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Article

Changes of serum miR-223-3p in patients with oral cancer treated with TPF regimen and the prognosis

  • Authors:
    • Chunru Li
    • Yao Feng
    • Weiran Shao
  • View Affiliations / Copyright

    Affiliations: Department of Endodontics, Affiliated Stomatological Hospital of Jiamusi University, Jiamusi, Heilongjiang 154002, P.R. China, Department of Emergency, Affiliated Stomatological Hospital of Jiamusi University, Jiamusi, Heilongjiang 154002, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2527-2532
    |
    Published online on: January 24, 2020
       https://doi.org/10.3892/ol.2020.11258
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Abstract

Changes of serum miR-223-3p in patients with oral cancer treated with TPF regimen and the prognosis were investigated. Fifty patients with oral cancer treated in the Affiliated Stomatological Hospital of Jiamusi University from March 2014 to January 2016 were enrolled in the study group, while 50 healthy subjects receiving physical examinations during the same period were enrolled in the control group. Serum expression of miR-223-3p was quantified by RT-qPCR. The diagnostic value of miR‑223-3p in oral cancer was analyzed by the receiver operating characteristic (ROC) curve. Expression of miR-223-3p before and after treatment was compared. The study group was divided into the remission and the non‑remission group based on the treatment outcome to analyze the predictive value of miR-223-3p. Patients were followed up for 3 years. Cox regression analysis was performed to analyze the independent prognostic factors. The relative serum miR‑223-3p level was lower in the study than in the control group (P<0.001). Expression of miR-223-3p was significantly higher after treatment than before (P<0.05). Spearman's correlation analysis indicated that miR‑223-3p expression before treatment gradually increased with the improvement of treatment outcome (r=0.617, P<0.001). The miR-223-3p level was markedly higher in the remission than in the non-remission group (P<0.05). The area under the ROC curve of miR-223-3p was 0.797. Multivariate Cox regression analysis demonstrated that the degree of differentiation [HR: 11.862 (95% CI: 2.730-51.547)] and miR-223-3p [HR: 3.489 (95% CI: 1.447-8.413)] were independent prognostic factors. The 3-year survival of patients with high differentiation and high miR-223-3p expression was significantly higher than that of patients with poor differentiation and low miR‑223-3p expression (P<0.05). In conclusion, miR-223-3p expression is low in oral cancer, and it shows potential for predicting the efficacy and prognosis of patients with oral squamous cell carcinoma (OSCC) after TPF regimen.
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1 

Chi AC, Day TA and Neville BW: Oral cavity and oropharyngeal squamous cell carcinoma - an update. CA Cancer J Clin. 65:401–421. 2015.PubMed/NCBI

2 

Li L, Li C, Wang S, Wang Z, Jiang J, Wang W, Li X, Chen J, Liu K, Li C, et al: Exosomes derived from hypoxic oral squamous cell carcinoma cells deliver miR-21 to normoxic cells to elicit a prometastatic phenotype. Cancer Res. 76:1770–1780. 2016.PubMed/NCBI

3 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015.PubMed/NCBI

4 

Tseng WT, Chiang WF, Liu SY, Roan J and Lin CN: The application of data mining techniques to oral cancer prognosis. J Med Syst. 39:592015.PubMed/NCBI

5 

Adami GR, Tang JL and Markiewicz MR: Improving accuracy of RNA-based diagnosis and prognosis of oral cancer by using noninvasive methods. Oral Oncol. 69:62–67. 2017.PubMed/NCBI

6 

Sharma A, Agarwal K, Agarwal S, Kumar S and Bharti AC: 354P-Study of immunohistochemical expression of VEGF and its association with HPV E6 and E7 oncoproteins in oral and oropharyngeal squamous cell carcinoma. Ann Oncol. 28:100–110. 2017.

7 

Smits RW, Koljenović S, Hardillo JA, Ten Hove I, Meeuwis CA, Sewnaik A, Dronkers EA, Bakker Schut TC, Langeveld TP, Molenaar J, et al: Resection margins in oral cancer surgery: Room for improvement. Head Neck. 38:2197–2203. 2016.

