Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
November-2019 Volume 18 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2019 Volume 18 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

The combined use of EphA2/MMP‑2 expression and MRI findings contributes to the determination of cerebral glioma grade

  • Authors:
    • Fangfang Suo
    • Binfeng Zhong
    • Fangfang Lu
    • Zhihui Dong
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Luoyang Central Hospital, Luoyang, Henan 471000, P.R. China, Department of Neurosurgery, Luoyang Central Hospital, Luoyang, Henan 471000, P.R. China
  • Pages: 5607-5613
    |
    Published online on: September 24, 2019
       https://doi.org/10.3892/ol.2019.10912
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Glioma is the most aggressive brain tumor and is associated with a high mortality rate. The aim of the present study was to explore the association between matrix metalloproteinase 2 (MMP‑2) and ephrin type‑A receptor 2 (EphA2) expression in glioma cells, and to investigate the contribution of magnetic resonance imaging (MRI) in glioma classification. A total of 43 patients with pathologically confirmed glioma were divided into two groups as follows: Low‑grade (grades I and II; n=21) and high‑grade (grades IV and IV; n=22). Subsequently, immunohistochemistry staining was performed to detect the expression levels of MMP‑2 and EphA2 in the low‑ and high‑grade groups. MRI routine and enhanced scans were used to measure the peritumoral edema index (EI), tumor enhancement percentage (EP) and maximum tumor diameter. The results demonstrated that the proportion of MMP‑2‑positive patients in the high‑grade group was 86.36% (19/22), which was significantly higher than that of the low‑grade group (57.14%; 12/21) (P<0.05). Furthermore, the proportion of EphA2‑positive patients in the high‑grade group was 90.91% (20/22), significantly higher than that in the low‑grade group (4.76%; 1/21) (P<0.01). In addition, the MRI results indicated that the EI, EP and maximum tumor diameter were significantly higher in the high‑grade group compared with the low‑grade group (P<0.01, P<0.01 and P<0.05, respectively). Finally, the expression levels of MMP‑2 and EphA2 were significantly associated with the EI, EP and maximum tumor diameter (all P<0.05). In conclusion, the expression levels of MMP‑2 and EphA2 were positively correlated with glioma invasion. The correlation between these expression levels and MRI assessment of the EI, EP and maximum tumor diameter indicated that the combination of these two methods may be used for the evaluation of the tumor grade and for further clinical treatment applications.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Appin CL and Brat DJ: Molecular genetics of gliomas. Cancer J. 20:66–72. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Goodenberger ML and Jenkins RB: Genetics of adult glioma. Cancer Genet. 205:613–621. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Ostrom QT, Gittleman H, Farah P, Ondracek A, Chen Y, Wolinsky Y, Stroup NE, Kruchko C and Barnholtz-Sloan JS: CBTRUS statistical report: Primary brain and central nervous system tumors diagnosed in the United States in 2006–2010. Neuro Oncol. 15 (Suppl 2):ii1–ii56. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P and Ellison DW: The 2016 world health organization classification of tumors of the central nervous system: A summary. Acta Neuropathol. 131:803–820. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Wu W, Lamborn KR, Buckner JC, Novotny PJ, Chang SM, O'Fallon JR, Jaeckle KA and Prados MD: Joint NCCTG and NABTC prognostic factors analysis for high-grade recurrent glioma. Neuro Oncol. 12:164–172. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Bauvois B: New facets of matrix metalloproteinases MMP-2 and MMP-9 as cell surface transducers: Outside-in signaling and relationship to tumor progression. Biochim Biophys Acta. 1825:29–36. 2012.PubMed/NCBI

7 

Yadav L, Puri N, Rastogi V, Satpute P, Ahmad R and Kaur G: Matrix metalloproteinases and cancer-roles in threat and therapy. Asian Pac J Cancer Prev. 15:1085–1091. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Fingleton B: Matrix metalloproteinases: Roles in cancer and metastasis. Front Biosci. 11:479–491. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Martin MD and Matrisian LM: The other side of MMPs: Protective roles in tumor progression. Cancer Metast Rev. 26:717–724. 2007. View Article : Google Scholar

