Open Access

Research progress on the interactions between long non‑coding RNAs and microRNAs in human cancer (Review)

  • Authors:
    • Binyu Sun
    • Chunxia Liu
    • Hao  Li
    • Lu Zhang
    • Gang Luo
    • Sicheng Liang
    • Muhan Lü
  • View Affiliations

  • Published online on: December 4, 2019     https://doi.org/10.3892/ol.2019.11182
  • Pages: 595-605
  • Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Numerous types of molecular mechanisms mediate the development of cancer. Non‑coding RNAs (ncRNAs) are being increasingly recognized to play important role in mediating the development of diseases, including cancer. Long non‑coding RNAs (lncRNAs) and microRNAs (miRNAs) are the two most widely studied ncRNAs. Thus far, lncRNAs are known to have biological roles through a variety of mechanisms, including genetic imprinting, chromatin remodeling, cell cycle control, splicing regulation, mRNA decay and translational regulation, and miRNAs regulate gene expression through the degradation of mRNAs and lncRNAs. Although ncRNAs account for a major proportion of the total RNA, the mechanisms underlying the physiological or pathological processes mediated by various types of ncRNAs, and the specific interaction mechanisms between miRNAs and lncRNAs in various physiological and pathological processes, remain largely unknown. Thus, further research in this field is required. In general, the interaction mechanisms between miRNAs and lncRNAs in human cancer have become important research topics, and the study thereof has led to the recent development of related technologies. By providing examples and descriptions, and performing chart analysis, the present study aimed to review the interaction mechanisms and research approaches for these two types of ncRNAs, as well as their roles in the occurrence and development of cancer. These details have far‑reaching significance for the utilization of these molecules in the diagnosis and treatment of cancer.
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January-2020
Volume 19 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Sun B, Liu C, Li H, Zhang L, Luo G, Liang S and Lü M: Research progress on the interactions between long non‑coding RNAs and microRNAs in human cancer (Review). Oncol Lett 19: 595-605, 2020
APA
Sun, B., Liu, C., Li, H., Zhang, L., Luo, G., Liang, S., & Lü, M. (2020). Research progress on the interactions between long non‑coding RNAs and microRNAs in human cancer (Review). Oncology Letters, 19, 595-605. https://doi.org/10.3892/ol.2019.11182
MLA
Sun, B., Liu, C., Li, H., Zhang, L., Luo, G., Liang, S., Lü, M."Research progress on the interactions between long non‑coding RNAs and microRNAs in human cancer (Review)". Oncology Letters 19.1 (2020): 595-605.
Chicago
Sun, B., Liu, C., Li, H., Zhang, L., Luo, G., Liang, S., Lü, M."Research progress on the interactions between long non‑coding RNAs and microRNAs in human cancer (Review)". Oncology Letters 19, no. 1 (2020): 595-605. https://doi.org/10.3892/ol.2019.11182