8 

Zhong LP, Ma H, Ju W and Zhang ZY: Relationship of low stathmin expression and benefit from TPF induction chemotherapy and its role in chemoresistance via mutant p53 in oral cancer. J Clin Oncol. 36:e180342018.

9 

Zhong LP, Zhang CP, Ren GX, Guo W, William WN Jr, Hong CS, Sun J, Zhu HG, Tu WY, Li J, et al: Long-term results of a randomized phase III trial of TPF induction chemotherapy followed by surgery and radiation in locally advanced oral squamous cell carcinoma. Oncotarget. 6:18707–18714. 2015.PubMed/NCBI

10 

Shi J, Bao X, Liu Z, Zhang Z, Chen W and Xu Q: Serum miR-626 and miR-5100 are promising prognosis predictors for oral squamous cell carcinoma. Theranostics. 9:920–931. 2019.PubMed/NCBI

11 

Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert BL, Mak RH, Ferrando AA, et al: MicroRNA expression profiles classify human cancers. Nature. 435:834–838. 2005.PubMed/NCBI

12 

Kasinski AL, Kelnar K, Stahlhut C, Orellana E, Zhao J, Shimer E, Dysart S, Chen X, Bader AG and Slack FJ: A combinatorial microRNA therapeutics approach to suppressing non-small cell lung cancer. Oncogene. 34:3547–3555. 2015.PubMed/NCBI

13 

Callegari E, Gramantieri L, Domenicali M, D'Abundo L, Sabbioni S and Negrini M: MicroRNAs in liver cancer: A model for investigating pathogenesis and novel therapeutic approaches. Cell Death Differ. 22:46–57. 2015.PubMed/NCBI

14 

Hannafon BN, Trigoso YD, Calloway CL, Zhao YD, Lum DH, Welm AL, Zhao ZJ, Blick KE, Dooley WC and Ding WQ: Plasma exosome microRNAs are indicative of breast cancer. Breast Cancer Res. 18:902016.PubMed/NCBI

15 

Zeljic K, Jovanovic I, Jovanovic J, Magic Z, Stankovic A and Supic G: MicroRNA meta-signature of oral cancer: Evidence from a meta-analysis. Ups J Med Sci. 123:43–49. 2018.PubMed/NCBI

16 

Tachibana H, Sho R, Takeda Y, Zhang X, Yoshida Y, Narimatsu H, Otani K, Ishikawa S, Fukao A, Asao H, et al: Circulating miR-223 in oral cancer: Its potential as a novel diagnostic biomarker and therapeutic target. PLoS One. 11:e01596932016.PubMed/NCBI

17 

Soga D, Yoshiba S, Shiogama S, Miyazaki H, Kondo S and Shintani S: microRNA expression profiles in oral squamous cell carcinoma. Oncol Rep. 30:579–583. 2013.PubMed/NCBI

18 

Kukreja P, Parekh D and Roy P: Practical challenges in measurement of depth of invasion in oral squamous cell carcinoma: Pictographical documentation to improve consistency of reporting per the AJCC 8th edition recommendations. Head Neck Pathol. 2019.doi: 10.1007/s12105-019-01047-9. PubMed/NCBI

19 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCq method. Methods. 25:402–408. 2001.PubMed/NCBI

20 

Necchi A, Lo Vullo S, Perrone F, Raggi D, Giannatempo P, Calareso G, Nicolai N, Piva L, Biasoni D, Catanzaro M, et al: First-line therapy with dacomitinib, an orally available pan-HER tyrosine kinase inhibitor, for locally advanced or metastatic penile squamous cell carcinoma: Results of an open-label, single-arm, single-centre, phase 2 study. BJU Int. 121:348–356. 2018.PubMed/NCBI

21 

Hosmer DW Jr, Lemeshow S and Sturdivant RX: Applied Logistic Regression. (3rd). John Wiley & Sons. (Hoboken, NJ). 173–182. 2013.

