Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
March-2020 Volume 19 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2020 Volume 19 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Expression of ADAM29 and FAM135B in the pathological evolution from normal esophageal epithelium to esophageal cancer: Their differences and clinical significance

  • Authors:
    • Tingting Wang
    • Xiaoyan Lv
    • Shen Jiang
    • Shaorong Han
    • Yanming Wang
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, PLA 960th Hospital, Jinan, Shandong 250031, P.R. China, Department of Emergency Internal Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 201203, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1727-1734
    |
    Published online on: January 9, 2020
       https://doi.org/10.3892/ol.2020.11272
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

A Disintegrin And Metalloprotease Domain 29 (ADAM29) and Family with sequence similarity 135 member B (FAM135B) genes have been reported to be associated with a carcinogenic risk of esophageal squamous cell carcinoma (ESCC). However, to the best of our knowledge, the expression of ADAM29 and FAM135B in the pathological evolution from normal esophageal epithelial cells to ESCC has not yet been investigated. The present study aimed to investigate the expression of ADAM29 and FAM135B in normal esophageal mucosal epithelium, low‑grade and high‑grade esophageal intraepithelial neoplasia, and ESCC. Furthermore, the present study aimed to investigate the role of ADAM29 and FAM135B in the development of esophageal lesions. Immunohistochemistry was performed in order to detect the expression levels of ADAM29 and FAM135B proteins in normal esophageal mucosa samples (40 cases), low‑grade intraepithelial neoplasia samples (20 cases), high‑grade intraepithelial neoplasia samples (20 cases) and ESCC samples (40 cases). The results of the present study demonstrated that the positive rates of ADAM29 and FAM135B proteins increased gradually from normal esophageal mucosal epithelium and esophageal intraepithelial neoplasia, to ESCC (P<0.05). Furthermore, the expression levels of ADAM29 and FAM135B proteins in ESCC were not associated with age and the tumor size (P>0.05); however, the protein levels were associated with the pathological stage, clinical stage and lymph node metastasis of ESCC (P<0.05). In addition, there was a significant association between the expression levels of ADAM29 protein and FAM135B protein (χ2=60.071; P<0.001). The results of the present study demonstrated that the expression levels of ADAM29 and FAM135B were associated with the tumor behavior characteristics and the progression of esophageal cancer, the expression of which could be used for the diagnosis of early esophageal cancer, and provide the basis for guiding individualized treatment.
View Figures

Figure 1

Figure 2

View References

1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018 GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Wei KR, Lian QH, Liu J and Liang ZH: Prevalence of esophageal cancer. Chin J Int Med. 51:156–158. 2012.(In Chinese).

3 

Malhotra GK, Yanala U, Ravipati A, Follet M, Vijayakumar M and Are C: Global trends in esophageal cancer. J Surg Oncol. 115:564–579. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Zhang Y: Epidemiology of esophageal cancer. World J Gastroenterol. 19:5598–5606. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Zhou MG, Wang XF, Hu JP, Li GL, Chen WQ, Zhang SW, Wan X, Wang LJ, Xiang C, Hu YS and Yang GH: Geographical distribution of cancer mortality in China, 2004–2005. Zhonghua Yu Fang Yi Xue Za Zhi. 44:303–308. 2010.(In Chinese). PubMed/NCBI

7 

Li QW, Yuan GJ, Du YX, Pan CN and He Y: Analysis of the prevalence and treatment of esophageal cancer in huai an area. J Clin Oncol. 17:142–145. 2012.

8 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2012. CA Cancer J Clin. 62:10–29. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Wang GQ, Jiao GG, Chang FB, Fang WH, Song JX, Lu N, Lin DM, Xie YQ and Yang L: Long-term results of operation for 420 patients with early squamous cell esophageal carcinoma discovered by screening. Ann Thorac Surg. 77:1740–1744. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Aminian A, Panahi N, Mirsharifi R, Karimian F, Meysamie A, Khorgami Z and Alibakhshi A: Predictors and outcome of cervical anastomotic leakage after esophageal cancer surgery. J Cancer Res Ther. 7:448–453. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Wang GQ, Zhang YM and He S: Present situation and prospect of diagnosis and treatment of early esophageal cancer and precancerous lesions in China. Chin Cancer. 18:690–694. 2009.(In Chinese).

12 

Siewert JR and Ott K: Are squamous and adenocarcinomas of the esophagus the same disease. Semin Radiat Oncol. 17:38–44. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Hao J and Shao K: Epidemiological status, diagnosis and treatment of esophageal cancer in China and China's future countermeasures. Chin J Cancer. 501–504. 2011.(In Chinese).

