Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
January-2020 Volume 19 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2020 Volume 19 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

A clinical metabolomics‑based biomarker signature as an approach for early diagnosis of gastric cardia adenocarcinoma

  • Authors:
    • Yuanfang Sun
    • Shasha Li
    • Jin Li
    • Xue Xiao
    • Zhaolai Hua
    • Xi Wang
    • Shikai Yan
  • View Affiliations / Copyright

    Affiliations: School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, P.R. China, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, P.R. China, Department of Oncology, The 903rd Hospital of PLA, Hangzhou, Zhejiang 310013, P.R. China, Institute of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, P.R. China, People's Hospital of Yangzhong, Yangzhong, Jiangsu 212200, P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 681-690
    |
    Published online on: December 2, 2019
       https://doi.org/10.3892/ol.2019.11173
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Gastric cardia adenocarcinoma (GCA) has a high mortality rate worldwide; however, current early diagnostic methods lack efficacy. Therefore, the aim of the present study was to identify potential biomarkers for the early diagnosis of GCA. Global metabolic profiles were obtained from plasma samples collected from 21 patients with GCA and 48 healthy controls using ultra‑performance liquid chromatography/quadrupole‑time‑of‑flight mass spectrometry. The orthogonal partial least squares discrimination analysis model was applied to distinguish patients with GCA from healthy controls and to identify potential biomarkers. Metabolic pathway analysis was performed using MetaboAnalyst (version 4.0) and revealed that ‘glycerophospholipid metabolism’, ‘linoleic acid metabolism’, ‘fatty acid biosynthesis’ and ‘primary bile acid biosynthesis’ were significantly associated with GCA. In addition, an early diagnostic model for GCA was established based on the relative levels of four key biomarkers, including phosphorylcholine, glycocholic acid, L‑acetylcarnitine and arachidonic acid. The area under the receiver operating characteristic curve revealed that the diagnostic model had a sensitivity and specificity of 0.977 and 0.952, respectively. The present study demonstrated that metabolomics may aid the identification of the mechanisms underlying the pathogenesis of GCA. In addition, the proposed diagnostic method may serve as a promising approach for the early diagnosis of GCA.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Colquhoun A, Arnold M, Ferlay J, Goodman KJ, Forman D and Soerjomataram I: Global patterns of cardia and non-cardia gastric cancer incidence in 2012. Gut. 64:1881–1888. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Wang LD, Zheng S, Zheng ZY and Casson AG: Primary adenocarcinomas of lower esophagus, esophagogastric junction and gastric cardia: In special reference to China. World J Gastroenterol. 9:1156–1164. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Huang Q, Li R, Xu GF, Zhou D, Fan XS and Zou XP: Emerging evidence supports grouping by location of early gastric carcinoma for appropriate clinical management in Chinese patients. J Dig Dis. 19:730–736. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Abdi E, Latifi-Navid S, Zahri S, Yazdanbod A and Pourfarzi F: Risk factors predisposing to cardia gastric adenocarcinoma: Insights and new perspectives. Cancer Med. 8:6114–6126. 2019. View Article : Google Scholar : PubMed/NCBI

5 

Ze-Long Y, Guo-Hui M, Lin Z, Wei-Hong Y, Ke-Cheng Z and Yan-Wen J: Survival trends of patients with surgically resected gastric cardia cancer from 1988 to 2015 a population-based study in the United States. Am J Clin Oncol. 42:581–587. 2019. View Article : Google Scholar : PubMed/NCBI

6 

Kutup A, Yekebas EF and Izbicki JR: Current diagnosis and future impact of micrometastases for therapeutic strategies in adenocarcinoma of the esophagus, gastric cardia, and upper gastric third. Recent Results Cancer Res. 182:115–125. 2010. View Article : Google Scholar : PubMed/NCBI

