Open Access

Clinical significance of serum melatonin in predicting the severity of oral squamous cell carcinoma

  • Authors:
    • Adina E. Stanciu
    • Adina Zamfir-Chiru-Anton
    • Marcel M. Stanciu
    • Anca Pantea Stoian
    • Viorel Jinga
    • Cornelia Nitipir
    • Alexandru Bucur
    • Teodora S. Pituru
    • Andreea L. Arsene
    • Cristina M. Dragoi
    • Razvan Hainarosie
    • Alina C. Nicolae
    • Mirela Gherghe
    • Dan C. Gheorghe
    • Demetrios A. Spandidos
    • Aristidis Tsatsakis
    • Maria Papasavva
    • Nikolaos Drakoulis
  • View Affiliations

  • Published online on: December 13, 2019     https://doi.org/10.3892/ol.2019.11215
  • Pages: 1537-1543
  • Copyright: © Stanciu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Melatonin, the primary hormone produced by the pineal gland, is intensely assessed for its anticancer properties. This study aimed to reveal the clinical significance of serum melatonin levels in predicting the severity of oral squamous cell carcinoma (OSCC). For this purpose, 40 male patients with OSCC and 30 healthy subjects were enrolled in this study. The serum levels of melatonin were determined by ELISA. The results revealed that the melatonin concentrations were significantly lower in the patients with OSCC compared with the controls (18.2 vs. 47.6 pg/ml, P<0.001). In addition, the serum melatonin levels had a high predictive accuracy for discriminating patients with OSCC with T-depth of invasion (DOI) II from the healthy controls (89.1%), as well as in discriminating patients with OSCC with nodal metastasis from those without nodal metastasis (83.8%). On the whole, the findings of this study suggest that the serum melatonin concentrations are closely related to the severity of OSCC and may thus be used to assess the different stages of oral cancer objectively and accurately. The present study also supports the conclusion that melatonin may be a potential therapeutic agent for use in the treatment of patients with OSCC.
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February-2020
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Spandidos Publications style
Stanciu AE, Zamfir-Chiru-Anton A, Stanciu MM, Stoian AP, Jinga V, Nitipir C, Bucur A, Pituru TS, Arsene AL, Dragoi CM, Dragoi CM, et al: Clinical significance of serum melatonin in predicting the severity of oral squamous cell carcinoma. Oncol Lett 19: 1537-1543, 2020
APA
Stanciu, A.E., Zamfir-Chiru-Anton, A., Stanciu, M.M., Stoian, A.P., Jinga, V., Nitipir, C. ... Drakoulis, N. (2020). Clinical significance of serum melatonin in predicting the severity of oral squamous cell carcinoma. Oncology Letters, 19, 1537-1543. https://doi.org/10.3892/ol.2019.11215
MLA
Stanciu, A. E., Zamfir-Chiru-Anton, A., Stanciu, M. M., Stoian, A. P., Jinga, V., Nitipir, C., Bucur, A., Pituru, T. S., Arsene, A. L., Dragoi, C. M., Hainarosie, R., Nicolae, A. C., Gherghe, M., Gheorghe, D. C., Spandidos, D. A., Tsatsakis, A., Papasavva, M., Drakoulis, N."Clinical significance of serum melatonin in predicting the severity of oral squamous cell carcinoma". Oncology Letters 19.2 (2020): 1537-1543.
Chicago
Stanciu, A. E., Zamfir-Chiru-Anton, A., Stanciu, M. M., Stoian, A. P., Jinga, V., Nitipir, C., Bucur, A., Pituru, T. S., Arsene, A. L., Dragoi, C. M., Hainarosie, R., Nicolae, A. C., Gherghe, M., Gheorghe, D. C., Spandidos, D. A., Tsatsakis, A., Papasavva, M., Drakoulis, N."Clinical significance of serum melatonin in predicting the severity of oral squamous cell carcinoma". Oncology Letters 19, no. 2 (2020): 1537-1543. https://doi.org/10.3892/ol.2019.11215