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Centromere protein F and Forkhead box M1 correlation with prognosis of non‑small cell lung cancer

  • Authors:
    • Rui Li
    • Xia Wang
    • Xiaoqian Zhao
    • Xiaohong Zhang
    • Honghai Chen
    • Yue Ma
    • Yandong Liu
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, Shenyang Fifth People's Hospital, Shenyang, Liaoning 110021, P.R. China, Admin Office, Shenyang Fifth People's Hospital, Shenyang, Liaoning 110021, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1368-1374
    |
    Published online on: December 20, 2019
       https://doi.org/10.3892/ol.2019.11232
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Abstract

Non‑small cell lung cancer (NSCLC) is the most common histological type of lung cancer. Altered expression of centromere protein F (CENPF), a transient kinetochore protein, has been found in a variety of human cancers. However, its clinical significance in NSCLC remains unknown. In the present study the results of quantitative PCR and western blot analyses demonstrated that CENPF and Forkhead box M1 (FOXM1) were significantly higher in NSCLC tissues than in the non‑cancerous controls at both transcriptional and translational levels. Immunohistochemical staining results showed 58.7% (44/75) and 64.0% (48/75) of NSCLC tissues displayed high expression of CENPF and FOXM1, respectively. CENPF protein expression showed a positive correlation with tumor size (P=0.0179), vital status (P=0.0008) and FOXM1 expression (P=0.0013) in NSCLC. Poor overall survival was correlated with high levels of CENPF and FOXM1 in NSCLC patients as evaluated by Kaplan‑Meier and log rank test. Multivariate analyses showed that CENPF expression was an independent prognostic factor for NSCLC. In conclusion, our study provides evidence of the prognostic function of CENPF in NSCLC.
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1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Zhang Y, Zheng T and Zhang W: Report of cancer incidence and mortality in China. 4:1–7. 2018.

4 

Bomont P, Maddox P, Shah JV, Desai AB and Cleveland DW: Unstable microtubule capture at kinetochores depleted of the centromere-associated protein CENP-F. EMBO J. 24:3927–3939. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Varis A, Salmela AL and Kallio MJ: Cenp-F (mitosin) is more than a mitotic marker. Chromosoma. 115:288–295. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Liao H, Winkfein RJ, Mack G, Rattner JB and Yen TJ: CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis. J Cell Biol. 130:507–518. 1995. View Article : Google Scholar : PubMed/NCBI

7 

Clark GM, Allred DC, Hilsenbeck SG, Chamness GC, Osborne CK, Jones D and Lee WH: Mitosin (a new proliferation marker) correlates with clinical outcome in node-negative breast cancer. Cancer Res. 57:5505–5508. 1997.PubMed/NCBI

8 

de la Guardia C, Casiano CA, Trinidad-Pinedo J and Báez A: CENP-F gene amplification and overexpression in head and neck squamous cell carcinomas. Head Neck. 23:104–112. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Kim HE, Kim DG, Lee KJ, Son JG, Song MY, Park YM, Kim JJ, Cho SW, Chi SG, Cheong HS, et al: Frequent amplification of CENPF, GMNN and CDK13 genes in hepatocellular carcinomas. PLoS One. 7:e432232012. View Article : Google Scholar : PubMed/NCBI

10 

O'Brien SL, Fagan A, Fox EJ, Millikan RC, Culhane AC, Brennan DJ, McCann AH, Hegarty S, Moyna S, Duffy MJ, et al: CENP-F expression is associated with poor prognosis and chromosomal instability in patients with primary breast cancer. Int J Cancer. 120:1434–1443. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Shahid M, Lee MY, Piplani H, Andres AM, Zhou B, Yeon A, Kim M, Kim HL and Kim J: Centromere protein F (CENPF), a microtubule binding protein, modulates cancer metabolism by regulating pyruvate kinase M2 phosphorylation signaling. Cell Cycle. 17:2802–2818. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Li P, You S, Nguyen C, Wang Y, Kim J, Sirohi D, Ziembiec A, Luthringer D, Lin SC, Daskivich T, et al: Genes involved in prostate cancer progression determine MRI visibility. Theranostics. 8:1752–1765. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Wang IC, Snyder J, Zhang Y, Lander J, Nakafuku Y, Lin J, Chen G, Kalin TV, Whitsett JA and Kalinichenko VV: Foxm1 mediates cross talk between Kras/mitogen-activated protein kinase and canonical Wnt pathways during development of respiratory epithelium. Mol Cell Biol. 32:3838–3850. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Bolte C, Zhang Y, Wang I-C, Kalin TV, Molkentin JD and Kalinichenko VV: Expression of Foxm1 transcription factor in cardiomyocytes is required for myocardial development. PLoS One. 6:e222172011. View Article : Google Scholar : PubMed/NCBI

