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Article

Stereotactic body radiotherapy feasibility for patients with peripheral stage Ι lung cancer and poor pulmonary function

  • Authors:
    • Aiko Koba
    • Kazuhiko Hayashi
    • Osamu Suzuki
    • Yoshifumi Kawaguchi
    • Kazuhiko Ogawa
    • Masashi Chatani
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Osaka University Graduate School of Medicine, Suita, Osaka 565‑0871, Japan, Department of Radiation Oncology, Osaka Rosai Hospital, Sakai, Osaka 591‑8025, Japan, Osaka Heavy Ion Therapy Center, Osaka, Osaka 540‑0008, Japan
  • Pages: 2515-2521
    |
    Published online on: January 22, 2020
       https://doi.org/10.3892/ol.2020.11333
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Abstract

The aim of the present study was to evaluate the toxicity and investigate the prognostic factors of stereotactic body radiotherapy (SBRT) for peripheral stage Ι lung cancer in patients with poor pulmonary function. Data from 95 patients with stage I lung cancer with poor pulmonary function treated using SBRT at Osaka Rosai Hospital were retrospectively analyzed. Poor pulmonary function was defined as the forced expiratory volume %/sec (FEV1/FVC) <70% or percentage of vital capacity (%VC) <80% during pretreatment spirometry testing. The median FEV1/FVC and %VC of the patients were 59.1 and 78.8%, respectively. The most commonly prescribed dose of SBRT was 50 Gy in four fractions (68 patients, 72%). The median follow‑up period was 34 months. Four patients developed adverse effects of grade ≥3, one patient developed grade 5 radiation pneumonitis, one grade 5 hemoptysis, one grade 3 radiation pneumonitis and one grade 3 chest wall pain. The 3‑year local control and overall survival (OS) rates were 78.8 and 59.9%, respectively. Univariate analysis revealed that Karnofsky performance status (KPS) significantly predicted OS (P=0.037). Thus, SBRT in patients with stage I lung cancer with poor pulmonary function may be effective with acceptable toxicity. A KPS score ≥80 indicated good prognosis.
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1 

Blomgren H, Lax I, Näslund I and Svanström R: Stereotactic high dose fraction radiation therapy of extracranial tumors using an accelerator. Clinical experience of the first thirty-one patients. Acta Oncol. 34:861–870. 1995. View Article : Google Scholar : PubMed/NCBI

2 

Uematsu M, Shioda A, Suda A, Fukui T, Ozeki Y, Hama Y, Wong JR and Kusano S: Computed tomography-guided frameless stereotactic radiotherapy for stage I non-small cell lung cancer: A 5-year experience. Int J Radiat Oncol Biol Phys. 51:666–670. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Nagata Y, Takayama K, Matsuo Y, Norihisa Y, Mizowaki T, Sakamoto T, Sakamoto M, Mitsumori M, Shibuya K, Araki N, et al: Clinical outcomes of a phase I/II study of 48 Gy of stereotactic body radiotherapy in 4 fractions for primary lung cancer using a stereotactic body frame. Int J Radiat Oncol Biol Phys. 63:1427–1431. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Onimaru R, Shirato H, Shimizu S, Kitamura K, Xu B, Fukumoto S, Chang TC, Fujita K, Oita M, Miyasaka K, et al: Tolerance of organs at risk in small-volume, hypofractionated, image-guided radiotherapy for primary and metastatic lung cancers. Int J Radiat Oncol Biol Phys. 56:126–135. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Timmerman R, Paulus R, Galvin J, Michalski J, Straube W, Bradley J, Fakiris A, Bezjak A, Videtic G, Johnstone D, et al: Stereotactic body radiation therapy for inoperable early stage lung cancer. JAMA. 303:1070–1076. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Wulf J, Haedinger U, Oppitz U, Thiele W, Mueller G and Flentje M: Stereotactic radiotherapy for primary lung cancer and pulmonary metastases: A noninvasive treatment approach in medically inoperable patients. Int J Radiat Oncol Biol Phys. 60:186–196. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Xia T, Li H, Sun Q, Wang Y, Fan N, Yu Y, Li P and Chang JY: Promising clinical outcome of stereotactic body radiation therapy for patients with inoperable Stage I/II non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 66:117–125. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Baumann P, Nyman J, Hoyer M, Wennberg B, Gagliardi G, Lax I, Drugge N, Ekberg L, Friesland S, Johansson K-A, et al: Outcome in a prospective phase II trial of medically inoperable stage I non-small-cell lung cancer patients treated with stereotactic body radiotherapy. J Clin Oncol. 27:3290–3296. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Nagata Y, Hiraoka M, Shibata T, Onishi H, Kokubo M, Karasawa K, Shioyama Y, Onimaru R, Kozuka T, Kunieda E, et al: Prospective trial of stereotactic body radiation therapy for both operable and inoperable T1N0M0 non-small cell lung cancer: Japan Clinical Oncology Group Study JCOG0403. Int J Radiat Oncol Biol Phys. 93:989–996. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Nagata Y and Kimura T: Stereotactic body radiotherapy (SBRT) for Stage I lung cancer. Jpn J Clin Oncol. 48:405–409. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Palma D, Lagerwaard F, Rodrigues G, Haasbeek C and Senan S: Curative treatment of Stage I non-small-cell lung cancer in patients with severe COPD: Stereotactic radiotherapy outcomes and systematic review. Int J Radiat Oncol Biol Phys. 82:1149–1156. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Chen H, Senan S, Nossent EJ, Boldt RG, Warner A, Palma DA and Louie AV: Treatment-related toxicity in patients with early-stage non-small cell lung cancer and coexisting interstitial lung disease: A systematic review. Int J Radiat Oncol Biol Phys. 98:622–631. 2017. View Article : Google Scholar : PubMed/NCBI

