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De novo metastatic breast cancer: Subgroup analysis of molecular subtypes and prognosis

  • Authors:
    • Li Zhang
    • Zhijun Li
    • Jie Zhang
    • Yansheng Wu
    • Yuying Zhu
    • Zhongsheng Tong
  • View Affiliations / Copyright

    Affiliations: Department of Breast Oncology, Key Laboratory of Breast Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, P.R. China, Department of Maxillofacial and Otorhinolaryngology, Head and Neck Surgery, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2884-2894
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    Published online on: January 30, 2020
       https://doi.org/10.3892/ol.2020.11359
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Abstract

The purpose of the present study was to analyze the clinical and pathological characteristics, treatment, and prognosis of de novo metastatic breast cancer (DnMBC). Information regarding 1,890 patients treated for advanced breast cancer at the Tianjin Medical University Cancer Hospital between January 2008 to December 2017 was collected. Clinicopathological characteristics, treatments and outcomes of these patients were compared using the chi‑square test, log‑rank test, and Cox regression analysis. A total of 171 patients were diagnosed with DnMBC. The median age at diagnosis was 53 years (range, 23‑77). The percentage of T4 staging was higher (37.4%), 69.6% of patients were estrogen receptor (ER) positive, 59.1% were progesterone receptor positive, 29.8% had positive human epidermal growth factor receptor 2 (HER2) status, 68.4% had Ki‑67 ≥20%, 55% had oligometastasis at the initial diagnosis, ~87.7% were treated with chemotherapy initially and 24% received palliative surgery for the primary tumor. After a median follow‑up time of 26 months, the median progression‑free survival (PFS) and overall survival (OS) among patients with DnMBC were 11 (8.7‑13.3) months and 34 (27.9‑40.1) months, respectively. In the multivariable model, ER status and sites of first metastasis (oligometastasis or polymetastasis) were identified to be independent predictors of PFS (P<0.05); ER status, primary tumor stage, and surgical treatment of primary tumors were identified to be independent predictors of OS (P<0.05). In conclusion, the clinicopathological characteristics of DnMBC are greater invasiveness and a higher risk of progression. Palliative surgical treatment may improve the prognosis of HR+/HER2‑patients with oligometastasis. Therefore, individualized treatment as required is particularly important.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang L, Li Z, Zhang J, Wu Y, Zhu Y and Tong Z: De novo metastatic breast cancer: Subgroup analysis of molecular subtypes and prognosis. Oncol Lett 19: 2884-2894, 2020.
APA
Zhang, L., Li, Z., Zhang, J., Wu, Y., Zhu, Y., & Tong, Z. (2020). De novo metastatic breast cancer: Subgroup analysis of molecular subtypes and prognosis. Oncology Letters, 19, 2884-2894. https://doi.org/10.3892/ol.2020.11359
MLA
Zhang, L., Li, Z., Zhang, J., Wu, Y., Zhu, Y., Tong, Z."De novo metastatic breast cancer: Subgroup analysis of molecular subtypes and prognosis". Oncology Letters 19.4 (2020): 2884-2894.
Chicago
Zhang, L., Li, Z., Zhang, J., Wu, Y., Zhu, Y., Tong, Z."De novo metastatic breast cancer: Subgroup analysis of molecular subtypes and prognosis". Oncology Letters 19, no. 4 (2020): 2884-2894. https://doi.org/10.3892/ol.2020.11359
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang L, Li Z, Zhang J, Wu Y, Zhu Y and Tong Z: De novo metastatic breast cancer: Subgroup analysis of molecular subtypes and prognosis. Oncol Lett 19: 2884-2894, 2020.
APA
Zhang, L., Li, Z., Zhang, J., Wu, Y., Zhu, Y., & Tong, Z. (2020). De novo metastatic breast cancer: Subgroup analysis of molecular subtypes and prognosis. Oncology Letters, 19, 2884-2894. https://doi.org/10.3892/ol.2020.11359
MLA
Zhang, L., Li, Z., Zhang, J., Wu, Y., Zhu, Y., Tong, Z."De novo metastatic breast cancer: Subgroup analysis of molecular subtypes and prognosis". Oncology Letters 19.4 (2020): 2884-2894.
Chicago
Zhang, L., Li, Z., Zhang, J., Wu, Y., Zhu, Y., Tong, Z."De novo metastatic breast cancer: Subgroup analysis of molecular subtypes and prognosis". Oncology Letters 19, no. 4 (2020): 2884-2894. https://doi.org/10.3892/ol.2020.11359
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