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Prediction of overall survival time in patients with colon adenocarcinoma using DNA methylation profiling of long non‑coding RNAs

  • Authors:
    • Qiongying Zhang
    • Zhuo Lin
    • Haiyan Zhang
    • Xiaodong Bao
    • Huxiang Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325015, P.R. China, Department of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325015, P.R. China, Department of Emergency, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325015, P.R. China, Department of Central Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325015, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1496-1504
    |
    Published online on: December 20, 2019
       https://doi.org/10.3892/ol.2019.11236
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Abstract

Long non‑coding RNAs (lncRNAs) are a subgroup of RNAs able to regulate gene expression at the epigenetic level, and are therefore central to the regulation of numerous biological processes and the progression of multiple cancer types. However, lncRNAs have not been identified to considerably influence overall survival (OS) outcome in numerous different types of cancer. The majority of studies investigating the association between lncRNAs and epigenetic regulation have focused on their altered expression levels in cancerous cells, and few studies have focused on determining the correlation between lncRNAs and OS time. In the present study, comprehensive lncRNA expression analysis was performed on a cohort of patients diagnosed with colon adenocarcinoma (COAD) using the least absolute shrinkage and selection operator method (LASSO). Subsequently, the construction of a prognostic methylation‑based predictive system was performed based on the results of LASSO analysis. Functional enrichment analysis of lncRNA co‑expression genes was also performed. According to the results of the present study, the classifier was able to significantly predict the prognosis of patients with COAD, and the investigation of the relevant elucidated genes further revealed the mechanism of COAD pathogenesis.
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1 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2013. CA Cancer J Clin. 63:11–30. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Robertson JH, Sarkar S, Yang SY, Seifalian AM and Winslet MC: In vivo models for early development of colorectal liver metastasis. Int J Exp Pathol. 89:1–12. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Alaiyan B, Ilyayev N, Stojadinovic A, Izadjoo M, Roistacher M, Pavlov V, Tzivin V, Halle D, Pan H, Trink B, et al: Differential expression of colon cancer associated transcript1 (CCAT1) along the colonic adenoma-carcinoma sequence. BMC Cancer. 13:1962013. View Article : Google Scholar : PubMed/NCBI

4 

Liu K, Yao H, Wen Y, Zhao H, Zhou N, Lei S and Xiong L: Functional role of a long non-coding RNA LIFR-AS1/miR-29a/TNFAIP3 axis in colorectal cancer resistance to pohotodynamic therapy. Biochim Biophys Acta Mol Basis Dis. 1864:2871–2880. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Olthof MR, Hollman PC and Katan MB: Chlorogenic acid and caffeic acid are absorbed in humans. J Nutr. 131:66–71. 2001. View Article : Google Scholar : PubMed/NCBI

6 

Hong J, Lu H, Meng X, Ryu JH, Hara Y and Yang CS: Stability, cellular uptake, biotransformation, and efflux of tea polyphenol (−)-epigallocatechin-3-gallate in HT-29 human colon adenocarcinoma cells. Cancer Res. 62:7241–7246. 2002.PubMed/NCBI

7 

Tsukuda K, Tanino M, Soga H, Shimizu N and Shimizu K: A novel activating mutation of the K-ras gene in human primary colon adenocarcinoma. Biochem Biophys Res Commun. 278:653–658. 2000. View Article : Google Scholar : PubMed/NCBI

8 

Yue B, Qiu S, Zhao S, Liu C, Zhang D, Yu F, Peng Z and Yan D: lncRNA-ATB mediated E-cadherin repression promotes the progression of colon cancer and predicts poor prognosis. J Gastroenterol Hepatol. 31:595–603. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Benson AB, Venook AP, Al-Hawary MM, Cederquist L, Chen YJ, Ciombor KK, Cohen S, Cooper HS, Deming D, Engstrom PF, et al: NCCN guidelines insights: Colon cancer, version 2.2018. J Natl Compr Canc Netw. 16:359–369. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Bernard D, Prasanth KV, Tripathi V, Colasse S, Nakamura T, Xuan Z, Zhang MQ, Sedel F, Jourdren L, Coulpier F, et al: A long nuclear-retained non-coding RNA regulates synaptogenesis by modulating gene expression. EMBO J. 29:3082–3093. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Ponting CP, Oliver PL and Reik W: Evolution and functions of long noncoding RNAs. Cell. 136:629–641. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Zhu P, Wang Y, Wu J, Huang G, Liu B, Ye B, Du Y, Gao G, Tian Y, He L and Fan Z: lncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells. Nat Commun. 7:136082016. View Article : Google Scholar : PubMed/NCBI

13 

Fatica A and Bozzoni I: Long non-coding RNAs: New players in cell differentiation and development. Nat Rev Genet. 15:7–21. 2014. View Article : Google Scholar : PubMed/NCBI

14 

He Y, Meng XM, Huang C, Wu BM, Zhang L, Lv XW and Li J: Long noncoding RNAs: Novel insights into hepatocelluar carcinoma. Cancer Lett. 44:20–27. 2013.