22 

Yu CC, Hu FW, Yu CH and Chou MY: Targeting CD133 in the enhancement of chemosensitivity in oral squamous cell carcinoma-derived side population cancer stem cells. Head Neck. 38:E231–E238. 2016.PubMed/NCBI

23 

Acunzo M, Romano G, Wernicke D and Croce CM: MicroRNA and cancer - a brief overview. Adv Biol Regul. 57:1–9. 2015.PubMed/NCBI

24 

Bhattacharya S, Steele R, Shrivastava S, Chakraborty S, Di Bisceglie AM and Ray RB: Serum miR-30e and miR-223 as novel noninvasive biomarkers for hepatocellular carcinoma. Am J Pathol. 186:242–247. 2016.PubMed/NCBI

25 

Lu W, Hu Y, Ma Q, Zhou L, Jiang L, Li Z, Zhao S, Xu Y, Shi W, Li S, et al: miR-223 increases gallbladder cancer cell sensitivity to docetaxel by downregulating STMN1. Oncotarget. 7:62364–62376. 2016.PubMed/NCBI

26 

Ding Q, Shen L, Nie X, Lu B, Pan X, Su Z, Yan A, Yan R, Zhou Y, Li L, et al: MiR-223-3p overexpression inhibits cell proliferation and migration by regulating inflammation-associated cytokines in glioblastomas. Pathol Res Pract. 214:1330–1339. 2018.PubMed/NCBI

27 

Bozec A, Zangari J, Butori-Pepino M, Ilie M, Lalvee S, Juhel T, Butori C, Brest P, Hofman P and Vouret-Craviari V: MiR-223-3p inhibits angiogenesis and promotes resistance to cetuximab in head and neck squamous cell carcinoma. Oncotarget. 8:57174–57186. 2017.PubMed/NCBI

28 

Zhou X, Jin W, Jia H, Yan J and Zhang G: MiR-223 promotes the cisplatin resistance of human gastric cancer cells via regulating cell cycle by targeting FBXW7. J Exp Clin Cancer Res. 34:282015.PubMed/NCBI

29 

Ramos-García P, Bravo M, González-Ruiz L and González-Moles MÁ: Significance of cytoplasmic cyclin D1 expression in oral oncogenesis. Oral Dis. 24:98–102. 2018.PubMed/NCBI

30 

Chen TC, Wu CT, Wang CP, Hsu WL, Yang TL, Lou PJ, Ko JY and Chang YL: Associations among pretreatment tumor necrosis and the expression of HIF-1α and PD-L1 in advanced oral squamous cell carcinoma and the prognostic impact thereof. Oral Oncol. 51:1004–1010. 2015.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li C, Feng Y and Shao W: Changes of serum miR-223-3p in patients with oral cancer treated with TPF regimen and the prognosis. Oncol Lett 19: 2527-2532, 2020.
APA
Li, C., Feng, Y., & Shao, W. (2020). Changes of serum miR-223-3p in patients with oral cancer treated with TPF regimen and the prognosis. Oncology Letters, 19, 2527-2532. https://doi.org/10.3892/ol.2020.11258
MLA
Li, C., Feng, Y., Shao, W."Changes of serum miR-223-3p in patients with oral cancer treated with TPF regimen and the prognosis". Oncology Letters 19.3 (2020): 2527-2532.
Chicago
Li, C., Feng, Y., Shao, W."Changes of serum miR-223-3p in patients with oral cancer treated with TPF regimen and the prognosis". Oncology Letters 19, no. 3 (2020): 2527-2532. https://doi.org/10.3892/ol.2020.11258
Copy and paste a formatted citation
x
Spandidos Publications style
Li C, Feng Y and Shao W: Changes of serum miR-223-3p in patients with oral cancer treated with TPF regimen and the prognosis. Oncol Lett 19: 2527-2532, 2020.
APA
Li, C., Feng, Y., & Shao, W. (2020). Changes of serum miR-223-3p in patients with oral cancer treated with TPF regimen and the prognosis. Oncology Letters, 19, 2527-2532. https://doi.org/10.3892/ol.2020.11258
MLA
Li, C., Feng, Y., Shao, W."Changes of serum miR-223-3p in patients with oral cancer treated with TPF regimen and the prognosis". Oncology Letters 19.3 (2020): 2527-2532.
Chicago
Li, C., Feng, Y., Shao, W."Changes of serum miR-223-3p in patients with oral cancer treated with TPF regimen and the prognosis". Oncology Letters 19, no. 3 (2020): 2527-2532. https://doi.org/10.3892/ol.2020.11258
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