Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
March-2020 Volume 19 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2020 Volume 19 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

NLRP1 and NLRP3 inflammasomes as a new approach to skin carcinogenesis (Review)

  • Authors:
    • Magdalena Ciążyńska
    • Igor A. Bednarski
    • Karolina Wódz
    • Joanna Narbutt
    • Aleksandra Lesiak
  • View Affiliations / Copyright

    Affiliations: Department of Proliferative Diseases, Nicolaus Copernicus Multidisciplinary Centre for Oncology and Traumatology, Lodz 93‑513, Poland, Department of Dermatology, Pediatric Dermatology and Dermatological Oncology, Medical University of Lodz, Lodz 91‑347, Poland, Laboratory of Molecular Biology, VET‑LAB, Brudzew 62‑720, Poland
    Copyright: © Ciążyńska et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1649-1656
    |
    Published online on: January 9, 2020
       https://doi.org/10.3892/ol.2020.11284
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Inflammasomes are key innate immune system receptors that detect pathogenic endo‑ and exogenous stressors like microorganisms or ultraviolet radiation (UVR) which activate the highly proinflammatory cytokines interleukin‑1β and interleukin‑18. Inflammasomes are not only involved in inflammation, but also in carcinogenesis and tumor progression. Due to the dynamic increase in non‑melanoma skin cancers (NMSC), it has become necessary to determine how UVR, which plays a key role in NMSC development, can regulate the structure and function of inflammasomes. In the present study, the regulatory mechanisms of NOD‑Like Receptor Family Pyrin Domain Containing 1 and 3 inflammasome activation as well as an effective inflammasome‑mediated immune response after UVR exposition are discussed. The differences and similarities between these molecular complexes that monitor cellular health, inflammation, and skin carcinogenesis are also highlighted. Despite numerous scientific data, more studies are still required to better understand the biology of inflammasomes in skin cancer development and to explore their therapeutic potential.
View Figures

Figure 1

Figure 2

View References

1 

Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Kantono M and Guo B: Inflammasomes and cancer: The dynamic role of the inflammasome in tumor development. Front Immunol. 8:11322017. View Article : Google Scholar : PubMed/NCBI

3 

Okamoto M, Liu W, Luo Y, Tanaka A, Cai X, Norris DA, Dinarello CA and Fujita M: Constitutively active inflammasome in human melanoma cells mediating autoinflammation via caspase-1 processing and secretion of interleukin-1beta. J Biol Chem. 285:6477–6488. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Nasti TH and Timares L: Inflammasome activation of IL-1 family mediators in response to cutaneous photodamage. Photochem Photobiol. 88:1111–1125. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Rathinam VAK and Fitzgerald KA: Inflammasome complexes: Emerging mechanisms and effector functions. Cell. 165:792–800. 2016. View Article : Google Scholar : PubMed/NCBI

6 

de Zoete MR, Palm NW, Zhu S and Flavell RA: Inflammasomes. Cold Spring Harb Perspect Biol. 6:a0162872014. View Article : Google Scholar : PubMed/NCBI

7 

Lamkanfi M: Emerging inflammasome effector mechanisms. Nat Rev Immunol. 11:213–220. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Martinon F, Burns K and Tschopp J: The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell. 10:417–426. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Frew BC, Joag VR and Mogridge J: Proteolytic processing of Nlrp1b is required for inflammasome activity. PLoS Pathog. 8:e10026592012. View Article : Google Scholar : PubMed/NCBI

10 

Nour AM, Yeung YG, Santambrogio L, Boyden ED, Stanley ER and Brojatsch J: Anthrax lethal toxin triggers the formation of a membrane-associated inflammasome complex in murine macrophages. Infect Immun. 77:1262–1271. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Faustin B, Lartigue L, Bruey JM, Luciano F, Sergienko E, Bailly-Maitre B, Volkmann N, Hanein D, Rouiller I and Reed JC: Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation. Mol Cell. 25:713–724. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Van Opdenbosch N, Gurung P, Vande Walle L, Fossoul A, Kanneganti TD and Lamkanfi M: Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation. Nat Commun. 5:32092014. View Article : Google Scholar : PubMed/NCBI