10 

Egeblad M and Werb Z: New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer. 2:161–174. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Cho HJ, Park JH, Nam JH, Chang YC, Park B and Hoe HS: Ascochlorin Suppresses MMP-2-Mediated Migration and Invasion by targeting FAK and JAK-STAT signaling cascades. J Cell Biochem. 119:300–313. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Farina P, Tabouret E, Lehmann P, Barrie M, Petrirena G, Campello C, Boucard C, Graillon T, Girard N and Chinot O: Relationship between magnetic resonance imaging characteristics and plasmatic levels of MMP2 and MMP9 in patients with recurrent high-grade gliomas treated by Bevacizumab and Irinotecan. J Neurooncol. 132:433–437. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Ou Y, Wu Q, Wu C, Liu X, Song Y and Zhan Q: Migfilin promotes migration and invasion in glioma by driving EGFR and MMP-2 signalings: A positive feedback loop regulation. J Genet Genomics. 44:557–565. 2017. View Article : Google Scholar : PubMed/NCBI

14 

van der Geer P, Hunter T and Lindberg RA: Receptor protein-tyrosine kinases and their signal transduction pathways. Annu Rev Cell Biol. 10:251–337. 1994. View Article : Google Scholar : PubMed/NCBI

15 

Miao H and Wang B: Eph/ephrin signaling in epithelial development and homeostasis. Int J Biochem Cell Biol. 41:762–770. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Kullander K and Klein R: Mechanisms and functions of Eph and ephrin signalling. Nat Rev Mol Cell Biol. 3:475–486. 2002. View Article : Google Scholar : PubMed/NCBI

17 

Nakamoto M and Bergemann AD: Diverse roles for the Eph family of receptor tyrosine kinases in carcinogenesis. Microsc Res Tech. 59:58–67. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Pasquale EB: Eph-ephrin bidirectional signaling in physiology and disease. Cell. 133:38–52. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Miao H, Li DQ, Mukherjee A, Guo H, Petty A, Cutter J, Basilion JP, Sedor J, Wu J, Danielpour D, et al: EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt. Cancer Cell. 16:9–20. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Ireton RC and Chen J: EphA2 receptor tyrosine kinase as a promising target for cancer therapeutics. Curr Cancer Drug Targets. 5:149–157. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Zeng G, Hu Z, Kinch MS, Pan CX, Flockhart DA, Kao C, Gardner TA, Zhang S, Li L, Baldridge LA, et al: High-level expression of EphA2 receptor tyrosine kinase in prostatic intraepithelial neoplasia. Am J Pathol. 163:2271–2276. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Miao H, Gale NW, Guo H, Qian J, Petty A, Kaspar J, Murphy AJ, Valenzuela DM, Yancopoulos G, Hambardzumyan D, et al: EphA2 promotes infiltrative invasion of glioma stem cells in vivo through cross-talk with Akt and regulates stem cell properties. Oncogene. 34:558–567. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Cheng N, Brantley DM, Liu H, Lin Q, Enriquez M, Gale N, Yancopoulos G, Cerretti DP, Daniel TO and Chen J: Blockade of EphA receptor tyrosine kinase activation inhibits vascular endothelial cell growth factor-induced angiogenesis. Mol Cancer Res. 1:2–11. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Ogawa K, Pasqualini R, Lindberg RA, Kain R, Freeman AL and Pasquale EB: The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization. Oncogene. 19:6043–6052. 2000. View Article : Google Scholar : PubMed/NCBI

25 

Khurshid SJ and Hussain AM: Nuclear magnetic resonance imaging (MRI). J Pak Med Assoc. 41:259–264. 1991.PubMed/NCBI

26 

Cavezian R, Cabanis EA, Pasquet G, Iba-Zizen MT, Le Bihan D, Tamraz J and Roger B: Magnetic resonance imaging. Physical principles, current biomedical applications, maxillofacial perspectives. Actual Odontostomatol (Paris). 40:219–232. 1986.(In French). PubMed/NCBI

27 

Guy RL, Benn JJ, Ayers AB, Bingham JB, Lowy C, Cox TC and Sonksen PH: A comparison of CT and MRI in the assessment of the pituitary and parasellar region. Clin Radiol. 43:156–161. 1991. View Article : Google Scholar : PubMed/NCBI