7 

An JY, Baik YH, Choi MG, Noh JH, Sohn TS, Bae JM and Kim S: The prognosis of gastric cardia cancer after R0 resection. Am J Surg. 199:725–729. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Nishimata H, Maruyama M, Shimaoka S, Nishimata Y, Ohi H, Niihara T, Nioh T, Matsuda A, Tashiro K and Torimaru H: Early gastric carcinomas in the cardiac region: Diagnosis with double-contrast x-ray studies. Abdom Imaging. 28:486–491. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Togo R, Yamamichi N, Mabe K, Takahashi Y, Takeuchi C, Kato M, Sakamoto N, Ishihara K, Ogawa T and Haseyama M: Detection of gastritis by a deep convolutional neural network from double-contrast upper gastrointestinal barium X-ray radiography. J Gastroenterol. 54:321–329. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Carandang N, Schuman BM and Priest RJ: The gastrocamera in the diagnosis of stomach disease. JAMA. 204:717–722. 1968. View Article : Google Scholar : PubMed/NCBI

11 

Fujiyoshi T, Miyahara R, Funasaka K, Furukawa K, Sawada T, Maeda K, Yamamura T, Ishikawa T, Ohno E, Nakamura M, et al: Utility of linked color imaging for endoscopic diagnosis of early gastric cancer. World J Gastroenterol. 25:1248–1258. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Shen L, Zhou C, Liu L, Zhang L, Lu D, Cai J, Zhao L, Chu R, Zhou J and Zhang J: Application of oral contrast trans-abdominal ultrasonography for initial screening of gastric cancer in rural areas of China. Dig Liver Dis. 49:918–923. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Dai CL, Yang ZG, Xue LP and Li YM: Application value of multi-slice spiral computed tomography for imaging determination of metastatic lymph nodes of gastric cancer. World J Gastroenterol. 19:5732–5737. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Jiang M, Wang X, Shan X, Pan D, Jia Y, Ni E, Hu Y and Huang H: Value of multi-slice spiral computed tomography in the diagnosis of metastatic lymph nodes and N-stage of gastric cancer. J Int Med Res. 47:281–292. 2019. View Article : Google Scholar : PubMed/NCBI

15 

Chan AW, Mercier P, Schiller D, Bailey R, Robbins S, Eurich DT, Sawyer MB and Broadhurst D: (1)H-NMR urinary metabolomic profiling for diagnosis of gastric cancer. Br J Cancer. 114:59–62. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Tatsubayashi T, Tanizawa Y, Miki Y, Tokunaga M, Bando E, Kawamura T, Sugiura T, Kinugasa Y, Uesaka K and Terashima M: Treatment outcomes of hepatectomy for liver metastases of gastric cancer diagnosed using contrast-enhanced magnetic resonance imaging. Gastric Cancer. 20:387–393. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Van Vliet EP, Hermans JJ, De Wever W, Eijkemans MJ, Steyerberg EW, Faasse C, van Helmond EP, de Leeuw AM, Sikkenk AC, de Vries AR, et al: Radiologist experience and CT examination quality determine metastasis detection in patients with esophageal or gastric cardia cancer. Eur Radiol. 18:2475–2484. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Li L, Pang X, Zhu Z, Lu L, Yang J, Cao J and Fei S: GTPBP4 promotes gastric cancer progression via regulating P53 activity. Cell Physiol Biochem. 45:667–676. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Zhou F, Xu Y, Shi J, Lan X, Zou X, Wang L and Huang Q: Expression profile of E-cadherin, estrogen receptors, and P53 in early-onset gastric cancers. Cancer Med. 5:3403–3411. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Yin J, Pan H, Long T, Lv L, Zhai P, Liu C, Shao A, Shi Y, Sun Y, Zhu J, et al: Polymorphisms of VDR gene and risk of gastric cardiac adenocarcinoma in Chinese population. Oncotarget. 8:45531–45543. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Zhou RM, Wang N, Chen ZF, Duan YN, Sun DL and Li Y: Polymorphisms in promoter region of FAS and FASL gene and risk of cardia gastric adenocarcinoma. J Gastroenterol Hepatol. 25:555–561. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Zhang J, Cui Y, Kuang G, Li Y, Wang N, Wang R, Guo W, Wen D, Wei L, Yu F and Wang S: Association of the thymidylate synthase polymorphisms with esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma. Carcinogenesis. 25:2479–2485. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Luo T, Chen W, Wang L and Zhao H: CA125 is a potential biomarker to predict surgically incurable gastric and cardia cancer: A retrospective study. Medicine (Baltimore). 95:e52972016. View Article : Google Scholar : PubMed/NCBI

