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Deregulation of cell adhesion molecules is associated with progression and poor outcomes in endometrial cancer: Analysis of The Cancer Genome Atlas data

  • Authors:
    • Xiangjun He
    • Shu Lei
    • Qi Zhang
    • Liping Ma
    • Na Li
    • Jianliu Wang
  • View Affiliations / Copyright

    Affiliations: Central Laboratory and Institute of Clinical Molecular Biology, Peking University People's Hospital, Beijing 100044, P.R. China, Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing 100044, P.R. China
    Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1906-1914
    |
    Published online on: January 13, 2020
       https://doi.org/10.3892/ol.2020.11295
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Abstract

Cell adhesion molecules (CAMs) determine the behavior of cancer cells during metastasis. Although some CAMs are dysregulated in certain types of cancer and are associated with cancer progression, to the best of our knowledge, a comprehensive study of CAMs has not been undertaken, particularly in endometrial cancer (EC). In the present study the expression of 225 CAMs in EC patients with various clinicopathological phenotypes were evaluated by statistical analysis using publicly available data from The Cancer Genome Atlas database. The Kaplan‑Meier method, and univariate and multivariate Cox proportional hazards regression models were used for survival analyses. Among the differentially expressed CAMs that were associated with aggressive clinicopathological phenotypes, 10 CAM genes were independent prognostic factors compared with other clinicopathological prognostic factors, including stage, grade, age, lymph node status, peritoneal cytology and histological subtype. A total of six genes (L1 cell adhesion molecule, mucin 15, cell surface associated, cell adhesion associated, oncogene regulated, immunoglobulin superfamily member 9B, protocadherin 9 and protocadherin β1) were selected for integrative analysis. The six‑gene signature was demonstrated to be an independent prognostic factor and could effectively stratify patients with different risks. Patients with more high‑expression CAMs had a higher risk of poor overall survival (OS) rate. The mortality risk for patients with elevation of >4 CAMs was 11 times of that in those without elevation of these 6 CAMs. Similar results were obtained when relapse‑free survival (RFS) time was used during the analysis. Prognostic reliability of the six‑gene model was validated using data of an independent cohort from the International Cancer Genome Consortium. In conclusion, a combination of CAM alterations contributed to progression and aggressiveness of EC. The six‑gene signature was effective for predicting worse OS and RFS in patients with EC and could be complementary to the present clinical prognostic criteria.
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1 

Van Nyen T, Moiola CP, Colas E, Annibali D and Amant F: Modeling endometrial cancer: Past, present, and future. Int J Mol Sci. 19:E23482018. View Article : Google Scholar : PubMed/NCBI

2 

Suhaimi SS, Ab Mutalib NS and Jamal R: Understanding molecular landscape of endometrial cancer through next generation sequencing: What we have learned so far? Front Pharmacol. 7:4092016. View Article : Google Scholar : PubMed/NCBI

3 

Jonathan SB: Uterine Cancer. Gynecology. Lippincott Williams & Wilkins; USA: pp. 1343–1402. 2011

4 

Thomas S, Hussein Y, Bandyopadhyay S, Cote M, Hassan O, Abdulfatah E, Alosh B, Guan H, Soslow RA and Ali-Fehmi R: Interobserver variability in the diagnosis of uterine high-grade endometrioid carcinoma. Arch Pathol Lab Med. 140:836–843. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Hoang LN, Kinloch MA, Leo JM, Grondin K, Lee CH, Ewanowich C, Köbel M, Cheng A, Talhouk A, McConechy M, et al: Interobserver agreement in endometrial carcinoma histotype diagnosis varies depending on the cancer genome atlas (TCGA)-based molecular subgroup. Am J Surg Pathol. 4:245–252. 2017. View Article : Google Scholar

6 

Bosse T, Nout RA, McAlpine JN, McConechy MK, Britton H, Hussein YR, Gonzalez C, Ganesan R, Steele JC, Harrison BT, et al: Molecular classification of grade 3 endometrioid endometrial cancers identifies distinct prognostic subgroups. Am J Surg Pathol. 42:561–568. 2018.PubMed/NCBI