28 

Qi S, Yu L, Li H, Ou Y, Qiu X, Ding Y, Han H and Zhang X: Isocitrate dehydrogenase mutation is associated with tumor location and magnetic resonance imaging characteristics in astrocytic neoplasms. Oncol Lett. 7:1895–1902. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Puttick S, Bell C, Dowson N, Rose S and Fay M: PET, MRI, and simultaneous PET/MRI in the development of diagnostic and therapeutic strategies for glioma. Drug Discov Today. 20:306–317. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Crooks V, Waller S, Smith T and Hahn TJ: The use of the karnofsky performance scale in determining outcomes and risk in geriatric outpatients. J Gerontol. 46:M139–M144. 1991. View Article : Google Scholar : PubMed/NCBI

31 

de Haan R, Aaronson N, Limburg M, Hewer RL and Van Crevel H: Measuring quality of life in stroke. Stroke. 24:320–327. 1993. View Article : Google Scholar : PubMed/NCBI

32 

Okada A: Roles of matrix metalloproteinases and tissue inhibitor of metalloproteinase (TIMP) in cancer invasion and metastasis. Gan To Kagaku Ryoho. 26:2247–2252. 1999.(In Japanese). PubMed/NCBI

33 

Itoh T, Tanioka M, Yoshida H, Yoshioka T, Nishimoto H and Itohara S: Reduced angiogenesis and tumor progression in gelatinase A-deficient mice. Cancer Res. 58:1048–1051. 1998.PubMed/NCBI

34 

Rao JS: Molecular mechanisms of glioma invasiveness: The role of proteases. Nat Rev Cancer. 3:489–501. 2003. View Article : Google Scholar : PubMed/NCBI

35 

Yue X, Lan F, Yang W, Yang Y, Han L, Zhang A, Liu J, Zeng H, Jiang T, Pu P and Kang C: Interruption of β-catenin suppresses the EGFR pathway by blocking multiple oncogenic targets in human glioma cells. Brain Res. 1366:27–37. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Chicoine MR and Silbergeld DL: The in vitro motility of human gliomas increases with increasing grade of malignancy. Cancer. 75:2904–2909. 1995. View Article : Google Scholar : PubMed/NCBI

37 

Wykosky J, Gibo DM, Stanton C and Debinski W: EphA2 as a novel molecular marker and target in glioblastoma multiforme. Mol Cancer Res. 3:541–551. 2005. View Article : Google Scholar : PubMed/NCBI

38 

Langer A: A systematic review of PET and PET/CT in oncology: A way to personalize cancer treatment in a cost-effective manner? BMC Health Serv Res. 10:2832010. View Article : Google Scholar : PubMed/NCBI

39 

Ross R: Advances in the application of imaging methods in applied and clinical physiology. Acta Diabetol. 40 (Suppl 1):S45–S50. 2003. View Article : Google Scholar : PubMed/NCBI

40 

Caravan P, Ellison JJ, McMurry TJ and Lauffer RB: Gadolinium(III) chelates as MRI contrast agents: Structure, dynamics, and applications. Chem Rev. 99:2293–2352. 1999. View Article : Google Scholar : PubMed/NCBI

41 

Zhou Z and Lu ZR: Gadolinium-based contrast agents for magnetic resonance cancer imaging. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 5:1–18. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Ye F, Liu J and Ouyang H: Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging and multidetector-row computed tomography for the diagnosis of hepatocellular carcinoma: A systematic review and meta-analysis. Medicine (Baltimore). 94:e11572015. View Article : Google Scholar : PubMed/NCBI

43 

Ying SH, Teng XD, Wang ZM, Wang QD, Zhao YL, Chen F and Xiao WB: Gd-EOB-DTPA-enhanced magnetic resonance imaging for bile duct intraductal papillary mucinous neoplasms. World J Gastroenterol. 21:7824–7833. 2015. View Article : Google Scholar : PubMed/NCBI

44 

Chung C, Metser U and Menard C: Advances in magnetic resonance imaging and positron emission tomography imaging for grading and molecular characterization of glioma. Semin Radiat Oncol. 25:164–171. 2015. View Article : Google Scholar : PubMed/NCBI