24 

Williams GH, Swinn R, Prevost AT, de Clive-Lowe P, Halsall I, Going JJ, Hales CN, Stoeber K and Middleton SJ: Diagnosis of oesophageal cancer by detection of minichromosome maintenance 5 protein in gastric aspirates. Br J Cancer. 91:714–719. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Liu M, Li JS, Tian DP, Huang B, Rosqvist S and Su M: MCM2 expression levels predict diagnosis and prognosis in gastric cardiac cancer. Histol Histopathol. 28:481–492. 2013.PubMed/NCBI

26 

Cheng Y, Zhang J, Li Y, Wang Y and Gong J: Proteome analysis of human gastric cardia adenocarcinoma by laser capture microdissection. BMC Cancer. 7:1912007. View Article : Google Scholar : PubMed/NCBI

27 

Liu HN, Liu TT, Wu H, Chen YJ, Tseng YJ, Yao C, Weng SQ, Dong L and Shen XZ: Serum microRNA signatures and metabolomics have high diagnostic value in colorectal cancer using two novel methods. Cancer Sci. 109:1185–1194. 2018. View Article : Google Scholar : PubMed/NCBI

28 

Zhang A, Sun H, Yan G, Wang P, Han Y and Wang X: Metabolomics in diagnosis and biomarker discovery of colorectal cancer. Cancer Lett. 345:17–20. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Wang X, Zhang A and Sun H: Power of metabolomics in diagnosis and biomarker discovery of hepatocellular carcinoma. Hepatology. 57:2072–2077. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Kobayashi T, Nishiumi S, Ikeda A, Yoshie T, Sakai A, Matsubara A, Izumi Y, Tsumura H, Tsuda M, Nishisaki H, et al: A novel serum metabolomics-based diagnostic approach to pancreatic cancer. Cancer Epidemiol Biomarkers Prev. 22:571–579. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Zhang G, He P, Tan H, Budhu A, Gaedcke J, Ghadimi BM, Ried T, Yfantis HG, Lee DH, Maitra A, et al: Integration of metabolomics and transcriptomics revealed a fatty acid network exerting growth inhibitory effects in human pancreatic cancer. Clin Cancer Res. 19:4983–4993. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Abbassi-Ghadi N, Kumar S, Huang J, Goldin R, Takats Z and Hanna GB: Metabolomic profiling of oesophago-gastric cancer: A systematic review. Eur J Cancer. 49:3625–3637. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Wang X, Yan SK, Dai WX, Liu XR, Zhang WD and Wang JJ: A metabonomic approach to chemosensitivity prediction of cisplatin plus 5-fluorouracil in a human xenograft model of gastric cancer. Int J Cancer. 127:2841–2850. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Cai Z, Zhao JS, Li JJ, Peng DN, Wang XY, Chen TL, Qiu YP, Chen PP, Li WJ, Xu LY, et al: A combined proteomics and metabolomics profiling of gastric cardia cancer reveals characteristic dysregulations in glucose metabolism. Mol Cell Proteomics. 9:2617–2628. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Zhen C: Glucose metabolic pathway in gastric cardia cancer and the role of microcilia in tumorogenesis [Chinese]. Shanghai Institutes for Biological Sciences; 2011

