Open Access

Bone morphogenic proteins‑2, ‑4, ‑6 and 7 in non‑muscle invasive bladder cancer

  • Authors:
    • Tvrtko Hudolin
    • Zeljko Kastelan
    • Ahmad El‑Saleh
    • Mirko Bakula
    • Marijana Coric
    • Petar Kes
    • Davor Tomas
    • Nikolina Basic‑Jukic
  • View Affiliations

  • Published online on: December 13, 2019     https://doi.org/10.3892/ol.2019.11218
  • Pages: 1291-1297
  • Copyright: © Hudolin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Bone morphogenetic proteins (BMPs) are members of the transforming growth factor‑β (TGF‑β) family and may play an important role in the regulation of malignant cells in bladder cancer. The aim of the present study was to investigate BMP expression in non‑muscle invasive bladder cancer. Tumor tissue samples from 71 patients treated with transurethral resection and 10 samples of normal bladder tissue were stained using immunohistochemistry for BMP‑2, ‑4, ‑6 and ‑7. The levels of BMP were correlated with the number and size of tumors in the bladder, the pathohistological findings as well as with tumor recurrence and progression. The results of the present study demonstrated that BMP‑2 and ‑7 are highly expressed in normal bladder tissue, but significantly downregulated in cancer samples. This reduction correlates with a faster rate of tumor recurrence as well as with an increase in the number of recurrent tumors. There was no evident interrelation between BMP‑2 and ‑7 reduction and changes in tumor grade and stage. In conclusion, BMP‑2 and ‑7 are potential prognostic factors for tumor recurrence and further studies on BMP and bladder cancer are needed to confirm these results.
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February-2020
Volume 19 Issue 2

Print ISSN: 1792-1074
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Spandidos Publications style
Hudolin T, Kastelan Z, El‑Saleh A, Bakula M, Coric M, Kes P, Tomas D and Basic‑Jukic N: Bone morphogenic proteins‑2, ‑4, ‑6 and 7 in non‑muscle invasive bladder cancer. Oncol Lett 19: 1291-1297, 2020
APA
Hudolin, T., Kastelan, Z., El‑Saleh, A., Bakula, M., Coric, M., Kes, P. ... Basic‑Jukic, N. (2020). Bone morphogenic proteins‑2, ‑4, ‑6 and 7 in non‑muscle invasive bladder cancer. Oncology Letters, 19, 1291-1297. https://doi.org/10.3892/ol.2019.11218
MLA
Hudolin, T., Kastelan, Z., El‑Saleh, A., Bakula, M., Coric, M., Kes, P., Tomas, D., Basic‑Jukic, N."Bone morphogenic proteins‑2, ‑4, ‑6 and 7 in non‑muscle invasive bladder cancer". Oncology Letters 19.2 (2020): 1291-1297.
Chicago
Hudolin, T., Kastelan, Z., El‑Saleh, A., Bakula, M., Coric, M., Kes, P., Tomas, D., Basic‑Jukic, N."Bone morphogenic proteins‑2, ‑4, ‑6 and 7 in non‑muscle invasive bladder cancer". Oncology Letters 19, no. 2 (2020): 1291-1297. https://doi.org/10.3892/ol.2019.11218