7 

Abdulfatah E, Ahmed Q, Alosh B, Bandyopadhyay S, Bluth MH and Ali-Fehmi R: Gynecologic cancers: Molecular updates 2018. Clin Lab Med. 38:421–438. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Cancer Genome Atlas Research Network, ; Kandoth C, Schultz N, Cherniack AD, Akbani R, Liu Y, Shen H, Robertson AG, Pashtan I, Shen R, et al: Integrated genomic characterization of endometrial carcinoma. Nature. 497:67–73. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Guan X: Cancer metastases: Challenges and opportunities. Acta Pharm Sin B. 5:402–418. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Bombardelli L and Cavallaro U: Immunoglobulin-like cell adhesion molecules: Novel signaling players in epithelial ovarian cancer. Int J Biochem Cell Biol. 42:590–594. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Byron A and Frame MC: Adhesion protein networks reveal functions proximal and distal to cell-matrix contacts. Curr Opin Cell Biol. 39:93–100. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Lewczuk L, Pryczynicz A and Guzinska-Ustymowicz K: Cell adhesion molecules in endometrial cancer-A systematic review. Adv Med Sci. 64:423–429. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Lodish H, Berk A, Zipursky SL, Matsudaira P, Baltimore D and Darnell J: Cell-Cell Adhesion and Communication. Molecular Cell Biology. 4th. W.H.Freeman; New York, NY USA: pp. 927–933. 2016

14 

Samatov TR, Wicklein D and Tonevitsky AG: L1CAM: Cell adhesion and more. Prog Histochem Cytochem. 51:25–32. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Dellinger TH, Smith DD, Ouyang C, Warden CD, Williams JC and Han ES: L1CAM is an independent predictor of poor survival in endometrial cancer-An analysis of the cancer genome atlas (TCGA). Gynecol Oncol. 141:336–340. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Kommoss F, Kommoss F, Grevenkamp F, Bunz AK, Taran FA, Fend F, Brucker SY, Wallwiener D, Schönfisch B, Greif K, et al: L1CAM: Amending the ‘low-risk’ category in endometrial carcinoma. J Cancer Res Clin Oncol. 143:255–262. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Nam KH, Noh TW, Chung SH, Lee SH, Lee MK, Hong SW, Chung WY, Lee EJ and Park CS: Expression of the membrane mucins MUC4 and MUC15, potential markers of malignancy and prognosis, in papillary thyroid carcinoma. Thyroid. 21:745–750. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Yang WB and Li CY: Correlations of MUC15 overexpression with clinicopathological features and prognosis of glioma. J Huazhong Univ Sci Technolog Med Sci. 34:254–259. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Leem YE, Ha HL, Bae JH, Baek KH and Kang JS: CDO, an Hh-coreceptor, mediates lung cancer cell proliferation and tumorigenicity through Hedgehog signaling. PLoS One. 9:e1117012014. View Article : Google Scholar : PubMed/NCBI

20 

Fonseca AL, da Silva VL, da Fonseca MM, Meira IT, da Silva TE, Kroll JE, Ribeiro-Dos-Santos AM, Freitas CR, Furtado R, de Souza JE, et al: Bioinformatics analysis of the human surfaceome reveals new targets for a variety of tumor types. Int J Genomics. 2016:83461982016. View Article : Google Scholar : PubMed/NCBI

21 

Chang HY, Chang HM, Wu TJ, Chaing CY, Tzai TS, Cheng HL, Raghavaraju G, Chow NH and Liu HS: The role of lutheran/basal cell adhesion molecule in human bladder carcinogenesis. J Biomed Sci. 24:612017. View Article : Google Scholar : PubMed/NCBI

