway, signal transducer and activation of transcription 3 (STAT3) phosphorylation and extrinsic apoptotic pathway in non-small cell lung cancer carcinoma (A549). Pharmacogn Mag. 13 (Suppl 3):S489–S498. 2017. View Article : Google Scholar : PubMed/NCBI

50 

Tang X, Sun L, Wang G, Chen B and Luo F: RUNX1: A regulator of NF-kB signaling in pulmonary diseases. Curr Protein Pept Sci. 19:172–178. 2018.PubMed/NCBI

51 

Dhara A and Sinai AP: A cell cycle-regulated toxoplasma deubiquitinase, TgOTUD3A, targets polyubiquitins with specific lysine linkages. mSphere. 1:e00085–16. 2016. View Article : Google Scholar : PubMed/NCBI

52 

Behnke MS, Wootton JC, Lehmann MM, Radke JB, Lucas O, Nawas J, Sibley LD and White MW: Coordinated progression through two subtranscriptomes underlies the tachyzoite cycle of Toxoplasma gondii. PLoS One. 5:e123542010. View Article : Google Scholar : PubMed/NCBI

53 

Huang OW, Ma X, Yin J, Flinders J, Maurer T, Kayagaki N, Phung Q, Bosanac I, Arnott D, Dixit VM, et al: Phosphorylation-dependent activity of the deubiquitinase DUBA. Nat Struct Mol Biol. 19:171–175. 2012. View Article : Google Scholar : PubMed/NCBI

54 

Kayagaki N, Phung Q, Chan S, Chaudhari R, Quan C, O'Rourke KM, Eby M, Pietras E, Cheng G, Bazan JF, et al: DUBA: A deubiquitinase that regulates type I interferon production. Science. 318:1628–1632. 2007. View Article : Google Scholar : PubMed/NCBI

55 

Santiago-Sim T, Burrage LC, Ebstein F, Tokita MJ, Miller M, Bi W, Braxton AA, Rosenfeld JA, Shahrour M, Lehmann A, et al: Biallelic variants in OTUD6B cause an intellectual disability syndrome associated with seizures and dysmorphic features. Am J Hum Genet. 100:676–688. 2017. View Article : Google Scholar : PubMed/NCBI

56 

Wang X, Weldeghiorghis T, Zhang G, Imperiali B and Prestegard JH: Solution structure of Alg13: The sugar donor subunit of a yeast N-acetylglucosamine transferase. Structure. 16:965–975. 2008. View Article : Google Scholar : PubMed/NCBI

57 

De Antonellis P, Carotenuto M, Vandenbussche J, De Vita G, Ferrucci V, Medaglia C, Boffa I, Galiero A, Di Somma S, Magliulo D, et al: Early targets of miR-34a in neuroblastoma. Mol Cell Proteomics. 13:2114–2131. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Deng J, Hou G, Fang Z, Liu J and Lv XD: Distinct expression and prognostic value of OTU domain‑containing proteins in non‑small‑cell lung cancer. Oncol Lett 18: 5417-5427, 2019.
APA
Deng, J., Hou, G., Fang, Z., Liu, J., & Lv, X. (2019). Distinct expression and prognostic value of OTU domain‑containing proteins in non‑small‑cell lung cancer. Oncology Letters, 18, 5417-5427. https://doi.org/10.3892/ol.2019.10883
MLA
Deng, J., Hou, G., Fang, Z., Liu, J., Lv, X."Distinct expression and prognostic value of OTU domain‑containing proteins in non‑small‑cell lung cancer". Oncology Letters 18.5 (2019): 5417-5427.
Chicago
Deng, J., Hou, G., Fang, Z., Liu, J., Lv, X."Distinct expression and prognostic value of OTU domain‑containing proteins in non‑small‑cell lung cancer". Oncology Letters 18, no. 5 (2019): 5417-5427. https://doi.org/10.3892/ol.2019.10883
Copy and paste a formatted citation
x
Spandidos Publications style
Deng J, Hou G, Fang Z, Liu J and Lv XD: Distinct expression and prognostic value of OTU domain‑containing proteins in non‑small‑cell lung cancer. Oncol Lett 18: 5417-5427, 2019.
APA
Deng, J., Hou, G., Fang, Z., Liu, J., & Lv, X. (2019). Distinct expression and prognostic value of OTU domain‑containing proteins in non‑small‑cell lung cancer. Oncology Letters, 18, 5417-5427. https://doi.org/10.3892/ol.2019.10883
MLA
Deng, J., Hou, G., Fang, Z., Liu, J., Lv, X."Distinct expression and prognostic value of OTU domain‑containing proteins in non‑small‑cell lung cancer". Oncology Letters 18.5 (2019): 5417-5427.
Chicago
Deng, J., Hou, G., Fang, Z., Liu, J., Lv, X."Distinct expression and prognostic value of OTU domain‑containing proteins in non‑small‑cell lung cancer". Oncology Letters 18, no. 5 (2019): 5417-5427. https://doi.org/10.3892/ol.2019.10883
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