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Identification of candidate RNA signatures in triple‑negative breast cancer by the construction of a competing endogenous RNA network with integrative analyses of Gene Expression Omnibus and The Cancer Genome Atlas data

  • Authors:
    • Ping Yan
    • Lingfeng Tang
    • Li Liu
    • Gang Tu
  • View Affiliations / Copyright

    Affiliations: Department of Endocrine and Breast Surgery, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, P.R. China
    Copyright: © Yan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1915-1927
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    Published online on: January 10, 2020
       https://doi.org/10.3892/ol.2020.11292
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Abstract

Triple‑negative breast cancer (TNBC) is a subtype of breast cancer that is characterized by aggressive and metastatic clinical characteristics and generally leads to earlier distant recurrence and poorer prognosis than other molecular subtypes. Accumulating evidence has demonstrated that long non‑coding RNAs (lncRNAs) serve a crucial role in a wide variety of biological processes by interacting with microRNAs (miRNAs) as competing endogenous RNAs (ceRNAs) and, thus, affect the expression of target genes in multiple types of cancer. Seven datasets from the Gene Expression Omnibus (GEO) database, including 444 tumor and 88 healthy tissue samples, were utilized to investigate the underlying mechanisms of TNBC and identify prognostic biomarkers. Differentially expressed genes (DEGs) were further validated in The Cancer Genome Atlas database and the associations between their expression levels and clinical information were analyzed to identify prognostic values. A potential lncRNA‑miRNA‑mRNA ceRNA network was also constructed. Finally, 69 mRNAs from the integrated Gene Expression Omnibus datasets were identified as DEGs using the robust rank aggregation method with |log2FC|>1 and adjusted P<0.01 set as the significance cut‑off levels. In addition, 29 lncRNAs, 21 miRNAs and 27 mRNAs were included in the construction of the ceRNA network. The present study elucidated the mechanisms underlying the progression of TNBC and identified novel prognostic biomarkers for TNBC.
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View References

1 

Onitilo AA, Engel JM, Greenlee RT and Mukesh BN: Breast cancer subtypes based on ER/PR and Her2 expression: Comparison of clinicopathologic features and survival. Clin Med Res. 7:4–13. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Bauer KR, Brown M, Cress RD, Parise CA and Caggiano V: Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype: A population-based study from the California cancer registry. Cancer. 109:1721–1728. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Dent R, Trudeau M, Pritchard KI, Hanna WM, Kahn HK, Sawka CA, Lickley LA, Rawlinson E, Sun P and Narod SA: Triple-negative breast cancer: Clinical features and patterns of recurrence. Clin Cancer Res. 13:4429–4434. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Rakha EA, Elrehim DA, Paish C, Green AR, Lee AH, Robertson JF, Blamey RW, Macmillan D and Ellis IO: Basal phenotype identifes a poor prognostic subgroup of breast cancer of clinical importance. Eur J Cancer. 42:3149–3156. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Zaky SS, Lund MJ, May KA, Godette KD, Beitler JJ, Holmes LR, O'Regan RM, Yu ES, Yu DS and Landry JC: The negative effect of triple-negative breast cancer on outcome after breast-conserving therapy. Ann Surg Oncol. 18:2858–2865. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Fatica A and Bozzoni I: Long non-coding RNAs: New players in cell differentiation and development. Nat Rev Genet. 15:7–21. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Deva Magendhra Rao AK, Patel K, Korivi Jyothiraj S, Meenakumari B, Sundersingh S, Sridevi V, Rajkumar T, Pandey A, Chatterjee A, Gowda H and Mani S: Identification of lncRNAs associated with early stage breast cancer and their prognostic implications. Mol Oncol. 13:1342–1355. 2019.PubMed/NCBI

8 

Chen X, Yan CC, Zhao X and You ZH: Long non-coding RNAs and complex diseases: From experimental results to computational models. Brief Bioinform. 18:558–576. 2017.PubMed/NCBI

