Distinct expression and prognostic value of OTU domain‑containing proteins in non‑small‑cell lung cancer

Deng,Jingjing; Hou,Gouxin; Fang,Zhixian; Liu,Jialiang; Lv,Xiao‑Dong

doi:10.3892/ol.2019.10883

Distinct expression and prognostic value of OTU domain‑containing proteins in non‑small‑cell lung cancer

Authors:
- Jingjing Deng
- Gouxin Hou
- Zhixian Fang
- Jialiang Liu
- Xiao‑Dong Lv
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Affiliations: Department of Respiration, Key Medical Discipline of Jiaxing, Jiaxing Lung Cancer Innovation Team, The First Hospital of Jiaxing, The First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang 314000, P.R. China, Department of Oncology, The First Hospital of Jiaxing, The First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang 314000, P.R. China
Published online on: September 19, 2019 https://doi.org/10.3892/ol.2019.10883
Pages: 5417-5427
Copyright: © Deng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The ubiquitin‑proteasome pathway is an important protein degradation regulatory system in cells. This pathway is also a reversible process that is strictly regulated, and the regulation of deubiquitinating enzymes (DUBs) represents an important facet of the process. Ovarian tumor‑associated proteases domain‑containing proteins (OTUDs), as a subfamily within the DUB family, serve an important role in regulatory mechanisms of several biological processes, through the regulation of gene transcription, cell cycle, immune response, inflammation and tumor growth processes, and may be important in the diagnosis of various diseases and constitute novel drug targets. However, the role of OTUDs in non‑small‑cell lung cancer (NSCLC) has not been fully elucidated. In the present study, the Oncomine database was used to examine gene expression in NSCLC, and the prognostic value of each gene was analyzed by Kaplan‑Meier analysis. The results indicated that high mRNA expression levels of OTUD1, OTUD3, OTUD4 and putative bifunctional UDP‑N‑acetylglucosamine transferase and deubiquitinase ALG13 were associated with improved prognosis in all NSCLC and adenocarcinoma, but not in squamous cell carcinoma. By contrast, high expression levels of OTUD2 mRNA were associated with poorer overall survival in patients with NSCLC. These data suggested that these OTUD isozymes may be a potential drug target for NSCLC.

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