Long non‑coding RNA ELF3‑antisense RNA 1 promotes osteosarcoma cell proliferation by upregulating Kruppel‑like factor 12 potentially via methylation of the microRNA‑205 gene

  • Authors:
    • Jianmin Yuan
    • Jianhui Kang
    • Min Yang
  • View Affiliations

  • Published online on: January 16, 2020     https://doi.org/10.3892/ol.2020.11312
  • Pages: 2475-2480
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Abstract

A recent study characterized the long non‑coding RNA (lncRNA) ELF3‑antisense RNA 1 (ELF3‑AS1) as an oncogenic lncRNA in bladder cancer. The present study aimed to investigate the role of ELF3‑AS1 in osteosarcoma (OS). It was found that ELF3‑AS1 was upregulated in OS tissues, and ELF3‑AS1 expression level increased with increasing clinical stage. In OS tissues, Kruppel‑like factor 12 (KLF12) was positively correlated with ELF3‑AS1, while microRNA (miR)‑205 was negatively correlated with ELF3‑AS1. ELF3‑AS1 overexpression resulted in the upregulation of KLF12, but the downregulation of miR‑205. Overexpression of miR‑205 caused downregulation of KLF12, but had no significant effects on ELF3‑AS1 expression. Overexpression of KLF12 showed no significant impact on ELF3‑AS1 and miR‑205. ELF3‑AS1 and KLF12 overexpression resulted in an increased proliferation rate in OS cells, while miR‑205 played an opposite role and attenuated the effects of ELF3‑AS1 overexpression. ELF3‑AS1 overexpression promoted the methylation of the miR‑205 gene. Therefore, ELF3‑AS1 may promote OS cell proliferation by upregulating KLF12 through the methylation of the miR‑205 gene.

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March 2020
Volume 19 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Yuan, J., Kang, J., & Yang, M. (2020). Long non‑coding RNA ELF3‑antisense RNA 1 promotes osteosarcoma cell proliferation by upregulating Kruppel‑like factor 12 potentially via methylation of the microRNA‑205 gene. Oncology Letters, 19, 2475-2480. https://doi.org/10.3892/ol.2020.11312
MLA
Yuan, J., Kang, J., Yang, M."Long non‑coding RNA ELF3‑antisense RNA 1 promotes osteosarcoma cell proliferation by upregulating Kruppel‑like factor 12 potentially via methylation of the microRNA‑205 gene". Oncology Letters 19.3 (2020): 2475-2480.
Chicago
Yuan, J., Kang, J., Yang, M."Long non‑coding RNA ELF3‑antisense RNA 1 promotes osteosarcoma cell proliferation by upregulating Kruppel‑like factor 12 potentially via methylation of the microRNA‑205 gene". Oncology Letters 19, no. 3 (2020): 2475-2480. https://doi.org/10.3892/ol.2020.11312