9 

Bertoli G, Cava C and Castiglioni I: MicroRNAs: New biomarkers for diagnosis, prognosis, therapy prediction and therapeutic tools for breast cancer. Theranostics. 5:1122–1143. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Haakensen VD, Nygaard V, Greger L, Aure MR, Fromm B, Bukholm IR, Luders T, Chin SF, Git A, Caldas C, et al: Subtype-specific micro-RNA expression signatures in breast cancer progression. Int J Cancer. 139:1117–1128. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Chen X, Xie D, Zhao Q and You ZH: Micrornas and complex diseases: From experimental results to computational models. Brief Bioinform. 20:515–539. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Salmena L, Poliseno L, Tay Y, Kats L and Pandolfi PP: A ceRNA hypothesis: The rosetta stone of a hidden RNA language? Cell. 146:353–358. 2011. View Article : Google Scholar : PubMed/NCBI

13 

He R, Liu P, Xie X, Zhou Y, Liao Q, Xiong W, Li X, Li G, Zeng Z and Tang H: circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a. J Exp Clin Cancer Res. 36:1452017. View Article : Google Scholar : PubMed/NCBI

14 

Li S, Zhou J, Wang Z, Wang P, Gao X and Wang Y: Long noncoding RNA GAS5 suppresses triple negative breast cancer progression through inhibition of proliferation and invasion by competitively binding miR-196a-5p. Biomed Pharmacother. 104:451–457. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Komatsu M, Yoshimaru T, Matsuo T, Kiyotani K, Miyoshi Y, Tanahashi T, Rokutan K, Yamaguchi R, Saito A, Imoto S, et al: Molecular features of triple negative breast cancer cells by genome-wide gene expression profiling analysis. Int J Oncol. 42:478–506. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Mathe A, Wong-Brown M, Morten B, Forbes JF, Braye SG, Avery-Kiejda KA and Scott RJ: Novel genes associated with lymph node metastasis in triple negative breast cancer. Sci Rep. 5:158322015. View Article : Google Scholar : PubMed/NCBI

17 

Liu YR, Jiang YZ, Xu XE, Hu X, Yu KD and Shao ZM: Comprehensive transcriptome profiling reveals multigene signatures in triple-negative breast cancer. Clin Cancer Res. 22:1653–1662. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Romero-Cordoba SL, Rodriguez-Cuevas S, Bautista-Pina V, Maffuz-Aziz A, D'Ippolito E, Cosentino G, Baroni S, Iorio MV and Hidalgo-Miranda A: Loss of function of miR-342-3p results in MCT1 over-expression and contributes to oncogenic metabolic reprogramming in triple negative breast cancer. Sci Rep. 8:122522018. View Article : Google Scholar : PubMed/NCBI

19 

Varley KE, Gertz J, Roberts BS, Davis NS, Bowling KM, Kirby MK, Nesmith AS, Oliver PG, Grizzle WE, Forero A, et al: Recurrent read-through fusion transcripts in breast cancer. Breast Cancer Res Treat. 146:287–297. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Moradifard S, Hoseinbeyki M, Ganji SM and Minuchehr Z: Analysis of microRNA and gene expression profiles in Alzheimer's disease: A meta analysis approach. Sci Rep. 8:47672018. View Article : Google Scholar : PubMed/NCBI

21 

Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W and Smyth GK: Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43:e472015. View Article : Google Scholar : PubMed/NCBI

22 

Kolde R, Laur S, Adler P and Vilo J: Robust rank aggregation for gene list integration and meta-analysis. Bioinformatics. 28:573–580. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Shi KQ, Lin Z, Chen XJ, Song M, Wang YQ, Cai YJ, Yang NB, Zheng MH, Dong JZ, Zhang L and Chen YP: Hepatocellular carcinoma associated microRNA expression signature: Integrated bioinformatics analysis, experimental validation and clinical significance. Oncotarget. 6:25093–25108. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Yang J, Han S, Huang W, Chen T, Liu Y, Pan S and Li S: A meta-analysis of microRNA expression in liver cancer. PLoS One. 9:e1145332014. View Article : Google Scholar : PubMed/NCBI

