Open Access

Tracking the important role of JUNB in hepatocellular carcinoma by single‑cell sequencing analysis

  • Authors:
    • Peng Yan
    • Bin Zhou
    • Yingdong Ma
    • Ani Wang
    • Xiaojun Hu
    • Youli Luo
    • Yajun Yuan
    • Yajun Wei
    • Pengfei Pang
    • Junjie Mao
  • View Affiliations

  • Published online on: December 20, 2019     https://doi.org/10.3892/ol.2019.11235
  • Pages: 1478-1486
  • Copyright: © Yan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Hepatocellular carcinoma (HCC) is the most commonly diagnosed liver cancer, accounting for ~90% of all primary malignancy of the liver. Although various medical treatments have been used as systemic therapies, patient survival time may be extended by only a few months. Moreover, the underlying mechanisms of HCC development and progression remain poorly understood. In the present study, the single‑cell transcriptome of one in vivo HCC tumor sample, two in vitro HCC cell lines and normal peripheral blood mononuclear cells were analysed in order to identify the potential mechanism underlying the development and progression of HCC. Interestingly, JunB proto‑oncogene was identified to serve a role in the immune response and in development and progression of HCC, potentially contributing to the development of novel therapeutics for HCC patients.
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February-2020
Volume 19 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Yan P, Zhou B, Ma Y, Wang A, Hu X, Luo Y, Yuan Y, Wei Y, Pang P, Mao J, Mao J, et al: Tracking the important role of JUNB in hepatocellular carcinoma by single‑cell sequencing analysis. Oncol Lett 19: 1478-1486, 2020
APA
Yan, P., Zhou, B., Ma, Y., Wang, A., Hu, X., Luo, Y. ... Mao, J. (2020). Tracking the important role of JUNB in hepatocellular carcinoma by single‑cell sequencing analysis. Oncology Letters, 19, 1478-1486. https://doi.org/10.3892/ol.2019.11235
MLA
Yan, P., Zhou, B., Ma, Y., Wang, A., Hu, X., Luo, Y., Yuan, Y., Wei, Y., Pang, P., Mao, J."Tracking the important role of JUNB in hepatocellular carcinoma by single‑cell sequencing analysis". Oncology Letters 19.2 (2020): 1478-1486.
Chicago
Yan, P., Zhou, B., Ma, Y., Wang, A., Hu, X., Luo, Y., Yuan, Y., Wei, Y., Pang, P., Mao, J."Tracking the important role of JUNB in hepatocellular carcinoma by single‑cell sequencing analysis". Oncology Letters 19, no. 2 (2020): 1478-1486. https://doi.org/10.3892/ol.2019.11235