Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
March-2020 Volume 19 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2020 Volume 19 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Triple negative endometrial cancer: Incidence and prognosis in a monoinstitutional series of 220 patients

  • Authors:
    • Rosa Porzio
    • Claudia Cordini
    • Anna Maria Rodolfi
    • Francesca Brigati
    • Alessandro Ubiali
    • Manuela Proietto
    • Camilla Di Nunzio
    • Luigi Cavanna
  • View Affiliations / Copyright

    Affiliations: Department of Oncology and Hematology, Piacenza General Hospital, Piacenza I‑29121, Italy, Department of Pathology, Piacenza General Hospital, Piacenza I‑29121, Italy, Department of Molecular Biology Unit, Piacenza General Hospital, Piacenza I‑29121, Italy
  • Pages: 2522-2526
    |
    Published online on: January 22, 2020
       https://doi.org/10.3892/ol.2020.11329
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Endometrial cancer (EC) represents the most frequently occuring gynecological tumor worldwide. The aim of the present study was to estimate the prognostic value of triple negative phenotype (TNP) in EC, and any associations with to pathological and clinical characteristics. The present study includes 220 cases of patients with EC who underwent to surgery at the Guglielmo da Saliceto Hospital of Piacenza (Italy) and the expressions of estrogen receptor (ER), progesterone receptor (PR) and oncoprotein c‑erbB‑2 (HER2) expression were examined. Pearson's Chi‑square and Fisher's exact test were used to evaluate the association of TNP cases with variables associated with a worse prognosis. Progression‑free survival (PFS) and overall survival (OS) were analyzed with Kaplan‑Meier curves. A total of 26 patients (12%) had a TNP, and these cases had a higher percentage of high‑risk histology, an advanced stage of disease at the time of diagnosis, with shorter PFS and OS when compared to non‑TNP. The present study confirmed that TNP represents prognostic significance in EC.
View Figures

Figure 1

View References

1 

Jemal A, Siegel R, Ward E, Hao Y, Xu J and Thun MJ: Cancer statistics, 2009. CA Cancer J Clin. 59:225–249. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Colombo N, Preti E, Landoni F, Carinelli S, Colombo A, Marini C and Sessa C; ESMO Guidelines Working Group, : Endometrial cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 24 (Suppl 6):vi33–vi38. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Kounelis S, Kapranos N, Kouri E, Coppola D, Papadaki H and Jones MW: Immunohistochemical profile of endometrial adenocarcinoma: A study of 61 cases and review of the literature. Mod Pathol. 13:379–388. 2000. View Article : Google Scholar : PubMed/NCBI

4 

Talhouk A, McConechy MK, Leung S, Li-Chang HH, Kwon JS, Melnyk N, Yang W, Senz J, Boyd N, Karnezis AN, et al: A clinically applicable molecular-based classification for endometrial cancers. Br J Cancer. 113:299–310. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Wu T, Wang Y, Jiang R, Lu X and Tian J: A pathways-based prediction model for classifying breast cancer subtypes. Oncotarget. 8:58809–58822. 2017.PubMed/NCBI

6 

Jahn B, Rochau U, Kurzthaler C, Hubalek M, Miksad R, Sroczynski G, Paulden M, Bundo M, Stenehjem D, Brixner D, et al: Personalized treatment of women with early breast cancer: A risk-group specific cost-effectiveness analysis of adjuvant chemotherapy accounting for companion prognostic tests OncotypeDX and Adjuvant!Online. BMC Cancer. 17:6852017. View Article : Google Scholar : PubMed/NCBI

7 

Prat A, Pineda E, Adamo B, Galván P, Fernández A, Gaba L, Díez M, Viladot M, Arance A and Muñoz M: Clinical implications of the intrinsic molecular subtypes of breast cancer. Breast. 24 (Suppl 2):S26–S35. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Dai X, Li T, Bai Z, Yang Y, Liu X, Zhan J and Shi B: Breast cancer intrinsic subtype classification, clinical use and future trends. Am J Cancer Res. 5:2929–2943. 2015.PubMed/NCBI

9 

Oakman C, Viale G and Di Leo A: Management of triple negative breast cancer. Breast. 19:312–321. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Trivers KF, Lund MJ, Porter PL, Liff JM, Flagg EW, Coates RJ and Eley JW: The epidemiology of triple-negative breast cancer, including race. Cancer Causes Control. 20:1071–1082. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Anders CK and Carey LA: Biology, metastatic patterns, and treatment of patients with triple-negative breast cancer. Clin Breast Cancer. 9 (Suppl 2):S73–S81. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Shabani N, Kuhn C, Kunze S, Schulze S, Mayr D, Dian D, Gingelmaier A, Schindlback C, Willgeroth F, Sommer H, et al: Prognostic significance of oestrogen receptor alpha (ERalpha) and beta (ERbeta), progesterone receptor A (PR-A) and B (PR-B) in endometrial carcinomas. Eur J Cancer. 43:2434–2444. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Khalifa MA, Mannel RS, Haraway SD, Walker J and Min KV: Expression of EGFR, HER2/neu, P53, and PCNA in endometrioid, serous papillary, and clear cell endometrial adenocarcinomas. Gynecol Oncol. 53:84–92. 1994. View Article : Google Scholar : PubMed/NCBI

14 

Samarnthai N, Hall K and Yeh IT: Molecular profiling of endometrial malignancies. Obstet Gynecol Int. 2010:1623632010. View Article : Google Scholar : PubMed/NCBI

