Open Access

Centromere protein F and Forkhead box M1 correlation with prognosis of non‑small cell lung cancer

  • Authors:
    • Rui Li
    • Xia Wang
    • Xiaoqian Zhao
    • Xiaohong Zhang
    • Honghai Chen
    • Yue Ma
    • Yandong Liu
  • View Affiliations

  • Published online on: December 20, 2019     https://doi.org/10.3892/ol.2019.11232
  • Pages: 1368-1374
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Non‑small cell lung cancer (NSCLC) is the most common histological type of lung cancer. Altered expression of centromere protein F (CENPF), a transient kinetochore protein, has been found in a variety of human cancers. However, its clinical significance in NSCLC remains unknown. In the present study the results of quantitative PCR and western blot analyses demonstrated that CENPF and Forkhead box M1 (FOXM1) were significantly higher in NSCLC tissues than in the non‑cancerous controls at both transcriptional and translational levels. Immunohistochemical staining results showed 58.7% (44/75) and 64.0% (48/75) of NSCLC tissues displayed high expression of CENPF and FOXM1, respectively. CENPF protein expression showed a positive correlation with tumor size (P=0.0179), vital status (P=0.0008) and FOXM1 expression (P=0.0013) in NSCLC. Poor overall survival was correlated with high levels of CENPF and FOXM1 in NSCLC patients as evaluated by Kaplan‑Meier and log rank test. Multivariate analyses showed that CENPF expression was an independent prognostic factor for NSCLC. In conclusion, our study provides evidence of the prognostic function of CENPF in NSCLC.
View Figures
View References

Related Articles

Journal Cover

February-2020
Volume 19 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Li R, Wang X, Zhao X, Zhang X, Chen H, Ma Y and Liu Y: Centromere protein F and Forkhead box M1 correlation with prognosis of non‑small cell lung cancer. Oncol Lett 19: 1368-1374, 2020
APA
Li, R., Wang, X., Zhao, X., Zhang, X., Chen, H., Ma, Y., & Liu, Y. (2020). Centromere protein F and Forkhead box M1 correlation with prognosis of non‑small cell lung cancer. Oncology Letters, 19, 1368-1374. https://doi.org/10.3892/ol.2019.11232
MLA
Li, R., Wang, X., Zhao, X., Zhang, X., Chen, H., Ma, Y., Liu, Y."Centromere protein F and Forkhead box M1 correlation with prognosis of non‑small cell lung cancer". Oncology Letters 19.2 (2020): 1368-1374.
Chicago
Li, R., Wang, X., Zhao, X., Zhang, X., Chen, H., Ma, Y., Liu, Y."Centromere protein F and Forkhead box M1 correlation with prognosis of non‑small cell lung cancer". Oncology Letters 19, no. 2 (2020): 1368-1374. https://doi.org/10.3892/ol.2019.11232