14 

Song Y, Li L, Ou Y, Gao Z, Li E, Li X, Zhang W, Wang J, Xu L, Zhou Y, et al: Identification of genomic alterations in oesophageal squamous cell cancer. Nature. 509:91–95. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Cerretti DP, DuBose RF, Black RA and Nelson N: Isolation of two novel metalloproteinase-disintegrin (ADAM) cDNAs that show testis-specific gene expression. Biochem Biophys Res Commun. 263:810–815. 1999. View Article : Google Scholar : PubMed/NCBI

16 

Edwards DR, Handsley MM and Pennington CJ: The ADAM metalloproteinases. Mol Aspects Med. 29:258–289. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Wang F, Xu R, Zhu P, Hu J, Ying B, Zhao S and Li C: Preliminarily functional analysis of a cloned novel human gene ADAM29. Sci China C Life Sci. 44:392–399. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Oria VO, Lopatta P, Schmitz T, Preca BT, Nyström A, Conrad C, Bartsch JW, Kulemann B, Hoeppner J, Maurer J, et al: ADAM9 contributes to vascular invasion in pancreatic ductal adenocarcinoma. Mol Oncol. 13:456–479. 2019. View Article : Google Scholar : PubMed/NCBI

19 

Luo ML, Zhou Z, Sun LC, Sun L, Yu L, Sun L, Liu J, Yang Z, Ran Y, Yao Y and Hu H: An ADAM12 and FAK positive feedback loop amplifies the interaction signal of tumor cells with extracellular matrix to promote esophageal cancer metastasis. Cancer Lett. 422:118–128. 2018. View Article : Google Scholar : PubMed/NCBI

20 

Li W, Wang D, Sun X, Zhang Y, Wang L and Suo J: ADAM17 promotes lymph node metastasis in gastric cancer via activation of the Notch and Wnt signaling pathways. Int J Mol Med. 43:914–926. 2019.PubMed/NCBI

21 

Mochizuki S and Okada Y: ADAMs in cancer cell proliferation and progression. Cancer Sci. 98:621–628. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Zhang B, Li Y, Li L, Chen M, Zhang C, Zuo XB, Zhou FS, Liang B, Zhu J, Li P, et al: Association study of susceptibility loci with specific breast cancer subtypes in Chinese women. Breast Cancer Res Treat. 146:503–514. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Shan Q, Lou X, Xiao T, Zhang J, Sun H, Gao Y, Cheng S, Wu L, Xu N and Liu S: A cancer/testis antigen microarray to screen autoantibody biomarkers of non-small cell lung cancer. Cancer Lett. 328:160–167. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Costa NR, Paulo P, Caffrey T, Hollingsworth MA and Santos-Silva F: Impact of MUC1 mucin down regulation in the phenotypic characteristics of MKN45 gastric carcinoma cell line. PLoS One. 6:e269702011. View Article : Google Scholar : PubMed/NCBI

25 

Brim H, Abu-Asab MS, Nouraie M, Salazar J, Deleo J, Razjouyan H, Mokarram P, Schaffer AA, Naghibhossaini F and Ashktorab H: An integrative CGH, MSI and candidate genes methylation analysis of colorectal tumors. PLoS One. 9:e821852014. View Article : Google Scholar : PubMed/NCBI

26 

Wei X, Moncada-Pazos A, Cal S, Soria-Valles C, Gartner J, Rudloff U, Lin JC; NISC Comparative Sequencing Program, ; Rosenberg SA, López-Otín C and Samuels Y: Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma. Hum Mutat. 32:E2148–E2175. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Oki NO, Motsinger-Reif AA, Antas PR, Levy S, Holland SM and Sterling TR: Novel human genetic variants associated with extrapulmonary tuberculosis A pilot genome wide association study. BMC Res Notes. 4:282011. View Article : Google Scholar : PubMed/NCBI

28 

Zhou C, Ye M, Ni S, Li Q, Ye D, Li J, Shen Z and Deng H: DNA methylation biomarkers for head and neck squamous cell carcinoma. Epigenetics. 13:398–409. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Rice TW: Esophageal cancer staging. Korean J Thorac Cardiovasc Surg. 48:157–163. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Rice TW, Rusch VW, Ishwaran H and Blackstone EH; Worldwide Esophageal Cancer Collaboration, : Cancer of the esophagus and esophagogastric junction Data-driven staging for the seventh edition of the American joint committee on cancer/international union against cancer staging manuals. Cancer. 116:3763–3773. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Edge SB, Byrd DR, Compton CC, et al: AJCC cancer staging manual. 7th. Springer; New York, NY: 2010

32 

Zhou ZJ, Xie JL, Wei P and Zhou XG: Pathologic subtyping of primary lymphoma of breast and prognostic analysis. Zhonghua Bing Li Xue Za Zhi. 46:618–622. 2017.(In Chinese; Abstract available in Chinese from the publisher). PubMed/NCBI