36 

Patriarca S, Ferretti S and Zanetti R: TNM Classification of malignant tumours-Eighth edition: Which news? Epidemiol Prev. 41:140–143. 2017.(In Italian). PubMed/NCBI

37 

Chong J, Soufan O, Li C, Caraus I, Li S, Bourque G, Wishart DS and Xia J: MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis. Nucleic Acids Res. 46:W486–W494. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Amini N, Spolverato G, Kim Y, Squires MH, Poultsides GA, Fields R, Schmidt C, Weber SM, Votanopoulos K, Maithel SK and Pawlik TM: Clinicopathological features and prognosis of gastric cardia adenocarcinoma: A multi-institutional US study. J Surg Oncol. 111:285–292. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Wang J, Zhang H, Zhou X, Wang T, Zhang J, Zhu W, Zhu H and Cheng W: Five serum-based miRNAs were identified as potential diagnostic biomarkers in gastric cardia adenocarcinoma. Cancer Biomark. 23:193–203. 2018. View Article : Google Scholar : PubMed/NCBI

40 

von Glutz G and Walter P: Compartmentation of acetyl-coA in rat-liver mitochondria. Eur J Biochem. 60:147–152. 1975. View Article : Google Scholar : PubMed/NCBI

41 

Svensson RU, Parker SJ, Eichner LJ, Kolar MJ, Wallace M, Brun SN, Lombardo PS, Van Nostrand JL, Hutchins A, Vera L, et al: Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models. Nat Med. 22:1108–1119. 2016. View Article : Google Scholar : PubMed/NCBI

42 

Scholz R, Olson MS, Schwab AJ, Schwabe U, Noell C and Braun W: The effect of fatty acids on the regulation of pyruvate dehydrogenase in perfused rat liver. Eur J Biochem. 86:519–530. 1978. View Article : Google Scholar : PubMed/NCBI

43 

Ke J, Behal RH, Back SL, Nikolau BJ, Wurtele ES and Oliver DJ: The role of pyruvate dehydrogenase and acetyl-coenzyme A synthetase in fatty acid synthesis in developing arabidopsis seeds. Plant Physiol. 123:497–508. 2000. View Article : Google Scholar : PubMed/NCBI

44 

Lucenteforte E, Bosetti C, Gallus S, Bertuccio P, Pelucchi C, Tavani A, La Vecchia C and Negri E: Macronutrients, fatty acids and cholesterol intake and stomach cancer risk. Ann Oncol. 20:1434–1438. 2009. View Article : Google Scholar : PubMed/NCBI

45 

Wen YA, Xing XP, Harris JW, Zaytseva YY, Mitov MI, Napier DL, Weiss HL, Mark Evers B and Gao T: Adipocytes activate mitochondrial fatty acid oxidation and autophagy to promote tumor growth in colon cancer. Cell Death Dis. 8:e25932017. View Article : Google Scholar : PubMed/NCBI

46 

Caligiuri G, Khallou-Laschet J, Vandaele M, Gaston AT, Delignat S, Mandet C, Kohler HV, Kaveri SV and Nicoletti A: Phosphorylcholine-targeting immunization reduces atherosclerosis. J Am Coll Cardiol. 50:540–546. 2007. View Article : Google Scholar : PubMed/NCBI

47 

Claflin JL, Lieberman R and Davie JM: Clonal nature of the immune response to phosphorylcholine. I. Specificity, class, and idiotype of phosphorylcholine-binding receptors on lymphoid cells. J Exp Med. 139:58–73. 1974. View Article : Google Scholar : PubMed/NCBI

48 

Sigal NH, Pickard AR, Metcalf ES, Gearhart PJ and Klinman NR: Expression of phosphorylcholine-specific B cells during murine development. J Exp Med. 146:933–948. 1977. View Article : Google Scholar : PubMed/NCBI

49 

Feldman DA, Rounsifer ME and Weinhold PA: The stimulation and binding of CTP: Phosphorylcholine cytidylyltransferase by phosphatidylcholine-oleic acid vesicles. Biochim Biophys Acta. 833:429–437. 1985. View Article : Google Scholar : PubMed/NCBI