22 

Kreuzinger C, Geroldinger A, Smeets D, Braicu EI, Sehouli J, Koller J, Wolf A, Darb-Esfahani S, Joehrens K, Vergote I, et al: A complex network of tumor microenvironment in human high-grade serous ovarian cancer. Clin Cancer Res. 23:7621–7632. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Boguslawska J, Kedzierska H, Poplawski P, Rybicka B, Tanski Z and Piekielko-Witkowska A: Expression of genes involved in cellular adhesion and extracellular matrix remodeling correlates with poor survival of patients with renal cancer. J Urol. 195:1892–1902. 2016. View Article : Google Scholar : PubMed/NCBI

24 

International Cancer Genome Consortium, ; Hudson TJ, Anderson W, Artez A, Barker AD, Bell C, Bernabé RR, Bhan MK, Calvo F, Eerola I, et al: International network of cancer genome projects. Nature. 464:993–998. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Camp RL, Dolled-Filhart M and Rimm DL: X-tile a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization. Clin Cancer Res. 10:7252–7259. 2004. View Article : Google Scholar : PubMed/NCBI

26 

FIGO Committee on Gynecologic Oncology, . FIGO staging for carcinoma of the vulva, cervix, and corpus uteri. Int J Gynaecol Obstet. 125:97–98. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Rimsza LM, Unger JM, Tome ME and Leblanc ML: A strategy for full interrogation of prognostic gene expression patterns: Exploring the biology of diffuse large B cell lymphoma. PLoS One. 6:e222672011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
He X, Lei S, Zhang Q, Ma L, Li N and Wang J: Deregulation of cell adhesion molecules is associated with progression and poor outcomes in endometrial cancer: Analysis of The Cancer Genome Atlas data. Oncol Lett 19: 1906-1914, 2020.
APA
He, X., Lei, S., Zhang, Q., Ma, L., Li, N., & Wang, J. (2020). Deregulation of cell adhesion molecules is associated with progression and poor outcomes in endometrial cancer: Analysis of The Cancer Genome Atlas data. Oncology Letters, 19, 1906-1914. https://doi.org/10.3892/ol.2020.11295
MLA
He, X., Lei, S., Zhang, Q., Ma, L., Li, N., Wang, J."Deregulation of cell adhesion molecules is associated with progression and poor outcomes in endometrial cancer: Analysis of The Cancer Genome Atlas data". Oncology Letters 19.3 (2020): 1906-1914.
Chicago
He, X., Lei, S., Zhang, Q., Ma, L., Li, N., Wang, J."Deregulation of cell adhesion molecules is associated with progression and poor outcomes in endometrial cancer: Analysis of The Cancer Genome Atlas data". Oncology Letters 19, no. 3 (2020): 1906-1914. https://doi.org/10.3892/ol.2020.11295
Copy and paste a formatted citation
x
Spandidos Publications style
He X, Lei S, Zhang Q, Ma L, Li N and Wang J: Deregulation of cell adhesion molecules is associated with progression and poor outcomes in endometrial cancer: Analysis of The Cancer Genome Atlas data. Oncol Lett 19: 1906-1914, 2020.
APA
He, X., Lei, S., Zhang, Q., Ma, L., Li, N., & Wang, J. (2020). Deregulation of cell adhesion molecules is associated with progression and poor outcomes in endometrial cancer: Analysis of The Cancer Genome Atlas data. Oncology Letters, 19, 1906-1914. https://doi.org/10.3892/ol.2020.11295
MLA
He, X., Lei, S., Zhang, Q., Ma, L., Li, N., Wang, J."Deregulation of cell adhesion molecules is associated with progression and poor outcomes in endometrial cancer: Analysis of The Cancer Genome Atlas data". Oncology Letters 19.3 (2020): 1906-1914.
Chicago
He, X., Lei, S., Zhang, Q., Ma, L., Li, N., Wang, J."Deregulation of cell adhesion molecules is associated with progression and poor outcomes in endometrial cancer: Analysis of The Cancer Genome Atlas data". Oncology Letters 19, no. 3 (2020): 1906-1914. https://doi.org/10.3892/ol.2020.11295
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