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Article Open Access

Upregulation of contactin‑1 expression promotes prostate cancer progression

  • Authors:
    • Boren Wang
    • Xi Yang
    • Ting Zhao
    • Hanghang Du
    • Tong Wang
    • Suping Zhong
    • Bo Yang
    • Hui Li
  • View Affiliations / Copyright

    Affiliations: Medical School of Jishou University, Jishou, Hunan 416000, P.R. China, Department of Pathology, First Affiliated Hospital of Jishou University, Jishou, Hunan 416000, P.R. China, Department of Microbiology and Immunology, Medical School of Jishou University, Jishou, Hunan 416000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1611-1618
    |
    Published online on: December 23, 2019
       https://doi.org/10.3892/ol.2019.11244
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Abstract

Contactin‑1 (CNTN‑1) has been reported to serve an oncogenic role in several cancer types. However, detailed mechanisms describing the influence of CNTN‑1 in prostate cancer progression have not yet been elucidated. The present study aimed to determine the clinical significance of CNTN‑1 expression in prostate cancer progression, and also to investigate the regulatory role of CNTN‑1 in the proliferation, migration and invasive ability of prostate cancer cells. The results of the present study indicated that expression levels of CNTN‑1 were significantly higher in prostate cancer tissues compared with adjacent normal tissues. Moreover, a high expression level of CNTN‑1 was positively correlated with tumor size, stage and metastasis, as well as a poorer prognosis in patients with prostate cancer. Furthermore, CNTN‑1‑knockdown in prostate cancer cells (using short hairpin RNA) resulted in the significant inhibition of cancer cell proliferation, colony formation, migration and invasiveness. Silencing of CNTN‑1 expression also suppressed epithelial‑mesenchymal transition in prostate cancer cells via the upregulation of E‑cadherin, and the downregulation of N‑cadherin and vimentin expression. Inhibition of CNTN‑1 expression also reduced the activity of the PI3K/AKT signaling pathway in prostate cancer cells. Thus, it was demonstrated that CNTN‑1 expression is upregulated, and plays an oncogenic role, in prostate cancer cells. The results of the current study suggest that CNTN‑1 may represent a promising therapeutic target, potentially improving the treatment of patients with prostate cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Wang B, Yang X, Zhao T, Du H, Wang T, Zhong S, Yang B and Li H: Upregulation of contactin‑1 expression promotes prostate cancer progression. Oncol Lett 19: 1611-1618, 2020.
APA
Wang, B., Yang, X., Zhao, T., Du, H., Wang, T., Zhong, S. ... Li, H. (2020). Upregulation of contactin‑1 expression promotes prostate cancer progression. Oncology Letters, 19, 1611-1618. https://doi.org/10.3892/ol.2019.11244
MLA
Wang, B., Yang, X., Zhao, T., Du, H., Wang, T., Zhong, S., Yang, B., Li, H."Upregulation of contactin‑1 expression promotes prostate cancer progression". Oncology Letters 19.2 (2020): 1611-1618.
Chicago
Wang, B., Yang, X., Zhao, T., Du, H., Wang, T., Zhong, S., Yang, B., Li, H."Upregulation of contactin‑1 expression promotes prostate cancer progression". Oncology Letters 19, no. 2 (2020): 1611-1618. https://doi.org/10.3892/ol.2019.11244
Copy and paste a formatted citation
x
Spandidos Publications style
Wang B, Yang X, Zhao T, Du H, Wang T, Zhong S, Yang B and Li H: Upregulation of contactin‑1 expression promotes prostate cancer progression. Oncol Lett 19: 1611-1618, 2020.
APA
Wang, B., Yang, X., Zhao, T., Du, H., Wang, T., Zhong, S. ... Li, H. (2020). Upregulation of contactin‑1 expression promotes prostate cancer progression. Oncology Letters, 19, 1611-1618. https://doi.org/10.3892/ol.2019.11244
MLA
Wang, B., Yang, X., Zhao, T., Du, H., Wang, T., Zhong, S., Yang, B., Li, H."Upregulation of contactin‑1 expression promotes prostate cancer progression". Oncology Letters 19.2 (2020): 1611-1618.
Chicago
Wang, B., Yang, X., Zhao, T., Du, H., Wang, T., Zhong, S., Yang, B., Li, H."Upregulation of contactin‑1 expression promotes prostate cancer progression". Oncology Letters 19, no. 2 (2020): 1611-1618. https://doi.org/10.3892/ol.2019.11244
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