15 

Huang JL, Zheng L, Hu YW and Wang Q: Characteristics of long non-coding RNA and its relation to hepatocellular carcinoma. Carcinogenesis. 35:507–514. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Lee JT: Epigenetic regulation by long noncoding RNAs. Science. 338:1435–1439. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Timp W and Feinberg AP: Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host. Nat Rev Cancer. 13:497–510. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Wu D, Yang B, Chen J, Xiong H, Li Y, Pan Z, Cao Y, Chen J, Li T, Zhou S, et al: Upregulation of long non-coding RNA RAB1A-2 induces FGF1 expression worsening lung cancer prognosis. Cancer Lett. 438:116–125. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Smolle MA, Bullock MD, Ling H, Pichler M and Haybaeck J: Long non-coding RNAs in endometrial carcinoma. Int J Mol Sci. 16:26463–26472. 2013. View Article : Google Scholar

20 

Kim J, Piao HL, Kim BJ, Yao F, Han Z, Wang Y, Xiao Z, Siverly AN, Lawhon SE, Ton BN, et al: Long noncoding RNA MALAT1 suppresses breast cancer metastasis. Nat Genet. 50:1705–1715. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Huang Y, Xiang B, Liu Y, Wang Y and Kan H: lncRNA CDKN2B-AS1 promotes tumor growth and metastasis of human hepatocellular carcinoma by targeting let-7c-5p/NAP1L1 axis. Cancer Lett. 437:56–66. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Yao H, Duan M, Lin L, Wu C, Fu X, Wang H, Guo L, Chen W, Huang L, Liu D, et al: TET2 and MEG3 promoter methylation is associated with acute myeloid leukemia in a hainan population. Oncotarget. 8:18337–18347. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Dawson MA and Kouzarides T: Cancer epigenetics: From mechanism to therapy. Cell. 150:12–27. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Guo W, Dong Z, Shi Y, Liu S, Liang J, Guo Y, Guo X, Shen S and Shan B: Aberrant methylation-mediated downregulation of long noncoding RNA LOC100130476 correlates with malignant progression of esophageal squamous cell carcinoma. Dig Liver Dis. 48:961–969. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Ranstam J and Cook JA: LASSO regression. Br J Surg. 105:13482018. View Article : Google Scholar

26 

Kulis M and Esteller M: DNA methylation and cancer. Adv Genet. 70:27–56. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Adler P, Kolde R, Kull M, Tkachenko A, Peterson H, Reimand J and Vilo J: Mining for coexpression across hundreds of datasets using novel rank aggregation and visualization methods. Genome Biol. 2009:R1392009. View Article : Google Scholar

28 

Xue W, Li J, Wang F, Han P, Liu Y and Cui B: A long non-coding RNA expression signature to predict survival of patients with colon adenocarcinoma. Oncotarget. 8:101298–101308. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Wang WJ, Li HT, Yu JP, Han XP, Xu ZP, Li YM, Jiao ZY and Liu HB: A competing endogenous RNA network reveals novel potential lncRNA, miRNA, and mRNA biomarkers in the prognosis of human colon adenocarcinoma. J Surg Res. 235:22–33. 2019. View Article : Google Scholar : PubMed/NCBI

30 

Wang JY, Wang CL, Wang XM and Liu FJ: Comprehensive analysis of microRNA/mRNA signature in colon adenocarcinoma. Eur Rev Med Pharmacol Sci. 21:2114–2129. 2017.PubMed/NCBI

31 

Chen F, Li Z and Zhou H: Identification of prognostic miRNA biomarkers for predicting overall survival of colonadenocarcinoma and bioinformatics analysis: A study based on the cancer genome atlas database. J Cell Biochem. 120:9839–9849. 2019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang Q, Lin Z, Zhang H, Bao X and Zhang H: Prediction of overall survival time in patients with colon adenocarcinoma using DNA methylation profiling of long non‑coding RNAs. Oncol Lett 19: 1496-1504, 2020.
APA
Zhang, Q., Lin, Z., Zhang, H., Bao, X., & Zhang, H. (2020). Prediction of overall survival time in patients with colon adenocarcinoma using DNA methylation profiling of long non‑coding RNAs. Oncology Letters, 19, 1496-1504. https://doi.org/10.3892/ol.2019.11236
MLA
Zhang, Q., Lin, Z., Zhang, H., Bao, X., Zhang, H."Prediction of overall survival time in patients with colon adenocarcinoma using DNA methylation profiling of long non‑coding RNAs". Oncology Letters 19.2 (2020): 1496-1504.
Chicago
Zhang, Q., Lin, Z., Zhang, H., Bao, X., Zhang, H."Prediction of overall survival time in patients with colon adenocarcinoma using DNA methylation profiling of long non‑coding RNAs". Oncology Letters 19, no. 2 (2020): 1496-1504. https://doi.org/10.3892/ol.2019.11236
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Q, Lin Z, Zhang H, Bao X and Zhang H: Prediction of overall survival time in patients with colon adenocarcinoma using DNA methylation profiling of long non‑coding RNAs. Oncol Lett 19: 1496-1504, 2020.
APA
Zhang, Q., Lin, Z., Zhang, H., Bao, X., & Zhang, H. (2020). Prediction of overall survival time in patients with colon adenocarcinoma using DNA methylation profiling of long non‑coding RNAs. Oncology Letters, 19, 1496-1504. https://doi.org/10.3892/ol.2019.11236
MLA
Zhang, Q., Lin, Z., Zhang, H., Bao, X., Zhang, H."Prediction of overall survival time in patients with colon adenocarcinoma using DNA methylation profiling of long non‑coding RNAs". Oncology Letters 19.2 (2020): 1496-1504.
Chicago
Zhang, Q., Lin, Z., Zhang, H., Bao, X., Zhang, H."Prediction of overall survival time in patients with colon adenocarcinoma using DNA methylation profiling of long non‑coding RNAs". Oncology Letters 19, no. 2 (2020): 1496-1504. https://doi.org/10.3892/ol.2019.11236
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