25 

Huang da W, Sherman BT and Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 4:44–57. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Szklarczyk D, Morris JH, Cook H, Kuhn M, Wyder S, Simonovic M, Santos A, Doncheva NT, Roth A, Bork P, et al: The STRING database in 2017: Quality-controlled protein-protein association networks, made broadly accessible. Nucleic Acids Res. 45:D362–D368. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

28 

Perou CM, Sørlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, et al: Molecular portraits of human breast tumours. Nature. 406:747–752. 2000. View Article : Google Scholar : PubMed/NCBI

29 

Sørlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey SS, et al: Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA. 98:10869–10874. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Sorlie T, Tibshirani R, Parker J, Hastie T, Marron JS, Nobel A, Deng S, Johnsen H, Pesich R, Geisler S, et al: Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc Natl Acad Sci USA. 100:8418–8423. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Prat A, Parker JS, Karginova O, Fan C, Livasy C, Herschkowitz JI, He X and Perou CM: Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer. Breast Cancer Res. 12:R682010. View Article : Google Scholar : PubMed/NCBI

32 

Blows FM, Driver KE, Schmidt MK, Broeks A, van Leeuwen FE, Wesseling J, Cheang MC, Gelmon K, Nielsen TO, Blomqvist C, et al: Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and long term survival: A collaborative analysis of data for 10,159 cases from 12 studies. PLoS Med. 7:e10002792010. View Article : Google Scholar : PubMed/NCBI

33 

Carey LA, Perou CM, Livasy CA, Dressler LG, Cowan D, Conway K, Karaca G, Troester MA, Tse CK, Edmiston S, et al: Race, breast cancer subtypes, and survival in the carolina breast cancer study. JAMA. 295:2492–2502. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Long J, Bai Y, Yang X, Lin J, Yang X, Wang D, He L, Zheng Y and Zhao H: Construction and comprehensive analysis of a ceRNA network to reveal potential prognostic biomarkers for hepatocellular carcinoma. Cancer Cell Int. 19:902019. View Article : Google Scholar : PubMed/NCBI

35 

Zhang X, Zhang W, Jiang Y, Liu K, Ran L and Song F: Identification of functional lncRNAs in gastric cancer by integrative analysis of GEO and TCGA data. J Cell Biochem. 120:17898–17911. 2019.PubMed/NCBI

36 

Wang X, Ding Y, Da B, Fei Y and Feng G: Identification of potential prognostic long non-coding RNA signatures based on a competing endogenous RNA network in lung adenocarcinoma. Oncol Rep. 40:3199–3212. 2018.PubMed/NCBI

37 

Zhu H, Dai M, Chen X, Chen X, Qin S and Dai S: Integrated analysis of the potential roles of miRNA-mRNA networks in triple negative breast cancer. Mol Med Rep. 16:1139–1146. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Yang R, Xing L, Wang M, Chi H, Zhang L and Chen J: Comprehensive analysis of differentially expressed profiles of lncRNAs/mRNAs and miRNAs with associated cerna networks in triple-negative breast cancer. Cell Physiol Biochem. 50:473–488. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Yuan N, Zhang G, Bie F, Ma M, Ma Y, Jiang X, Wang Y and Hao X: Integrative analysis of lncRNAs and miRNAs with coding RNAs associated with ceRNA crosstalk network in triple negative breast cancer. Onco Targets Ther. 10:5883–5897. 2017. View Article : Google Scholar : PubMed/NCBI

40 

Võsa U, Kolde R, Vilo J, Metspalu A and Annilo T: Comprehensive meta-analysis of microrna expression using a robust rank aggregation approach. Methods Mol Biol. 1182:361–373. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Cheang MC, Chia SK, Voduc D, Gao D, Leung S, Snider J, Watson M, Davies S, Bernard PS, Parker JS, et al: Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer. J Natl Cancer Inst. 101:736–750. 2009. View Article : Google Scholar : PubMed/NCBI

