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A natural compound obtained from Valeriana jatamansi selectively inhibits glioma stem cells

  • Authors:
    • Shi‑Gang Qi
    • Li‑Qiu Quan
    • Xiao‑Yue Cui
    • Hong‑Mei Li
    • Xu‑Dong Zhao
    • Rong‑Tao Li
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, P.R. China, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650500, P.R. China
    Copyright: © Qi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1384-1392
    |
    Published online on: December 23, 2019
       https://doi.org/10.3892/ol.2019.11239
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Abstract

Glioblastoma is one of the most malignant tumors with very poor prognosis. Glioma stem cells (GSCs) occupy a small proportion in glioma, but they are closely associated with radiotherapy and chemotherapy resistance, promoting tumor angiogenesis, hypoxia response, invasion and recurrence. Therefore, GSCs have become a new target for tumor treatment and are used in drug screening. Rupesin E is a natural compound obtained from Valeriana jatamansi, and its antitumor activity has not been reported. In the present study, the antitumor activity of rupesin E was investigated, and the results demonstrated that it inhibited the proliferation of GSCs (GSC‑3#, GSC‑12#, GSC‑18#) with the IC50 values of 7.13±1.41, 13.51±1.46 and 4.44±0.22 µg/ml, respectively. In addition, immunofluorescence cell staining and flow cytometry techniques demonstrated that rupesin E inhibited GSC proliferation and induced apoptosis. Furthermore, rupesin E inhibited the ability of GSC colony formation, indicating its antitumor activity against GSCs in vitro.
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Copy and paste a formatted citation
Spandidos Publications style
Qi SG, Quan LQ, Cui XY, Li HM, Zhao XD and Li RT: A natural compound obtained from Valeriana jatamansi selectively inhibits glioma stem cells. Oncol Lett 19: 1384-1392, 2020.
APA
Qi, S., Quan, L., Cui, X., Li, H., Zhao, X., & Li, R. (2020). A natural compound obtained from Valeriana jatamansi selectively inhibits glioma stem cells. Oncology Letters, 19, 1384-1392. https://doi.org/10.3892/ol.2019.11239
MLA
Qi, S., Quan, L., Cui, X., Li, H., Zhao, X., Li, R."A natural compound obtained from Valeriana jatamansi selectively inhibits glioma stem cells". Oncology Letters 19.2 (2020): 1384-1392.
Chicago
Qi, S., Quan, L., Cui, X., Li, H., Zhao, X., Li, R."A natural compound obtained from Valeriana jatamansi selectively inhibits glioma stem cells". Oncology Letters 19, no. 2 (2020): 1384-1392. https://doi.org/10.3892/ol.2019.11239
Copy and paste a formatted citation
x
Spandidos Publications style
Qi SG, Quan LQ, Cui XY, Li HM, Zhao XD and Li RT: A natural compound obtained from Valeriana jatamansi selectively inhibits glioma stem cells. Oncol Lett 19: 1384-1392, 2020.
APA
Qi, S., Quan, L., Cui, X., Li, H., Zhao, X., & Li, R. (2020). A natural compound obtained from Valeriana jatamansi selectively inhibits glioma stem cells. Oncology Letters, 19, 1384-1392. https://doi.org/10.3892/ol.2019.11239
MLA
Qi, S., Quan, L., Cui, X., Li, H., Zhao, X., Li, R."A natural compound obtained from Valeriana jatamansi selectively inhibits glioma stem cells". Oncology Letters 19.2 (2020): 1384-1392.
Chicago
Qi, S., Quan, L., Cui, X., Li, H., Zhao, X., Li, R."A natural compound obtained from Valeriana jatamansi selectively inhibits glioma stem cells". Oncology Letters 19, no. 2 (2020): 1384-1392. https://doi.org/10.3892/ol.2019.11239
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