50 

Gasull T, Sarri E, DeGregorio-Rocasolano N and Trullas R: NMDA receptor overactivation inhibits phospholipid synthesis by decreasing choline-ethanolamine phosphotransferase activity. J Neurosci. 23:4100–4107. 2003. View Article : Google Scholar : PubMed/NCBI

51 

Mori N, Wildes F, Kakkad S, Jacob D, Solaiyappan M, Glunde K and Bhujwalla ZM: Choline kinase-alpha protein and phosphatidylcholine but not phosphocholine are required for breast cancer cell survival. NMR Biomed. 28:1697–1706. 2015. View Article : Google Scholar : PubMed/NCBI

52 

Zhang H, Song H, Yuan R, Zhang X, Yu H, Zhao Y and Jiang T: Polyene phosphatidylcholine overcomes oxaliplatin resistance in human gastric cancer BGC823 cells. Biochem Biophys Res Commun. 497:108–114. 2018. View Article : Google Scholar : PubMed/NCBI

53 

Bereziat G, Chambaz J, Trugnan G, Pepin D and Polonovski J: Turnover of phospholipid linoleic and arachidonic acids in human platelets from plasma lecithins. J Lipid Res. 19:495–500. 1978.PubMed/NCBI

54 

Wang D and Dubois RN: Eicosanoids and cancer. Nat Rev Cancer. 10:181–193. 2010. View Article : Google Scholar : PubMed/NCBI

55 

Nieves D and Moreno JJ: Effect of arachidonic and eicosapentaenoic acid metabolism on RAW 264.7 macrophage proliferation. J Cell Physiol. 208:428–434. 2006. View Article : Google Scholar : PubMed/NCBI

56 

Yarla NS, Bishayee A, Sethi G, Reddanna P, Kalle AM, Dhananjaya BL, Dowluru KS, Chintala R and Duddukuri GR: Targeting arachidonic acid pathway by natural products for cancer prevention and therapy. Semin Cancer Biol. 40-41:48–81. 2016. View Article : Google Scholar : PubMed/NCBI

57 

Poligone B and Baldwin AS: Positive and negative regulation of NF-kappaB by COX-2: roles of different prostaglandins. J Biol Chem. 276:38658–38664. 2001. View Article : Google Scholar : PubMed/NCBI

58 

Bortuzzo C, Hanif R, Kashfi K, Staiano-Coico L, Shiff SJ and Rigas B: The effect of leukotrienes B and selected HETEs on the proliferation of colon cancer cells. Biochim Biophys Acta. 1300:240–246. 1996. View Article : Google Scholar : PubMed/NCBI

59 

Yu L, Wu WK, Li ZJ, Li HT, Wu YC and Cho CH: Prostaglandin E-2 promotes cell proliferation via protein kinase C/extracellular signal regulated kinase pathway-dependent induction of c-Myc expression in human esophageal squamous cell carcinoma cells. Int J Cancer. 125:2540–2546. 2009. View Article : Google Scholar : PubMed/NCBI

60 

Ul Islam S, Shehzad A and Lee YS: Prostaglandin E-2 inhibits resveratrol-induced apoptosis through activation of survival signaling pathways in HCT-15 cell lines. Anim Cells Syst. 19:374–384. 2015. View Article : Google Scholar

61 

Kauer WK, Peters JH, DeMeester TR, Feussner H, Ireland AP, Stein HJ and Siewert RJ: Composition and concentration of bile acid reflux into the esophagus of patients with gastroesophageal reflux disease. Surgery. 122:874–881. 1997. View Article : Google Scholar : PubMed/NCBI

62 

Fitzgerald RC, Abdalla S, Onwuegbusi BA, Sirieix P, Saeed IT, Burnham WR and Farthing MJ: Inflammatory gradient in Barrett's oesophagus: Implications for disease complications. Gut. 51:316–322. 2002. View Article : Google Scholar : PubMed/NCBI