33 

Seals DF and Courtneidge SA: The ADAMs family of metalloproteases: Multidomain proteins with multiple functions. Genes Dev. 17:7–30. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Rocks N, Paulissen G, El Hour M, Quesada F, Crahay C, Gueders M, Foidart JM, Noel A and Cataldo D: Emerging roles of ADAM and ADAMTS metalloproteinases in cancer. Biochimie. 90:369–379. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Noël A, Gutiérrez-Fernández A, Sounni NE, Behrendt N, Maquoi E, Lund IK, Cal S, Hoyer-Hansen G and López-Otín C: New and paradoxical roles of matrix metalloproteinases in the tumor microenvironment. Front Pharmacol. 3:1402012. View Article : Google Scholar : PubMed/NCBI

36 

Lu X, Lu D, Scully M and Kakkar V: ADAM proteins-therapeutic potential in cancer. Curr Cancer Drug Targets. 8:720–732. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Murphy G: The ADAMs Signalling scissors in the tumour microenvironment. Nat Rev Cancer. 8:929–941. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Maloum K, Settegrana C, Chapiro E, Cazin B, Leprêtre S, Delmer A, Leporrier M, Dreyfus B, Tournilhac O, Mahe B, et al: IGHV gene mutational status and LPL/ADAM29 gene expression as clinical outcome predictors in CLL patients in remission following treatment with oral fludarabine plus cyclophosphamide. Ann Hematol. 88:1215–1221. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Quilter CR, Sargent CA, Bauer J, Bagga MR, Reiter CP, Hutchinson EL, Southwood OI, Evans G, Mileham A, Griffin DK and Affara NA: An association and haplotype analysis of porcine maternal infanticide A model for human puerperal psychosis. Am J Med Genet B Neuropsychiatr Genet. 159:908–927. 2012. View Article : Google Scholar

40 

Tsang KM, Croen LA, Torres AR, Kharrazi M, Delorenze GN, Windham GC, Yoshida CK, Zerbo O and Weiss LA: A genome-wide survey of transgenerational genetic effects in autism. PLoS One. 8:e769782013. View Article : Google Scholar : PubMed/NCBI

41 

Lin JQ, Huang ZJ, Chen ZR, et al: Relationship between FAM135B gene and lymph node metastasis of esophageal squamous cell carcinoma. Chin J Exp Surg. 6:1170–1171. 2018.(In Chinese).

42 

Dong DZ: The Function and Mechanism of FAM135B in the Deveopment of esophageal squamous cell carcinoma (unpublished PhD thesis). Peking Union Medical College; 2018

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang T, Lv X, Jiang S, Han S and Wang Y: Expression of ADAM29 and FAM135B in the pathological evolution from normal esophageal epithelium to esophageal cancer: Their differences and clinical significance. Oncol Lett 19: 1727-1734, 2020.
APA
Wang, T., Lv, X., Jiang, S., Han, S., & Wang, Y. (2020). Expression of ADAM29 and FAM135B in the pathological evolution from normal esophageal epithelium to esophageal cancer: Their differences and clinical significance. Oncology Letters, 19, 1727-1734. https://doi.org/10.3892/ol.2020.11272
MLA
Wang, T., Lv, X., Jiang, S., Han, S., Wang, Y."Expression of ADAM29 and FAM135B in the pathological evolution from normal esophageal epithelium to esophageal cancer: Their differences and clinical significance". Oncology Letters 19.3 (2020): 1727-1734.
Chicago
Wang, T., Lv, X., Jiang, S., Han, S., Wang, Y."Expression of ADAM29 and FAM135B in the pathological evolution from normal esophageal epithelium to esophageal cancer: Their differences and clinical significance". Oncology Letters 19, no. 3 (2020): 1727-1734. https://doi.org/10.3892/ol.2020.11272
Copy and paste a formatted citation
x
Spandidos Publications style
Wang T, Lv X, Jiang S, Han S and Wang Y: Expression of ADAM29 and FAM135B in the pathological evolution from normal esophageal epithelium to esophageal cancer: Their differences and clinical significance. Oncol Lett 19: 1727-1734, 2020.
APA
Wang, T., Lv, X., Jiang, S., Han, S., & Wang, Y. (2020). Expression of ADAM29 and FAM135B in the pathological evolution from normal esophageal epithelium to esophageal cancer: Their differences and clinical significance. Oncology Letters, 19, 1727-1734. https://doi.org/10.3892/ol.2020.11272
MLA
Wang, T., Lv, X., Jiang, S., Han, S., Wang, Y."Expression of ADAM29 and FAM135B in the pathological evolution from normal esophageal epithelium to esophageal cancer: Their differences and clinical significance". Oncology Letters 19.3 (2020): 1727-1734.
Chicago
Wang, T., Lv, X., Jiang, S., Han, S., Wang, Y."Expression of ADAM29 and FAM135B in the pathological evolution from normal esophageal epithelium to esophageal cancer: Their differences and clinical significance". Oncology Letters 19, no. 3 (2020): 1727-1734. https://doi.org/10.3892/ol.2020.11272
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team