13 

International Union Against Cancer: TNM Classification of Malignant Tumours. Sobin LH, Gospodarowicz MK and Wittekind C: 7th. Wiley-Blackwell Inc.; New York, NY: 2009

14 

Péus D, Newcomb N and Hofer S: Appraisal of the Karnofsky Performance Status and proposal of a simple algorithmic system for its evaluation. BMC Med Inform Decis Mak. 13:722013. View Article : Google Scholar : PubMed/NCBI

15 

U.S. Department of Health and Human Services, National Institutes of Health National Cancer Institute, . Common Terminology Criteria for Adverse Events (CTCAE). Version 4.0. https://www.eortc.be/services/doc/ctc/CTCAE_4.03_2010-06-14_QuickReference_5×7.pdfMay 28–2009

16 

Guckenberger M, Kestin LL, Hope AJ, Belderbos J, Werner-Wasik M, Yan D, Sonke J-J, Bissonnette JP, Wilbert J, Xiao Y, et al: Is there a lower limit of pretreatment pulmonary function for safe and effective stereotactic body radiotherapy for early-stage non-small cell lung cancer? J Thorac Oncol. 7:542–551. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Henderson M, McGarry R, Yiannoutsos C, Fakiris A, Hoopes D, Williams M and Timmerman R: Baseline pulmonary function as a predictor for survival and decline in pulmonary function over time in patients undergoing stereotactic body radiotherapy for the treatment of stage I non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 72:404–409. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Stone B, Mangona VS, Johnson MD, Ye H and Grills IS: Changes in Pulmonary Function Following Image-Guided Stereotactic Lung Radiotherapy: Neither Lower Baseline Nor Post-SBRT Pulmonary Function Are Associated with Worse Overall Survival. J Thorac Oncol. 10:1762–1769. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Shibamoto Y, Hashizume C, Baba F, Ayakawa S, Manabe Y, Nagai A, Miyakawa A, Murai T, Iwata H, Mori Y, et al: Stereotactic body radiotherapy using a radiobiology-based regimen for stage I nonsmall cell lung cancer: A multicenter study. Cancer. 118:2078–2084. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Koba A, Hayashi K, Suzuki O, Kawaguchi Y, Ogawa K and Chatani M: Stereotactic body radiotherapy feasibility for patients with peripheral stage Ι lung cancer and poor pulmonary function. Oncol Lett 19: 2515-2521, 2020.
APA
Koba, A., Hayashi, K., Suzuki, O., Kawaguchi, Y., Ogawa, K., & Chatani, M. (2020). Stereotactic body radiotherapy feasibility for patients with peripheral stage Ι lung cancer and poor pulmonary function. Oncology Letters, 19, 2515-2521. https://doi.org/10.3892/ol.2020.11333
MLA
Koba, A., Hayashi, K., Suzuki, O., Kawaguchi, Y., Ogawa, K., Chatani, M."Stereotactic body radiotherapy feasibility for patients with peripheral stage Ι lung cancer and poor pulmonary function". Oncology Letters 19.3 (2020): 2515-2521.
Chicago
Koba, A., Hayashi, K., Suzuki, O., Kawaguchi, Y., Ogawa, K., Chatani, M."Stereotactic body radiotherapy feasibility for patients with peripheral stage Ι lung cancer and poor pulmonary function". Oncology Letters 19, no. 3 (2020): 2515-2521. https://doi.org/10.3892/ol.2020.11333
Copy and paste a formatted citation
x
Spandidos Publications style
Koba A, Hayashi K, Suzuki O, Kawaguchi Y, Ogawa K and Chatani M: Stereotactic body radiotherapy feasibility for patients with peripheral stage Ι lung cancer and poor pulmonary function. Oncol Lett 19: 2515-2521, 2020.
APA
Koba, A., Hayashi, K., Suzuki, O., Kawaguchi, Y., Ogawa, K., & Chatani, M. (2020). Stereotactic body radiotherapy feasibility for patients with peripheral stage Ι lung cancer and poor pulmonary function. Oncology Letters, 19, 2515-2521. https://doi.org/10.3892/ol.2020.11333
MLA
Koba, A., Hayashi, K., Suzuki, O., Kawaguchi, Y., Ogawa, K., Chatani, M."Stereotactic body radiotherapy feasibility for patients with peripheral stage Ι lung cancer and poor pulmonary function". Oncology Letters 19.3 (2020): 2515-2521.
Chicago
Koba, A., Hayashi, K., Suzuki, O., Kawaguchi, Y., Ogawa, K., Chatani, M."Stereotactic body radiotherapy feasibility for patients with peripheral stage Ι lung cancer and poor pulmonary function". Oncology Letters 19, no. 3 (2020): 2515-2521. https://doi.org/10.3892/ol.2020.11333
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