63 

Tatsugami M, Ito M, Tanaka S, Yoshihara M, Matsui H, Haruma K and Chayama K: Bile acid promotes intestinal metaplasia and gastric carcinogenesis. Cancer Epidemiol Biomarkers Prev. 21:2101–2107. 2012. View Article : Google Scholar : PubMed/NCBI

64 

Messner CJ, Mauch L and Suter-Dick L: Bile salts regulate CYP7A1 expression and elicit a fibrotic response and abnormal lipid production in 3D liver microtissues. Toxicol In Vitro. 60:261–271. 2019. View Article : Google Scholar : PubMed/NCBI

65 

Heubi JE, Setchell KD, Jha P, Buckley D, Zhang WJ, Rosenthal P, Potter C, Horslen S and Suskind D: Treatment of bile acid amidation defects with glycocholic acid. Hepatology. 61:268–274. 2015. View Article : Google Scholar : PubMed/NCBI

66 

Abreu MT and Peek RM Jr: Gastrointestinal malignancy and the microbiome. Gastroenterology. 146:1534–1166. 2014. View Article : Google Scholar : PubMed/NCBI

67 

Hu H, Krasinskas A and Willis J: Perspectives on current tumor-node-metastasis (TNM) staging of cancers of the colon and rectum. Semin Oncol. 38:500–510. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Sun Y, Li S, Li J, Xiao X, Hua Z, Wang X and Yan S: A clinical metabolomics‑based biomarker signature as an approach for early diagnosis of gastric cardia adenocarcinoma. Oncol Lett 19: 681-690, 2020.
APA
Sun, Y., Li, S., Li, J., Xiao, X., Hua, Z., Wang, X., & Yan, S. (2020). A clinical metabolomics‑based biomarker signature as an approach for early diagnosis of gastric cardia adenocarcinoma. Oncology Letters, 19, 681-690. https://doi.org/10.3892/ol.2019.11173
MLA
Sun, Y., Li, S., Li, J., Xiao, X., Hua, Z., Wang, X., Yan, S."A clinical metabolomics‑based biomarker signature as an approach for early diagnosis of gastric cardia adenocarcinoma". Oncology Letters 19.1 (2020): 681-690.
Chicago
Sun, Y., Li, S., Li, J., Xiao, X., Hua, Z., Wang, X., Yan, S."A clinical metabolomics‑based biomarker signature as an approach for early diagnosis of gastric cardia adenocarcinoma". Oncology Letters 19, no. 1 (2020): 681-690. https://doi.org/10.3892/ol.2019.11173
Copy and paste a formatted citation
x
Spandidos Publications style
Sun Y, Li S, Li J, Xiao X, Hua Z, Wang X and Yan S: A clinical metabolomics‑based biomarker signature as an approach for early diagnosis of gastric cardia adenocarcinoma. Oncol Lett 19: 681-690, 2020.
APA
Sun, Y., Li, S., Li, J., Xiao, X., Hua, Z., Wang, X., & Yan, S. (2020). A clinical metabolomics‑based biomarker signature as an approach for early diagnosis of gastric cardia adenocarcinoma. Oncology Letters, 19, 681-690. https://doi.org/10.3892/ol.2019.11173
MLA
Sun, Y., Li, S., Li, J., Xiao, X., Hua, Z., Wang, X., Yan, S."A clinical metabolomics‑based biomarker signature as an approach for early diagnosis of gastric cardia adenocarcinoma". Oncology Letters 19.1 (2020): 681-690.
Chicago
Sun, Y., Li, S., Li, J., Xiao, X., Hua, Z., Wang, X., Yan, S."A clinical metabolomics‑based biomarker signature as an approach for early diagnosis of gastric cardia adenocarcinoma". Oncology Letters 19, no. 1 (2020): 681-690. https://doi.org/10.3892/ol.2019.11173
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team