Long non‑coding RNA mortal obligate RNA transcript inhibits the migration and invasion of colon cancer cells by inactivating transforming growth factor β1

Zhou,Taicheng; Wu,Lili; Zong,Zhen; Ma,Ning; Li,Yingru; Jiang,Zhipeng; Wang,Qirui; Chen,Shuang

doi:10.3892/ol.2019.11189

Long non‑coding RNA mortal obligate RNA transcript inhibits the migration and invasion of colon cancer cells by inactivating transforming growth factor β1

Authors:
- Taicheng Zhou
- Lili Wu
- Zhen Zong
- Ning Ma
- Yingru Li
- Zhipeng Jiang
- Qirui Wang
- Shuang Chen
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Affiliations: Department of Gastroenterological Surgery and Hernia Center, The Sixth Affiliated Hospital of Sun Yat‑Sen University, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, Guangzhou, Guangdong 510655, P.R. China, Department of Ultrasonology, The Third Affiliated Hospital of Sun Yat‑Sen University, Guangzhou, Guangdong 510630, P.R. China, Department of Gastroenterological Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 510655, P.R. China, Department of Molecular Biology, State Administration of Traditional Chinese Medicine of the People's Republic of China, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China
Published online on: December 9, 2019 https://doi.org/10.3892/ol.2019.11189
Pages: 1131-1136
Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Long non‑coding (lnc)RNA mortal obligate RNA transcript (MORT) is inhibited in numerous types of cancer in humans, indicating its role as a tumor suppressor. The present study demonstrated downregulation of lncRNA MORT in the tumor tissues of patients with colon cancer. The expression of MORT in tumor tissues was linearly associated with its expression levels in plasma. Low MORT expression was associated with low overall survival rate. Moreover, the overexpression of MORT resulted in decreased, whereas treatment with transforming growth factor β1 (TGF‑β1) resulted in increased, invasion and migration rates of colon cancer cells. In addition, TGF‑β1 treatment attenuated the inhibitory effect of MORT overexpression on the invasion and migration rates of colon cancer cells. The overexpression of MORT inhibited TGF‑β1 expression in colon cancer cells, whereas treatment with TGF‑β1 failed to affect the expression of the lncRNA. Therefore, it is postulated that MORT inhibits invasion and migration colon cancer cells by inactivating TGF‑β1.

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