Open Access

Clinical characteristics of malignant melanoma in central China and predictors of metastasis

  • Authors:
    • Ke Shi
    • Xuran Zhu
    • Zhongyang Liu
    • Nan Sun
    • Luosha Gu
    • Yang Wei
    • Xu Cheng
    • Zewei Zhang
    • Baihui Xie
    • Shuaixi Yang
    • Guangshuai Li
    • Linbo Liu
  • View Affiliations

  • Published online on: December 16, 2019     https://doi.org/10.3892/ol.2019.11219
  • Pages: 1452-1464
  • Copyright: © Shi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cutaneous malignant melanoma (MM) is the most malignant type of all skin neoplasms. There is wide variability in the characteristics of MM between patients of different races. The aim of the present study was to investigate the clinicopathological characteristics of patients with MM in central China and to assess the value of specific hematological and biochemical indices for predicting metastasis. The data of 167 patients with MM from the First Affiliated Hospital of Zhengzhou University (Henan, China) were retrospectively analyzed and compared with the data of patients with MM available from cBioPortal for Cancer Genomics. Following analysis of the clinicopathological characteristics of the 167 patients, the median overall survival time was 50 months, and the median disease‑free survival time was 35 months. Albumin/D‑dimer prognosis score (ADPS), lactate dehydrogenase, sex, T stage, tumor‑node‑metastasis stage, Breslow thickness, Clark level, histological type, growth phase, ulceration and metastasis were all significantly associated with prognosis. An ADPS of <341.01 was identified as an independent predictor of metastasis. The trial registration no. is 2018‑LW‑037 and this clinical trial was registered in the First Affiliated Hospital of Zhengzhou University Clinical Trial Registry in March 1, 2018.
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February-2020
Volume 19 Issue 2

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Spandidos Publications style
Shi K, Zhu X, Liu Z, Sun N, Gu L, Wei Y, Cheng X, Zhang Z, Xie B, Yang S, Yang S, et al: Clinical characteristics of malignant melanoma in central China and predictors of metastasis. Oncol Lett 19: 1452-1464, 2020
APA
Shi, K., Zhu, X., Liu, Z., Sun, N., Gu, L., Wei, Y. ... Liu, L. (2020). Clinical characteristics of malignant melanoma in central China and predictors of metastasis. Oncology Letters, 19, 1452-1464. https://doi.org/10.3892/ol.2019.11219
MLA
Shi, K., Zhu, X., Liu, Z., Sun, N., Gu, L., Wei, Y., Cheng, X., Zhang, Z., Xie, B., Yang, S., Li, G., Liu, L."Clinical characteristics of malignant melanoma in central China and predictors of metastasis". Oncology Letters 19.2 (2020): 1452-1464.
Chicago
Shi, K., Zhu, X., Liu, Z., Sun, N., Gu, L., Wei, Y., Cheng, X., Zhang, Z., Xie, B., Yang, S., Li, G., Liu, L."Clinical characteristics of malignant melanoma in central China and predictors of metastasis". Oncology Letters 19, no. 2 (2020): 1452-1464. https://doi.org/10.3892/ol.2019.11219