13 

Guey B, Bodnar M, Manié SN, Tardivel A and Petrilli V: Caspase-1 autoproteolysis is differentially required for NLRP1b and NLRP3 inflammasome function. Proc Natl Acad Sci USA. 111:17254–17259. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Bauernfeind F and Ablasser A: Inflammasomes: Current understanding and open questions. Cell Mol Life Sci. 68:765–783. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Finger JN, Lich JD, Dare LC, Cook MN, Brown KK, Duraiswami C, Bertin J and Gough PJ: Autolytic proteolysis within the function to find domain (FIIND) is required for NLRP1 inflammasome activity. J Biol Chem. 287:25030–25037. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Yu CH, Moecking J, Geyer M and Masters SL: Mechanisms of NLRP1 mediated autoinflammatory disease in humans and mice. J Mol Biol. 430:142–152. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Lamkanfi M and Dixit VM: Mechanisms and functions of inflammasomes. Cell. 157:1013–1022. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Kayagaki N, Warming S, Lamkanfi M, Vande Walle L, Louie S, Dong J, Newton K, Qu Y, Liu J, Heldens S, et al: Non-canonical inflammasome activation targets caspase-11. Nature. 479:117–121. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Shi J, Zhao Y, Wang Y, Gao W, Ding J, Li P, Hu L and Shao F: Inflammatory caspases are innate immune receptors for intracellular LPS. Nature. 514:187–192. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Liu X and Lieberman J: A mechanistic understanding of pyroptosis: The fiery death triggered by invasive infection. Adv Immunol. 135:81–117. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Zhao D, Wu Y, Zhuang J, Xu C and Zhang F: Activation of NLRP1 and NLRP3 inflammasomes contributed to cyclic stretch-induced pyroptosis and release of IL-1β in human periodontal ligament cells. Oncotarget. 7:68292–68302. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Feldmeyer L, Keller M, Niklaus G, Hohl D, Werner S and Beer HD: The inflammasome mediates UVB-induced activation and secretion of interleukin-1beta by keratinocytes. Curr Biol. 17:1140–1145. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Hasegawa T, Nakashima M and Suzuki Y: Nuclear DNA damage-triggered NLRP3 inflammasome activation promotes UVB-induced inflammatory responses in human keratinocytes. Biochem Biophys Res Commun. 477:329–335. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Strittmatter GE, Sand J, Sauter M, Seyffert M, Steigerwald R, Fraefel C, Smola S, French LE and Beer HD: IFN-γ primes keratinocytes for HSV-1-induced inflammasome activation. J Invest Dermatol. 136:610–620. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Reinholz M, Kawakami Y, Salzer S, Kreuter A, Dombrowski Y, Koglin S, Kresse S, Ruzicka T and Schauber J: HPV16 activates the AIM2 inflammasome in keratinocytes. Arch Dermatol Res. 305:723–732. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Ekman AK, Verma D, Fredrikson M, Bivik C and Enerbäck C: Genetic variations of NLRP1: susceptibility in psoriasis. Br J Dermatol. 171:1517–1520. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Bivik C, Verma D, Winge MC, Lieden A, Bradley M, Rosdahl I and Söderkvist P: Genetic variation in the inflammasome and atopic dermatitis susceptibility. J Invest Dermatol. 133:2486–2489. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Levandowski CB, Mailloux CM, Ferrara TM, Gowan K, Ben S, Jin Y, McFann KK, Holland PJ, Fain PR, Dinarello CA and Spritz RA: NLRP1 haplo-types associated with vitiligo and autoimmunity increase interleukin-1β processing via the NLRP1 inflammasome. Proc Natl Acad Sci USA. 110:2952e29562013. View Article : Google Scholar

29 

Faustin B and Reed JC: Sunburned skin activates inflammasomes. Trends Cell Biol. 18:4–8. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Faustin B, Chen Y, Zhai D, Le Negrate G, Lartigue L, Satterthwait A and Reed JC: Mechanism of Bcl-2 and Bcl-X(L) inhibition of NLRP1 inflammasome: Loop domain-dependent suppression of ATP binding and oligomerization. Proc Natl Acad Sci USA. 106:3935–3940. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Reagan-Shaw S, Breur J and Ahmad N: Enhancement of UVB radiation-mediated apoptosis by sanguinarine in HaCaT human immortalized keratinocytes. Mol Cancer Ther. 5:418–429. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Sand J, Haertel E, Biedermann T, Contassot E, Reichmann E, French LE, Werner S and Beer HD: Expression of inflammasome proteins and inflammasome activation occurs in human, but not in murine keratinocytes. Cell Death Dis. 9:242018. View Article : Google Scholar : PubMed/NCBI