15 

Ustiyan V, Wert SE, Ikegami M, Wang IC, Kalin TV, Whitsett JA and Kalinichenko VV: Foxm1 transcription factor is critical for proliferation and differentiation of Clara cells during development of conducting airways. Dev Biol. 370:198–212. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Kim I-M, Ramakrishna S, Gusarova GA, Yoder HM, Costa RH and Kalinichenko VV: The forkhead box m1 transcription factor is essential for embryonic development of pulmonary vasculature. J Biol Chem. 280:22278–22286. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Zeng J, Wang L, Li Q, Li W, Björkholm M, Jia J and Xu D: FoxM1 is up-regulated in gastric cancer and its inhibition leads to cellular senescence, partially dependent on p27 kip1. J Pathol. 218:419–427. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Yang C, Chen H, Tan G, Gao W, Cheng L, Jiang X, Yu L and Tan Y: FOXM1 promotes the epithelial to mesenchymal transition by stimulating the transcription of Slug in human breast cancer. Cancer Lett. 340:104–112. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Wang Z, Ahmad A, Li Y, Banerjee S, Kong D and Sarkar FH: Forkhead box M1 transcription factor: A novel target for cancer therapy. Cancer Treat Rev. 36:151–156. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Liu M, Dai B, Kang S-H, Ban K, Huang FJ, Lang FF, Aldape KD, Xie TX, Pelloski CE, Xie K, et al: FoxM1B is overexpressed in human glioblastomas and critically regulates the tumorigenicity of glioma cells. Cancer Res. 66:3593–3602. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Kim I-M, Ackerson T, Ramakrishna S, Tretiakova M, Wang IC, Kalin TV, Major ML, Gusarova GA, Yoder HM, Costa RH, et al: The Forkhead Box m1 transcription factor stimulates the proliferation of tumor cells during development of lung cancer. Cancer Res. 66:2153–2161. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Xu N, Jia D, Chen W, Wang H, Liu F, Ge H, Zhu X, Song Y, Zhang X, Zhang D, et al: FoxM1 is associated with poor prognosis of non-small cell lung cancer patients through promoting tumor metastasis. PLoS One. 8:e594122013. View Article : Google Scholar : PubMed/NCBI

23 

Yang DK, Son CH, Lee SK, Choi PJ, Lee KE and Roh MS: Forkhead box M1 expression in pulmonary squamous cell carcinoma: Correlation with clinicopathologic features and its prognostic significance. Hum Pathol. 40:464–470. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Aytes A, Mitrofanova A, Lefebvre C, Alvarez MJ, Castillo-Martin M, Zheng T, Eastham JA, Gopalan A, Pienta KJ, Shen MM, et al: Cross-species regulatory network analysis identifies a synergistic interaction between FOXM1 and CENPF that drives prostate cancer malignancy. Cancer Cell. 25:638–651. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Lin SC, Kao CY, Lee HJ, Creighton CJ, Ittmann MM, Tsai SJ, Tsai SY and Tsai MJ: Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer. Nat Commun. 7:114182016. View Article : Google Scholar : PubMed/NCBI

26 

Lokody I: Signalling: FOXM1 and CENPF: co-pilots driving prostate cancer. Nat Rev Cancer. 14:450–451. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Lee JJ, Maeng CH, Baek SK, Kim GY, Yoo JH, Choi CW, Kim YH, Kwak YT, Kim DH, Lee YK, et al: The immunohistochemical overexpression of ribonucleotide reductase regulatory subunit M1 (RRM1) protein is a predictor of shorter survival to gemcitabine-based chemotherapy in advanced non-small cell lung cancer (NSCLC). Lung Cancer. 70:205–210. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Mizuno K, Mataki H, Arai T, Okato A, Kamikawaji K, Kumamoto T, Hiraki T, Hatanaka K, Inoue H and Seki N: The microRNA expression signature of small cell lung cancer: Tumor suppressors of miR-27a-5p and miR-34b-3p and their targeted oncogenes. J Hum Genet. 62:671–678. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Ma J, Qi G, Xu J, et al: Overexpression of forkhead box m1 and urokinase-type plasminogen activator in gastric cancer is associated with cancer progression and poor prognosis. Oncol Lett. 14:7288–7296. 2017.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li R, Wang X, Zhao X, Zhang X, Chen H, Ma Y and Liu Y: Centromere protein F and Forkhead box M1 correlation with prognosis of non‑small cell lung cancer. Oncol Lett 19: 1368-1374, 2020.
APA
Li, R., Wang, X., Zhao, X., Zhang, X., Chen, H., Ma, Y., & Liu, Y. (2020). Centromere protein F and Forkhead box M1 correlation with prognosis of non‑small cell lung cancer. Oncology Letters, 19, 1368-1374. https://doi.org/10.3892/ol.2019.11232
MLA
Li, R., Wang, X., Zhao, X., Zhang, X., Chen, H., Ma, Y., Liu, Y."Centromere protein F and Forkhead box M1 correlation with prognosis of non‑small cell lung cancer". Oncology Letters 19.2 (2020): 1368-1374.
Chicago
Li, R., Wang, X., Zhao, X., Zhang, X., Chen, H., Ma, Y., Liu, Y."Centromere protein F and Forkhead box M1 correlation with prognosis of non‑small cell lung cancer". Oncology Letters 19, no. 2 (2020): 1368-1374. https://doi.org/10.3892/ol.2019.11232
Copy and paste a formatted citation
x
Spandidos Publications style
Li R, Wang X, Zhao X, Zhang X, Chen H, Ma Y and Liu Y: Centromere protein F and Forkhead box M1 correlation with prognosis of non‑small cell lung cancer. Oncol Lett 19: 1368-1374, 2020.
APA
Li, R., Wang, X., Zhao, X., Zhang, X., Chen, H., Ma, Y., & Liu, Y. (2020). Centromere protein F and Forkhead box M1 correlation with prognosis of non‑small cell lung cancer. Oncology Letters, 19, 1368-1374. https://doi.org/10.3892/ol.2019.11232
MLA
Li, R., Wang, X., Zhao, X., Zhang, X., Chen, H., Ma, Y., Liu, Y."Centromere protein F and Forkhead box M1 correlation with prognosis of non‑small cell lung cancer". Oncology Letters 19.2 (2020): 1368-1374.
Chicago
Li, R., Wang, X., Zhao, X., Zhang, X., Chen, H., Ma, Y., Liu, Y."Centromere protein F and Forkhead box M1 correlation with prognosis of non‑small cell lung cancer". Oncology Letters 19, no. 2 (2020): 1368-1374. https://doi.org/10.3892/ol.2019.11232
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