15 

Trovik J, Wik E, Werner HM, Krakstad C, Helland H, Vandenput I, Njolstad TS, Stefansson IM, Marcickiewicz J, Tingulstad S, et al: Hormone receptor loss in endometrial carcinoma curettage predicts lymph node metastasis and poor outcome in prospective multicentre trial. Eur J Cancer. 49:3431–3441. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Kothari R, Morrison C, Richardson D, Seward S, O'Malley D, Copeland L, Fowler J and Cohn DE: The prognostic significance of the triple negative phenotype in endometrial cancer. Gynecol Oncol. 118:172–175. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Liu N, Wang X and Sheng X: The clinicopathological characteristics of ‘triple-negative’ epithelial ovarian cancer. J Clin Pathol. 63:240–243. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Bulsa M and Urasińska E: Triple negative endometrial cancer. Ginekol Pol. 88:212–214. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Domagala P, Huzarski T, Lubinski J, Gugala K and Domagala W: PARP-1 expression in breast cancer including BRCA1-associated, triple negative and basal-like tumors: Possible implications for PARP-1 inhibitor therapy. Breast Cancer Res Treat. 127:861–869. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Dedes KJ, Wetterskog D, Mendes-Pereira AM, Natrajan R, Lambros MB, Geyer FC, Vatcheva R, Savage K, Mackay A, Lord CJ, et al: PTEN deficiency in endometrioid endometrial adenocarcinomas predicts sensitivity to PARP inhibitors. Sci Transl Med. 2:53ra752010. View Article : Google Scholar : PubMed/NCBI

21 

Zhou C, Bae-Jump VL, Whang YE, Gehrig PA and Boggess JF: The PTEN tumor suppressor inhibits telomerase activity in endometrial cancer cells by decreasing hTERT mRNA levels. Gynecol Oncol. 101:305–310. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Łapińska-Szumczyk SM, Supernat AM, Majewska HI, Gulczyński J, Biernat W, Wydra D and Żaczek AJ: Immunohistochemical characterisation of molecular subtypes in endometrial cancer. Int J Clin Exp Med. 8:21981–21990. 2015.PubMed/NCBI

23 

Jiang XF, Tang QL, Shen XM, Li HG, Chen LH, Wang XY, Luo X, Lin ZQ and Jiang GY: Tumor-associated macrophages, epidermal growth factor receptor correlated with the triple negative phenotype in endometrial endometrioid adenocarcinoma. Pathol Res Pract. 208:730–735. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Kwon MJ, Park S, Choi JY, Oh E, Kim YJ, Park YH, Cho EY, Know MJ, Nam SJ, Im YH, et al: Clinical significance of CD151 overexpression in subtypes of invasive breast cancer. Br J Cancer. 106:923–930. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Colombo N, Creutzberg C, Amant F, Bosse T, González-Martín A, Ledermann J, Marth C, Nout R, Querleu D, Mirza MR, et al: ESMO-ESGO-ESTRO consensus conference on endometrial cancer: Diagnosis, treatment and follow-up. Ann Oncol. 27:16–41. 2016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Porzio R, Cordini C, Rodolfi AM, Brigati F, Ubiali A, Proietto M, Di Nunzio C and Cavanna L: Triple negative endometrial cancer: Incidence and prognosis in a monoinstitutional series of 220 patients. Oncol Lett 19: 2522-2526, 2020.
APA
Porzio, R., Cordini, C., Rodolfi, A.M., Brigati, F., Ubiali, A., Proietto, M. ... Cavanna, L. (2020). Triple negative endometrial cancer: Incidence and prognosis in a monoinstitutional series of 220 patients. Oncology Letters, 19, 2522-2526. https://doi.org/10.3892/ol.2020.11329
MLA
Porzio, R., Cordini, C., Rodolfi, A. M., Brigati, F., Ubiali, A., Proietto, M., Di Nunzio, C., Cavanna, L."Triple negative endometrial cancer: Incidence and prognosis in a monoinstitutional series of 220 patients". Oncology Letters 19.3 (2020): 2522-2526.
Chicago
Porzio, R., Cordini, C., Rodolfi, A. M., Brigati, F., Ubiali, A., Proietto, M., Di Nunzio, C., Cavanna, L."Triple negative endometrial cancer: Incidence and prognosis in a monoinstitutional series of 220 patients". Oncology Letters 19, no. 3 (2020): 2522-2526. https://doi.org/10.3892/ol.2020.11329
Copy and paste a formatted citation
x
Spandidos Publications style
Porzio R, Cordini C, Rodolfi AM, Brigati F, Ubiali A, Proietto M, Di Nunzio C and Cavanna L: Triple negative endometrial cancer: Incidence and prognosis in a monoinstitutional series of 220 patients. Oncol Lett 19: 2522-2526, 2020.
APA
Porzio, R., Cordini, C., Rodolfi, A.M., Brigati, F., Ubiali, A., Proietto, M. ... Cavanna, L. (2020). Triple negative endometrial cancer: Incidence and prognosis in a monoinstitutional series of 220 patients. Oncology Letters, 19, 2522-2526. https://doi.org/10.3892/ol.2020.11329
MLA
Porzio, R., Cordini, C., Rodolfi, A. M., Brigati, F., Ubiali, A., Proietto, M., Di Nunzio, C., Cavanna, L."Triple negative endometrial cancer: Incidence and prognosis in a monoinstitutional series of 220 patients". Oncology Letters 19.3 (2020): 2522-2526.
Chicago
Porzio, R., Cordini, C., Rodolfi, A. M., Brigati, F., Ubiali, A., Proietto, M., Di Nunzio, C., Cavanna, L."Triple negative endometrial cancer: Incidence and prognosis in a monoinstitutional series of 220 patients". Oncology Letters 19, no. 3 (2020): 2522-2526. https://doi.org/10.3892/ol.2020.11329
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team