33 

Gurung P and Kanneganti TD: Autoinflammatory skin disorders: The inflammasome in focus. Trends Mol Med. 22:545–564. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Liu-Bryan R: Intracellular innate immunity in gouty arthritis: Role of NALP3 inflammasome. Immunol Cell Biol. 88:20–23. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Shi F, Kouadir M and Yang Y: NALP3 inflammasome activation in protein misfolding diseases. Life Sci. 135:9–14. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Liu W, Luo Y, Dunn JH, Norris DA, Dinarello CA and Fujita M: Dual role of apoptosis-associated speck-like protein containing a CARD (ASC) in tumorigenesis of human melanoma. J Invest Dermatol. 133:518–527. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Wang Y, Kong H, Zeng X, Liu W, Wang Z, Yan X, Wang H and Xie W: Activation of NLRP3 inflammasome enhances the proliferation and migration of A549 lung cancer cells. Oncol Rep. 35:2053–2064. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Allen IC, TeKippe EM, Woodford RM, Uronis JM, Holl EK, Rogers AB, Herfarth HH, Jobin C and Ting JP: The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer. J Exp Med. 207:1045–1056. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Drexler SK, Bonsignore L, Masin M, Tardivel A, Jackstadt R, Hermeking H, Schneider P, Gross O, Tschopp J and Yazdi AS: Tissue-specific opposing functions of the inflammasome adaptor ASC in the regulation of epithelial skin carcinogenesis. Proc Natl Acad Sci. 109:18384–18389. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Melvin JC, Holmberg L, Rohrmann S, Loda M and Van Hemelrijck M: Serum lipid profiles and cancer risk in the context of obesity: Four meta-analyses. J Cancer Epidemiol. 2013:8238492013. View Article : Google Scholar : PubMed/NCBI

41 

Zhai Z, Liu W, Kaur M, Luo Y, Domenico J, Samson JM, Shellman YG, Norris DA, Dinarello CA, Spritz RA and Fujita M: NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing apoptosis in metastatic melanoma. Oncogene. 36:3820–3830. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Zhong FL, Mamaï O, Sborgi L, Boussofara L, Hopkins R, Robinson K, Szeverényi I, Takeichi T, Balaji R, Lau A, et al: Germline NLRP1 mutations cause skin inflammatory and cancer susceptibility syndromes via inflammasome activation. Cell. 167:187–202.e17. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Elaraj DM, Weinreich DM, Varghese S, Puhlmann M, Hewitt SM, Carroll SM, Feldman ED, Turner EM and Alexander HR: The role of interleukin 1 in growth and metastasis of human cancer xenografts. Clin Cancer Res. 12:1088–1096. 2006. View Article : Google Scholar : PubMed/NCBI

44 

Pazyar N, Feily A and Yaghoobi R: An overview of interleukin-1 receptor antagonist, anakinra, in the treatment of cutaneous diseases. Curr Clin Pharmacol. 7:271–275. 2012. View Article : Google Scholar : PubMed/NCBI

45 

La E, Rundhaug JE and Fischer SM: Role of intracellular interleukin-1 antagonist in skin carcinogenesis. Mol Carcinog. 30:218–223. 2001. View Article : Google Scholar : PubMed/NCBI

46 

Bar D, Apte RN, Voronov E, Dinarello CA and Cohen S: A continuous delivery system of IL-1 receptor antagonist reduces angiogenesis and inhibits tumor development. FASEB J. 18:161–163. 2004. View Article : Google Scholar : PubMed/NCBI

47 

McKenzie RC, Oran A, Dinarello CA and Sauder DN: Interleukin-1 receptor antagonist inhibits subcutaneous B 16 melanoma growth in vivo. Anticancer Res. 16:437–441. 1996.PubMed/NCBI

48 

Weinreich DM, Elaraj DM, Puhlmann M, Hewitt SM, Carroll NM, Feldman ED, Turner EM, Spiess PJ and Alexander HR: Effect of interleukin 1 receptor antagonist gene transduction on human melanoma xenografts in nude mice. Cancer Res. 63:5957–5961. 2003.PubMed/NCBI

49 

Triozzi PL and Aldrich W: Effects of interleukin-1 receptor antagonist and chemotherapy on host-tumor interactions in established melanoma. Anticancer Res. 30:345–354. 2010.PubMed/NCBI

50 

Hoshino T, Okamoto M, Sakazaki Y, Kato S, Young HA and Aizawa H: Role of proinflammatory cytokine IL-18 and IL-1beta in bleomycin-induced lung injury in humans and mice. Am J Respir Cell Mol Biol. 41:661–670. 2009. View Article : Google Scholar : PubMed/NCBI