42 

Ali HR, Dawson SJ, Blows FM, Provenzano E, Pharoah PD and Caldas C: Aurora kinase A outperforms Ki67 as a prognostic marker in ER-positive breast cancer. Br J Cancer. 106:1798–1806. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Dawson SJ, Makretsov N, Blows FM, Driver KE, Provenzano E, Le Quesne J, Baglietto L, Severi G, Giles GG, McLean CA, et al: BCL2 in breast cancer: A favourable prognostic marker across molecular subtypes and independent of adjuvant therapy received. Br J Cancer. 103:668–675. 2010. View Article : Google Scholar : PubMed/NCBI

44 

Chen X and Huang L: LRSSLMDA: Laplacian regularized sparse subspace learning for miRNA-disease association prediction. PLoS Comput Biol. 13:e10059122017. View Article : Google Scholar : PubMed/NCBI

45 

Chen X, Yin J, Qu J and Huang L: MDHGI: Matrix decomposition and heterogeneous graph inference for miRNA-disease association prediction. PLoS Comput Biol. 14:e10064182018. View Article : Google Scholar : PubMed/NCBI

46 

Chen X, Wang L, Qu J, Guan NN and Li JQ: Predicting miRNA-disease association based on inductive matrix completion. Bioinformatics. 34:4256–4265. 2018.PubMed/NCBI

47 

Chen X, Zhu CC and Yin J: Ensemble of decision tree reveals potential miRNA-disease associations. PLoS Comput Biol. 15:e10072092019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yan P, Tang L, Liu L and Tu G: Identification of candidate RNA signatures in triple‑negative breast cancer by the construction of a competing endogenous RNA network with integrative analyses of Gene Expression Omnibus and The Cancer Genome Atlas data. Oncol Lett 19: 1915-1927, 2020.
APA
Yan, P., Tang, L., Liu, L., & Tu, G. (2020). Identification of candidate RNA signatures in triple‑negative breast cancer by the construction of a competing endogenous RNA network with integrative analyses of Gene Expression Omnibus and The Cancer Genome Atlas data. Oncology Letters, 19, 1915-1927. https://doi.org/10.3892/ol.2020.11292
MLA
Yan, P., Tang, L., Liu, L., Tu, G."Identification of candidate RNA signatures in triple‑negative breast cancer by the construction of a competing endogenous RNA network with integrative analyses of Gene Expression Omnibus and The Cancer Genome Atlas data". Oncology Letters 19.3 (2020): 1915-1927.
Chicago
Yan, P., Tang, L., Liu, L., Tu, G."Identification of candidate RNA signatures in triple‑negative breast cancer by the construction of a competing endogenous RNA network with integrative analyses of Gene Expression Omnibus and The Cancer Genome Atlas data". Oncology Letters 19, no. 3 (2020): 1915-1927. https://doi.org/10.3892/ol.2020.11292
Copy and paste a formatted citation
x
Spandidos Publications style
Yan P, Tang L, Liu L and Tu G: Identification of candidate RNA signatures in triple‑negative breast cancer by the construction of a competing endogenous RNA network with integrative analyses of Gene Expression Omnibus and The Cancer Genome Atlas data. Oncol Lett 19: 1915-1927, 2020.
APA
Yan, P., Tang, L., Liu, L., & Tu, G. (2020). Identification of candidate RNA signatures in triple‑negative breast cancer by the construction of a competing endogenous RNA network with integrative analyses of Gene Expression Omnibus and The Cancer Genome Atlas data. Oncology Letters, 19, 1915-1927. https://doi.org/10.3892/ol.2020.11292
MLA
Yan, P., Tang, L., Liu, L., Tu, G."Identification of candidate RNA signatures in triple‑negative breast cancer by the construction of a competing endogenous RNA network with integrative analyses of Gene Expression Omnibus and The Cancer Genome Atlas data". Oncology Letters 19.3 (2020): 1915-1927.
Chicago
Yan, P., Tang, L., Liu, L., Tu, G."Identification of candidate RNA signatures in triple‑negative breast cancer by the construction of a competing endogenous RNA network with integrative analyses of Gene Expression Omnibus and The Cancer Genome Atlas data". Oncology Letters 19, no. 3 (2020): 1915-1927. https://doi.org/10.3892/ol.2020.11292
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