45 

Zuo N, Cheng J and Jiang T: Diffusion magnetic resonance imaging for Brainnetome: A critical review. Neurosci Bull. 28:375–388. 2012. View Article : Google Scholar : PubMed/NCBI

46 

Jahng GH, Li KL, Ostergaard L and Calamante F: Perfusion magnetic resonance imaging: A comprehensive update on principles and techniques. Korean J Radiol. 15:554–577. 2014. View Article : Google Scholar : PubMed/NCBI

47 

Ledezma CJ, Chen W, Sai V, Freitas B, Cloughesy T, Czernin J and Pope W: 18F-FDOPA PET/MRI fusion in patients with primary/recurrent gliomas: Initial experience. Eur J Radiol. 71:242–248. 2009. View Article : Google Scholar : PubMed/NCBI

48 

Chen W and Silverman DH: Advances in evaluation of primary brain tumors. Semin Nucl Med. 38:240–250. 2008. View Article : Google Scholar : PubMed/NCBI

49 

Costello JF: DNA methylation in brain development and gliomagenesis. Front Biosci. 8 (Suppl):S175–S184. 2003. View Article : Google Scholar : PubMed/NCBI

50 

Carlson MR, Pope WB, Horvath S, Braunstein JG, Nghiemphu P, Tso CL, Mellinghoff I, Lai A, Liau LM, Mischel PS, et al: Relationship between survival and edema in malignant gliomas: Role of vascular endothelial growth factor and neuronal pentraxin 2. Clin Cancer Res. 13:2592–2598. 2007. View Article : Google Scholar : PubMed/NCBI

51 

Pope WB, Sayre J, Perlina A, Villablanca JP, Mischel PS and Cloughesy TF: MR imaging correlates of survival in patients with high-grade gliomas. AJNR Am J Neuroradiol. 26:2466–2474. 2005.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Suo F, Zhong B, Lu F and Dong Z: The combined use of EphA2/MMP‑2 expression and MRI findings contributes to the determination of cerebral glioma grade. Oncol Lett 18: 5607-5613, 2019.
APA
Suo, F., Zhong, B., Lu, F., & Dong, Z. (2019). The combined use of EphA2/MMP‑2 expression and MRI findings contributes to the determination of cerebral glioma grade. Oncology Letters, 18, 5607-5613. https://doi.org/10.3892/ol.2019.10912
MLA
Suo, F., Zhong, B., Lu, F., Dong, Z."The combined use of EphA2/MMP‑2 expression and MRI findings contributes to the determination of cerebral glioma grade". Oncology Letters 18.5 (2019): 5607-5613.
Chicago
Suo, F., Zhong, B., Lu, F., Dong, Z."The combined use of EphA2/MMP‑2 expression and MRI findings contributes to the determination of cerebral glioma grade". Oncology Letters 18, no. 5 (2019): 5607-5613. https://doi.org/10.3892/ol.2019.10912
Copy and paste a formatted citation
x
Spandidos Publications style
Suo F, Zhong B, Lu F and Dong Z: The combined use of EphA2/MMP‑2 expression and MRI findings contributes to the determination of cerebral glioma grade. Oncol Lett 18: 5607-5613, 2019.
APA
Suo, F., Zhong, B., Lu, F., & Dong, Z. (2019). The combined use of EphA2/MMP‑2 expression and MRI findings contributes to the determination of cerebral glioma grade. Oncology Letters, 18, 5607-5613. https://doi.org/10.3892/ol.2019.10912
MLA
Suo, F., Zhong, B., Lu, F., Dong, Z."The combined use of EphA2/MMP‑2 expression and MRI findings contributes to the determination of cerebral glioma grade". Oncology Letters 18.5 (2019): 5607-5613.
Chicago
Suo, F., Zhong, B., Lu, F., Dong, Z."The combined use of EphA2/MMP‑2 expression and MRI findings contributes to the determination of cerebral glioma grade". Oncology Letters 18, no. 5 (2019): 5607-5613. https://doi.org/10.3892/ol.2019.10912
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team