51 

Ledeboer A, Jekich BM, Sloane EM, Mahoney JH, Langer SJ, Milligan ED, Martin D, Maier SF, Johnson KW, Leinwand LA, et al: Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats. Brain Behav Immun. 21:686–698. 2007. View Article : Google Scholar : PubMed/NCBI

52 

Twining CM, Sloane EM, Milligan ED, Chacur M, Martin D, Poole S, Marsh H, Maier SF and Watkins LR: Peri-sciatic proinflammatory cytokines, reactive oxygen species, and complement induce mirror-image neuropathic pain in rats. Pain. 110:299–309. 2004. View Article : Google Scholar : PubMed/NCBI

53 

Surguladze D, Deevi D, Claros N, Corcoran E, Wang W, Plym MJ, Wu Y, Doody J, Mauro DJ, Witte L, et al: Tumor necrosis factor-alpha and interleukin-1 antagonists alleviate inflammatory skin changes associated with epidermal growth factor receptor antibody therapy in mice. Cancer Res. 69:5643–5647. 2009. View Article : Google Scholar : PubMed/NCBI

54 

Wang X, Bi Z, Chu W and Wan Y: IL-1 receptor antagonist attenuates MAP kinase/AP-1 activation and MMP1 expression in UVA-irradiated human fibroblasts induced by culture medium from UVB-irradiated human skin keratinocytes. Int J Mol Med. 16:1117–1124. 2005.PubMed/NCBI

55 

van de Veerdonk FL, Netea MG, Dinarello CA and Joosten LA: Inflammasome activation and IL-1β and IL-18 processing during infection. Trends Immunol. 32:110–116. 2011. View Article : Google Scholar : PubMed/NCBI

56 

Abdelmeguid NE, Fakhoury R, Kamal SM and Al Wafai RJ: Effects of Nigella sativa and thymoquinone on biochemical and subcellular changes in pancreatic β-cells of streptozotocin-induced diabetic rats. J Diabetes. 2:256–266. 2010. View Article : Google Scholar : PubMed/NCBI

57 

Kanter M: Nigella sativa and derived thymoquinone prevents hippocampal neurodegeneration after chronic toluene exposure in rats. Neurochem Res. 33:579–588. 2008. View Article : Google Scholar : PubMed/NCBI

58 

Woo CC, Kumar AP, Sethi G and Tan KH: Thymoquinone: Potential cure for inflammatory disorders and cancer. Biochem Pharmacol. 83:443–451. 2012. View Article : Google Scholar : PubMed/NCBI

59 

Banerjee S, Padhye S, Azmi A, Wang Z, Philip PA, Kucuk O, Sarkar FH and Mohammad RM: Review on molecular and therapeutic potential of thymoquinone in cancer. Nutr Cancer. 62:938–946. 2010. View Article : Google Scholar : PubMed/NCBI

60 

Ahmad I, Muneer KM, Tamimi IA, Chang ME, Ata MO and Yusuf N: Thymoquinone suppresses metastasis of melanoma cells by inhibition of NLRP3 inflammasome. Toxicol Appl Pharmacol. 270:70–76. 2013. View Article : Google Scholar : PubMed/NCBI

61 

Ellis LZ, Liu W, Luo Y, Okamoto M, Qu D, Dunn JH and Fujita M: Green tea polyphenol epigallocatechin-3-gallate suppresses melanoma growth by inhibiting inflammasome and IL-1β secretion. Biochem Biophys Res Commun. 414:551–556. 2011. View Article : Google Scholar : PubMed/NCBI

62 

Tsai PY, Ka SM, Chang JM, Chen HC, Shui HA, Li CY, Hua KF, Chang WL, Huang JJ, Yang SS and Chen A: Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation. Free Radic Biol Med. 51:744–754. 2011. View Article : Google Scholar : PubMed/NCBI

63 

Li D, Han T, Liao J, Hu X, Xu S, Tian K, Gu X, Cheng K, Li Z, Hua H and Xu J: Oridonin, a promising ent-Kaurane diterpenoid lead compound. Int J Mol Sci. 17:E13952016. View Article : Google Scholar : PubMed/NCBI

64 

Li D, Han T, Xu S, Zhou T, Tian K, Hu X, Cheng K, Li Z, Hua H and Xu J: Antitumor and antibacterial derivatives of oridonin: A main composition of Dong-Ling-Cao. Molecules. 21:E5752016. View Article : Google Scholar : PubMed/NCBI

