Triple negative endometrial cancer: Incidence and prognosis in a monoinstitutional series of 220 patients

  • Authors:
    • Rosa Porzio
    • Claudia Cordini
    • Anna Maria Rodolfi
    • Francesca Brigati
    • Alessandro Ubiali
    • Manuela Proietto
    • Camilla Di Nunzio
    • Luigi Cavanna
  • View Affiliations

  • Published online on: January 22, 2020     https://doi.org/10.3892/ol.2020.11329
  • Pages: 2522-2526
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Abstract

Endometrial cancer (EC) represents the most frequently occuring gynecological tumor worldwide. The aim of the present study was to estimate the prognostic value of triple negative phenotype (TNP) in EC, and any associations with to pathological and clinical characteristics. The present study includes 220 cases of patients with EC who underwent to surgery at the Guglielmo da Saliceto Hospital of Piacenza (Italy) and the expressions of estrogen receptor (ER), progesterone receptor (PR) and oncoprotein c‑erbB‑2 (HER2) expression were examined. Pearson's Chi‑square and Fisher's exact test were used to evaluate the association of TNP cases with variables associated with a worse prognosis. Progression‑free survival (PFS) and overall survival (OS) were analyzed with Kaplan‑Meier curves. A total of 26 patients (12%) had a TNP, and these cases had a higher percentage of high‑risk histology, an advanced stage of disease at the time of diagnosis, with shorter PFS and OS when compared to non‑TNP. The present study confirmed that TNP represents prognostic significance in EC.

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March 2020
Volume 19 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Porzio, R., Cordini, C., Rodolfi, A.M., Brigati, F., Ubiali, A., Proietto, M. ... Cavanna, L. (2020). Triple negative endometrial cancer: Incidence and prognosis in a monoinstitutional series of 220 patients. Oncology Letters, 19, 2522-2526. https://doi.org/10.3892/ol.2020.11329
MLA
Porzio, R., Cordini, C., Rodolfi, A. M., Brigati, F., Ubiali, A., Proietto, M., Di Nunzio, C., Cavanna, L."Triple negative endometrial cancer: Incidence and prognosis in a monoinstitutional series of 220 patients". Oncology Letters 19.3 (2020): 2522-2526.
Chicago
Porzio, R., Cordini, C., Rodolfi, A. M., Brigati, F., Ubiali, A., Proietto, M., Di Nunzio, C., Cavanna, L."Triple negative endometrial cancer: Incidence and prognosis in a monoinstitutional series of 220 patients". Oncology Letters 19, no. 3 (2020): 2522-2526. https://doi.org/10.3892/ol.2020.11329