65 

Lu J, Chen X, Qu S, Yao B, Xu Y, Wu J, Jin Y and Ma C: Oridonin induces G2/M cell cycle arrest and apoptosis via the PI3K/Akt signaling pathway in hormone-independent prostate cancer cells. Oncol Lett. 13:2838–2846. 2017. View Article : Google Scholar : PubMed/NCBI

66 

Wang XH, Zhang SF, Bao JT and Liu FY: Oridonin synergizes with Nutlin-3 in osteosarcoma cells by modulating the levels of multiple Bcl-2 family proteins. Tumour Biol. 39:10104283177016382017.PubMed/NCBI

67 

Xia S, Zhang X, Li C and Guan H: Oridonin inhibits breast cancer growth and metastasis through blocking the Notch signaling. Saudi Pharm J. 25:638–643. 2017. View Article : Google Scholar : PubMed/NCBI

68 

Zhang Y, Wang L, Zi Y, Zhang L, Guo Y and Huang Y: Oridonin effectively reverses the drug resistance of cisplatin involving induction of cell apoptosis and inhibition of MMP expression in human acute myeloid leukemia cells. Saudi J Biol Sci. 24:678–686. 2017. View Article : Google Scholar : PubMed/NCBI

69 

Wang HJ, Li D, Yang FY, Tashiro S, Onodera S and Ikejima T: Oridonin induces human melanoma A375-S2 cell death partially through inhibiting insulin-like growth factor 1 receptor signaling. J Asian Nat Prod Res. 10:787–798. 2008. View Article : Google Scholar : PubMed/NCBI

70 

Gu Z, Wang X, Qi R, Wei L, Huo Y, Ma Y, Shi L, Chang Y, Li and Zhou L: Oridonin induces apoptosis in uveal melanoma cells by upregulation of Bim and downregulation of fatty acid synthase. Biochem Biophys Res Commun. 457:187–193. 2015. View Article : Google Scholar : PubMed/NCBI

71 

He H and Jiang Y: Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity. Nat Commun. 9:25502018. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ciążyńska M, Bednarski IA, Wódz K, Narbutt J and Lesiak A: NLRP1 and NLRP3 inflammasomes as a new approach to skin carcinogenesis (Review). Oncol Lett 19: 1649-1656, 2020.
APA
Ciążyńska, M., Bednarski, I.A., Wódz, K., Narbutt, J., & Lesiak, A. (2020). NLRP1 and NLRP3 inflammasomes as a new approach to skin carcinogenesis (Review). Oncology Letters, 19, 1649-1656. https://doi.org/10.3892/ol.2020.11284
MLA
Ciążyńska, M., Bednarski, I. A., Wódz, K., Narbutt, J., Lesiak, A."NLRP1 and NLRP3 inflammasomes as a new approach to skin carcinogenesis (Review)". Oncology Letters 19.3 (2020): 1649-1656.
Chicago
Ciążyńska, M., Bednarski, I. A., Wódz, K., Narbutt, J., Lesiak, A."NLRP1 and NLRP3 inflammasomes as a new approach to skin carcinogenesis (Review)". Oncology Letters 19, no. 3 (2020): 1649-1656. https://doi.org/10.3892/ol.2020.11284
Copy and paste a formatted citation
x
Spandidos Publications style
Ciążyńska M, Bednarski IA, Wódz K, Narbutt J and Lesiak A: NLRP1 and NLRP3 inflammasomes as a new approach to skin carcinogenesis (Review). Oncol Lett 19: 1649-1656, 2020.
APA
Ciążyńska, M., Bednarski, I.A., Wódz, K., Narbutt, J., & Lesiak, A. (2020). NLRP1 and NLRP3 inflammasomes as a new approach to skin carcinogenesis (Review). Oncology Letters, 19, 1649-1656. https://doi.org/10.3892/ol.2020.11284
MLA
Ciążyńska, M., Bednarski, I. A., Wódz, K., Narbutt, J., Lesiak, A."NLRP1 and NLRP3 inflammasomes as a new approach to skin carcinogenesis (Review)". Oncology Letters 19.3 (2020): 1649-1656.
Chicago
Ciążyńska, M., Bednarski, I. A., Wódz, K., Narbutt, J., Lesiak, A."NLRP1 and NLRP3 inflammasomes as a new approach to skin carcinogenesis (Review)". Oncology Letters 19, no. 3 (2020): 1649-1656. https://doi.org/10.3892/ol.2020.11284
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team